SMEK1

General Information

Gene Name       : SMEK1
Gene ID             :
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SMEK1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SMEK1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SMEK1 RNA is bound by 25 proteins.  







eCLIP assay for SMEK1 is not avaliable on ENCORE database.





25 proteins are bound to SMEK1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr149192851891928581-3'-UTR,CDS,intron-Distal,intron-Proximal4.7105520.44120HepG2BCLAF1
chr149192509191925139-3'-UTR,CDS,intron-Distal,intron-Proximal5.3840011.47391HepG2BCLAF1
chr149192839191928435-3'-UTR,CDS,intron-Distal,intron-Proximal,polyA_site5.7348311.85134HepG2BCLAF1
chr149192793891927950-3'-UTR,CDS,intron-Distal5.6240710.81699HepG2BCLAF1
chr149192840591928445-3'-UTR,CDS,intron-Distal3.821185.47804K562ZNF622
chr149192908191929100-3'-UTR,CDS,intron-Distal5.452039.44272HepG2BCLAF1
chr149192501891925113-3'-UTR,CDS,intron-Distal,intron-Proximal3.631104.49016HepG2FXR2
chr149192791991927951-3'-UTR,CDS,intron-Distal4.574163.29312HepG2FXR2
chr149192848491928570-3'-UTR,CDS,intron-Distal,intron-Proximal3.229924.04703HepG2FXR2
chr149192847291928567-3'-UTR,CDS,intron-Distal,intron-Proximal4.284904.02380K562TRA2A
chr149192788691927938-3'-UTR,CDS,intron-Distal5.4663218.60206HepG2BCLAF1
chr149193160991931689-3'-UTR,CDS,intron-Distal3.8247413.87674HepG2BCLAF1
chr149192846091928532-3'-UTR,CDS,intron-Distal4.320098.94398K562UCHL5
chr149192775791927890-3'-UTR,CDS,intron-Distal3.341117.92361K562ZNF622
chr149192776791927812-3'-UTR,CDS,intron-Distal4.221035.13243HepG2GRWD1
chr149193164091931678-3'-UTR,CDS,intron-Distal3.266593.60157HepG2GRWD1
chr149192847491928518-3'-UTR,CDS,intron-Distal5.8950213.58086HepG2BCLAF1
chr149192847291928565-3'-UTR,CDS,intron-Distal4.380014.28240HepG2TRA2A
chr149193272691932787-3'-UTR,intron-Distal,intron-Proximal4.844676.35567HepG2PRPF8
chr149193707591937190-3'-UTR,CDS,intron-Distal,intron-Proximal3.207303.28806K562KHSRP
chr149192783491927878-3'-UTR,CDS,intron-Distal4.434834.72838K562UCHL5
chr149192792091927950-3'-UTR,CDS,intron-Distal3.475843.66187K562ZNF622
chr149197650691976554-5'-UTR,intron-Distal,intron-Proximal4.790756.46917K562ZNF622
chr149197645891976607-5'-UTR,intron-Distal,intron-Proximal3.5481219.61903HepG2DDX3X
chr149197649591976628-5'-UTR,intron-Distal,intron-Proximal3.303595.09292HepG2UCHL5
chr149197641291976477-5'-UTR,intron-Distal4.157825.77244K562UCHL5
chr149197597091976023-5'-UTR,CDS,intron-Distal,intron-Proximal3.901373.28989K562RBM15
chr149197598791976032-5'-UTR,CDS,intron-Distal,intron-Proximal3.362556.27275HepG2DDX3X
chr149197623391976281-5'-UTR,intron-Distal3.586237.70473HepG2DDX3X
chr149197629491976336-5'-UTR,intron-Distal3.187556.22359HepG2BUD13
chr149197623691976286-5'-UTR,intron-Distal3.685523.97086HepG2FTO
chr149197651391976584-5'-UTR,intron-Distal,intron-Proximal3.824886.43326K562UCHL5
chr149192513391925175-CDS,intron-Distal,intron-Proximal3.543144.88141HepG2GRWD1
chr149193964791939702-CDS,intron-Distal,intron-Proximal3.525914.44431K562BUD13
chr149194834491948407-CDS,intron-Distal,intron-Proximal5.113667.34525K562ZNF622
chr149195197591951987-CDS,intron-Distal,intron-Proximal3.907913.15232HepG2LIN28B
chr149194786291947938-CDS,intron-Distal,intron-Proximal3.130954.21588K562PRPF8
chr149194845591948536-CDS,intron-Distal3.822053.25843K562SRSF1
chr149197584291975946-CDS,intron-Distal,intron-Proximal4.130383.62765K562SRSF1
chr149193967291939757-CDS,intron-Distal,intron-Proximal4.3255210.09522K562GPKOW
chr149194846191948540-CDS,intron-Distal,intron-Proximal4.229677.73669HepG2LIN28B
chr149192513391925214-CDS,intron-Distal,intron-Proximal3.2635010.62736K562ZNF622
chr149194808591948145-CDS,intron-Distal3.098875.66840K562ZNF622
chr149194804791948096-CDS,intron-Distal3.704309.43524HepG2BCLAF1
chr149193970791939766-CDS,intron-Distal,intron-Proximal4.7444511.17285K562SF3B4
chr149193962291939734-CDS,intron-Distal,intron-Proximal3.001965.40388HepG2U2AF2
chr149194327291943333-CDS,intron-Distal,intron-Proximal3.087694.38519K562BUD13
chr149194788291947942-CDS,intron-Distal,intron-Proximal3.780033.71591HepG2PRPF8
chr149194227691942310-CDS,intron-Distal3.730927.83567HepG2BCLAF1
chr149194790791947968-CDS,intron-Distal,intron-Proximal3.480144.24159K562RBM15
chr149194848091948538-CDS,intron-Distal,intron-Proximal4.973577.16913K562LIN28B
chr149194810791948228-CDS,intron-Distal,intron-Proximal3.267836.63825HepG2GRWD1
chr149193961591939659-CDS,intron-Distal,intron-Proximal3.503064.41784HepG2GRWD1
chr149194834191948507-CDS,intron-Distal,intron-Proximal3.219076.64273K562YBX3
chr149194275191942798-CDS,intron-Distal,intron-Proximal4.1523010.35753HepG2BCLAF1
chr149197580091975883-CDS,intron-Distal,intron-Proximal3.9323812.76115HepG2PRPF8
chr149194833191948391-CDS,intron-Distal,intron-Proximal3.743866.04229K562RBM15
chr149195205391952100-CDS,intron-Distal,intron-Proximal3.800555.75388HepG2BUD13
chr149195197591951995-CDS,intron-Distal,intron-Proximal4.019203.69113K562LIN28B
chr149194840691948525-CDS,intron-Distal,intron-Proximal3.7296611.28431K562UCHL5
chr149194848991948528-CDS,intron-Distal3.205183.05460HepG2PPIG
chr149193958591939688-CDS,intron-Distal,intron-Proximal3.8098613.26331HepG2BCLAF1
chr149194843691948502-CDS,intron-Distal,intron-Proximal3.197465.75243K562ZNF622
chr149192517191925220-CDS,intron-Distal,intron-Proximal3.809516.65791HepG2BUD13
chr149192515591925227-CDS,intron-Distal,intron-Proximal4.443473.95187HepG2AQR
chr149193725791937326-CDS,intron-Distal3.6633912.82131HepG2BCLAF1
chr149193323591933310-intron-Distal4.021133.22972K562TARDBP
chr149194484891944933-intron-Distal3.044973.48890K562KHSRP
chr149195164491951707-intron-Distal3.361873.84025HepG2SUGP2
chr149197567191975746-intron-Distal4.8869517.19527HepG2EFTUD2
chr149197578191975800-intron-Distal,intron-Proximal4.261773.70131HepG2PRPF8
chr149197577991975845-intron-Distal,intron-Proximal3.315407.59371HepG2EFTUD2
chr149195165991951758-intron-Distal3.075443.27276HepG2HNRNPL
chr149194069591940849-intron-Distal3.019346.69005HepG2HNRNPL
chr149193633091936459-intron-Distal4.231485.02888K562KHSRP
chr149193187291931935-intron-Distal4.242863.79000HepG2U2AF2
chr149197468291974755-intron-Distal3.470283.32861HepG2U2AF2
chr149195003991950109-intron-Distal3.535274.57452HepG2SUGP2
chr149195038991950458-intron-Distal3.530635.08575HepG2SUGP2
chr149196142791961571-intron-Distal3.063974.14643HepG2KHSRP
chr149193706391937155-intron-Distal,intron-Proximal4.796645.70555K562PRPF8
chr149195050091950563-intron-Distal4.037523.50357HepG2QKI
chr149196354791963635-intron-Distal3.722725.90050K562TARDBP
chr149196248991962561-intron-Distal4.110213.71677HepG2HNRNPL
chr149195104291951118-intron-Distal3.123505.12506HepG2SUGP2
chr149194177091941837-intron-Distal3.856865.55177K562PRPF8
chr149194203691942072-intron-Distal,intron-Proximal4.321663.49003K562PRPF8
chr149195133091951421-intron-Distal3.972096.51675HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SMEK1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SMEK1 is not available on ENCORE database.

  • 66 RBPs can affect the levels of SMEK1.  








The Knockdown/knockout RNA-Seq assay for SMEK1 is not available on ENCORE database.





66 RBPs can affect the gene expression of SMEK1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SMEK1ENSG00000100796.131087.357802470.18690-1.183804.906603.59460HepG2CCAR1
SMEK1ENSG00000100796.131046.144401280.48860-0.291602.285301.46450HepG2DDX24
SMEK1ENSG00000100796.13742.702301044.62880-0.492102.827701.42260HepG2DDX28
SMEK1ENSG00000100796.131668.953302063.53890-0.306201.985701.44700HepG2DDX3X
SMEK1ENSG00000100796.131031.654401310.54090-0.345203.827403.01080HepG2DNAJC21
SMEK1ENSG00000100796.131008.241801298.91950-0.365505.454304.58420HepG2DNAJC2
SMEK1ENSG00000100796.131289.506401704.07270-0.402203.051702.43000HepG2EIF2S1
SMEK1ENSG00000100796.131516.085101235.646700.295002.547301.51210HepG2EIF3G
SMEK1ENSG00000100796.132540.642402075.811600.291403.953202.98430HepG2EIF4G1
SMEK1ENSG00000100796.133029.889702459.608300.300704.805504.05250HepG2ETF1
SMEK1ENSG00000100796.131423.845001899.83710-0.416103.378102.61780HepG2FXR1
SMEK1ENSG00000100796.131367.554401762.56170-0.366102.449401.82130HepG2G3BP1
SMEK1ENSG00000100796.131075.210301323.09570-0.299302.262301.67340HepG2HNRNPA1
SMEK1ENSG00000100796.131060.950801579.88600-0.574505.943105.05710HepG2HNRNPLL
SMEK1ENSG00000100796.131070.082401461.95440-0.450207.289506.34220HepG2HNRNPU
SMEK1ENSG00000100796.131058.243401493.34080-0.4969010.961909.60750HepG2ILF2
SMEK1ENSG00000100796.131486.437101911.19260-0.362602.363501.77710HepG2MATR3
SMEK1ENSG00000100796.131711.596202086.49490-0.285703.065702.26360HepG2NOL12
SMEK1ENSG00000100796.131515.057001757.02190-0.213801.936301.46330HepG2PTBP1
SMEK1ENSG00000100796.131873.316402114.25640-0.174602.283801.73460HepG2PUM1
SMEK1ENSG00000100796.132296.064801508.017100.606403.473802.68610HepG2RAVER1
SMEK1ENSG00000100796.131795.214802055.76490-0.195501.878801.43040HepG2RBM22
SMEK1ENSG00000100796.132096.458901726.961300.279602.464601.82440HepG2RBM25
SMEK1ENSG00000100796.131681.105501955.36650-0.218002.195101.70210HepG2NELFE
SMEK1ENSG00000100796.132539.889701718.559700.563507.779506.72470HepG2RPLP0
SMEK1ENSG00000100796.131295.255001052.434300.299402.024401.34200HepG2RRP9
SMEK1ENSG00000100796.131130.377001301.94460-0.203901.940601.38490HepG2SAFB2
SMEK1ENSG00000100796.13851.274101121.14900-0.397302.811001.86410HepG2SERBP1
SMEK1ENSG00000100796.132948.928401983.454200.572104.291803.44170HepG2SF3A3
SMEK1ENSG00000100796.132240.040601563.723300.518405.901204.90410HepG2SF3B1
SMEK1ENSG00000100796.132151.737501829.221500.234202.726502.13890HepG2SF3B4
SMEK1ENSG00000100796.133002.436802321.888700.370707.543206.82700HepG2SRFBP1
SMEK1ENSG00000100796.132404.914001909.337800.332805.404004.79870HepG2SRSF1
SMEK1ENSG00000100796.131823.280601553.370900.231002.729102.18030HepG2SRSF9
SMEK1ENSG00000100796.132570.933902015.910400.350806.129305.42140HepG2SSB
SMEK1ENSG00000100796.132226.597801716.261000.375505.186904.45940HepG2TAF15
SMEK1ENSG00000100796.13973.541801433.25670-0.5580010.480909.48890HepG2TRIM56
SMEK1ENSG00000100796.132506.737801449.381400.7903012.9940011.59830HepG2U2AF1
SMEK1ENSG00000100796.131092.491501698.26400-0.6364014.1485012.95430HepG2UTP3
SMEK1ENSG00000100796.131737.596201237.709800.4893010.225209.07030HepG2ZC3H8
SMEK1ENSG00000100796.131612.905601934.58530-0.262403.992003.36740HepG2ZNF622
SMEK1ENSG00000100796.132039.576201506.026900.437402.712301.43350HepG2ZRANB2
SMEK1ENSG00000100796.131963.541101589.668500.304602.651702.01130K562AKAP8L
SMEK1ENSG00000100796.134439.428302102.299701.0783026.0111024.40880K562AQR
SMEK1ENSG00000100796.13375.87330528.41250-0.491403.341902.16010K562CCAR1
SMEK1ENSG00000100796.134025.167603194.196000.333504.427203.18690K562CELF1
SMEK1ENSG00000100796.132844.860602044.020900.4768010.252809.08880K562DDX47
SMEK1ENSG00000100796.131447.56810962.002300.589404.938703.18900K562EEF2
SMEK1ENSG00000100796.13768.78790537.500200.516202.431301.49330K562EIF3A
SMEK1ENSG00000100796.131602.73000995.448400.687006.958405.20850K562EIF3D
SMEK1ENSG00000100796.131304.899601093.379500.255002.300801.57120K562EIF3G
SMEK1ENSG00000100796.133316.547102597.916400.352205.944104.58510K562EIF4G2
SMEK1ENSG00000100796.131089.890901503.51580-0.464204.533403.42790K562FIP1L1
SMEK1ENSG00000100796.131464.463801142.173300.358504.347203.61300K562FXR1
SMEK1ENSG00000100796.131735.726001190.449100.543903.999803.11070K562G3BP2
SMEK1ENSG00000100796.131627.377902246.41590-0.465105.460904.39520K562GRSF1
SMEK1ENSG00000100796.132331.169801541.186800.596902.598101.42760K562HNRNPA2B1
SMEK1ENSG00000100796.131120.243301332.06580-0.249902.096701.32070K562HNRNPU
SMEK1ENSG00000100796.131581.850902038.44390-0.365903.210502.35730K562HSPD1
SMEK1ENSG00000100796.132233.509101686.984900.404802.965802.10970K562KIF1C
SMEK1ENSG00000100796.132020.041101324.656800.608705.123303.79820K562NAA15
SMEK1ENSG00000100796.131280.385801706.79230-0.414703.720502.74780K562PPIG
SMEK1ENSG00000100796.131651.32040904.579600.8682013.0294011.38910K562PRPF8
SMEK1ENSG00000100796.134154.209802834.540700.551407.521506.17340K562PUF60
SMEK1ENSG00000100796.132447.441901576.411600.634506.701405.89870K562PUS1
SMEK1ENSG00000100796.131726.572801135.867600.604003.613801.95360K562RAVER1
SMEK1ENSG00000100796.132216.241201536.061300.528809.362708.29570K562RBM15
SMEK1ENSG00000100796.131439.212001129.316500.349703.242101.79370K562RBM25
SMEK1ENSG00000100796.131410.478201081.767800.382702.497201.57470K562SF3B1
SMEK1ENSG00000100796.131825.454601238.018600.560108.656507.09980K562SF3B4
SMEK1ENSG00000100796.13878.176101126.66240-0.359502.896001.81170K562SRSF4
SMEK1ENSG00000100796.131269.06200978.622000.374803.717702.76680K562SYNCRIP
SMEK1ENSG00000100796.13646.15210884.01080-0.452203.599202.49410K562TRIM56
SMEK1ENSG00000100796.131783.200101154.113000.627604.575003.10070K562U2AF1
SMEK1ENSG00000100796.132026.163101191.888300.7654015.5951013.66090K562U2AF2
SMEK1ENSG00000100796.132345.003701490.431100.6538019.7971017.84400K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SMEK1 is not available on ENCORE database.





9 RBPs can affect the splicing of SMEK1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESMEK1ENSG00000100796.13chr14-919326049193276091931593919317639193718091937339-0.155000.001890.05981excludedK562PRPF8
SESMEK1ENSG00000100796.13chr14-9193260491932760919315939193176391937180919373390.202000.000060.02362includedHepG2ILF3
SESMEK1ENSG00000100796.13chr14-919326049193276091931593919317639193718091937339-0.195000.002370.02900excludedHepG2U2AF2
SESMEK1ENSG00000100796.13chr14-919326049193276091931593919317639193718091937339-0.161000.002080.08626excludedK562EFTUD2
A3SSSMEK1ENSG00000100796.13chr14-9192839291928583919283929192856591929078919292210.056000.000310.01012longerHepG2U2AF2
A3SSSMEK1ENSG00000100796.13chr14-9195197591952113919519759195207491957090919571790.057000.000070.00063longerK562AQR
A3SSSMEK1ENSG00000100796.13chr14-9194325291943419919432529194333091947919919482170.081000.000010.00009longerK562AQR
A3SSSMEK1ENSG00000100796.13chr14-9193260491932799919326049193276091937180919373760.487000.000000.00000longerK562AQR
A3SSSMEK1ENSG00000100796.13chr14-919396929193985391939692919397149194215491942310-0.089000.013980.07042shorterK562AQR
A3SSSMEK1ENSG00000100796.13chr14-919283929192856591928392919285569192907891929280-0.268000.014500.07265shorterK562AQR
A3SSSMEK1ENSG00000100796.13chr14-919283929192858391928392919285659192907891929221-0.083000.000240.07186shorterHepG2PCBP2
A5SSSMEK1ENSG00000100796.13chr14-919421549194231091942193919423109193958291939714-0.349000.000210.01079shorterHepG2U2AF2
A5SSSMEK1ENSG00000100796.13chr14-919421549194231091942193919423109193958291939714-0.451000.000010.00276shorterHepG2SFPQ
A5SSSMEK1ENSG00000100796.13chr14-919421549194231091942193919423109193958291939714-0.269000.000010.00160shorterHepG2SRSF1
A5SSSMEK1ENSG00000100796.13chr14-919421549194231091942193919423109193958291939714-0.454000.000000.00265shorterHepG2HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SMEK1 is not avaliable on ENCORE database.