MTHFS

General Information

Gene Name       : MTHFS
Gene ID             : ENSG00000136371.10
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MTHFS)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MTHFSENSG00000136371.1014.1519.3216.73ENCSR000AEF
HepG2MTHFSENSG00000136371.1046.9940.1043.55ENCSR985KAT
K562MTHFSENSG00000136371.1037.9926.6232.30ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MTHFS is not avaliable on ENCORE database.



Proteins bound to RNA
  • MTHFS RNA is bound by 14 proteins.  







eCLIP assay for MTHFS is not avaliable on ENCORE database.





14 proteins are bound to MTHFS RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr158013745280137539-3'-UTR,5'-UTR,intron-Distal,intron-Proximal3.1634910.27880K562PABPC4
chr158018152580181641-3'-UTR,CDS,intron-Distal5.001498.32768HepG2GRWD1
chr158013736280137489-3'-UTR,intron-Distal,intron-Proximal3.509036.34584K562PUM2
chr158018155480181603-3'-UTR,CDS,intron-Distal3.869373.67607K562YBX3
chr158018916880189339-5'-UTR,CDS,intron-Distal3.999908.84023K562ZNF622
chr158018919480189359-5'-UTR,CDS,intron-Distal,intron-Proximal3.6999115.13050K562DDX3X
chr158018917480189349-5'-UTR,CDS,intron-Distal,intron-Proximal4.103193.86058K562GRWD1
chr158018913680189277-5'-UTR,CDS,intron-Distal3.599385.58683HepG2GRWD1
chr158013775380137801-CDS,intron-Distal,intron-Proximal4.300997.29386HepG2U2AF2
chr158013763280137748-CDS,intron-Distal,intron-Proximal4.337923.90287K562LIN28B
chr158013774480137776-CDS,intron-Distal,intron-Proximal3.689866.44666K562U2AF2
chr158013774480137797-CDS,intron-Distal,intron-Proximal4.500844.52791K562U2AF1
chr158017724780177309-intron-Distal3.221944.86332HepG2SUGP2
chr158017698480177031-intron-Distal4.016543.39864HepG2SUGP2
chr158017679580176825-intron-Distal4.062503.16028HepG2SUGP2
chr158018348280183588-intron-Distal3.419616.79980HepG2SUGP2
chr158017642680176559-intron-Distal4.939566.23638HepG2QKI
chr158018328380183396-intron-Distal3.385023.10640HepG2SUGP2
chr158018121280181371-intron-Distal,intron-Proximal3.335758.56786K562KHSRP
chr158017739280177442-intron-Distal4.296254.78128HepG2SUGP2
chr158017717480177290-intron-Distal3.498924.61500HepG2HNRNPM
chr158018118480181351-intron-Distal,intron-Proximal5.217697.22833HepG2KHSRP
chr158017645280176487-intron-Distal3.839983.29248HepG2SUGP2
chr158018111380181212-intron-Distal4.885547.91159K562KHSRP
chr158014167180141774-intron-Distal3.386283.98726HepG2RBFOX2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MTHFS is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MTHFS is not available on ENCORE database.

  • 60 RBPs can affect the levels of MTHFS.  








The Knockdown/knockout RNA-Seq assay for MTHFS is not available on ENCORE database.





60 RBPs can affect the gene expression of MTHFS :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MTHFSENSG00000136371.5656.78660506.683500.374202.049201.36920HepG2ASCC1
MTHFSENSG00000136371.5365.13800243.433500.584802.946702.01750HepG2BCLAF1
MTHFSENSG00000136371.5829.86060481.381100.785607.914606.65950HepG2CIRBP
MTHFSENSG00000136371.5227.24600158.886200.516202.022501.42460HepG2CPSF6
MTHFSENSG00000136371.5311.91020214.644600.539103.234402.13140HepG2YBX3
MTHFSENSG00000136371.5123.58740255.96580-1.050407.210906.16800HepG2DDX21
MTHFSENSG00000136371.5407.82950257.732000.662003.088901.73270HepG2DDX27
MTHFSENSG00000136371.5772.16180586.612100.396402.338901.75870HepG2DDX3X
MTHFSENSG00000136371.5314.55820214.990400.549002.865101.83620HepG2DDX5
MTHFSENSG00000136371.5308.97630203.302700.603803.124102.08480HepG2DHX30
MTHFSENSG00000136371.5562.68210307.301900.8726011.1971010.02360HepG2DKC1
MTHFSENSG00000136371.5310.27260174.228100.832504.755403.57600HepG2EEF2
MTHFSENSG00000136371.5342.41010484.42430-0.500502.825102.22590HepG2EIF2S1
MTHFSENSG00000136371.5326.59690521.21250-0.674403.641902.85820HepG2EIF4B
MTHFSENSG00000136371.5679.96510415.041100.712109.372208.00770HepG2EIF4G1
MTHFSENSG00000136371.5314.16600540.09460-0.781706.151805.14650HepG2FXR1
MTHFSENSG00000136371.5299.57020501.05390-0.742105.356604.44420HepG2G3BP1
MTHFSENSG00000136371.5300.10490180.104600.736503.792303.05260HepG2GPKOW
MTHFSENSG00000136371.5294.80670212.816000.470102.081601.51170HepG2HNRNPA1
MTHFSENSG00000136371.5320.62930507.27620-0.661904.725603.83450HepG2HNRNPK
MTHFSENSG00000136371.5324.92060171.877600.918606.031705.13950HepG2HNRNPLL
MTHFSENSG00000136371.5161.00030235.13920-0.546502.241601.69030HepG2HNRNPU
MTHFSENSG00000136371.5125.96810207.22430-0.718103.410702.51430HepG2MSI2
MTHFSENSG00000136371.5228.28360152.406200.582802.389301.69260HepG2NSUN2
MTHFSENSG00000136371.5372.74280503.56920-0.434003.329702.74080HepG2PTBP1
MTHFSENSG00000136371.5732.13730398.204100.8785010.923009.84430HepG2PUF60
MTHFSENSG00000136371.5309.26770422.40530-0.449802.683802.02290HepG2PUM2
MTHFSENSG00000136371.5589.03340327.169600.8482012.2827011.14310HepG2PUS1
MTHFSENSG00000136371.5324.37060545.38370-0.749607.582206.62540HepG2QKI
MTHFSENSG00000136371.5367.29180494.96860-0.430402.723302.05400HepG2RBM25
MTHFSENSG00000136371.5354.07040560.42650-0.662506.718005.93840HepG2NELFE
MTHFSENSG00000136371.5337.43340521.95700-0.629306.081405.21680HepG2RECQL
MTHFSENSG00000136371.5522.50700303.718700.782606.502705.51920HepG2RPLP0
MTHFSENSG00000136371.5373.37580230.856500.693503.482502.42280HepG2RPS10
MTHFSENSG00000136371.5363.58400194.257800.904204.439003.42660HepG2RPS3A
MTHFSENSG00000136371.5531.79330321.564800.725703.635902.85950HepG2SF3A3
MTHFSENSG00000136371.5243.69060170.121800.518402.129301.50470HepG2SF3B1
MTHFSENSG00000136371.5426.82290524.28550-0.296701.856501.35560HepG2SF3B4
MTHFSENSG00000136371.5616.82820458.762000.427003.689603.13650HepG2SRFBP1
MTHFSENSG00000136371.5659.97100547.238500.270101.741601.34180HepG2SRSF1
MTHFSENSG00000136371.5276.39910445.20600-0.687707.049806.24180HepG2SRSF9
MTHFSENSG00000136371.5913.12940398.287601.1969029.0533027.78950HepG2SSB
MTHFSENSG00000136371.5460.65390274.211800.748304.519403.68580HepG2SUPV3L1
MTHFSENSG00000136371.5333.36740491.87380-0.561204.679703.98110HepG2TAF15
MTHFSENSG00000136371.5242.07850451.97090-0.900809.151807.64990HepG2TIA1
MTHFSENSG00000136371.5334.13990219.041600.609103.031002.37470HepG2U2AF1
MTHFSENSG00000136371.5371.01270285.178200.379502.341201.69050HepG2UPF1
MTHFSENSG00000136371.5379.31720251.083700.595102.530401.57310HepG2UPF2
MTHFSENSG00000136371.5445.24110269.931600.721904.491903.57610HepG2XRN2
MTHFSENSG00000136371.5284.94010206.225100.466302.528201.88100HepG2ZC3H8
MTHFSENSG00000136371.5451.80330313.642200.526504.819904.14890HepG2ZNF622
MTHFSENSG00000136371.5661.00390499.290600.404702.575201.38010K562APOBEC3C
MTHFSENSG00000136371.5351.36120540.33140-0.620904.495903.78150K562AQR
MTHFSENSG00000136371.5465.06040316.639800.554503.839503.08970K562DDX47
MTHFSENSG00000136371.5267.89970360.76220-0.429402.483401.63630K562HNRNPU
MTHFSENSG00000136371.5486.83640356.043600.451302.742801.95130K562HSPD1
MTHFSENSG00000136371.5189.67070273.68580-0.529003.020002.17700K562MTPAP
MTHFSENSG00000136371.5195.65820289.76150-0.566502.620901.81380K562PCBP3
MTHFSENSG00000136371.5414.03850298.164200.473602.780801.95810K562PPIG
MTHFSENSG00000136371.5128.01780201.65310-0.655502.633601.75510K562PSIP1
MTHFSENSG00000136371.5371.43040281.949600.397602.226201.62040K562PTBP1
MTHFSENSG00000136371.5177.61940307.39390-0.791305.031303.81500K562SRPK2
MTHFSENSG00000136371.5362.32000276.406900.390401.952901.34610K562SRSF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MTHFS is not available on ENCORE database.





1 RBPs can affect the splicing of MTHFS :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A5SSMTHFSENSG00000136371.5chr15-801814348018169680181537801816968013731780137784-0.064000.000380.00817shorterK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MTHFS is not avaliable on ENCORE database.