NPL

General Information

Gene Name       : NPL
Gene ID             : ENSG00000135838.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: NPL)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NPLENSG00000135838.137.6010.499.04ENCSR000AEF
HepG2NPLENSG00000135838.130.920.080.50ENCSR985KAT
K562NPLENSG00000135838.1310.6312.9011.77ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NPL is not avaliable on ENCORE database.



Proteins bound to RNA
  • NPL RNA is bound by 3 proteins.  







eCLIP assay for NPL is not avaliable on ENCORE database.





3 proteins are bound to NPL RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr1182772889182772984+5'-UTR,CDS,intron-Proximal3.691789.84724K562PRPF8
chr1182759121182759195+intron-Distal3.942173.12843K562PRPF8
chr1182766692182766800+intron-Distal5.148567.56720K562PTBP1
chr1182781116182781241+intron-Distal,intron-Proximal4.060243.29026K562KHDRBS1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NPL is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NPL is not available on ENCORE database.

  • 66 RBPs can affect the levels of NPL.  








The Knockdown/knockout RNA-Seq assay for NPL is not available on ENCORE database.





66 RBPs can affect the gene expression of NPL :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NPLENSG00000135838.911.877601.251603.246301.784501.34730HepG2AKAP1
NPLENSG00000135838.917.562901.200503.870703.307502.63140HepG2DDX3X
NPLENSG00000135838.931.682302.033303.961706.732706.00910HepG2RBM22
NPLENSG00000135838.96.822700.0000099999.999901.739201.33970HepG2SRSF1
NPLENSG00000135838.9238.24090389.03250-0.707504.295803.61560K562AGGF1
NPLENSG00000135838.9623.85590438.315800.509104.041702.49170K562APOBEC3C
NPLENSG00000135838.9368.21210272.839200.432402.652201.37650K562BCCIP
NPLENSG00000135838.9602.62780204.156901.5615018.3180016.06190K562BOP1
NPLENSG00000135838.9530.62380366.352900.534403.122201.57350K562CKAP4
NPLENSG00000135838.9742.22770268.251801.4682013.5518011.24780K562CNOT7
NPLENSG00000135838.9553.02370217.079001.349004.502303.50310K562CPSF6
NPLENSG00000135838.9188.29380106.486500.822203.558901.43960K562YBX3
NPLENSG00000135838.91036.03200610.609100.7626011.544209.63490K562CELF1
NPLENSG00000135838.9268.67130456.44040-0.764604.962902.97020K562DDX19B
NPLENSG00000135838.9787.62160338.038401.2202025.9333024.13170K562DDX47
NPLENSG00000135838.9588.56780363.307300.695906.587705.54680K562EIF2S2
NPLENSG00000135838.9193.6603099.166200.965503.565402.40830K562EIF3A
NPLENSG00000135838.9290.53060193.388200.587103.188002.31020K562EIF4A3
NPLENSG00000135838.9217.65170106.437801.031904.038301.60010K562EIF4G1
NPLENSG00000135838.9687.77810496.717700.469404.438703.26050K562EIF4G2
NPLENSG00000135838.9534.30910220.869501.2744014.9963012.91930K562FMR1
NPLENSG00000135838.9426.99550187.205501.1895011.318909.34460K562FTO
NPLENSG00000135838.9330.67010201.114600.717305.281304.48320K562FXR1
NPLENSG00000135838.9349.92340234.182000.579303.938002.58170K562GLRX3
NPLENSG00000135838.9429.02290207.258401.049509.902808.38990K562GPKOW
NPLENSG00000135838.9908.86260484.234900.9083011.490409.92610K562GRSF1
NPLENSG00000135838.9565.46920238.798701.2436018.1818015.78140K562HNRNPA1
NPLENSG00000135838.9468.79000251.036000.900905.288703.11200K562HNRNPAB
NPLENSG00000135838.9505.60110204.156801.3082016.2784014.91040K562HNRNPC
NPLENSG00000135838.9549.74590244.843201.166807.613705.25670K562ILF2
NPLENSG00000135838.9211.90320101.851101.056806.176203.95830K562ILF3
NPLENSG00000135838.9506.22360176.969301.5162014.8786012.56310K562KRR1
NPLENSG00000135838.9345.32350244.786800.496302.969702.00960K562MATR3
NPLENSG00000135838.9316.04690481.29830-0.606803.686802.61220K562MBNL1
NPLENSG00000135838.9409.62770202.306801.017709.334407.66020K562METAP2
NPLENSG00000135838.9901.61150529.474700.767809.366107.37230K562MSI2
NPLENSG00000135838.9519.42090246.207701.0769011.058209.55960K562MTPAP
NPLENSG00000135838.9495.15220273.582100.8558010.692809.35640K562NSUN2
NPLENSG00000135838.9510.40840257.711400.985806.177604.32100K562PABPC1
NPLENSG00000135838.9161.16350264.66560-0.715602.196201.33510K562PABPN1
NPLENSG00000135838.9737.81660321.841501.1968014.4214012.55590K562PCBP3
NPLENSG00000135838.9515.19280246.863901.0613012.8298011.16880K562POLR2G
NPLENSG00000135838.9169.35630238.28070-0.492602.360401.73940K562PTBP1
NPLENSG00000135838.9736.86440541.975100.443103.604902.67670K562PUF60
NPLENSG00000135838.9842.80280576.343200.548206.147404.50430K562PUM1
NPLENSG00000135838.9735.58380564.837300.381003.555202.46780K562PUM2
NPLENSG00000135838.9236.95150391.16010-0.723204.139103.42970K562RBM15
NPLENSG00000135838.9382.54180239.262100.676903.013301.35620K562RPS3A
NPLENSG00000135838.9323.29110219.960000.555503.062901.92350K562SAFB
NPLENSG00000135838.9476.66730269.921200.820305.566404.44000K562SF3A3
NPLENSG00000135838.9465.51300197.105201.2398011.406809.34250K562SF3B1
NPLENSG00000135838.9198.37280107.383600.885304.553002.89250K562SLBP
NPLENSG00000135838.9378.16490276.537000.451402.916701.95930K562SRPK2
NPLENSG00000135838.9841.13200410.023501.0365013.3826010.32810K562SSRP1
NPLENSG00000135838.9674.02750472.888100.511205.086503.12080K562SUCLG1
NPLENSG00000135838.9432.62060205.641601.072909.170707.25810K562SUPV3L1
NPLENSG00000135838.9395.29660247.610200.674805.206104.07110K562SYNCRIP
NPLENSG00000135838.9291.12700176.058200.725504.028102.88530K562TIAL1
NPLENSG00000135838.9519.09150217.631301.2540014.1351011.78030K562UCHL5
NPLENSG00000135838.9504.69890290.083100.798909.285208.06300K562UPF1
NPLENSG00000135838.9421.90840282.622500.578003.099901.82180K562UTP3
NPLENSG00000135838.9450.89080248.217900.861103.296202.34410K562WDR3
NPLENSG00000135838.9488.00400258.097200.9189012.2759010.64700K562WDR43
NPLENSG00000135838.9686.68630479.824400.517004.203802.60270K562WRN
NPLENSG00000135838.9328.23030221.585800.566703.068401.77470K562XRN2
NPLENSG00000135838.9657.38310456.429600.526204.181403.08290K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NPL is not available on ENCORE database.





6 RBPs can affect the splicing of NPL :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SENPLENSG00000135838.9chr1+1827648641827649751827634901827635741827728321827729060.074000.009500.07796includedK562AQR
SENPLENSG00000135838.9chr1+1827648641827649751827634901827635741827728321827729060.055000.000890.09627includedK562DROSHA
SENPLENSG00000135838.9chr1+1827755531827756661827752791827753671827812901827813480.454000.000000.00052includedK562HNRNPK
A5SSNPLENSG00000135838.9chr1+1827752791827756661827752791827753671827812901827813480.320000.000110.01652longerK562EFTUD2
A5SSNPLENSG00000135838.9chr1+1827752791827756661827752791827753671827812901827813480.484000.000000.00245longerK562HNRNPK
MXENPLENSG00000135838.9chr1+182791249182791334182794915182794955182787947182787994182798737182799519-0.350000.005000.066092includedK562SRSF1
MXENPLENSG00000135838.9chr1+182787947182787994182791177182791334182787675182787824182794915182796155-0.292000.004370.050202includedK562U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NPL is not avaliable on ENCORE database.