CDK11B

General Information

Gene Name       : CDK11B
Gene ID             : ENSG00000248333.8
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CDK11B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CDK11BENSG00000248333.827.6521.0624.35ENCSR000AEF
HepG2CDK11BENSG00000248333.823.4320.0221.73ENCSR985KAT
K562CDK11BENSG00000248333.836.7335.1235.92ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
CDK11B5524S3Submitted, ENCORE2


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
CDK11BK562CRISPRCDK11B-BGKcLV42-15,CDK11B-BGKcLV42-16NT-BGKcLV42-1,NT-BGKcLV42-250.3,52.4SequencedENCORE2
CDK11BHepG2CRISPRBGHcLV45-11,BGHcLV45-12BGHcLV45-1,BGHcLV45-267.8,60.8SequencingENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
CDK11BProduct_ID: 5524S
Lot_ID: 3
Source: Cell Signaling Technology
Target Name: CDK11B-human		 CST_5524S_3_CDK11B.png<br>Caption: IP-WB analysis of 5524S whole cell lysate using the CDK11B specific antibody, 5524S. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the CDK11B-specific antibody, 5524S. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.








RNA Targets

  • eCLIP assay for CDK11B is not avaliable on ENCORE database.



Proteins bound to RNA
  • CDK11B RNA is bound by 12 proteins.  







eCLIP assay for CDK11B is not avaliable on ENCORE database.





12 proteins are bound to CDK11B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr115903761590430-5'-UTR,intron-Distal4.805544.78571K562UCHL5
chr115903311590426-5'-UTR,intron-Distal3.763825.73990HepG2PRPF8
chr115720591572143-CDS,intron-Distal3.991313.12746HepG2GRWD1
chr115723231572340-CDS,intron-Distal4.189883.01428K562UCHL5
chr115886461588809-CDS,intron-Distal,intron-Proximal4.347109.02572K562EFTUD2
chr115757071575757-CDS,intron-Distal4.128159.03438K562ZNF622
chr115725491572586-CDS,intron-Distal,intron-Proximal3.915933.28461K562BUD13
chr115720461572142-CDS,intron-Distal3.041144.42352K562ZNF622
chr115727101572772-CDS,intron-Distal,intron-Proximal3.735955.00154HepG2AQR
chr115756561575748-CDS,intron-Distal3.7130310.47889K562UCHL5
chr115727381572833-CDS,intron-Distal,intron-Proximal4.326245.35719HepG2GRWD1
chr115722751572363-CDS,intron-Distal,intron-Proximal4.668137.25648HepG2GRWD1
chr115717771571843-CDS,intron-Distal3.554596.98424K562UCHL5
chr115757171575809-CDS,intron-Distal3.033396.09968K562PUM1
chr115868731586934-CDS,intron-Distal5.387078.87880K562ZNF622
chr115724381572473-CDS,intron-Distal,intron-Proximal3.190924.14618K562ZNF622
chr115720051572053-CDS,intron-Distal,intron-Proximal5.381505.01842HepG2PRPF8
chr115731211573200-CDS,intron-Distal,intron-Proximal3.300013.17744HepG2GRWD1
chr115725411572566-CDS,intron-Distal,intron-Proximal3.807386.42898K562AQR
chr115756601575707-CDS,intron-Distal3.764667.71102K562ZNF622
chr115868661586939-CDS,intron-Distal,intron-Proximal3.479524.63109K562GRWD1
chr115725021572572-CDS,intron-Distal,intron-Proximal3.717267.56654HepG2PRPF8
chr115722771572366-CDS,intron-Distal,intron-Proximal3.611579.48271K562ZNF622
chr115868651586937-CDS,intron-Distal4.9403913.64917K562UCHL5
chr115867801586823-intron-Distal,intron-Proximal4.842339.04436K562AQR
chr115837461583798-intron-Distal4.670909.58295K562SLTM
chr115822431582302-intron-Distal3.032834.49816K562UCHL5
chr115834061583483-intron-Distal4.712953.83566K562YWHAG
chr115842391584315-intron-Distal3.273694.02149K562SLTM
chr115818071581899-intron-Distal4.032529.05161K562SAFB2
chr115827171582806-intron-Distal3.9341221.81386K562SLTM
chr115727651572770-intron-Distal,intron-Proximal5.4784127.94932HepG2PRPF8
chr115725661572588-intron-Distal,intron-Proximal3.562236.16312K562AQR
chr115835141583590-intron-Distal4.665427.10192K562SAFB2
chr115720001572023-intron-Distal,intron-Proximal4.618603.70761K562AQR
chr115827181582795-intron-Distal5.237825.44000HepG2SLTM
chr115903311590375-intron-Distal5.331155.69951K562AQR
chr115834141583481-intron-Distal4.9355718.06942K562SLTM
chr115821511582204-intron-Distal3.112753.73364K562SAFB2
chr115827021582784-intron-Distal4.354753.24150HepG2HLTF
chr115835241583601-intron-Distal3.065016.29223K562UCHL5
chr115727101572731-intron-Distal,intron-Proximal3.7713211.43407HepG2PRPF8
chr115727311572752-intron-Distal,intron-Proximal5.1975329.86178HepG2PRPF8
chr115818151581881-intron-Distal3.347076.32494K562UCHL5
chr115827011582805-intron-Distal4.3048815.36400K562UCHL5
chr115821221582178-intron-Distal4.159456.11943K562UCHL5
chr115726951572770-intron-Distal,intron-Proximal5.7982724.96343K562AQR
chr115827121582802-intron-Distal3.885277.16266K562YWHAG
chr115818201581927-intron-Distal5.227946.65708K562YWHAG
chr115720231572044-intron-Distal,intron-Proximal4.492114.09264K562AQR
chr115727521572765-intron-Distal,intron-Proximal6.1226930.58090HepG2PRPF8
chr115817971581932-intron-Distal3.166186.93851K562BUD13
chr115827051582801-intron-Distal4.6062216.39540K562SAFB2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CDK11B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CDK11B is not available on ENCORE database.

  • 67 RBPs can affect the levels of CDK11B.  








The Knockdown/knockout RNA-Seq assay for CDK11B is not available on ENCORE database.





67 RBPs can affect the gene expression of CDK11B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CDK11BENSG00000248333.3839.14440618.937400.439005.260104.47480HepG2ACO1
CDK11BENSG00000248333.3919.48760550.358600.740406.034505.28350HepG2AKAP1
CDK11BENSG00000248333.3813.56240618.801500.394704.502503.69330HepG2CKAP4
CDK11BENSG00000248333.3344.12690480.74130-0.482302.874902.17680HepG2CPSF6
CDK11BENSG00000248333.3395.75890296.596100.416003.028202.35160HepG2DNAJC2
CDK11BENSG00000248333.3225.39890369.28730-0.712302.671201.58670HepG2AGO1
CDK11BENSG00000248333.3829.80170485.510200.773207.468506.37270HepG2FXR1
CDK11BENSG00000248333.3590.59740450.277500.391302.008801.43860HepG2G3BP1
CDK11BENSG00000248333.3861.75380456.190400.9175010.890309.58420HepG2HNRNPK
CDK11BENSG00000248333.3455.90360340.973300.419003.458102.64540HepG2ILF2
CDK11BENSG00000248333.3700.27910485.680600.527803.547202.80310HepG2MAGOH
CDK11BENSG00000248333.3728.55750488.366600.577003.812803.08180HepG2MATR3
CDK11BENSG00000248333.3678.01110499.844100.439702.554401.94420HepG2NCBP2
CDK11BENSG00000248333.3435.57160330.409300.398602.683801.84690HepG2PARN
CDK11BENSG00000248333.3748.52870493.283900.601507.884806.94450HepG2PCBP1
CDK11BENSG00000248333.3406.82180297.729500.450303.068202.29550HepG2PPIL4
CDK11BENSG00000248333.3741.87070630.853700.233801.865801.35810HepG2PUM1
CDK11BENSG00000248333.3709.95930558.612400.345802.820702.27590HepG2NELFE
CDK11BENSG00000248333.3449.55680297.269100.596602.387301.78220HepG2SAFB2
CDK11BENSG00000248333.31383.84190695.987000.9914010.819909.42200HepG2SF3A3
CDK11BENSG00000248333.3673.74480522.559700.366503.087402.46710HepG2SF3B4
CDK11BENSG00000248333.3504.33910346.663400.540805.395904.54830HepG2SMN1
CDK11BENSG00000248333.3327.65200545.45790-0.735307.738007.03960HepG2SRSF1
CDK11BENSG00000248333.3318.91300553.88620-0.796405.468704.01930HepG2SRSF3
CDK11BENSG00000248333.3757.07460586.761700.367603.313802.63980HepG2SRSF5
CDK11BENSG00000248333.3498.28540620.79240-0.317102.462201.80160HepG2SRSF7
CDK11BENSG00000248333.3516.86920337.705400.613903.786402.48040HepG2STIP1
CDK11BENSG00000248333.3862.08600667.319100.369403.793403.08610HepG2SUCLG1
CDK11BENSG00000248333.3340.83110490.33070-0.524704.128203.46470HepG2TAF15
CDK11BENSG00000248333.3362.32250506.95090-0.484603.035502.27950HepG2TARDBP
CDK11BENSG00000248333.3909.89680525.749200.791203.648802.43020HepG2TBRG4
CDK11BENSG00000248333.3421.76070324.346600.378802.135501.68540HepG2TIAL1
CDK11BENSG00000248333.3499.31440327.257000.609406.289405.50050HepG2TRIM56
CDK11BENSG00000248333.3839.66820627.127000.421002.866602.22790HepG2U2AF1
CDK11BENSG00000248333.3346.64110248.409500.480602.222401.54210HepG2UCHL5
CDK11BENSG00000248333.3643.91270413.982700.637204.141103.26190HepG2XRN2
CDK11BENSG00000248333.31926.944401499.335800.361905.623904.86000K562AGGF1
CDK11BENSG00000248333.32143.969001647.587200.379803.779802.59010K562AKAP8
CDK11BENSG00000248333.32146.747801560.137600.460405.289504.37150K562AKAP8L
CDK11BENSG00000248333.32744.045301764.145300.637209.305208.33120K562AQR
CDK11BENSG00000248333.3992.13050796.206800.317303.079902.07120K562BCLAF1
CDK11BENSG00000248333.31851.671101617.010800.195401.946001.38140K562DDX47
CDK11BENSG00000248333.32076.514601678.752100.306703.896402.83440K562DKC1
CDK11BENSG00000248333.31145.82970677.002500.759103.748002.22900K562EEF2
CDK11BENSG00000248333.31279.55550653.995600.9682013.9641011.74420K562EFTUD2
CDK11BENSG00000248333.31011.00570700.025700.530203.593302.39810K562EIF3D
CDK11BENSG00000248333.3705.32130448.251500.653907.431706.13660K562EIF3G
CDK11BENSG00000248333.3996.27640741.072400.426804.282802.62720K562EWSR1
CDK11BENSG00000248333.31212.41010882.901700.457505.931905.09510K562FXR1
CDK11BENSG00000248333.3161.84340383.37210-1.244109.450507.98930K562G3BP2
CDK11BENSG00000248333.3854.78240657.778500.377902.731401.94150K562GPKOW
CDK11BENSG00000248333.31398.29220916.425500.609507.910206.94860K562HNRNPC
CDK11BENSG00000248333.31125.77290559.187801.009408.485506.31980K562IGF2BP2
CDK11BENSG00000248333.3835.16470587.116400.508302.096001.35930K562MAGOH
CDK11BENSG00000248333.31993.183201584.902900.330603.078101.92970K562MAK16
CDK11BENSG00000248333.31245.435401454.46940-0.223802.141401.42440K562MTPAP
CDK11BENSG00000248333.3884.76870574.172600.623703.425501.91850K562PCBP1
CDK11BENSG00000248333.31096.59270522.284501.0700012.7909010.59380K562PCBP2
CDK11BENSG00000248333.31434.855301149.602700.319702.997602.16270K562POLR2G
CDK11BENSG00000248333.31519.55900636.418301.2555022.9756020.79810K562PRPF8
CDK11BENSG00000248333.31041.58350570.462800.868508.773107.63320K562PTBP1
CDK11BENSG00000248333.33071.097802383.509300.365603.711102.76900K562PUF60
CDK11BENSG00000248333.31992.968502535.56510-0.347404.427503.04990K562PUM1
CDK11BENSG00000248333.32153.499002484.01600-0.206002.230301.36630K562PUM2
CDK11BENSG00000248333.32050.784501547.151300.406504.110203.46770K562PUS1
CDK11BENSG00000248333.31897.146401507.529800.331503.956503.26290K562RBM15
CDK11BENSG00000248333.3802.66530546.695400.554002.587501.77600K562RBM22
CDK11BENSG00000248333.31012.40470648.114600.643403.721802.77130K562RPS19
CDK11BENSG00000248333.31288.730001633.76440-0.342205.181403.94570K562SRPK2
CDK11BENSG00000248333.3856.20150528.381600.696304.150002.82130K562SRSF5
CDK11BENSG00000248333.31161.20830565.918301.0369010.827309.27050K562TARDBP
CDK11BENSG00000248333.31062.41740545.928200.960507.506606.05490K562TIA1
CDK11BENSG00000248333.3965.82490536.043100.849305.626503.94220K562TRA2A
CDK11BENSG00000248333.3889.65600664.141800.421702.739501.54190K562XRN2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CDK11B is not available on ENCORE database.





1 RBPs can affect the splicing of CDK11B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSCDK11BENSG00000248333.3chr1-1572769157299715727691572875157312315732450.277000.000000.00000longerK562AQR
A3SSCDK11BENSG00000248333.3chr1-1571694157189715716941571843157204315720720.257000.000000.00000longerK562AQR
A3SSCDK11BENSG00000248333.3chr1-1572442157259715724421572564157276915728900.138000.000000.00000longerK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CDK11B is not avaliable on ENCORE database.