MKNK1

General Information

Gene Name       : MKNK1
Gene ID             : ENSG00000079277.20
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MKNK1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MKNK1ENSG00000079277.2021.8717.8819.88ENCSR000AEF
HepG2MKNK1ENSG00000079277.2017.4921.8019.64ENCSR985KAT
K562MKNK1ENSG00000079277.2029.2228.3128.77ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MKNK1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MKNK1 RNA is bound by 13 proteins.  







eCLIP assay for MKNK1 is not avaliable on ENCORE database.





13 proteins are bound to MKNK1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr14702844047028530-3'-UTR,CDS,intron-Distal,intron-Proximal3.313733.32039HepG2PPIG
chr14702327147023383-3'-UTR,intron-Distal3.605166.40324K562UPF1
chr14704621247046301-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.091703.18789HepG2BCLAF1
chr14703071247030810-3'-UTR,CDS,intron-Distal,intron-Proximal3.950115.65086HepG2BCLAF1
chr14702357747023620-3'-UTR,intron-Distal3.410413.06830K562UPF1
chr14704889347049002-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.483405.44868K562ZNF622
chr14702825147028324-3'-UTR,CDS,intron-Distal,intron-Proximal5.473858.88118K562AQR
chr14704889847049011-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.437066.62505K562UCHL5
chr14704620947046300-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.393964.08604HepG2PPIG
chr14702331847023368-3'-UTR,intron-Distal4.314763.14995K562ZC3H11A
chr14702329847023385-3'-UTR,intron-Distal3.024843.29111K562FAM120A
chr14704063447040725-3'-UTR,CDS,intron-Distal,intron-Proximal3.176885.19836HepG2U2AF2
chr14703070947030765-3'-UTR,CDS,intron-Distal,intron-Proximal4.173683.49905HepG2PPIG
chr14702350047023544-3'-UTR,intron-Distal4.199433.87930K562UPF1
chr14705158847051672-5'-UTR,CDS,intron-Distal,intron-Proximal3.916834.36528HepG2U2AF2
chr14706984947069919-5'-UTR,intron-Distal,intron-Proximal4.346203.86664K562DDX3X
chr14706986147069923-5'-UTR,intron-Distal,intron-Proximal4.520695.05409HepG2NCBP2
chr14707483747074940-3'-UTR,intron-Distal4.566206.48464K562TARDBP
chr14705712347057186-intron-Distal4.651574.64001HepG2U2AF2
chr14705857147058622-intron-Distal3.621284.84707HepG2HNRNPK
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MKNK1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MKNK1 is not available on ENCORE database.

  • 48 RBPs can affect the levels of MKNK1.  








The Knockdown/knockout RNA-Seq assay for MKNK1 is not available on ENCORE database.





48 RBPs can affect the gene expression of MKNK1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MKNK1ENSG00000079277.15699.42400512.784500.447704.816704.05600HepG2ACO1
MKNK1ENSG00000079277.15709.66760515.195200.461904.758503.77470HepG2AKAP8L
MKNK1ENSG00000079277.15403.16860512.67490-0.346702.634201.98130HepG2CKAP4
MKNK1ENSG00000079277.15566.39250669.14050-0.240501.957601.31780HepG2DAZAP1
MKNK1ENSG00000079277.15731.89290389.858300.9086010.900709.65710HepG2DDX21
MKNK1ENSG00000079277.15589.93000408.230700.531103.275102.27930HepG2EEF2
MKNK1ENSG00000079277.15620.20900381.845300.699705.456804.64030HepG2EIF2S1
MKNK1ENSG00000079277.15492.60280331.374000.571903.432902.43160HepG2EIF3D
MKNK1ENSG00000079277.15783.16610421.990500.892008.555707.43420HepG2EIF4A3
MKNK1ENSG00000079277.15931.82640713.709000.384602.134801.45470HepG2FIP1L1
MKNK1ENSG00000079277.15646.72790425.751100.603004.384603.52780HepG2FXR1
MKNK1ENSG00000079277.15620.91430394.956900.652604.836303.96800HepG2G3BP1
MKNK1ENSG00000079277.15397.36800295.040300.429502.151201.36680HepG2GEMIN5
MKNK1ENSG00000079277.15781.91400406.961000.9420011.7994010.61430HepG2HNRNPA1
MKNK1ENSG00000079277.15331.90510449.67580-0.438103.453902.78410HepG2HNRNPU
MKNK1ENSG00000079277.15530.89660401.468700.403002.182501.57470HepG2IGF2BP2
MKNK1ENSG00000079277.15633.48690376.746300.749602.640701.68160HepG2IGF2BP3
MKNK1ENSG00000079277.15579.23810459.329000.334502.957702.20240HepG2ILF2
MKNK1ENSG00000079277.15595.25930425.899600.482902.976702.29770HepG2MAGOH
MKNK1ENSG00000079277.15486.81840663.51520-0.446703.972503.05870HepG2NOL12
MKNK1ENSG00000079277.15345.00400472.08240-0.452402.351101.65930HepG2NSUN2
MKNK1ENSG00000079277.15580.71070393.904800.559905.441604.72890HepG2PTBP1
MKNK1ENSG00000079277.15431.55510633.36670-0.553504.674403.92330HepG2PUF60
MKNK1ENSG00000079277.15695.20110522.304600.412404.119003.39390HepG2PUS1
MKNK1ENSG00000079277.15645.81640438.374000.558905.559704.83510HepG2NELFE
MKNK1ENSG00000079277.15527.66970408.293500.369902.582401.98390HepG2RECQL
MKNK1ENSG00000079277.15507.99420322.460700.655605.305904.48630HepG2RPS19
MKNK1ENSG00000079277.15585.38120433.786000.432302.417301.66500HepG2RPS2
MKNK1ENSG00000079277.15224.34810336.28070-0.583902.703401.92410HepG2RRP9
MKNK1ENSG00000079277.151182.49980810.861500.544208.732107.97930HepG2SRFBP1
MKNK1ENSG00000079277.15691.98200428.055800.692808.682107.95030HepG2SRSF1
MKNK1ENSG00000079277.15470.15770348.249400.432903.427402.82680HepG2SRSF9
MKNK1ENSG00000079277.15899.92010703.987600.354103.562002.99650HepG2SSB
MKNK1ENSG00000079277.15653.13170438.695000.574103.451802.70650HepG2SUPV3L1
MKNK1ENSG00000079277.15649.62120436.945000.572005.638804.97420HepG2TIAL1
MKNK1ENSG00000079277.15773.93630610.568700.342002.010701.46620HepG2U2AF1
MKNK1ENSG00000079277.15374.56570492.05600-0.393603.039502.34220HepG2ZC3H8
MKNK1ENSG00000079277.15860.56510629.279200.451506.049305.32240HepG2ZNF622
MKNK1ENSG00000079277.15933.617501258.46970-0.430804.032603.35030K562AQR
MKNK1ENSG00000079277.15911.921501098.53360-0.268602.281201.45930K562ATP5C1
MKNK1ENSG00000079277.151007.64260817.934600.300802.215201.50610K562CPSF6
MKNK1ENSG00000079277.151610.689201297.890800.311403.942703.18440K562DDX47
MKNK1ENSG00000079277.15865.06370652.971400.405702.231201.31240K562EIF3D
MKNK1ENSG00000079277.15429.50910543.50240-0.339602.441301.37780K562EIF4B
MKNK1ENSG00000079277.151099.32920832.220700.401503.139902.22390K562FMR1
MKNK1ENSG00000079277.15850.81140627.658600.438804.405403.66590K562FXR1
MKNK1ENSG00000079277.15367.34130510.44950-0.474602.332801.69150K562G3BP2
MKNK1ENSG00000079277.151086.71140766.836300.502905.149204.35800K562HNRNPC
MKNK1ENSG00000079277.15653.58540932.50890-0.512705.988504.66410K562HNRNPU
MKNK1ENSG00000079277.151052.99720762.273100.466004.231203.13390K562METAP2
MKNK1ENSG00000079277.15800.26120604.533100.404502.188301.46590K562RPS19
MKNK1ENSG00000079277.15417.93800530.81260-0.344902.189601.43020K562SF3B4
MKNK1ENSG00000079277.151087.30850653.051100.7354010.308608.95660K562SRSF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MKNK1 is not available on ENCORE database.





19 RBPs can affect the splicing of MKNK1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMKNK1ENSG00000079277.15chr1-470259054702594947023089470244724702714947027314-0.304000.000090.00466excludedK562AKAP8L
SEMKNK1ENSG00000079277.15chr1-4703926547039367470377344703783947040618470406920.080000.000000.00647includedK562UTP3
SEMKNK1ENSG00000079277.15chr1-4703708847037211470341144703417047037734470378690.499000.000000.00000includedK562XRCC6
SEMKNK1ENSG00000079277.15chr1-470370884703721147034114470341704703773447037839-0.067000.000190.05411excludedK562PUM1
SEMKNK1ENSG00000079277.15chr1-4702590547025949470230904702447247027149470273140.339000.000110.00450includedHepG2HNRNPK
SEMKNK1ENSG00000079277.15chr1-4702590547025949470230904702447247027149470273140.316000.000260.02836includedHepG2QKI
SEMKNK1ENSG00000079277.15chr1-470259054702594947023090470244724702714947027314-0.314000.000000.00012excludedHepG2U2AF2
SEMKNK1ENSG00000079277.15chr1-4703926547039367470377344703783947040618470406920.075000.001860.02057includedK562AQR
SEMKNK1ENSG00000079277.15chr1-470283204702851547027149470273144703071247030808-0.094000.011980.09375excludedK562AQR
SEMKNK1ENSG00000079277.15chr1-4702590547025949470230904702447247027149470273140.252000.002230.07220includedK562FXR1
SEMKNK1ENSG00000079277.15chr1-4703926547039367470377344703783947040618470406920.086000.000050.00626includedK562HNRNPL
SEMKNK1ENSG00000079277.15chr1-4705154547051646470488994704900147051905470519310.578000.000050.01662includedK562SBDS
SEMKNK1ENSG00000079277.15chr1-4702590547025949470230904702447247027149470273140.408000.000070.00291includedHepG2SRSF1
SEMKNK1ENSG00000079277.15chr1-4702590547025949470230904702447247027149470273140.348000.000330.03034includedHepG2IGF2BP3
SEMKNK1ENSG00000079277.15chr1-4703926547039367470377344703783947040618470406920.159000.000830.02964includedK562UTP18
SEMKNK1ENSG00000079277.15chr1-470259054702594947023090470244724702714947027314-0.280000.000070.00415excludedK562UTP18
SEMKNK1ENSG00000079277.15chr1-4703708847037211470341144703417047037734470378390.121000.000400.01849includedK562HNRNPU
SEMKNK1ENSG00000079277.15chr1-470462014704629947042246470423264704889947049001-0.087000.002740.08082excludedK562HNRNPU
SEMKNK1ENSG00000079277.15chr1-4705154547051646470488994704900147059784470599520.076000.000040.00295includedK562PTBP1
SEMKNK1ENSG00000079277.15chr1-4703708847037211470341144703417047037734470378690.326000.000010.00044includedK562HNRNPC
SEMKNK1ENSG00000079277.15chr1-470283204702851547027149470273144703071247030808-0.253000.004430.06328excludedK562HNRNPC
A3SSMKNK1ENSG00000079277.15chr1-4703773447037869470377344703783947040618470406920.137000.000010.00009longerK562AQR
A3SSMKNK1ENSG00000079277.15chr1-4702714947027392470271494702731447028320470285150.241000.000000.00003longerK562AQR
A3SSMKNK1ENSG00000079277.15chr1-4703071247030914470307124703080847034114470341700.057000.001160.00794longerK562AQR
A5SSMKNK1ENSG00000079277.15chr1-4706985647069966470698984706996647059784470599520.505000.000020.00580longerHepG2PRPF8
MXEMKNK1ENSG00000079277.15chr1-47046201470462994704889947049001470422464704232647059784470599520.188000.000000.000001includedK562PUS1
MXEMKNK1ENSG00000079277.15chr1-47046201470462994704889947049001470422464704232647059784470599520.113000.001340.064401includedK562UTP18
MXEMKNK1ENSG00000079277.15chr1-4704620147046299470488994704900147042246470423264705978447059952-0.076000.002980.062672includedK562SBDS

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MKNK1 is not avaliable on ENCORE database.