PTPN2

General Information

Gene Name       : PTPN2
Gene ID             : ENSG00000175354.19
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PTPN2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PTPN2ENSG00000175354.1953.2253.2753.25ENCSR000AEF
HepG2PTPN2ENSG00000175354.1927.4940.3233.91ENCSR985KAT
K562PTPN2ENSG00000175354.1934.7639.2036.98ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PTPN2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PTPN2 RNA is bound by 11 proteins.  







eCLIP assay for PTPN2 is not avaliable on ENCORE database.





11 proteins are bound to PTPN2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr181278556712785678-3'-UTR,intron-Distal,intron-Proximal4.422593.38968HepG2BCLAF1
chr181280195912802017-3'-UTR,CDS,intron-Distal,intron-Proximal3.310053.28366HepG2BCLAF1
chr181281425912814351-3'-UTR,CDS,intron-Distal,intron-Proximal3.650844.51739HepG2BCLAF1
chr181279305912793239-3'-UTR,intron-Distal3.337453.51696K562KHSRP
chr181280201712802150-3'-UTR,CDS,intron-Distal4.124076.22576HepG2BCLAF1
chr181278573812785793-3'-UTR,intron-Distal3.173845.00751HepG2BCLAF1
chr181279421512794331-3'-UTR,CDS,intron-Distal,intron-Proximal4.784666.45599K562PRPF8
chr181288406912884218-5'-UTR,CDS,intron-Distal,intron-Proximal4.893288.20930HepG2DDX3X
chr181279438412794487-CDS,intron-Distal,intron-Proximal4.111846.65960HepG2BCLAF1
chr181279440112794485-CDS,intron-Distal,intron-Proximal3.439283.12941K562UCHL5
chr181285466712854785-intron-Distal4.835405.72657HepG2MATR3
chr181288008512880223-intron-Distal3.749403.59803HepG2PTBP1
chr181285465712854771-intron-Distal3.095505.00956HepG2SUGP2
chr181279183712792014-intron-Distal4.849207.27881HepG2KHSRP
chr181287279012872887-intron-Distal4.077093.89294K562KHSRP
chr181285610912856194-intron-Distal3.482534.84410HepG2SUGP2
chr181288354012883626-intron-Distal3.596287.07923HepG2CSTF2T
chr181288334112883434-intron-Distal4.145964.08332K562NONO
chr181285574312855798-intron-Distal3.270023.69184HepG2SUGP2
chr181288336512883431-intron-Distal3.253033.48042HepG2NKRF
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PTPN2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PTPN2 is not available on ENCORE database.

  • 58 RBPs can affect the levels of PTPN2.  








The Knockdown/knockout RNA-Seq assay for PTPN2 is not available on ENCORE database.





58 RBPs can affect the gene expression of PTPN2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PTPN2ENSG00000175354.14798.50390606.123300.397602.051701.58600HepG2AKAP1
PTPN2ENSG00000175354.14395.18480559.49380-0.501604.747603.76420HepG2AKAP8L
PTPN2ENSG00000175354.14594.04550915.49360-0.624009.217308.08550HepG2AUH
PTPN2ENSG00000175354.14600.13940805.81840-0.425203.042002.41720HepG2BOP1
PTPN2ENSG00000175354.14704.65740909.28160-0.367804.180703.29830HepG2DAZAP1
PTPN2ENSG00000175354.14468.88710684.96430-0.546804.230202.98820HepG2DDX5
PTPN2ENSG00000175354.14387.11870519.04700-0.423103.167102.41900HepG2DNAJC21
PTPN2ENSG00000175354.14411.81800514.44160-0.321002.485501.86170HepG2DNAJC2
PTPN2ENSG00000175354.14832.46830515.913100.690204.518803.65040HepG2EIF4B
PTPN2ENSG00000175354.14653.96720859.37430-0.394102.660501.86080HepG2EIF4G2
PTPN2ENSG00000175354.14421.40380741.03700-0.814303.209702.11220HepG2FTO
PTPN2ENSG00000175354.14561.76720838.66260-0.578104.214003.43510HepG2GPKOW
PTPN2ENSG00000175354.14399.47660582.86730-0.545103.876303.06640HepG2HNRNPC
PTPN2ENSG00000175354.14524.52880732.83350-0.482505.339504.38310HepG2HNRNPF
PTPN2ENSG00000175354.14681.94760502.366700.440802.830402.12280HepG2HNRNPK
PTPN2ENSG00000175354.14617.36890800.34740-0.374502.214201.64460HepG2HNRNPLL
PTPN2ENSG00000175354.14472.59500721.63030-0.610706.436605.37460HepG2IGF2BP1
PTPN2ENSG00000175354.14465.93510590.66050-0.342202.113201.40120HepG2MSI2
PTPN2ENSG00000175354.14663.44540533.283200.315002.381101.65710HepG2PRPF4
PTPN2ENSG00000175354.14752.83710913.71310-0.279402.647702.06480HepG2PUM1
PTPN2ENSG00000175354.14752.56700913.03180-0.278801.866301.31000HepG2PUM2
PTPN2ENSG00000175354.14423.30920567.19610-0.422103.798903.10020HepG2PUS1
PTPN2ENSG00000175354.14693.61980543.887900.350703.024602.38360HepG2RECQL
PTPN2ENSG00000175354.14590.77720789.46410-0.418303.213902.48580HepG2RPLP0
PTPN2ENSG00000175354.14428.35650605.48040-0.499302.599701.82480HepG2RPS3A
PTPN2ENSG00000175354.14409.42050515.64220-0.332802.395801.78960HepG2SAFB2
PTPN2ENSG00000175354.14916.44740656.404800.481402.735302.06540HepG2SF3A3
PTPN2ENSG00000175354.14733.80920546.191300.425904.184203.48080HepG2SF3B4
PTPN2ENSG00000175354.14616.29970825.34070-0.421404.715203.83750HepG2SLBP
PTPN2ENSG00000175354.14829.49710570.138900.540806.769806.10970HepG2SRSF1
PTPN2ENSG00000175354.14557.61590719.99000-0.368703.272602.52400HepG2SRSF7
PTPN2ENSG00000175354.14382.97460492.79990-0.363802.303701.44030HepG2SUPT6H
PTPN2ENSG00000175354.14844.21640512.556000.719808.520007.62460HepG2TAF15
PTPN2ENSG00000175354.14468.58970779.98140-0.735107.277606.17830HepG2TARDBP
PTPN2ENSG00000175354.14446.77830562.64810-0.332702.118101.66940HepG2TIAL1
PTPN2ENSG00000175354.14652.69290840.92200-0.365602.617701.76920HepG2TUFM
PTPN2ENSG00000175354.14618.44490890.12670-0.525403.203602.30340HepG2UBE2L3
PTPN2ENSG00000175354.14473.92540582.13040-0.296702.148901.52080HepG2UPF1
PTPN2ENSG00000175354.14844.38600562.024500.587208.075007.13770HepG2UTP3
PTPN2ENSG00000175354.141459.815101067.830400.451006.767305.93700K562AGGF1
PTPN2ENSG00000175354.14722.395901048.47180-0.537405.854904.72010K562CPSF6
PTPN2ENSG00000175354.142059.714901472.363900.484209.401308.28580K562DDX47
PTPN2ENSG00000175354.141705.632901195.696300.512408.277906.61310K562DKC1
PTPN2ENSG00000175354.14950.778701135.97950-0.256802.146101.49880K562EIF2S2
PTPN2ENSG00000175354.14739.017801066.91470-0.529804.914903.76730K562FMR1
PTPN2ENSG00000175354.14641.72520904.35830-0.494903.774302.69130K562FTO
PTPN2ENSG00000175354.141067.44410806.552100.404202.248801.62030K562G3BP2
PTPN2ENSG00000175354.14743.675001000.98320-0.428703.540902.64710K562GPKOW
PTPN2ENSG00000175354.14500.02420798.32980-0.675007.114206.19950K562HNRNPC
PTPN2ENSG00000175354.14807.31060964.89270-0.257202.165801.44510K562MTPAP
PTPN2ENSG00000175354.141446.54060925.923800.643505.107103.78460K562NAA15
PTPN2ENSG00000175354.14871.555901072.13210-0.298803.556502.72090K562NSUN2
PTPN2ENSG00000175354.14522.11200715.78760-0.455203.263302.26860K562PSIP1
PTPN2ENSG00000175354.14696.58860869.32030-0.319602.396101.77080K562PTBP1
PTPN2ENSG00000175354.141851.026401101.985800.7481010.034209.04640K562PUS1
PTPN2ENSG00000175354.141430.295801073.667400.413704.872504.10610K562RBM15
PTPN2ENSG00000175354.141029.72960838.877500.295602.397401.60420K562SF3B4
PTPN2ENSG00000175354.14491.26760644.55270-0.391802.525501.52720K562SRSF4
PTPN2ENSG00000175354.14882.56680670.809500.395703.502602.57910K562SYNCRIP
PTPN2ENSG00000175354.14616.19360862.54120-0.485203.851003.01010K562TARDBP
PTPN2ENSG00000175354.14509.97850688.46720-0.433002.624301.71460K562TIAL1
PTPN2ENSG00000175354.14513.87070731.41460-0.509303.976602.79930K562TRIM56
PTPN2ENSG00000175354.14489.45890667.72190-0.448102.883401.83930K562UCHL5
PTPN2ENSG00000175354.14937.224701136.80040-0.278502.848002.11920K562UPF1
PTPN2ENSG00000175354.141282.218101011.483000.342104.466103.40990K562WDR43
PTPN2ENSG00000175354.141293.277501598.23840-0.305502.389301.59600K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PTPN2 is not available on ENCORE database.





15 RBPs can affect the splicing of PTPN2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPTPN2ENSG00000175354.14chr18-128591621285925312836789128368901288407112884280-0.117000.000010.00024excludedHepG2U2AF2
SEPTPN2ENSG00000175354.14chr18-128171541281736412814195128143541282580812825943-0.192000.000160.00301excludedHepG2U2AF2
SEPTPN2ENSG00000175354.14chr18-127943821279448412785683127858431280196812802150-0.060000.000020.00043excludedK562AQR
SEPTPN2ENSG00000175354.14chr18-128258081282594312817179128173641283094112831122-0.058000.000310.00445excludedK562AQR
SEPTPN2ENSG00000175354.14chr18-128591621285925312836789128368901288407112884213-0.054000.000240.00514excludedK562PUS1
SEPTPN2ENSG00000175354.14chr18-1279348012793573127854791278584312794382127944840.083000.000850.04967includedHepG2NCBP2
SEPTPN2ENSG00000175354.14chr18-128171541281736412814195128143541282580812825943-0.208000.001740.08873excludedHepG2FTO
SEPTPN2ENSG00000175354.14chr18-128192121281928112817154128173641282580812825943-0.070000.000370.05829excludedK562LARP4
SEPTPN2ENSG00000175354.14chr18-127934801279357312785479127858431279438212794484-0.062000.001720.09999excludedHepG2HNRNPL
SEPTPN2ENSG00000175354.14chr18-128591621285925312836789128368901288407112884213-0.086000.000850.02699excludedHepG2SF3A3
SEPTPN2ENSG00000175354.14chr18-1281921212819281128171541281736412825808128259430.102000.000930.07832includedHepG2SUPV3L1
SEPTPN2ENSG00000175354.14chr18-1281921212819281128171541281736412825808128259430.160000.000020.06846includedHepG2LSM11
SEPTPN2ENSG00000175354.14chr18-128258081282594312817179128173641283094112831040-0.080000.001710.05085excludedK562UTP18
A3SSPTPN2ENSG00000175354.14chr18-1278568312785867127856831278584312794382127944840.055000.004720.02745longerK562AQR
MXEPTPN2ENSG00000175354.14chr18-12817154128173641282580812825943128142011281435412830941128310400.185000.001360.036971includedHepG2MATR3
MXEPTPN2ENSG00000175354.14chr18-12814201128143541281715412817364128019871280215012830941128310400.054000.000010.000111includedK562AQR
MXEPTPN2ENSG00000175354.14chr18-1281715412817364128258081282594312801968128021501283094112831040-0.060000.000080.000972includedK562AQR
MXEPTPN2ENSG00000175354.14chr18-12825808128259431283094112831040128171541281736412836789128368900.217000.000000.000331includedHepG2NOL12
MXEPTPN2ENSG00000175354.14chr18-12814201128143541282580812825943128019681280215012830941128310400.215000.000000.000001includedHepG2HNRNPUL1
MXEPTPN2ENSG00000175354.14chr18-1281420112814354128258081282594312801968128021501283094112831040-0.109000.005930.091562includedK562FXR2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PTPN2 is not avaliable on ENCORE database.