POLR3A

General Information

Gene Name       : POLR3A
Gene ID             : ENSG00000148606.12
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLR3A)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLR3AENSG00000148606.129.9611.1610.56ENCSR000AEF
HepG2POLR3AENSG00000148606.1215.7818.2317.00ENCSR985KAT
K562POLR3AENSG00000148606.1220.5022.2821.39ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLR3A is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLR3A RNA is bound by 23 proteins.  







eCLIP assay for POLR3A is not avaliable on ENCORE database.





23 proteins are bound to POLR3A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr107973580779735824-3'-UTR,intron-Distal3.600464.24288K562UPF1
chr107973616579736202-3'-UTR,intron-Distal4.023476.42251K562FAM120A
chr107973622079736258-3'-UTR,intron-Distal4.136677.12652K562UPF1
chr107973693679736979-3'-UTR,intron-Distal3.899043.19668HepG2UPF1
chr107973614979736200-3'-UTR,intron-Distal6.3199819.34122K562UPF1
chr107973630779736335-3'-UTR,intron-Distal3.832114.50550K562UPF1
chr107976191079761997-3'-UTR,CDS,intron-Distal,intron-Proximal4.066475.34978HepG2PRPF8
chr107976199879762016-3'-UTR,CDS,intron-Distal3.143816.77366K562YBX3
chr107976201679762041-3'-UTR,CDS,intron-Distal3.205587.37965K562YBX3
chr107973692379736989-3'-UTR,intron-Distal3.976323.61011HepG2AKAP1
chr107973569079735735-3'-UTR,intron-Distal3.171145.75802K562UPF1
chr107973664379736688-3'-UTR,intron-Distal3.632735.67957K562UPF1
chr107973712279737224-3'-UTR,intron-Distal3.889109.91457K562PUM2
chr107973628579736334-3'-UTR,intron-Distal4.134203.95192HepG2UPF1
chr107976200079762065-3'-UTR,CDS,intron-Distal3.539585.86107HepG2PPIG
chr107976747679767539-3'-UTR,CDS,intron-Distal3.481964.70460K562DDX24
chr107973568279735748-3'-UTR,intron-Distal5.9500512.43562K562FAM120A
chr107973676379736799-3'-UTR,intron-Distal5.046035.76540K562PUM2
chr107976755679767625-3'-UTR,CDS,intron-Distal,intron-Proximal4.485005.23727HepG2G3BP1
chr107973552479735568-3'-UTR,intron-Distal4.786454.90799K562UPF1
chr107973709179737160-3'-UTR,intron-Distal4.749265.17229HepG2UPF1
chr107973523679735327-3'-UTR,intron-Distal3.311703.50893K562TARDBP
chr107973534579735395-3'-UTR,intron-Distal3.927103.02250K562YBX3
chr107973614679736207-3'-UTR,intron-Distal3.759975.64093HepG2UPF1
chr107978916179789245-5'-UTR,CDS,intron-Distal4.057693.15232HepG2LIN28B
chr107978914879789264-5'-UTR,CDS,intron-Distal3.9031810.40970K562LIN28B
chr107978912579789206-5'-UTR,CDS,intron-Distal3.173686.54857HepG2PPIG
chr107978915379789222-5'-UTR,CDS,intron-Distal3.355883.95805K562DDX3X
chr107978430679784366-CDS,intron-Distal,intron-Proximal3.899056.97808HepG2BCLAF1
chr107975075579750817-CDS,intron-Distal,intron-Proximal4.842335.26064K562AQR
chr107977734879777416-CDS,intron-Distal4.124546.36347HepG2PPIG
chr107978173079781751-CDS,intron-Distal3.372823.28366HepG2BCLAF1
chr107977021179770231-CDS,intron-Distal,intron-Proximal5.153075.69951K562AQR
chr107978534179785400-CDS,intron-Distal,intron-Proximal5.007564.02817HepG2PRPF8
chr107977740879777472-CDS,intron-Distal3.580345.97823HepG2BCLAF1
chr107976972579769789-CDS,intron-Distal,intron-Proximal3.401114.63311K562AQR
chr107977337079773425-CDS,intron-Distal,intron-Proximal5.522748.72621HepG2PRPF8
chr107978472379784768-CDS,intron-Distal,intron-Proximal3.563893.36945K562ZNF622
chr107974566879745709-CDS,intron-Distal3.636093.68471HepG2BCLAF1
chr107978137979781387-CDS,intron-Distal3.688568.50021K562YBX3
chr107978160679781711-CDS,intron-Distal,intron-Proximal5.457919.91399K562UCHL5
chr107974114279741197-CDS,intron-Distal,intron-Proximal3.133538.18981HepG2PRPF8
chr107978581379785857-CDS,intron-Distal,intron-Proximal3.127143.18246K562PRPF8
chr107976083079760874-CDS,intron-Distal,intron-Proximal4.566614.79708HepG2U2AF2
chr107978135479781379-CDS,intron-Distal4.4819911.40770K562YBX3
chr107978585679785902-CDS,intron-Distal3.566134.20387K562ZNF622
chr107978431079784367-CDS,intron-Distal4.196784.01763HepG2GRWD1
chr107975076679750843-CDS,intron-Distal,intron-Proximal4.1654414.10710HepG2PRPF8
chr107978196379782059-CDS,intron-Distal3.088854.73488HepG2GRWD1
chr107976083479760946-CDS,intron-Distal,intron-Proximal4.381265.91698K562KHSRP
chr107978440779784459-CDS,intron-Distal4.042326.22576HepG2BCLAF1
chr107977900579779039-CDS,intron-Distal,intron-Proximal3.346786.52492K562SF3B4
chr107978469079784768-CDS,intron-Distal,intron-Proximal5.611049.75034HepG2PRPF8
chr107977028279770370-CDS,intron-Distal,intron-Proximal4.598648.54916K562SF3B4
chr107977341279773443-CDS,intron-Distal3.349943.05460HepG2PPIG
chr107977734679777467-CDS,intron-Distal3.433758.10388HepG2GRWD1
chr107978472879784847-CDS,intron-Distal,intron-Proximal3.707589.28015HepG2GRWD1
chr107978168379781754-CDS,intron-Distal3.746416.62597HepG2GRWD1
chr107976933679769414-CDS,intron-Distal4.596206.00552HepG2G3BP1
chr107974568879745744-CDS,intron-Distal,intron-Proximal4.261633.68241HepG2G3BP1
chr107974493679745014-CDS,intron-Distal3.388683.72202HepG2G3BP1
chr107974483179744932-CDS,intron-Distal,intron-Proximal5.268385.17615K562AQR
chr107976970279769770-CDS,intron-Distal,intron-Proximal3.059404.56061K562BUD13
chr107975977179759837-CDS,intron-Distal3.434775.10442K562YBX3
chr107977894379778995-CDS,intron-Distal3.805324.82082K562ZNF622
chr107974493979744991-CDS,intron-Distal3.031183.41665HepG2GRWD1
chr107976926179769315-CDS,intron-Distal,intron-Proximal4.906526.59451HepG2PRPF8
chr107977734879777430-CDS,intron-Distal4.5596210.01989K562UCHL5
chr107974508179745151-CDS,intron-Distal,intron-Proximal5.143395.58150K562SF3B4
chr107978592379785976-CDS,intron-Distal4.049053.12746HepG2GRWD1
chr107978894579789105-intron-Distal5.369557.28294K562AQR
chr107977018479770211-intron-Distal,intron-Proximal4.435874.98250K562AQR
chr107975937079759473-intron-Distal5.5317711.38012HepG2QKI
chr107975927779759350-intron-Distal5.626289.73701HepG2QKI
chr107977903979779073-intron-Distal,intron-Proximal3.798918.08874K562SF3B4
chr107976120479761273-intron-Distal3.317864.95320HepG2U2AF2
chr107976111979761192-intron-Distal4.333343.09122HepG2PTBP1
chr107978464479784727-intron-Distal,intron-Proximal5.035846.04760K562AQR
chr107974114379741164-intron-Distal,intron-Proximal5.424418.43521K562AQR
chr107977321779773344-intron-Distal,intron-Proximal3.709845.42334HepG2QKI
chr107976113579761204-intron-Distal5.201348.16423HepG2U2AF2
chr107974116479741186-intron-Distal,intron-Proximal4.429357.15298K562AQR
chr107974485079744924-intron-Distal,intron-Proximal4.288113.12843K562PRPF8
chr107976114579761239-intron-Distal4.862384.40618K562PTBP1
chr107974358379743678-intron-Distal,intron-Proximal4.955115.69951K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLR3A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLR3A is not available on ENCORE database.

  • 52 RBPs can affect the levels of POLR3A.  








The Knockdown/knockout RNA-Seq assay for POLR3A is not available on ENCORE database.





52 RBPs can affect the gene expression of POLR3A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLR3AENSG00000148606.81140.639801442.67890-0.338904.698603.94640HepG2ACO1
POLR3AENSG00000148606.82520.622702108.817800.257203.266102.53010HepG2AUH
POLR3AENSG00000148606.8713.62030984.83950-0.464703.808203.01410HepG2CPSF6
POLR3AENSG00000148606.81528.709201334.205400.196202.040401.31510HepG2DDX19B
POLR3AENSG00000148606.81152.931301792.36790-0.636605.883705.01210HepG2DDX6
POLR3AENSG00000148606.81082.438701722.97590-0.670607.393006.45930HepG2EIF2S1
POLR3AENSG00000148606.81793.880002421.28890-0.432707.917606.99030HepG2ETF1
POLR3AENSG00000148606.81093.744101465.69340-0.422302.553301.81060HepG2FIP1L1
POLR3AENSG00000148606.81556.743701921.21710-0.303502.044001.44600HepG2FXR1
POLR3AENSG00000148606.81252.305801782.15600-0.509004.333303.50890HepG2G3BP1
POLR3AENSG00000148606.8926.008101213.66940-0.390303.181202.44410HepG2HNRNPC
POLR3AENSG00000148606.81355.733401660.79500-0.292804.145103.33280HepG2HNRNPL
POLR3AENSG00000148606.8781.661001011.36940-0.371702.941901.96100HepG2HNRNPM
POLR3AENSG00000148606.81030.402001231.51990-0.257202.951802.19680HepG2ILF2
POLR3AENSG00000148606.8916.822101241.15620-0.437003.915302.55610HepG2LARP7
POLR3AENSG00000148606.81166.366401807.91440-0.6323011.105709.61600HepG2NOL12
POLR3AENSG00000148606.81009.983001193.34510-0.240702.156301.40120HepG2PARN
POLR3AENSG00000148606.81641.756701342.037900.290703.338802.49570HepG2PRPF4
POLR3AENSG00000148606.81094.360001830.72460-0.7423013.9021012.46970HepG2PUM2
POLR3AENSG00000148606.81500.847001841.69590-0.295302.649101.98660HepG2RBM25
POLR3AENSG00000148606.81181.104501496.63030-0.341602.406001.48840HepG2RBM27
POLR3AENSG00000148606.81698.597302085.23560-0.295903.733003.12240HepG2NELFE
POLR3AENSG00000148606.81623.342301942.03700-0.258603.178402.52430HepG2RECQL
POLR3AENSG00000148606.81087.043401380.29470-0.344602.461301.70310HepG2RPS2
POLR3AENSG00000148606.81084.372001408.97600-0.377802.802601.72130HepG2RPS5
POLR3AENSG00000148606.81664.736101950.80350-0.228802.591902.01560HepG2SF3B4
POLR3AENSG00000148606.81412.156701656.50820-0.230202.646102.10360HepG2SRSF9
POLR3AENSG00000148606.8990.680801251.54740-0.337201.894701.32100HepG2SUPV3L1
POLR3AENSG00000148606.81141.577801830.09400-0.6809014.1811013.05760HepG2TAF15
POLR3AENSG00000148606.81313.809101681.71670-0.356203.662602.70650HepG2TIA1
POLR3AENSG00000148606.8939.368001181.98700-0.331503.843003.20110HepG2TRIM56
POLR3AENSG00000148606.8951.351601232.01120-0.373002.467601.77980HepG2XRN2
POLR3AENSG00000148606.81559.770901831.67290-0.231802.652801.71470K562BCLAF1
POLR3AENSG00000148606.8722.11380917.45840-0.345402.288701.34620K562CCAR1
POLR3AENSG00000148606.83320.979802346.536600.5010011.7118010.47200K562DDX47
POLR3AENSG00000148606.81784.355502132.35200-0.257002.839001.95270K562DKC1
POLR3AENSG00000148606.81775.430602393.63650-0.431007.168506.09020K562EIF2S2
POLR3AENSG00000148606.81299.88990933.223200.478002.225401.33540K562EIF3A
POLR3AENSG00000148606.81706.619101288.227800.405705.452304.34840K562EIF3G
POLR3AENSG00000148606.81456.594301954.99740-0.424604.164003.11060K562FIP1L1
POLR3AENSG00000148606.82377.993401526.752000.6392014.6389013.35930K562FXR1
POLR3AENSG00000148606.82078.894903189.79450-0.6176010.399208.90730K562GRSF1
POLR3AENSG00000148606.81076.482201353.31560-0.330202.761402.16510K562HNRNPC
POLR3AENSG00000148606.81161.816001608.06800-0.468903.721802.62940K562HNRNPM
POLR3AENSG00000148606.81981.268202650.48470-0.419804.234503.25620K562HSPD1
POLR3AENSG00000148606.81562.491201837.43940-0.233802.611601.82520K562MTPAP
POLR3AENSG00000148606.81723.643502219.38770-0.364703.154702.27060K562PPIG
POLR3AENSG00000148606.82178.815401637.859600.411604.922904.06090K562PTBP1
POLR3AENSG00000148606.83096.340803715.53940-0.263003.047502.04320K562PUM2
POLR3AENSG00000148606.82094.566901675.637300.321802.252501.51890K562RPS19
POLR3AENSG00000148606.82017.767901534.006700.395404.132102.79980K562SAFB
POLR3AENSG00000148606.82046.876601605.657700.350203.675302.86630K562SRSF1
POLR3AENSG00000148606.82367.581801726.789900.455206.404005.14760K562SYNCRIP
POLR3AENSG00000148606.81163.287201625.01050-0.482204.629503.70850K562TARDBP
POLR3AENSG00000148606.82174.999202680.46610-0.301504.693203.03380K562TROVE2
POLR3AENSG00000148606.81741.001702221.38110-0.351502.561001.41110K562UTP3
POLR3AENSG00000148606.82267.267301926.146700.235103.213402.30780K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLR3A is not available on ENCORE database.





4 RBPs can affect the splicing of POLR3A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLR3AENSG00000148606.8chr10-797436777974377079742410797425757974396279744056-0.056000.002610.02735excludedK562AQR
SEPOLR3AENSG00000148606.8chr10-7974685279747023797458307974591779750811797509250.057000.000070.00415includedK562UTP18
SEPOLR3AENSG00000148606.8chr10-7974685279747023797458307974591779750811797509250.069000.000090.00398includedK562AGGF1
A3SSPOLR3AENSG00000148606.8chr10-7974118579741414797411857974131779741911797420760.064000.000000.00000longerK562AQR
A3SSPOLR3AENSG00000148606.8chr10-7974396279744136797439627974405679744927797451540.120000.000000.00000longerK562AQR
A3SSPOLR3AENSG00000148606.8chr10-7975295479753166797529547975312579759738797598760.105000.000000.00000longerK562AQR
MXEPOLR3AENSG00000148606.8chr10-7974241079742575797436777974377079741911797420767974396279744056-0.153000.000270.059512includedK562EIF4G2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLR3A is not avaliable on ENCORE database.