POLR2D

General Information

Gene Name       : POLR2D
Gene ID             : ENSG00000144231.10
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: POLR2D)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878POLR2DENSG00000144231.1039.0836.5337.80ENCSR000AEF
HepG2POLR2DENSG00000144231.1047.7871.3359.55ENCSR985KAT
K562POLR2DENSG00000144231.1069.5872.7271.15ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for POLR2D is not avaliable on ENCORE database.



Proteins bound to RNA
  • POLR2D RNA is bound by 8 proteins.  







eCLIP assay for POLR2D is not avaliable on ENCORE database.





8 proteins are bound to POLR2D RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr2128605428128605487-3'-UTR,intron-Distal3.711214.22460K562RBM15
chr2128604619128604684-3'-UTR,intron-Distal3.119394.31863K562RBM15
chr2128605115128605210-3'-UTR,intron-Distal3.6452545.34565K562UPF1
chr2128604436128604458-3'-UTR,intron-Distal4.380013.80461HepG2RBM15
chr2128604640128604684-3'-UTR,intron-Distal3.053047.72714K562UPF1
chr2128604310128604417-3'-UTR,intron-Distal3.218815.62019K562YBX3
chr2128605134128605211-3'-UTR,intron-Distal4.1342012.83776HepG2UPF1
chr2128605433128605514-3'-UTR,intron-Distal3.159194.66920HepG2RBM15
chr2128605007128605055-3'-UTR,intron-Distal4.403838.40334HepG2RBM15
chr2128604868128604914-3'-UTR,intron-Distal5.584379.12015K562UPF1
chr2128615604128615696-5'-UTR,CDS,intron-Distal,intron-Proximal4.4170115.73138K562DDX3X
chr2128615625128615719-5'-UTR,CDS,intron-Distal,intron-Proximal4.002618.12455HepG2DDX3X
chr2128610506128610623-CDS,intron-Distal3.663367.67656HepG2GRWD1
chr2128615546128615616-CDS,intron-Distal,intron-Proximal5.3863815.13298HepG2PRPF8
chr2128615105128615226-intron-Distal4.103413.88642HepG2TAF15
chr2128613328128613395-intron-Distal4.023983.69425K562TARDBP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for POLR2D is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for POLR2D is not available on ENCORE database.

  • 82 RBPs can affect the levels of POLR2D.  








The Knockdown/knockout RNA-Seq assay for POLR2D is not available on ENCORE database.





82 RBPs can affect the gene expression of POLR2D :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
POLR2DENSG00000144231.6707.311501055.54770-0.577608.973507.69030HepG2AKAP8L
POLR2DENSG00000144231.61023.861001305.09380-0.350102.287201.57040HepG2ASCC1
POLR2DENSG00000144231.6646.383601018.58610-0.656102.993602.05710HepG2BCLAF1
POLR2DENSG00000144231.6802.010301001.69460-0.320802.635601.88240HepG2CALR
POLR2DENSG00000144231.61052.953501795.74290-0.7701023.5992021.83490HepG2DAZAP1
POLR2DENSG00000144231.61194.939801510.97300-0.338502.184201.62120HepG2DDX3X
POLR2DENSG00000144231.6796.725101152.28810-0.532302.107201.42260HepG2DDX55
POLR2DENSG00000144231.6758.89550972.56440-0.357902.672901.70530HepG2DHX30
POLR2DENSG00000144231.6812.353201005.14040-0.307202.879802.18940HepG2DKC1
POLR2DENSG00000144231.6687.455601008.36520-0.552707.401306.29550HepG2DNAJC21
POLR2DENSG00000144231.6665.14200999.44790-0.5875010.459809.29030HepG2DNAJC2
POLR2DENSG00000144231.6875.927301247.76180-0.510504.165303.44620HepG2EIF2S1
POLR2DENSG00000144231.6520.57560698.95240-0.425102.162201.35390HepG2EIF3D
POLR2DENSG00000144231.61498.216701771.76990-0.241902.422601.63060HepG2EIF4G1
POLR2DENSG00000144231.61231.562901697.21360-0.462704.324903.32170HepG2EIF4G2
POLR2DENSG00000144231.6411.13230752.60640-0.872303.667602.49300HepG2FTO
POLR2DENSG00000144231.6895.161201290.59420-0.527804.241703.42610HepG2G3BP1
POLR2DENSG00000144231.6803.575901003.02980-0.319903.281202.22210HepG2HDGF
POLR2DENSG00000144231.6636.266901018.02550-0.678107.720506.72330HepG2HNRNPA1
POLR2DENSG00000144231.6947.498001635.72830-0.7877022.8325021.09150HepG2HNRNPL
POLR2DENSG00000144231.6616.77330812.72470-0.398002.506401.90280HepG2HNRNPLL
POLR2DENSG00000144231.6937.108201124.87460-0.263502.586002.00040HepG2HNRNPU
POLR2DENSG00000144231.6749.394101149.02290-0.6166013.2476011.77370HepG2ILF2
POLR2DENSG00000144231.6616.711001399.44960-1.1822016.8202015.36650HepG2MATR3
POLR2DENSG00000144231.6629.92580846.19700-0.425803.046402.19800HepG2MSI2
POLR2DENSG00000144231.6533.57380710.48300-0.413102.707901.50420HepG2NAA15
POLR2DENSG00000144231.61087.246101780.66490-0.7117013.4162011.79450HepG2NOL12
POLR2DENSG00000144231.6851.947001275.80240-0.582605.219604.23930HepG2PABPC4
POLR2DENSG00000144231.6793.348101003.29900-0.338703.223502.43360HepG2PPIL4
POLR2DENSG00000144231.6740.13780907.96360-0.294802.490001.75190HepG2PRPF4
POLR2DENSG00000144231.61084.392801313.88160-0.276902.992802.42780HepG2PTBP1
POLR2DENSG00000144231.61321.603701699.85170-0.363103.226002.58860HepG2PUF60
POLR2DENSG00000144231.61494.982201804.52760-0.271503.733803.06690HepG2PUM1
POLR2DENSG00000144231.61523.998001803.17220-0.242701.896801.33550HepG2PUM2
POLR2DENSG00000144231.6875.077901070.10270-0.290303.073802.43260HepG2PUS1
POLR2DENSG00000144231.61144.610401423.08940-0.314203.148702.48890HepG2QKI
POLR2DENSG00000144231.6880.984301069.47910-0.279702.261801.47680HepG2RBM15
POLR2DENSG00000144231.6937.439401291.49860-0.462204.990204.10840HepG2RBM25
POLR2DENSG00000144231.61241.216601462.27210-0.236502.390001.88100HepG2NELFE
POLR2DENSG00000144231.6754.403301001.75310-0.409105.261804.42570HepG2SAFB2
POLR2DENSG00000144231.61182.009301368.02400-0.210902.006501.48990HepG2SF3B4
POLR2DENSG00000144231.61026.376001630.01590-0.6673016.5962015.14090HepG2SLBP
POLR2DENSG00000144231.61428.326401762.06290-0.302904.093503.51870HepG2SRFBP1
POLR2DENSG00000144231.61822.778201427.878600.352204.861604.27910HepG2SRSF1
POLR2DENSG00000144231.6547.21970865.60560-0.661604.778303.43150HepG2SRSF3
POLR2DENSG00000144231.6896.055301078.53630-0.267402.032701.42570HepG2SRSF7
POLR2DENSG00000144231.6795.312901283.31550-0.6903012.3730011.31640HepG2TAF15
POLR2DENSG00000144231.6549.77430792.22970-0.527104.222903.35100HepG2TARDBP
POLR2DENSG00000144231.6475.51020769.02120-0.693503.263502.18560HepG2TFIP11
POLR2DENSG00000144231.6912.420001179.31670-0.370203.583402.63640HepG2TIA1
POLR2DENSG00000144231.6653.681601102.79570-0.7545015.4637014.28110HepG2TRIM56
POLR2DENSG00000144231.61053.504501757.97490-0.738707.785206.35160HepG2UBE2L3
POLR2DENSG00000144231.6401.81110677.78790-0.754303.420602.58110HepG2UCHL5
POLR2DENSG00000144231.6789.283101020.15450-0.370204.373703.52890HepG2UPF1
POLR2DENSG00000144231.6757.67970984.91850-0.378404.286003.56660HepG2UTP3
POLR2DENSG00000144231.6770.845101121.97410-0.541509.998909.12130HepG2ZNF622
POLR2DENSG00000144231.6790.131601286.56070-0.703409.204007.93100K562AKAP8L
POLR2DENSG00000144231.62773.384502227.631100.316002.707201.47940K562APOBEC3C
POLR2DENSG00000144231.61122.151201443.51450-0.363305.069303.75260K562BCLAF1
POLR2DENSG00000144231.6648.56380850.51750-0.391102.583101.74220K562BOP1
POLR2DENSG00000144231.6381.66780630.31990-0.723803.814502.53680K562CCAR1
POLR2DENSG00000144231.6834.641501095.12110-0.391903.783602.52160K562CSTF2
POLR2DENSG00000144231.62150.018501698.249100.340205.196004.34190K562DDX47
POLR2DENSG00000144231.61435.156601205.890600.251002.074901.37800K562EIF3G
POLR2DENSG00000144231.6860.029201140.06640-0.406703.770302.25870K562EXOSC5
POLR2DENSG00000144231.6637.80310933.32110-0.549304.374402.90220K562FKBP4
POLR2DENSG00000144231.6693.90110920.12950-0.407102.856601.98760K562FMR1
POLR2DENSG00000144231.6420.25110779.87510-0.892009.527707.72900K562FTO
POLR2DENSG00000144231.61912.479101034.328300.8866013.9402012.68590K562FXR1
POLR2DENSG00000144231.61009.186201296.09820-0.361003.864102.52340K562GLRX3
POLR2DENSG00000144231.6575.53230863.46280-0.585205.626404.49800K562GPKOW
POLR2DENSG00000144231.6681.445001075.30020-0.658107.897006.93710K562HNRNPC
POLR2DENSG00000144231.61824.405101185.837400.621406.375604.87270K562HNRNPM
POLR2DENSG00000144231.6491.09140737.24570-0.586202.416701.55120K562KRR1
POLR2DENSG00000144231.61796.636301463.347100.295902.602901.78680K562MAGOH
POLR2DENSG00000144231.61199.148801460.34880-0.284302.299301.46470K562MATR3
POLR2DENSG00000144231.62103.493602690.93890-0.355303.176901.96340K562MSI2
POLR2DENSG00000144231.61153.747401362.68360-0.240102.336401.59170K562MTPAP
POLR2DENSG00000144231.61059.891001514.03390-0.5145011.4900010.11180K562NSUN2
POLR2DENSG00000144231.6486.12420944.24650-0.957805.316103.81870K562PABPN1
POLR2DENSG00000144231.61579.277401227.203000.363803.060602.27150K562PRPF8
POLR2DENSG00000144231.62240.983601421.747900.6564011.3792010.09280K562PTBP1
POLR2DENSG00000144231.6801.113401275.99190-0.671507.634706.77950K562PUS1
POLR2DENSG00000144231.6974.634201243.19830-0.351103.519202.86370K562RBM15
POLR2DENSG00000144231.6690.15150879.52730-0.349802.544301.59740K562RCC2
POLR2DENSG00000144231.6876.12390662.942700.402202.384701.46400K562RPS3
POLR2DENSG00000144231.6621.27760821.12280-0.402402.286601.41160K562SF3B1
POLR2DENSG00000144231.61692.061601393.808800.279602.368101.70580K562SRSF1
POLR2DENSG00000144231.6949.538601168.70810-0.299603.059701.82350K562SRSF7
POLR2DENSG00000144231.61499.933801115.678400.426904.888303.79010K562SYNCRIP
POLR2DENSG00000144231.6709.88840985.05170-0.472604.234503.00890K562TRIM56
POLR2DENSG00000144231.6811.433101257.79010-0.632303.358802.22910K562UCHL5
POLR2DENSG00000144231.61289.505101605.36460-0.316104.241903.37090K562UPF1
POLR2DENSG00000144231.6899.142501373.65590-0.611408.157906.61300K562WDR3
POLR2DENSG00000144231.62161.328502746.93380-0.345903.040202.13140K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for POLR2D is not available on ENCORE database.





8 RBPs can affect the splicing of POLR2D :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPOLR2DENSG00000144231.6chr2-128610498128610679128608163128608259128615339128615523-0.053000.000820.01039excludedK562AQR
SEPOLR2DENSG00000144231.6chr2-1286104981286106791286081631286082591286156011286157310.109000.000050.01656includedK562HNRNPA1
SEPOLR2DENSG00000144231.6chr2-128610498128610679128608163128608259128615601128615731-0.106000.000360.04635excludedHepG2PCBP2
SEPOLR2DENSG00000144231.6chr2-128608163128608259128605414128605759128610498128610679-0.114000.000010.00154excludedK562HNRNPL
SEPOLR2DENSG00000144231.6chr2-128608163128608259128603839128605759128610498128610679-0.169000.000010.00060excludedHepG2SRSF1
SEPOLR2DENSG00000144231.6chr2-128610498128610679128604272128605759128615601128615731-0.093000.003280.08196excludedK562UTP18
SEPOLR2DENSG00000144231.6chr2-1286104981286106791286081631286082591286156011286157310.092000.000230.01173includedK562HNRNPU
SEPOLR2DENSG00000144231.6chr2-1286081631286082591286054141286057591286104981286106790.124000.000980.03805includedHepG2HNRNPC
SEPOLR2DENSG00000144231.6chr2-128610498128610679128608163128608259128615339128615523-0.148000.002120.03562excludedK562HNRNPC
A3SSPOLR2DENSG00000144231.6chr2-1286104981286107171286104981286106791286156011286157310.087000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for POLR2D is not avaliable on ENCORE database.