PSEN1

General Information

Gene Name       : PSEN1
Gene ID             : ENSG00000080815.18
Essential Gene : No

Functions

Localization

Domains (AlphaFold: PSEN1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PSEN1ENSG00000080815.1823.5321.9822.76ENCSR000AEF
HepG2PSEN1ENSG00000080815.1821.4025.0523.23ENCSR985KAT
K562PSEN1ENSG00000080815.1814.5216.9815.75ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PSEN1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PSEN1 RNA is bound by 7 proteins.  







eCLIP assay for PSEN1 is not avaliable on ENCORE database.





7 proteins are bound to PSEN1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr147368689373686950+3'-UTR4.473184.07810K562UPF1
chr147368619573686311+3'-UTR5.3524910.94465HepG2UPF1
chr147368624073686313+3'-UTR3.601435.05467HepG2LIN28B
chr147364031973640416+3'-UTR,CDS,intron-Proximal3.682693.02850K562YBX3
chr147368617973686239+3'-UTR3.974093.34655HepG2AKAP1
chr147367851673678639+3'-UTR,CDS,intron-Distal5.038927.93299HepG2SND1
chr147368690973686968+3'-UTR4.241583.61011HepG2AKAP1
chr147363755273637644+3'-UTR,5'-UTR,CDS3.342093.39306HepG2GRWD1
chr147368655673686626+3'-UTR3.378665.75802K562UPF1
chr147368646373686518+3'-UTR4.421245.14974HepG2UPF1
chr147368684773686926+3'-UTR5.222578.46737HepG2UPF1
chr147360322573603299+5'-UTR,intron-Distal,intron-Proximal3.151913.76820HepG2NCBP2
chr147365935173659552+CDS,intron-Proximal3.043634.31260K562SND1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PSEN1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PSEN1 is not available on ENCORE database.

  • 68 RBPs can affect the levels of PSEN1.  








The Knockdown/knockout RNA-Seq assay for PSEN1 is not available on ENCORE database.





68 RBPs can affect the gene expression of PSEN1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PSEN1ENSG00000080815.141645.255001305.910600.333204.908404.14210HepG2ACO1
PSEN1ENSG00000080815.141531.659301312.052300.223202.194601.50250HepG2AKAP8L
PSEN1ENSG00000080815.142458.990801652.667900.5732013.3265012.01780HepG2AUH
PSEN1ENSG00000080815.141170.07630914.627500.355202.461901.61480HepG2BCLAF1
PSEN1ENSG00000080815.141621.452401123.466700.529205.947705.11020HepG2BOP1
PSEN1ENSG00000080815.141773.932601363.642900.379404.101703.18750HepG2CALR
PSEN1ENSG00000080815.142626.049001922.548000.449804.362003.40360HepG2CIRBP
PSEN1ENSG00000080815.141871.012401578.939400.244802.656802.02520HepG2CELF1
PSEN1ENSG00000080815.141610.566301215.023900.406504.176303.04310HepG2DDX24
PSEN1ENSG00000080815.142104.981901171.254400.845705.943204.53250HepG2DDX59
PSEN1ENSG00000080815.141036.331801231.74810-0.249202.779402.12630HepG2DNAJC2
PSEN1ENSG00000080815.14775.325801005.79630-0.375502.499101.44510HepG2EFTUD2
PSEN1ENSG00000080815.141200.628601934.72420-0.688307.919006.95230HepG2EIF2S1
PSEN1ENSG00000080815.14899.186201175.22130-0.386203.462502.15240HepG2EIF2S2
PSEN1ENSG00000080815.141304.86590979.379000.413903.216002.24720HepG2EIF3D
PSEN1ENSG00000080815.142601.054301897.484100.454908.581007.62300HepG2ETF1
PSEN1ENSG00000080815.142327.660401564.301500.573305.151704.13040HepG2FIP1L1
PSEN1ENSG00000080815.141217.78330861.358900.499504.127302.59910HepG2FKBP4
PSEN1ENSG00000080815.141615.059002156.97990-0.417403.508302.73480HepG2FXR1
PSEN1ENSG00000080815.141648.038801169.271200.495004.142103.37070HepG2GPKOW
PSEN1ENSG00000080815.141523.094901254.607900.279701.962301.40670HepG2HNRNPA1
PSEN1ENSG00000080815.141448.100602025.82510-0.484304.959904.04570HepG2HNRNPK
PSEN1ENSG00000080815.141265.057501546.45650-0.289804.022503.22180HepG2HNRNPL
PSEN1ENSG00000080815.141883.586401115.851000.7552010.204009.08270HepG2HNRNPLL
PSEN1ENSG00000080815.141159.038201386.29890-0.258302.684702.08730HepG2HNRNPU
PSEN1ENSG00000080815.141236.010401416.05730-0.196202.252701.58240HepG2ILF2
PSEN1ENSG00000080815.141113.253901628.27220-0.548603.558302.03350HepG2ILF3
PSEN1ENSG00000080815.141560.062402157.73110-0.467904.037403.24610HepG2MAGOH
PSEN1ENSG00000080815.141629.494702169.87380-0.413202.991202.33800HepG2MATR3
PSEN1ENSG00000080815.142026.183901266.094500.6783010.775109.28850HepG2MSI2
PSEN1ENSG00000080815.141347.122401063.132100.341502.840301.61170HepG2NAA15
PSEN1ENSG00000080815.141741.751102221.04030-0.350702.400801.80810HepG2NCBP2
PSEN1ENSG00000080815.141526.400701934.77010-0.342005.114804.32960HepG2PCBP1
PSEN1ENSG00000080815.141389.797401090.876800.349304.288703.34900HepG2PRPF4
PSEN1ENSG00000080815.141079.69880798.490400.435203.490202.59340HepG2PRPF8
PSEN1ENSG00000080815.141458.900801968.67340-0.432307.129706.33200HepG2PTBP1
PSEN1ENSG00000080815.142139.895101704.662000.328003.624002.86130HepG2PUM2
PSEN1ENSG00000080815.141612.924601330.155800.278003.541502.86320HepG2PUS1
PSEN1ENSG00000080815.141729.654402132.18040-0.301803.351402.67350HepG2QKI
PSEN1ENSG00000080815.142091.712601455.526000.523002.681001.98610HepG2RAVER1
PSEN1ENSG00000080815.143142.774901585.945600.9866034.0917032.66310HepG2RBM22
PSEN1ENSG00000080815.141106.776001481.82720-0.421003.308302.21790HepG2RBM27
PSEN1ENSG00000080815.141629.059102190.96730-0.427507.589106.77190HepG2NELFE
PSEN1ENSG00000080815.141689.721502040.54690-0.272203.482702.80080HepG2RECQL
PSEN1ENSG00000080815.142561.319501596.121200.6822010.582309.39630HepG2RPLP0
PSEN1ENSG00000080815.141059.707901429.39380-0.431702.254801.39980HepG2RPS10
PSEN1ENSG00000080815.141047.22820789.895400.406702.820202.02700HepG2RRP9
PSEN1ENSG00000080815.141730.310801104.510800.647508.407007.23990HepG2SF3B1
PSEN1ENSG00000080815.141573.303002049.69240-0.381606.154405.33110HepG2SF3B4
PSEN1ENSG00000080815.142536.055801228.948001.045105.297004.20500HepG2SNRNP70
PSEN1ENSG00000080815.142999.573601791.267100.7437026.3841025.24860HepG2SRFBP1
PSEN1ENSG00000080815.141386.240202139.41500-0.6260015.8100014.87700HepG2SRSF1
PSEN1ENSG00000080815.141879.350901586.698500.244102.827802.19530HepG2SRSF5
PSEN1ENSG00000080815.142000.465801740.510700.200702.188001.68540HepG2SRSF9
PSEN1ENSG00000080815.142004.486801555.243800.366006.088105.38240HepG2SSB
PSEN1ENSG00000080815.141919.469701030.183200.8977012.2772011.02120HepG2SUPV3L1
PSEN1ENSG00000080815.14886.341801892.91850-1.094707.054005.43390HepG2TBRG4
PSEN1ENSG00000080815.141044.12960690.537300.596405.341504.02220HepG2TFIP11
PSEN1ENSG00000080815.142210.132901338.187400.7238010.131908.91360HepG2U2AF1
PSEN1ENSG00000080815.141966.664101559.563700.334505.243204.33070HepG2UPF1
PSEN1ENSG00000080815.141271.501401076.532800.240002.595201.94160HepG2ZC3H8
PSEN1ENSG00000080815.143084.608301715.216700.8466041.2067039.74070HepG2ZNF622
PSEN1ENSG00000080815.141635.840001071.465500.610307.171506.29670K562AQR
PSEN1ENSG00000080815.14798.78310946.68380-0.245102.369501.67480K562NSUN2
PSEN1ENSG00000080815.142054.920901539.832900.416203.988903.01330K562PUF60
PSEN1ENSG00000080815.14660.49960956.97900-0.534907.949206.45670K562SRPK2
PSEN1ENSG00000080815.14614.23480789.04430-0.361302.282601.63640K562TARDBP
PSEN1ENSG00000080815.14844.59210633.665600.414402.538701.49720K562U2AF1
PSEN1ENSG00000080815.14829.51550654.419000.342002.678501.88770K562U2AF2
PSEN1ENSG00000080815.141172.096301003.785900.223501.986901.37130K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PSEN1 is not available on ENCORE database.





2 RBPs can affect the splicing of PSEN1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPSEN1ENSG00000080815.14chr14+7362671673626846736147067361480273637504736377550.277000.000670.01223includedK562PUS1
SEPSEN1ENSG00000080815.14chr14+7362671673626846736147067361480273637504736377550.338000.000660.01978includedK562RBM15

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PSEN1 is not avaliable on ENCORE database.