MORC2

General Information

Gene Name : MORC2
Gene ID : ENSG00000133422.12
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: MORC2)

Not Available

Antibody Validation

Thermo Fisher: PA5-51172

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	MORC2	ENSG00000133422.12	7.66	9.10	8.38	ENCSR000AEF
HepG2	MORC2	ENSG00000133422.12	26.58	21.16	23.87	ENCSR985KAT
K562	MORC2	ENSG00000133422.12	22.23	21.52	21.88	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 4139	ENCSR168VUE	MORC2	K562	Released	ENCAB179RUB	ENCSR790SPV
knockdown followed by RNA-seq	MORC2-BGKcLV19-K562	ENCSR990DKW	MORC2	K562	Released		ENCSR978MMZ	CRISPR	KD% = 73.8,85.0
knockdown followed by RNA-seq	MORC2-BGHcLV20-HepG2	ENCSR444IOJ	MORC2	HepG2	Released		ENCSR306EWE	CRISPR	KD% = 61.6,63.0

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
MORC2	4139	K562	ENCSR168VUE	ENCSR790SPV	ENCAB179RUB	PA5-51172	UF2796314	Released	ENCODE4

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
MORC2	ENCAB179RUB	PA5-51172	UF2796314				BGHcLV20-13, Released, ENCODE4	BGKcLV19-23, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
MORC2	K562	CRISPR	ENCSR990DKW	ENCSR978MMZ	MORC2-BGKcLV19-23,MORC2-BGKcLV19-24	NT-BGKcLV19-1,NT-BGKcLV19-2	73.8,85.0	Released	ENCODE4
MORC2	HepG2	CRISPR	ENCSR444IOJ	ENCSR306EWE	MORC2-BGHcLV20-13,MORC2-BGHcLV20-14	NT-BGHcLV20-1,NT-BGHcLV20-2	61.6,63.0	Released	ENCODE4
MORC2	Ribo-STAMP-293T	shRNA			BGRSLV03-37,BGRSLV03-38	BGRSLV03-1,BGRSLV03-2		NotSatisfied	ENCORE2
MORC2	Ribo-STAMP-293T	shRNA			BGRSLV06-7,BGRSLV06-8	BGRSLV06-1,BGRSLV06-2		NotSatisfied	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
MORC2	Product_ID: PA5-51172 Lot_ID: UF2796314 Source: Thermo Fisher Target Name: MORC2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for MORC2 is not avaliable on ENCORE database.

Proteins bound to RNA

MORC2 RNA is bound by 16 proteins.

eCLIP assay for MORC2 is not avaliable on ENCORE database.

16 proteins are bound to MORC2 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr22	31322782	31322853	-	3'-UTR,CDS,intron-Distal	3.06679	5.88770	HepG2	PABPN1
chr22	31364175	31364216	-	5'-UTR,intron-Distal,intron-Proximal	3.17758	4.62770	HepG2	HLTF
chr22	31363828	31363891	-	5'-UTR,CDS,intron-Distal	3.28367	6.40644	HepG2	HLTF
chr22	31334054	31334082	-	CDS,intron-Distal,intron-Proximal	3.24130	4.74886	HepG2	BCLAF1
chr22	31335569	31335619	-	CDS,intron-Distal,intron-Proximal	5.04494	6.26248	HepG2	PRPF8
chr22	31345750	31345812	-	CDS,intron-Distal	3.75810	18.16789	HepG2	PPIG
chr22	31331234	31331273	-	CDS,intron-Distal,intron-Proximal	3.02352	4.35275	HepG2	HLTF
chr22	31332924	31332943	-	CDS,intron-Distal	4.05410	4.09885	HepG2	BCLAF1
chr22	31333897	31333936	-	CDS,intron-Distal	3.13585	6.09950	HepG2	BCLAF1
chr22	31333904	31333928	-	CDS,intron-Distal	3.60621	4.22917	HepG2	PPIG
chr22	31328921	31328983	-	CDS,intron-Distal,intron-Proximal	4.03520	8.65131	HepG2	PABPN1
chr22	31332988	31333019	-	CDS,intron-Distal,intron-Proximal	3.31019	4.99842	HepG2	PPIG
chr22	31337384	31337424	-	CDS,intron-Distal,intron-Proximal	4.02274	6.23016	HepG2	PRPF8
chr22	31334085	31334164	-	CDS,intron-Distal	3.46658	5.50142	HepG2	ZNF800
chr22	31345736	31345750	-	CDS,intron-Distal,intron-Proximal	5.34360	8.65687	HepG2	PPIG
chr22	31331017	31331114	-	CDS,intron-Distal	3.82602	9.22328	HepG2	PABPN1
chr22	31330045	31330082	-	CDS,intron-Distal,intron-Proximal	3.88120	6.13978	HepG2	PPIG
chr22	31332921	31332956	-	CDS,intron-Distal	3.40053	3.73423	K562	UCHL5
chr22	31332466	31332518	-	CDS,intron-Distal,intron-Proximal	3.98529	5.64484	HepG2	PRPF8
chr22	31323964	31324014	-	CDS,intron-Distal,intron-Proximal	3.54529	4.54206	HepG2	PRPF8
chr22	31331234	31331271	-	CDS,intron-Distal,intron-Proximal	3.10962	5.00905	HepG2	BCLAF1
chr22	31335885	31335994	-	CDS,intron-Distal,intron-Proximal	3.83185	17.24590	HepG2	PRPF8
chr22	31328875	31328921	-	CDS,intron-Distal,intron-Proximal	3.48873	6.65788	HepG2	PABPN1
chr22	31335616	31335666	-	CDS,intron-Distal	3.95170	9.27186	HepG2	PPIG
chr22	31333620	31333696	-	CDS,intron-Distal	3.53100	5.73766	K562	YBX3
chr22	31328879	31328916	-	CDS,intron-Distal,intron-Proximal	3.77000	7.26626	HepG2	PPIG
chr22	31331008	31331051	-	CDS,intron-Distal	3.56248	5.90680	HepG2	PPIG
chr22	31345794	31345828	-	CDS,intron-Distal	3.46758	3.12941	K562	UCHL5
chr22	31328876	31328916	-	CDS,intron-Distal,intron-Proximal	4.28866	7.16838	HepG2	BCLAF1
chr22	31331123	31331148	-	CDS,intron-Distal,intron-Proximal	3.65334	3.97821	HepG2	PABPN1
chr22	31329493	31329507	-	CDS,intron-Distal	3.14410	3.17635	HepG2	PPIG
chr22	31328371	31328391	-	CDS,intron-Distal	4.71589	4.97342	HepG2	PPIG
chr22	31334099	31334159	-	CDS,intron-Distal	3.84707	5.85226	K562	UCHL5
chr22	31346362	31346399	-	CDS,intron-Distal,intron-Proximal	4.72495	11.12920	HepG2	PPIG
chr22	31330904	31330988	-	CDS,intron-Distal	3.19034	6.23765	HepG2	PABPN1
chr22	31333891	31333931	-	CDS,intron-Distal	5.04548	7.20668	HepG2	PABPN1
chr22	31334092	31334146	-	CDS,intron-Distal	3.54496	9.28980	HepG2	BCLAF1
chr22	31334109	31334162	-	CDS,intron-Distal	4.15100	8.83457	HepG2	GRWD1
chr22	31330046	31330095	-	CDS,intron-Distal,intron-Proximal	4.33763	3.61890	HepG2	G3BP1
chr22	31330046	31330097	-	CDS,intron-Distal,intron-Proximal	3.12539	5.03836	HepG2	PABPN1
chr22	31342423	31342436	-	CDS,intron-Distal	5.01593	6.21892	HepG2	PPIG
chr22	31335943	31335988	-	CDS,intron-Distal,intron-Proximal	3.77292	9.75394	HepG2	PPIG
chr22	31346362	31346403	-	CDS,intron-Distal,intron-Proximal	5.42344	12.82870	HepG2	GRWD1
chr22	31324082	31324160	-	CDS,intron-Distal	4.77641	13.86986	HepG2	PABPN1
chr22	31331134	31331148	-	CDS,intron-Distal,intron-Proximal	4.31130	4.42137	HepG2	HLTF
chr22	31328375	31328438	-	CDS,intron-Distal,intron-Proximal	3.31757	7.42509	HepG2	PABPN1
chr22	31338140	31338163	-	CDS,intron-Distal	4.00930	4.21087	HepG2	GRWD1
chr22	31330046	31330060	-	CDS,intron-Distal,intron-Proximal	3.02688	3.71797	HepG2	BCLAF1
chr22	31335949	31335960	-	CDS,intron-Distal	3.66530	4.09885	HepG2	BCLAF1
chr22	31333903	31333921	-	CDS,intron-Distal	4.08272	4.50960	HepG2	GRWD1
chr22	31332926	31332953	-	CDS,intron-Distal	3.31843	4.24993	HepG2	PPIG
chr22	31345810	31345828	-	CDS,intron-Distal	4.23090	10.04397	HepG2	GRWD1
chr22	31333834	31333866	-	CDS,intron-Distal	4.20210	3.77023	K562	ZNF622
chr22	31328934	31328952	-	CDS,intron-Distal,intron-Proximal	3.66530	4.46864	HepG2	BCLAF1
chr22	31345812	31345829	-	CDS,intron-Distal,intron-Proximal	3.24126	8.60746	HepG2	PPIG
chr22	31330813	31330873	-	CDS,intron-Distal	4.31204	5.43239	K562	YBX3
chr22	31345737	31345748	-	CDS,intron-Distal,intron-Proximal	3.14495	3.39306	HepG2	GRWD1
chr22	31323936	31323977	-	intron-Distal,intron-Proximal	4.10997	4.37625	HepG2	RBM22
chr22	31360512	31360585	-	intron-Distal	3.51186	8.92112	HepG2	HNRNPM
chr22	31358337	31358386	-	intron-Distal	3.54427	6.43306	HepG2	ILF3
chr22	31330002	31330047	-	intron-Distal,intron-Proximal	4.93374	6.69228	HepG2	PRPF8
chr22	31344950	31345004	-	intron-Distal	4.27489	4.86210	HepG2	HNRNPM
chr22	31346206	31346279	-	intron-Distal,intron-Proximal	4.20666	5.60471	HepG2	U2AF2
chr22	31358321	31358382	-	intron-Distal	3.54076	5.35827	HepG2	HNRNPC
chr22	31360667	31360800	-	intron-Distal	4.03396	6.01218	HepG2	HNRNPM
chr22	31345091	31345168	-	intron-Distal	4.37455	3.62366	HepG2	HNRNPM
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for MORC2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for MORC2 is not available on ENCORE database.
56 RBPs can affect the levels of MORC2.

The Knockdown/knockout RNA-Seq assay for MORC2 is not available on ENCORE database.

56 RBPs can affect the gene expression of MORC2 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MORC2	ENSG00000133422.8	944.46330	1174.68010	-0.31470	3.01190	1.94710	HepG2	YBX3
MORC2	ENSG00000133422.8	959.40640	1176.57890	-0.29440	2.06930	1.47300	HepG2	DDX21
MORC2	ENSG00000133422.8	2341.20270	1325.42460	0.82070	7.91940	6.78480	HepG2	EIF4B
MORC2	ENSG00000133422.8	2069.09230	2512.56520	-0.28020	3.83770	3.14970	HepG2	ETF1
MORC2	ENSG00000133422.8	1703.48670	1397.39470	0.28570	2.37710	1.60410	HepG2	EWSR1
MORC2	ENSG00000133422.8	1404.11670	997.49920	0.49320	5.08590	4.03190	HepG2	FUBP3
MORC2	ENSG00000133422.8	934.79600	1354.18500	-0.53470	3.38910	2.15230	HepG2	FUS
MORC2	ENSG00000133422.8	687.62930	874.36190	-0.34660	2.28990	1.48200	HepG2	GEMIN5
MORC2	ENSG00000133422.8	1608.26160	1290.28420	0.31770	2.31660	1.67400	HepG2	HNRNPK
MORC2	ENSG00000133422.8	1014.93750	1286.78460	-0.34240	4.31690	3.57380	HepG2	HNRNPU
MORC2	ENSG00000133422.8	1719.32690	1295.07540	0.40870	3.24710	2.52230	HepG2	IGF2BP2
MORC2	ENSG00000133422.8	1416.72970	1971.05110	-0.47640	2.81320	1.83780	HepG2	MTPAP
MORC2	ENSG00000133422.8	1773.40930	1414.22570	0.32640	2.09990	1.54470	HepG2	NCBP2
MORC2	ENSG00000133422.8	1513.98600	1824.04150	-0.26880	2.51320	1.78850	HepG2	NOL12
MORC2	ENSG00000133422.8	1660.65990	1259.39070	0.39890	2.97570	2.22930	HepG2	PABPC4
MORC2	ENSG00000133422.8	2137.57850	1252.68590	0.77090	22.81460	21.35170	HepG2	PCBP1
MORC2	ENSG00000133422.8	1715.83990	1274.76050	0.42860	6.05430	5.30740	HepG2	PTBP1
MORC2	ENSG00000133422.8	1325.64780	1741.22650	-0.39340	3.84100	3.15170	HepG2	PUF60
MORC2	ENSG00000133422.8	1180.01390	1456.62620	-0.30380	3.88410	3.17880	HepG2	PUS1
MORC2	ENSG00000133422.8	2008.23580	1380.37160	0.54080	9.12580	8.09070	HepG2	QKI
MORC2	ENSG00000133422.8	2860.30250	2148.23270	0.41290	5.80070	4.61700	HepG2	RBM15
MORC2	ENSG00000133422.8	1782.98990	1418.59820	0.32970	4.16590	3.52630	HepG2	NELFE
MORC2	ENSG00000133422.8	1687.38050	1321.39090	0.35260	4.56520	3.79970	HepG2	RECQL
MORC2	ENSG00000133422.8	1483.02360	1921.53840	-0.37370	3.48210	2.72950	HepG2	RPLP0
MORC2	ENSG00000133422.8	2842.34700	2047.16300	0.47340	3.12980	2.41290	HepG2	SF3A3
MORC2	ENSG00000133422.8	2482.10600	1912.89980	0.37570	3.50160	2.71680	HepG2	SF3B1
MORC2	ENSG00000133422.8	1622.71850	1327.00050	0.29010	3.11260	2.49020	HepG2	SF3B4
MORC2	ENSG00000133422.8	2841.73540	2371.87890	0.26060	3.84000	3.27870	HepG2	SRFBP1
MORC2	ENSG00000133422.8	1382.47730	1752.47370	-0.34210	4.78880	3.91240	HepG2	SRSF7
MORC2	ENSG00000133422.8	1566.82200	1126.98330	0.47530	4.40750	3.74150	HepG2	SRSF9
MORC2	ENSG00000133422.8	1705.44140	2059.31140	-0.27200	3.71720	3.14230	HepG2	SSB
MORC2	ENSG00000133422.8	1870.41780	1396.22190	0.42170	2.69890	1.61360	HepG2	STIP1
MORC2	ENSG00000133422.8	1558.35950	1101.78880	0.50010	4.08230	3.28450	HepG2	SUPV3L1
MORC2	ENSG00000133422.8	1594.62560	1144.00320	0.47900	6.22460	4.97790	HepG2	TIA1
MORC2	ENSG00000133422.8	1518.25410	1261.51830	0.26720	3.04460	2.45980	HepG2	TRIM56
MORC2	ENSG00000133422.8	1227.60320	1815.52410	-0.56450	12.65280	11.36120	HepG2	UPF1
MORC2	ENSG00000133422.8	1532.66340	1866.07850	-0.28400	3.01010	1.92340	HepG2	UTP18
MORC2	ENSG00000133422.8	1974.95320	1735.17460	0.18660	2.11320	1.51410	HepG2	ZC3H8
MORC2	ENSG00000133422.8	1223.06700	1611.43310	-0.39780	5.82780	5.05240	K562	AGGF1
MORC2	ENSG00000133422.8	1480.07880	1896.99590	-0.35800	3.27740	2.64880	K562	AQR
MORC2	ENSG00000133422.8	1008.89980	1218.01750	-0.27180	2.79230	1.82760	K562	BCLAF1
MORC2	ENSG00000133422.8	1176.32910	1465.35430	-0.31700	2.77850	1.99410	K562	CPSF6
MORC2	ENSG00000133422.8	2698.39910	2266.66860	0.25140	3.27900	2.57930	K562	DDX47
MORC2	ENSG00000133422.8	1290.05950	1716.17070	-0.41180	5.87660	4.88670	K562	EIF2S2
MORC2	ENSG00000133422.8	991.68770	762.50820	0.37900	3.56640	2.66970	K562	EIF3G
MORC2	ENSG00000133422.8	1383.86270	1726.51030	-0.31920	2.57680	1.75980	K562	FIP1L1
MORC2	ENSG00000133422.8	1471.24530	1013.14410	0.53810	6.83160	5.94160	K562	FXR1
MORC2	ENSG00000133422.8	1686.88460	2286.89630	-0.43900	5.31560	4.26220	K562	GRSF1
MORC2	ENSG00000133422.8	1109.42430	1420.07830	-0.35620	2.31060	1.46480	K562	HNRNPM
MORC2	ENSG00000133422.8	1618.03210	2340.78300	-0.53280	6.26860	5.08150	K562	HSPD1
MORC2	ENSG00000133422.8	2181.11380	2747.03520	-0.33280	2.92840	1.76150	K562	MSI2
MORC2	ENSG00000133422.8	1420.80300	1959.92920	-0.46410	4.63060	3.52980	K562	PPIG
MORC2	ENSG00000133422.8	914.93510	1663.00770	-0.86210	12.93460	11.80790	K562	PUS1
MORC2	ENSG00000133422.8	1392.29130	1620.24200	-0.21870	1.85630	1.35290	K562	RBM15
MORC2	ENSG00000133422.8	1223.98810	1014.97860	0.27000	2.01780	1.40280	K562	SRSF1
MORC2	ENSG00000133422.8	1863.90680	1475.30730	0.33720	3.51290	2.58750	K562	SYNCRIP
MORC2	ENSG00000133422.8	1799.18260	2371.26880	-0.39830	7.09150	5.03000	K562	TROVE2
MORC2	ENSG00000133422.8	1803.72020	2151.85690	-0.25460	3.33950	2.55460	K562	UPF1
MORC2	ENSG00000133422.8	1157.86080	1841.27130	-0.66920	10.71320	8.94570	K562	WDR3
MORC2	ENSG00000133422.8	1709.71950	2137.03270	-0.32180	2.83270	1.95760	K562	ZC3H8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for MORC2 is not available on ENCORE database.

4 RBPs can affect the splicing of MORC2 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	MORC2	ENSG00000133422.8	chr22	-	31337419	31337545	31336744	31336824	31337877	31337989	0.09800	0.00018	0.03794	included	HepG2	RBM15
A3SS	MORC2	ENSG00000133422.8	chr22	-	31338098	31338282	31338098	31338258	31342327	31342544	0.06100	0.00021	0.00173	longer	K562	AQR
A3SS	MORC2	ENSG00000133422.8	chr22	-	31336744	31336845	31336744	31336824	31337419	31337545	0.05300	0.00396	0.02353	longer	K562	AQR
A3SS	MORC2	ENSG00000133422.8	chr22	-	31334051	31334220	31334051	31334192	31335607	31335693	0.07800	0.00000	0.00004	longer	K562	AQR
A3SS	MORC2	ENSG00000133422.8	chr22	-	31332918	31333074	31332918	31333024	31333569	31333698	0.05200	0.00052	0.00384	longer	K562	AQR
A3SS	MORC2	ENSG00000133422.8	chr22	-	31329452	31329615	31329452	31329507	31330046	31330178	0.06900	0.00000	0.00001	longer	K562	AQR
A3SS	MORC2	ENSG00000133422.8	chr22	-	31332564	31332646	31332564	31332630	31332918	31333074	0.11000	0.00000	0.00002	longer	K562	AQR
A3SS	MORC2	ENSG00000133422.8	chr22	-	31334051	31334192	31334051	31334102	31335607	31335693	-0.19000	0.00004	0.00246	shorter	HepG2	U2AF1
A5SS	MORC2	ENSG00000133422.8	chr22	-	31324005	31324194	31324014	31324194	31322597	31322858	0.23800	0.00005	0.00315	longer	HepG2	U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

MORC2

General Information

Functions

Localization

Domains (AlphaFold: MORC2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for MORC2 is not avaliable on ENCORE database.

16 proteins are bound to MORC2 RNA:

eCLIP assay for MORC2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for MORC2 is not available on ENCORE database.

56 RBPs can affect the gene expression of MORC2 :

The Knockdown/knockout RNA-Seq assay for MORC2 is not available on ENCORE database.

4 RBPs can affect the splicing of MORC2 :

The Knockdown/knockout RNA-Seq assay for MORC2 is not avaliable on ENCORE database.