TLK2

General Information

Gene Name       : TLK2
Gene ID             : ENSG00000146872.17
Essential Gene : No

Functions

Localization

Domains (AlphaFold: TLK2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878TLK2ENSG00000146872.1728.3624.5826.47ENCSR000AEF
HepG2TLK2ENSG00000146872.1731.5536.0233.79ENCSR985KAT
K562TLK2ENSG00000146872.1721.8119.7620.79ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for TLK2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • TLK2 RNA is bound by 21 proteins.  







eCLIP assay for TLK2 is not avaliable on ENCORE database.





21 proteins are bound to TLK2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr176059817660598206+3'-UTR,5'-UTR,CDS,intron-Proximal3.366973.73423K562UCHL5
chr176059955960599606+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.223044.24005HepG2BCLAF1
chr176069066460690707+3'-UTR3.257173.07801K562UPF1
chr176059816560598206+3'-UTR,5'-UTR,CDS,intron-Proximal5.319618.75788K562ZNF622
chr176059955960599574+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.313307.48753K562ZNF622
chr176059815460598206+3'-UTR,5'-UTR,CDS,intron-Proximal3.082723.63043HepG2GRWD1
chr176059957460599601+3'-UTR,5'-UTR,CDS,intron-Distal3.539086.14048K562ZNF622
chr176055625560556395+5'-UTR,intron-Distal4.295355.11568K562PUM1
chr176055845860558585+5'-UTR,CDS,intron-Proximal3.738873.99908K562BUD13
chr176055659660556761+5'-UTR,intron-Distal,intron-Proximal3.797034.86221HepG2SUPV3L1
chr176060155860601635+5'-UTR,CDS,intron-Distal,intron-Proximal4.049855.47926K562AQR
chr176055633360556420+5'-UTR,intron-Distal3.979509.76063HepG2DDX3X
chr176065582160655883+CDS,intron-Proximal3.673003.02321K562U2AF2
chr176061368260613740+CDS,intron-Proximal3.491487.85990HepG2PRPF8
chr176065406860654135+CDS,intron-Proximal3.475843.61259K562ZNF622
chr176067950460679593+CDS,intron-Proximal4.2194010.87706HepG2PRPF8
chr176065063060650736+CDS,intron-Proximal3.758635.03335K562UCHL5
chr176062975260629882+CDS,intron-Distal,intron-Proximal4.606169.80019K562AQR
chr176067952260679593+CDS,intron-Proximal3.960438.82110K562PRPF8
chr176065063760650726+CDS3.057144.56310K562ZNF622
chr176064239560642508+CDS,intron-Proximal3.698865.15776HepG2BCLAF1
chr176066343560663521+CDS,intron-Proximal4.143395.63851K562SF3B4
chr176065740060657479+CDS,intron-Proximal4.256273.59236HepG2AQR
chr176060857160608642+intron-Distal3.714913.06150K562KHSRP
chr176064778960647877+intron-Distal4.018083.93366K562RBFOX2
chr176061045160610520+intron-Distal3.838823.02234K562KHSRP
chr176065618160656244+intron-Distal3.856813.66668K562KHSRP
chr176060482560604892+intron-Distal6.2336711.11632HepG2QKI
chr176057883060578894+intron-Distal4.520124.96063K562LIN28B
chr176060845260608552+intron-Distal4.265743.96879HepG2MATR3
chr176065308360653108+intron-Distal6.2585518.58569HepG2PTBP1
chr176064373360643842+intron-Distal3.310663.84494HepG2QKI
chr176060951060609590+intron-Distal3.436224.30679K562KHSRP
chr176060266560602739+intron-Distal3.038093.07751K562KHSRP
chr176055917160559296+intron-Distal4.564555.41654K562KHSRP
chr176060957660609636+intron-Distal5.277348.16423HepG2U2AF2
chr176065597460656117+intron-Distal,intron-Proximal3.9248915.59356K562KHSRP
chr176063003660630092+intron-Distal4.408864.45977HepG2U2AF2
chr176066361860663731+intron-Distal,intron-Proximal3.842686.19377K562KHSRP
chr176065732060657463+intron-Distal,intron-Proximal3.884475.56048K562KHSRP
chr176055668860556745+intron-Distal,intron-Proximal4.062176.89981K562EFTUD2
chr176056847260568567+intron-Distal3.888625.42334HepG2QKI
chr176061965360619701+intron-Distal4.127163.27946HepG2HNRNPM
chr176064780560647861+intron-Distal4.517804.70434HepG2RBFOX2
chr176065595660656078+intron-Distal,intron-Proximal4.365065.07255HepG2KHSRP
chr176061057160610652+intron-Distal4.131303.42844K562KHSRP
chr176065302960653058+intron-Distal4.019575.16181K562PTBP1
chr176061029460610386+intron-Distal3.021323.29251K562KHSRP
chr176065306560653083+intron-Distal5.0104720.38222HepG2PTBP1
chr176065305860653116+intron-Distal5.7063017.58839K562PTBP1
chr176065303360653115+intron-Distal4.189233.72005K562MATR3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for TLK2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for TLK2 is not available on ENCORE database.

  • 52 RBPs can affect the levels of TLK2.  








The Knockdown/knockout RNA-Seq assay for TLK2 is not available on ENCORE database.





52 RBPs can affect the gene expression of TLK2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
TLK2ENSG00000146872.131347.833101043.531700.369105.225404.44250HepG2ACO1
TLK2ENSG00000146872.131513.880701749.74650-0.208902.107001.49310HepG2AUH
TLK2ENSG00000146872.13882.285701133.14720-0.361002.596301.52500HepG2CPSF7
TLK2ENSG00000146872.13813.02990969.42180-0.253802.001401.39320HepG2DNAJC21
TLK2ENSG00000146872.13704.24130960.83730-0.448206.416905.48310HepG2DNAJC2
TLK2ENSG00000146872.13920.513101229.77080-0.417903.025102.40610HepG2EIF2S1
TLK2ENSG00000146872.131045.00800776.663600.428103.149302.19090HepG2EIF3D
TLK2ENSG00000146872.131159.11900934.502200.310702.433301.42010HepG2EIF3G
TLK2ENSG00000146872.131104.116501329.39720-0.267902.578001.88460HepG2HNRNPF
TLK2ENSG00000146872.131113.909401391.89430-0.321404.636003.78010HepG2HNRNPL
TLK2ENSG00000146872.131054.085201423.69770-0.433703.491202.79350HepG2HNRNPLL
TLK2ENSG00000146872.13871.103801292.95170-0.569805.271804.36650HepG2IGF2BP2
TLK2ENSG00000146872.13993.333401379.43840-0.473703.453702.75560HepG2MATR3
TLK2ENSG00000146872.131155.011401515.13330-0.391504.650803.66200HepG2NOL12
TLK2ENSG00000146872.13990.239001302.17390-0.395105.407204.60520HepG2PCBP1
TLK2ENSG00000146872.131100.587401446.30420-0.394103.763103.07980HepG2PUF60
TLK2ENSG00000146872.131356.328601535.28870-0.178802.021201.49830HepG2PUM1
TLK2ENSG00000146872.131533.776801058.748100.534602.678201.98350HepG2RAVER1
TLK2ENSG00000146872.13739.45530963.06410-0.381204.533503.74260HepG2SAFB2
TLK2ENSG00000146872.131159.770301386.72470-0.257803.105202.36840HepG2SLBP
TLK2ENSG00000146872.132163.275301896.476600.189802.240001.77360HepG2SRFBP1
TLK2ENSG00000146872.131939.858801439.908200.429907.428806.74110HepG2SRSF1
TLK2ENSG00000146872.131091.354601306.06520-0.259102.441501.78470HepG2SRSF7
TLK2ENSG00000146872.131407.73150953.031900.562704.596103.75730HepG2SUPV3L1
TLK2ENSG00000146872.13946.573601387.57640-0.551805.700104.71520HepG2TARDBP
TLK2ENSG00000146872.13670.863401060.20080-0.6602012.1256011.06760HepG2TRIM56
TLK2ENSG00000146872.131853.805901188.403500.641405.622304.74270HepG2U2AF1
TLK2ENSG00000146872.131081.537601302.61300-0.268303.317402.73490HepG2ZNF622
TLK2ENSG00000146872.131800.410501346.043800.419506.801805.96970K562AGGF1
TLK2ENSG00000146872.132267.213701515.359300.581206.978606.11630K562AQR
TLK2ENSG00000146872.131798.445501469.583800.291203.149302.17120K562ATP5C1
TLK2ENSG00000146872.132951.133002431.677900.279202.950101.94400K562CELF1
TLK2ENSG00000146872.131094.00340896.482300.287202.250901.31810K562DDX3X
TLK2ENSG00000146872.132683.430701608.043300.7387021.9151020.25200K562DDX47
TLK2ENSG00000146872.131763.001501507.172800.226102.170501.40590K562DKC1
TLK2ENSG00000146872.13860.58350472.908500.863705.765004.27560K562EIF3A
TLK2ENSG00000146872.131219.29450887.602200.458003.254902.12680K562EIF3D
TLK2ENSG00000146872.131284.98030884.846700.538107.382606.09490K562EIF3G
TLK2ENSG00000146872.132425.717601977.684000.294503.505602.45010K562EIF4G2
TLK2ENSG00000146872.131401.643501017.919300.461402.919002.18970K562G3BP2
TLK2ENSG00000146872.132018.371201486.410100.441305.261504.04880K562KIF1C
TLK2ENSG00000146872.13934.474601184.62740-0.342202.894601.94870K562MATR3
TLK2ENSG00000146872.132007.963601665.154300.270002.105301.32800K562MBNL1
TLK2ENSG00000146872.13902.756501143.84800-0.341503.848702.90900K562MTPAP
TLK2ENSG00000146872.131916.578501167.152200.715405.888804.42610K562NAA15
TLK2ENSG00000146872.131038.27450806.677500.364002.501601.78840K562PRPF8
TLK2ENSG00000146872.13609.97330857.58840-0.491504.165603.02380K562PSIP1
TLK2ENSG00000146872.13910.128101153.23470-0.341502.969802.28400K562PTBP1
TLK2ENSG00000146872.132671.465302157.806800.308002.664201.86370K562PUF60
TLK2ENSG00000146872.132220.592201389.037300.676808.657607.74590K562PUS1
TLK2ENSG00000146872.131963.992101353.400800.537103.668302.99940K562RBM15
TLK2ENSG00000146872.13593.75450782.45070-0.398102.981401.95050K562RCC2
TLK2ENSG00000146872.131245.65930821.714900.600105.314104.17890K562RPS19
TLK2ENSG00000146872.13998.351801601.25110-0.681602.814001.49600K562SFPQ
TLK2ENSG00000146872.13518.60550741.74100-0.516304.026902.71650K562SRFBP1
TLK2ENSG00000146872.13693.18530876.31570-0.338202.180801.35630K562TRIM56
TLK2ENSG00000146872.131364.78600986.623200.468003.505302.24160K562U2AF1
TLK2ENSG00000146872.131305.546401018.990400.357403.488102.58700K562U2AF2
TLK2ENSG00000146872.131493.998401199.084400.317103.390002.46250K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for TLK2 is not available on ENCORE database.





21 RBPs can affect the splicing of TLK2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.121000.003240.05372excludedK562SRSF1
SETLK2ENSG00000146872.13chr17+6062966260629758606135306061369860631023606311160.223000.000110.00617includedK562PRPF8
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.223000.000000.00000excludedHepG2RBM22
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.082000.002070.03755excludedHepG2U2AF1
SETLK2ENSG00000146872.13chr17+6062966260629758606135306061369860631023606311160.124000.003670.08338includedK562AKAP8L
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.152000.000080.00415excludedK562AKAP8L
SETLK2ENSG00000146872.13chr17+606310236063111660629662606297586063737660637395-0.059000.001180.03597excludedK562AKAP8L
SETLK2ENSG00000146872.13chr17+6058474160584810605584846055856760585768605858720.375000.000500.00779includedHepG2U2AF2
SETLK2ENSG00000146872.13chr17+606004946060053860599564605996346061353060613698-0.175000.000350.00506excludedK562AQR
SETLK2ENSG00000146872.13chr17+606505756065082160642361606424986065406960654136-0.074000.009340.07684excludedK562AQR
SETLK2ENSG00000146872.13chr17+6062966260629758606135306061369860631023606311160.115000.002030.03045includedK562PUS1
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.189000.000000.00000excludedK562PUS1
SETLK2ENSG00000146872.13chr17+606015966060169260600494606005386061353060613698-0.335000.000090.00222excludedK562PUS1
SETLK2ENSG00000146872.13chr17+606310236063111660613530606136986063737660637395-0.168000.000000.00004excludedK562PUS1
SETLK2ENSG00000146872.13chr17+606310236063111660629662606297586063737660637395-0.076000.001040.06122excludedHepG2FTO
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.143000.000180.00607excludedHepG2SRSF1
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.136000.000490.05768excludedHepG2SSB
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.121000.000110.00648excludedK562UTP18
SETLK2ENSG00000146872.13chr17+606310236063111660613530606136986063737660637395-0.134000.000130.00729excludedK562UTP18
SETLK2ENSG00000146872.13chr17+6062966260629758606135306061369860631023606311160.132000.001540.03789includedK562RBM15
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.157000.000000.00006excludedK562RBM15
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.171000.000000.00001excludedK562AGGF1
SETLK2ENSG00000146872.13chr17+6060159660601692606004946060053860613530606136980.269000.000780.09227includedK562ZC3H8
SETLK2ENSG00000146872.13chr17+606310236063111660613530606136986063737660637395-0.084000.000620.08242excludedK562ZC3H8
SETLK2ENSG00000146872.13chr17+605857686058591460558484605585676059813360598205-0.148000.000340.05910excludedK562EIF3G
SETLK2ENSG00000146872.13chr17+6067458060674619606739456067403560678011606781280.071000.000450.02143includedK562PTBP1
SETLK2ENSG00000146872.13chr17+606310236063111660613530606136986063737660637395-0.090000.000020.00801excludedK562NPM1
A3SSTLK2ENSG00000146872.13chr17+6055848160558567605584846055856760556385605566510.632000.000020.02950longerHepG2HNRNPM
A3SSTLK2ENSG00000146872.13chr17+6068973660689934606897526068993460685401606855090.154000.000000.00000longerK562AQR
A3SSTLK2ENSG00000146872.13chr17+6065052160650728606505756065072860642361606424980.100000.000000.00000longerK562AQR
MXETLK2ENSG00000146872.13chr17+60655780606559356065747160657553606540696065413660663495606635870.051000.002810.022151includedK562AQR
MXETLK2ENSG00000146872.13chr17+60584741605848106058576860585914605584846055856760598133605982050.382000.000020.000261includedHepG2U2AF2
MXETLK2ENSG00000146872.13chr17+60631023606311166063737660637487606135306061369860642361606424980.171000.000660.048091includedK562RBM22
MXETLK2ENSG00000146872.13chr17+6063102360631116606373766063748760613530606136986064236160642498-0.079000.001100.075182includedK562CPSF6
MXETLK2ENSG00000146872.13chr17+6063102360631116606373766063748760613530606136986064236160642498-0.103000.000000.000372includedK562PPIL4
MXETLK2ENSG00000146872.13chr17+6060049460600538606135306061369860599564605996346062966260629758-0.293000.002310.039732includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for TLK2 is not avaliable on ENCORE database.