MAP2K4

General Information

Gene Name       : MAP2K4
Gene ID             : ENSG00000065559.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: MAP2K4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878MAP2K4ENSG00000065559.1417.1816.9117.05ENCSR000AEF
HepG2MAP2K4ENSG00000065559.1415.4226.3220.87ENCSR985KAT
K562MAP2K4ENSG00000065559.146.897.257.07ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for MAP2K4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • MAP2K4 RNA is bound by 19 proteins.  







eCLIP assay for MAP2K4 is not avaliable on ENCORE database.





19 proteins are bound to MAP2K4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr171199893311999027+3'-UTR,CDS,intron-Proximal3.619346.39464HepG2BCLAF1
chr171199898611999013+3'-UTR,CDS,intron-Proximal3.958703.30425K562LIN28B
chr171198473711984844+3'-UTR,CDS,intron-Distal3.306924.74886HepG2BCLAF1
chr171201657012016684+3'-UTR,CDS,intron-Proximal3.130083.85127HepG2GRWD1
chr171198469611984830+3'-UTR,CDS,intron-Distal3.820497.03378HepG2GRWD1
chr171204613012046223+3'-UTR3.368444.36355HepG2LIN28B
chr171201110412011136+3'-UTR,CDS,intron-Distal,intron-Proximal4.215883.43975HepG2LIN28B
chr171201110512011132+3'-UTR,CDS,intron-Distal,intron-Proximal4.032893.53569K562LIN28B
chr171203243212032494+3'-UTR,CDS,intron-Distal,intron-Proximal5.390598.57494HepG2U2AF2
chr171199892611999038+3'-UTR,CDS,intron-Proximal3.906353.12746HepG2GRWD1
chr171204317312043239+3'-UTR,CDS,intron-Proximal3.584435.06115HepG2PRPF8
chr171192418611924288+5'-UTR,CDS3.325815.64139HepG2NCBP2
chr171192419511924249+5'-UTR,CDS3.574573.76880HepG2DDX3X
chr171192428111924391+CDS,intron-Proximal4.4115513.47152HepG2PRPF8
chr171192431611924360+CDS,intron-Proximal3.608543.96535HepG2AQR
chr171198510911985187+intron-Distal4.158968.51210HepG2KHSRP
chr171193440911934490+intron-Distal3.119353.12255HepG2XPO5
chr171198524911985293+intron-Distal7.7229447.14026K562DGCR8
chr171198513411985190+intron-Distal5.7330711.34542K562DGCR8
chr171198526811985304+intron-Distal7.0745427.14325HepG2DGCR8
chr171198507911985218+intron-Distal4.5649119.65236HepG2DROSHA
chr171198524111985304+intron-Distal6.6617313.19418K562DROSHA
chr171193396211934041+intron-Distal3.852933.50031HepG2HNRNPL
chr171195265111952711+intron-Distal3.432283.11000HepG2HNRNPM
chr171198534511985400+intron-Distal6.0467813.11190HepG2DGCR8
chr171198547911985536+intron-Distal4.645385.94964HepG2DROSHA
chr171196618511966264+intron-Distal5.9249013.78241HepG2PCBP2
chr171192439411924510+intron-Distal,intron-Proximal3.743833.06084HepG2HNRNPK
chr171198522411985268+intron-Distal7.3795035.46824HepG2DGCR8
chr171198534311985383+intron-Distal5.075326.79336K562DGCR8
chr171198500511985064+intron-Distal4.841547.47946HepG2DROSHA
chr171198535911985479+intron-Distal6.1068016.04874HepG2DROSHA
chr171193076411930848+intron-Distal3.124223.54232HepG2HNRNPL
chr171198519011985214+intron-Distal4.754864.96989HepG2DGCR8
chr171198511511985190+intron-Distal5.2113823.34044HepG2DGCR8
chr171194983311949881+intron-Distal4.204804.31871HepG2HNRNPM
chr171198560011985660+intron-Distal4.110498.47350HepG2DROSHA
chr171198522211985272+intron-Distal3.654343.41096HepG2DROSHA
chr171196480711964865+intron-Distal4.025973.84389HepG2SUGP2
chr171198538111985481+intron-Distal6.5076710.96787K562DROSHA
chr171196626411966322+intron-Distal4.8710212.47085HepG2PCBP2
chr171196092011960972+intron-Distal4.076483.27829HepG2MATR3
chr171199355411993643+intron-Distal3.239323.46325HepG2SUGP2
chr171196486811964982+intron-Distal4.910667.65425HepG2SUGP2
chr171193427211934323+intron-Distal3.437633.39857HepG2HNRNPM
chr171196540811965479+intron-Distal3.318453.35050HepG2SUGP2
chr171199861011998789+intron-Distal3.767849.74134K562KHSRP
chr171196567111965719+intron-Distal3.258803.59523HepG2SUGP2
chr171204159812041657+intron-Distal3.477873.94088HepG2QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for MAP2K4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for MAP2K4 is not available on ENCORE database.

  • 65 RBPs can affect the levels of MAP2K4.  








The Knockdown/knockout RNA-Seq assay for MAP2K4 is not available on ENCORE database.





65 RBPs can affect the gene expression of MAP2K4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
MAP2K4ENSG00000065559.101624.358801083.280400.5844012.9536011.84170HepG2ACO1
MAP2K4ENSG00000065559.102418.684701744.935500.470903.327202.75160HepG2AKAP1
MAP2K4ENSG00000065559.102260.355201578.714700.5177011.044209.82570HepG2AUH
MAP2K4ENSG00000065559.10640.60800910.67870-0.507502.452001.60700HepG2BCLAF1
MAP2K4ENSG00000065559.101520.273501168.427500.379703.818202.93380HepG2CALR
MAP2K4ENSG00000065559.10911.349601371.75600-0.589902.372501.65130HepG2CIRBP
MAP2K4ENSG00000065559.10803.273601083.03820-0.431106.348705.41640HepG2CKAP4
MAP2K4ENSG00000065559.10487.47460895.40050-0.8772010.335809.09080HepG2CPSF6
MAP2K4ENSG00000065559.101817.941901312.711800.469707.633506.66420HepG2CELF1
MAP2K4ENSG00000065559.101812.299801016.787400.833705.693704.30690HepG2DDX59
MAP2K4ENSG00000065559.102179.855501435.568000.602505.673204.81600HepG2DDX6
MAP2K4ENSG00000065559.10653.53960860.56610-0.397003.878803.05810HepG2DNAJC21
MAP2K4ENSG00000065559.10868.433601380.51350-0.668702.963602.34970HepG2EIF2S1
MAP2K4ENSG00000065559.101717.052701392.527200.302103.625402.68850HepG2EIF4G1
MAP2K4ENSG00000065559.102529.853901812.521900.481009.950008.92440HepG2ETF1
MAP2K4ENSG00000065559.10520.29110837.93760-0.687505.096503.61530HepG2FASTKD2
MAP2K4ENSG00000065559.102054.642901202.093500.773209.069707.77830HepG2FIP1L1
MAP2K4ENSG00000065559.10683.727301015.05320-0.570104.408003.61220HepG2GPKOW
MAP2K4ENSG00000065559.10951.352001285.83690-0.434707.266506.22060HepG2HNRNPL
MAP2K4ENSG00000065559.10557.58470968.67970-0.796808.589007.54500HepG2HNRNPLL
MAP2K4ENSG00000065559.10741.67190960.02360-0.372304.084703.35930HepG2HNRNPU
MAP2K4ENSG00000065559.10938.381501124.21630-0.260702.014301.38970HepG2IGF2BP1
MAP2K4ENSG00000065559.10964.743901459.73830-0.597502.649101.67180HepG2KHSRP
MAP2K4ENSG00000065559.10812.40450990.24990-0.285603.045301.97860HepG2KIF1C
MAP2K4ENSG00000065559.10663.74570987.82490-0.573603.245702.19020HepG2MTPAP
MAP2K4ENSG00000065559.101128.72290950.230700.248202.245301.47430HepG2PARN
MAP2K4ENSG00000065559.10636.167701415.35650-1.1537035.8456034.08480HepG2PCBP1
MAP2K4ENSG00000065559.101228.36350918.822300.418805.542504.48660HepG2PRPF4
MAP2K4ENSG00000065559.101842.367101418.316300.377307.035506.17880HepG2PUM1
MAP2K4ENSG00000065559.101037.057201417.29360-0.450605.366004.44620HepG2PUM2
MAP2K4ENSG00000065559.101435.124701103.390400.379105.646304.82220HepG2PUS1
MAP2K4ENSG00000065559.10647.922301066.14220-0.718503.722702.90900HepG2RAVER1
MAP2K4ENSG00000065559.101677.309101400.188500.260402.059901.30560HepG2RBM15
MAP2K4ENSG00000065559.102499.772001514.944100.7224017.7379016.65760HepG2RBM22
MAP2K4ENSG00000065559.101744.234601415.574000.301102.569501.91620HepG2RBM25
MAP2K4ENSG00000065559.101282.506901492.74810-0.219002.102401.55550HepG2RECQL
MAP2K4ENSG00000065559.101119.66460786.562500.509304.303003.34530HepG2RRP9
MAP2K4ENSG00000065559.101951.736301220.281200.677405.923704.91310HepG2SF3A3
MAP2K4ENSG00000065559.101332.81550958.828600.475004.471603.59160HepG2SF3B1
MAP2K4ENSG00000065559.10833.411801499.42140-0.8473020.9132019.53800HepG2SF3B4
MAP2K4ENSG00000065559.10547.51320996.97050-0.8647020.2859018.79020HepG2SMN1
MAP2K4ENSG00000065559.103541.454601711.093501.0493053.7389052.26070HepG2SRFBP1
MAP2K4ENSG00000065559.101315.986201565.06160-0.250102.673302.20650HepG2SRSF1
MAP2K4ENSG00000065559.101841.888001485.668900.310004.450303.83150HepG2SSB
MAP2K4ENSG00000065559.101316.815001025.699800.360302.807802.12660HepG2SUPV3L1
MAP2K4ENSG00000065559.101800.886601028.359000.8083011.3563010.06000HepG2U2AF1
MAP2K4ENSG00000065559.10374.58790605.98290-0.694003.702602.82580HepG2UCHL5
MAP2K4ENSG00000065559.101301.830901044.823600.317203.705903.02830HepG2UTP3
MAP2K4ENSG00000065559.101154.77960906.755100.348704.471903.64990HepG2ZC3H8
MAP2K4ENSG00000065559.101952.867601190.215600.7143023.4077022.20500HepG2ZNF622
MAP2K4ENSG00000065559.10303.83790405.96220-0.418002.236201.64620K562AKAP8L
MAP2K4ENSG00000065559.101025.27410666.328400.621606.476305.64030K562AQR
MAP2K4ENSG00000065559.10267.37550374.42790-0.485802.432501.62000K562BOP1
MAP2K4ENSG00000065559.10608.55480466.261400.384102.619001.48350K562CCDC124
MAP2K4ENSG00000065559.10280.92960431.19470-0.618104.361602.73970K562CIRBP
MAP2K4ENSG00000065559.10205.82500398.11440-0.951808.870407.44850K562CPSF6
MAP2K4ENSG00000065559.10522.50510304.175100.780408.617707.62120K562FXR1
MAP2K4ENSG00000065559.10217.56720296.17680-0.445001.961901.44810K562HNRNPC
MAP2K4ENSG00000065559.10626.91510482.649700.377202.605601.72770K562MBNL1
MAP2K4ENSG00000065559.10373.11270462.94100-0.311202.017801.36850K562NSUN2
MAP2K4ENSG00000065559.10459.77840312.577400.556603.492402.64860K562PRPF8
MAP2K4ENSG00000065559.10662.82130410.808200.690107.658906.59080K562PTBP1
MAP2K4ENSG00000065559.101142.72560769.995800.569505.261004.13860K562PUF60
MAP2K4ENSG00000065559.101133.83260819.012300.469204.845603.40280K562PUM1
MAP2K4ENSG00000065559.10147.57290242.26640-0.715203.732902.58070K562RCC2
MAP2K4ENSG00000065559.10248.25200332.48350-0.421502.282601.50840K562SF3B4
MAP2K4ENSG00000065559.10419.22260300.863600.478503.118702.24600K562SYNCRIP
MAP2K4ENSG00000065559.10438.24510320.078800.453203.062302.21640K562U2AF2
MAP2K4ENSG00000065559.10220.78410320.36780-0.537102.489801.52880K562UCHL5
MAP2K4ENSG00000065559.10288.32810424.15090-0.556904.051902.00200K562UPF2
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for MAP2K4 is not available on ENCORE database.





4 RBPs can affect the splicing of MAP2K4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMAP2K4ENSG00000065559.10chr17+1203281012032901120324551203260412043155120432010.143000.005620.06800includedK562PUS1
MXEMAP2K4ENSG00000065559.10chr17+1195820511958308119846721198484711924186119243181199889111999011-0.199000.000010.014582includedHepG2NKRF
MXEMAP2K4ENSG00000065559.10chr17+12032372120326041204315512043201120286101202868812044463120445770.194000.016210.093161includedK562AQR
MXEMAP2K4ENSG00000065559.10chr17+11958205119583081198467211984847119241861192431811998891119990110.222000.000000.000041includedHepG2HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for MAP2K4 is not avaliable on ENCORE database.