SNW1

General Information

Gene Name       : SNW1
Gene ID             : ENSG00000100603.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SNW1)


Antibody Validation

 View validation images for all SNW1 antibodies

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SNW1ENSG00000100603.1387.7873.8880.83ENCSR000AEF
HepG2SNW1ENSG00000100603.1345.9489.1967.56ENCSR985KAT
K562SNW1ENSG00000100603.1360.0274.6367.33ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq SNW1-BGKcLV33-K562SNW1K562Released   CRISPRKD% = band isn't on the position,
knockdown followed by RNA-seq SNW1-BGKcLV33-K562ENCSR458FLKSNW1K562ReleasedENCSR271ZAB   CRISPRKD% = no band on the position,






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
SNW1ENCAB440BLEA300-785A1Released, ENCODE4BGKcLV33-65, Released, ENCODE4
SNW1ENCAB574RLFA300-784A1Released, ENCODE4BGKcLV33-65, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
SNW1K562CRISPRBGKcLV33-61,BGKcLV33-62BGKcLV33-1,BGKcLV33-2band isn't on the position,ReleasedENCODE4
SNW1K562CRISPRENCSR458FLKENCSR271ZABSNW1-BGKcLV33-65,SNW1-BGKcLV33-66NT-BGKcLV33-1,NT-BGKcLV33-2no band on the position,ReleasedENCODE4
SNW1HepG2CRISPRBGHcLV31-61,BGHcLV31-62BGHcLV31-1,BGHcLV31-20.0,0.0NotSatisfiedENCODE4
SNW1HepG2CRISPRBGHcLV34-55,BGHcLV34-56BGHcLV34-1,BGHcLV34-20.0,0.0NotSatisfiedENCORE2
SNW1HepG2CRISPRBGHcLV36-31,BGHcLV36-32BGHcLV36-1,BGHcLV36-2NO CLEAR BAND ON THE POSITION,NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
SNW1Product_ID: A300-784A
Lot_ID: 1
Source: Bethyl Labs
Target Name: SNW1-human		 Bethyl_A300-784A_1_SNW1.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the SNW1 specific antibody, A300-784A. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the SNW1-specific antibody, A300-784A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 SNW1-K562-CRISPR-A300-784A.png<br>Caption: Western blot following CRISPR against SNW1 in K562 whole cell lysate using SNW1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SNW1. SNW1 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.
SNW1Product_ID: A300-785A
Lot_ID: 1
Source: Bethyl Labs
Target Name: SNW1-human		 Bethyl_A300-785A_1_SNW1.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the SNW1 specific antibody, A300-785A. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the SNW1-specific antibody, A300-785A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 SNW1-K562-CRISPR-A300-785A.png<br>Caption: Western blot following CRISPR against SNW1 in K562 whole cell lysate using SNW1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against SNW1. SNW1 protein appears as the green arrow, Beta-actin serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for SNW1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SNW1 RNA is bound by 15 proteins.  







eCLIP assay for SNW1 is not avaliable on ENCORE database.





15 proteins are bound to SNW1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr147820506078205128-3'-UTR,CDS,intron-Distal,intron-Proximal4.405174.22101K562PRPF8
chr147818420178184249-3'-UTR,intron-Distal,intron-Proximal3.071616.48920K562UPF1
chr147818413978184201-3'-UTR,intron-Distal,intron-Proximal3.468953.91938K562UPF1
chr147818431678184397-3'-UTR,intron-Distal5.084346.68732K562PUM2
chr147818395978184017-3'-UTR,intron-Distal,intron-Proximal4.126208.65685K562TIA1
chr147818406078184109-3'-UTR,intron-Distal,intron-Proximal4.342148.51000K562YBX3
chr147820513078205173-3'-UTR,CDS,intron-Distal3.834423.36483HepG2G3BP1
chr147820513178205199-3'-UTR,CDS,intron-Distal3.725096.97808HepG2BCLAF1
chr147818450678184538-3'-UTR,CDS,intron-Distal3.729545.08388K562UCHL5
chr147818410978184157-3'-UTR,intron-Distal,intron-Proximal3.718107.80648K562YBX3
chr147819890678198951-3'-UTR,CDS,intron-Distal,intron-Proximal3.126273.89662K562BUD13
chr147821776178217824-5'-UTR,CDS,intron-Distal,intron-Proximal4.616454.96063K562LIN28B
chr147822131778221456-CDS,intron-Distal,intron-Proximal3.397195.80517HepG2GRWD1
chr147822133278221431-CDS,intron-Distal3.474704.22917HepG2PPIG
chr147822134778221436-CDS,intron-Distal3.266696.72164K562UCHL5
chr147819873978198811-intron-Distal,intron-Proximal4.027315.63763K562AQR
chr147821681078216885-intron-Distal4.477874.85866HepG2QKI
chr147822735678227425-intron-Distal4.547203.69482HepG2RBM22
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SNW1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SNW1 is not available on ENCORE database.

  • 68 RBPs can affect the levels of SNW1.  








The Knockdown/knockout RNA-Seq assay for SNW1 is not available on ENCORE database.





68 RBPs can affect the gene expression of SNW1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SNW1ENSG00000100603.9917.809701182.43340-0.365504.347503.40140HepG2AKAP8L
SNW1ENSG00000100603.91431.254901802.16060-0.332404.615203.76830HepG2AUH
SNW1ENSG00000100603.9745.459401004.60540-0.430402.444601.60090HepG2BCLAF1
SNW1ENSG00000100603.91627.801602053.72730-0.335302.878602.26850HepG2BOP1
SNW1ENSG00000100603.91345.990602246.23390-0.738807.122805.54480HepG2CCAR1
SNW1ENSG00000100603.9968.066501176.64850-0.281503.271302.55880HepG2CKAP4
SNW1ENSG00000100603.9945.186001885.41930-0.9962017.4592015.90900HepG2CPSF6
SNW1ENSG00000100603.91450.503501844.78050-0.346905.928504.90060HepG2DAZAP1
SNW1ENSG00000100603.91217.452801612.51110-0.405403.015502.36620HepG2DDX3X
SNW1ENSG00000100603.9781.085101058.86230-0.439005.132604.20190HepG2DNAJC21
SNW1ENSG00000100603.9852.838201049.49020-0.299303.509402.78980HepG2DNAJC2
SNW1ENSG00000100603.91221.164001743.44180-0.513705.402704.28610HepG2EIF4G2
SNW1ENSG00000100603.91631.868602069.15640-0.342504.666103.92290HepG2ETF1
SNW1ENSG00000100603.91006.931401377.34100-0.451903.353702.62550HepG2G3BP1
SNW1ENSG00000100603.9683.05860948.72690-0.474003.419802.41100HepG2GEMIN5
SNW1ENSG00000100603.91484.758702137.23050-0.525504.772003.94660HepG2GPKOW
SNW1ENSG00000100603.91369.207101671.31870-0.287603.183902.41830HepG2HNRNPF
SNW1ENSG00000100603.91495.315102039.60200-0.447804.099203.34870HepG2HNRNPLL
SNW1ENSG00000100603.91296.733601645.78140-0.343903.213502.43750HepG2IGF2BP1
SNW1ENSG00000100603.91026.313701408.20580-0.456402.796001.78880HepG2KHSRP
SNW1ENSG00000100603.91793.500102370.97440-0.402702.599701.79650HepG2LARP4
SNW1ENSG00000100603.91233.179501528.79700-0.310001.849001.32510HepG2NCBP2
SNW1ENSG00000100603.91174.544101442.53670-0.296503.483802.82040HepG2PCBP1
SNW1ENSG00000100603.91121.656401467.81650-0.388005.255704.55140HepG2PTBP1
SNW1ENSG00000100603.91340.684201746.21250-0.381303.688903.01190HepG2PUF60
SNW1ENSG00000100603.91488.014001853.68580-0.317005.303004.53600HepG2PUM1
SNW1ENSG00000100603.91005.351201198.75220-0.253802.648302.04170HepG2PUS1
SNW1ENSG00000100603.91836.947801314.059200.483202.366101.71090HepG2RAVER1
SNW1ENSG00000100603.92099.110201729.424600.279403.034902.49920HepG2RBM22
SNW1ENSG00000100603.91031.385201368.33040-0.407802.777001.78280HepG2RBM27
SNW1ENSG00000100603.91221.437901633.55430-0.419406.177105.42320HepG2NELFE
SNW1ENSG00000100603.91267.274501521.40580-0.263702.869902.24390HepG2RECQL
SNW1ENSG00000100603.92238.896801800.275500.314502.691702.01580HepG2RPLP0
SNW1ENSG00000100603.92108.424801532.850200.459803.241602.51080HepG2SF3A3
SNW1ENSG00000100603.91249.477601528.21980-0.290503.303702.66390HepG2SF3B4
SNW1ENSG00000100603.91425.569801674.35400-0.232102.791402.08640HepG2SLBP
SNW1ENSG00000100603.91372.923501724.13540-0.328604.316503.56520HepG2SRSF5
SNW1ENSG00000100603.91366.879401641.98210-0.264602.749002.05470HepG2SRSF7
SNW1ENSG00000100603.91203.033601433.71560-0.253102.363701.83870HepG2TAF15
SNW1ENSG00000100603.91147.472901988.08420-0.7929012.1337010.77910HepG2TARDBP
SNW1ENSG00000100603.9929.121801158.01840-0.317703.630203.00300HepG2TRIM56
SNW1ENSG00000100603.91356.088001705.98240-0.331203.031602.11320HepG2TUFM
SNW1ENSG00000100603.91818.233601460.440800.316002.438901.84580HepG2U2AF1
SNW1ENSG00000100603.91218.558601805.75990-0.567405.105903.94960HepG2UBE2L3
SNW1ENSG00000100603.91135.308901359.40410-0.259902.877002.16670HepG2UPF1
SNW1ENSG00000100603.91864.990601312.450700.506809.998008.97250HepG2UTP3
SNW1ENSG00000100603.91055.539201243.44390-0.236402.457101.81830HepG2ZC3H8
SNW1ENSG00000100603.92456.693001785.964300.459905.459303.73480K562AARS
SNW1ENSG00000100603.93988.037302971.023700.4246010.135209.13840K562AGGF1
SNW1ENSG00000100603.91505.531701822.75910-0.275902.817501.48980K562BCCIP
SNW1ENSG00000100603.92313.838003066.94960-0.406504.978003.93220K562CPSF6
SNW1ENSG00000100603.94634.626203484.559500.411409.197708.09290K562DDX47
SNW1ENSG00000100603.92186.973502557.94330-0.226002.402601.72460K562EIF2S2
SNW1ENSG00000100603.93375.827904036.33800-0.257803.461502.41410K562EIF4G2
SNW1ENSG00000100603.91174.728801429.40660-0.283102.628601.37410K562EWSR1
SNW1ENSG00000100603.92780.958103408.79970-0.293702.839102.07480K562GRSF1
SNW1ENSG00000100603.91524.376901954.40920-0.358503.499402.83880K562HNRNPC
SNW1ENSG00000100603.92887.329702168.274600.413103.326702.29840K562HNRNPM
SNW1ENSG00000100603.94462.172003280.765300.443605.915704.60440K562KIF1C
SNW1ENSG00000100603.92159.014102858.26620-0.404804.625303.47160K562METAP2
SNW1ENSG00000100603.92234.737702595.33870-0.215802.703101.90350K562MTPAP
SNW1ENSG00000100603.93547.490102576.128600.461502.545201.70690K562NAA15
SNW1ENSG00000100603.92214.053501459.186600.601407.166905.96160K562PRPF8
SNW1ENSG00000100603.91417.269701752.30740-0.306102.160901.37100K562PSIP1
SNW1ENSG00000100603.95400.456603065.721400.8168015.3020014.06630K562PUS1
SNW1ENSG00000100603.94139.544002987.260000.470509.215208.15570K562RBM15
SNW1ENSG00000100603.91983.173901486.247100.416003.141602.26820K562RPS19
SNW1ENSG00000100603.91216.471201515.47310-0.317102.394501.45770K562SRFBP1
SNW1ENSG00000100603.92561.771102915.20890-0.186502.476001.58520K562SRPK2
SNW1ENSG00000100603.91078.623702309.87100-1.0986021.8484019.44470K562TARDBP
SNW1ENSG00000100603.92469.342302086.796400.242702.183701.46990K562U2AF2
SNW1ENSG00000100603.93516.938602720.639200.370308.414107.01600K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SNW1 is not available on ENCORE database.





18 RBPs can affect the splicing of SNW1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESNW1ENSG00000100603.9chr14-7818952378189620781870537818717178197330781974720.053000.001400.02749includedK562SRSF1
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.168000.000000.00000excludedK562SF3B4
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.080000.000090.00525excludedK562PRPF8
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.103000.000040.00120excludedHepG2U2AF1
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.157000.000000.00000excludedK562AKAP8L
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.116000.000000.00136excludedK562FMR1
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.224000.000000.00000excludedK562AQR
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.217000.000000.00000excludedK562PUS1
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.067000.000160.03301excludedK562NSUN2
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.233000.000000.00000excludedK562U2AF1
SESNW1ENSG00000100603.9chr14-7818952378189620781870537818717178197330781974720.051000.000610.07010includedHepG2HNRNPUL1
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.155000.000000.00000excludedK562UTP18
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.215000.000000.00000excludedK562U2AF2
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.160000.000000.00000excludedK562RBM15
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.150000.000000.00000excludedK562AGGF1
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.086000.000220.03170excludedK562CPSF6
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.143000.000000.00005excludedK562SF3B1
SESNW1ENSG00000100603.9chr14-7818952378189620781870537818717178197330781974720.052000.001020.04087includedK562PTBP1
SESNW1ENSG00000100603.9chr14-781895237818962078187053781871717819733078197472-0.097000.000310.00703excludedK562HNRNPC
A3SSSNW1ENSG00000100603.9chr14-7818705378187285781870537818717178189523781896200.084000.000000.00000longerK562AQR
A3SSSNW1ENSG00000100603.9chr14-7820530878205527782053087820540478217661782178230.053000.000000.00000longerK562AQR
MXESNW1ENSG00000100603.9chr14-7818480378184873781895237818962078183941781846297819733078197472-0.054000.000000.000022includedK562AQR
MXESNW1ENSG00000100603.9chr14-7818705378187171781895237818962078184295781848737819733078197472-0.103000.001380.012042includedK562AQR
MXESNW1ENSG00000100603.9chr14-7818474878184873781895237818962078183941781846297819733078197472-0.065000.000000.000002includedK562AQR
MXESNW1ENSG00000100603.9chr14-7818705378187171781895237818962078184295781848737819733078197472-0.134000.000770.015492includedHepG2HNRNPUL1
MXESNW1ENSG00000100603.9chr14-7818705378187171781895237818962078184295781848737819733078197472-0.165000.000000.000112includedK562SF3B4

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SNW1 is not avaliable on ENCORE database.