CRBN

General Information

Gene Name       : CRBN
Gene ID             : ENSG00000113851.14
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CRBN)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CRBNENSG00000113851.1422.5717.7620.16ENCSR000AEF
HepG2CRBNENSG00000113851.1419.4727.0923.28ENCSR985KAT
K562CRBNENSG00000113851.1431.9532.5132.23ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CRBN is not avaliable on ENCORE database.



Proteins bound to RNA
  • CRBN RNA is bound by 9 proteins.  







eCLIP assay for CRBN is not avaliable on ENCORE database.





9 proteins are bound to CRBN RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr331919933192063-3'-UTR,intron-Distal3.273335.13864K562PUM2
chr332159233215948-CDS,intron-Distal,intron-Proximal3.043193.19733K562ZNF622
chr332157733215827-CDS,intron-Distal,intron-Proximal4.319363.71570HepG2BCLAF1
chr332213043221344-CDS,intron-Distal4.418587.60776K562ZNF622
chr331963773196433-CDS,intron-Distal,intron-Proximal4.027314.98250K562AQR
chr331951083195183-CDS,intron-Distal,intron-Proximal3.448205.85200K562BUD13
chr332213033221342-CDS,intron-Distal5.022027.02609K562UCHL5
chr332168913216957-CDS,intron-Distal,intron-Proximal5.7232112.88554K562UCHL5
chr332169343216955-CDS,intron-Distal,intron-Proximal3.392076.97987K562ZNF622
chr332157393215839-CDS,intron-Distal,intron-Proximal4.300014.04622HepG2GRWD1
chr331964663196558-CDS,intron-Distal,intron-Proximal4.084215.55508K562BUD13
chr332156893215747-CDS,intron-Distal,intron-Proximal3.8401111.47097K562AQR
chr332093173209391-CDS,intron-Distal,intron-Proximal4.204877.60776K562ZNF622
chr332157443215859-CDS,intron-Distal,intron-Proximal3.169318.20368K562ZNF622
chr332093123209385-CDS,intron-Distal,intron-Proximal3.819343.60441HepG2GRWD1
chr331977993197895-intron-Distal,intron-Proximal4.078858.79285K562AQR
chr332212613221290-intron-Distal4.9692110.24966K562AQR
chr332141373214199-intron-Distal4.573683.31283K562PRPF8
chr332212903221305-intron-Distal3.495957.36655K562AQR
chr332164623216565-intron-Distal4.905885.58608K562QKI
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CRBN is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CRBN is not available on ENCORE database.

  • 56 RBPs can affect the levels of CRBN.  








The Knockdown/knockout RNA-Seq assay for CRBN is not available on ENCORE database.





56 RBPs can affect the gene expression of CRBN :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CRBNENSG00000113851.9330.18650551.96470-0.741309.568508.57700HepG2ACO1
CRBNENSG00000113851.9434.95670554.57230-0.350502.604801.85740HepG2AKAP8L
CRBNENSG00000113851.9537.86910669.06100-0.314902.489601.87360HepG2CELF1
CRBNENSG00000113851.9281.98610390.39410-0.469302.129801.44290HepG2DDX55
CRBNENSG00000113851.9432.74270757.41060-0.807606.898605.95830HepG2DDX6
CRBNENSG00000113851.9310.44870423.97050-0.449603.076602.33920HepG2DNAJC21
CRBNENSG00000113851.9342.44120420.20000-0.295201.885501.32920HepG2DNAJC2
CRBNENSG00000113851.9487.72600728.06860-0.578004.319803.58840HepG2EIF2S1
CRBNENSG00000113851.9221.75670337.04050-0.603903.172802.21180HepG2EIF3D
CRBNENSG00000113851.9493.92650783.41430-0.665504.207403.36870HepG2EIF4B
CRBNENSG00000113851.91009.35370829.011000.283902.806002.20180HepG2ETF1
CRBNENSG00000113851.9576.98560811.85650-0.492703.512602.73860HepG2FXR1
CRBNENSG00000113851.9570.20860753.07850-0.401302.314101.70310HepG2G3BP1
CRBNENSG00000113851.9504.42760374.597900.429202.320401.73820HepG2HNRNPLL
CRBNENSG00000113851.9574.99880765.47450-0.412802.507301.86090HepG2IGF2BP2
CRBNENSG00000113851.9288.94190483.10490-0.741609.451008.17590HepG2ILF2
CRBNENSG00000113851.9377.54130816.67410-1.1131012.3746011.10780HepG2MATR3
CRBNENSG00000113851.9552.53690835.90190-0.597304.631903.82420HepG2NCBP2
CRBNENSG00000113851.9568.58250713.45630-0.327502.586101.84920HepG2NOL12
CRBNENSG00000113851.9357.93290529.91400-0.566102.440301.61660HepG2PABPC1
CRBNENSG00000113851.9528.91890744.38190-0.493003.320302.53410HepG2PABPC4
CRBNENSG00000113851.9372.72800468.15120-0.328902.060101.31990HepG2PARN
CRBNENSG00000113851.9562.65090749.53230-0.413803.193702.55000HepG2PCBP1
CRBNENSG00000113851.9783.30180531.418400.559603.127402.02620HepG2PCBP2
CRBNENSG00000113851.9582.34370429.010400.440803.869202.96800HepG2PRPF4
CRBNENSG00000113851.9503.64070762.61720-0.598605.472004.75750HepG2PTBP1
CRBNENSG00000113851.9575.95410722.90810-0.327903.471202.82180HepG2PUM1
CRBNENSG00000113851.9561.11180722.40070-0.364502.755402.08660HepG2PUM2
CRBNENSG00000113851.9843.38390692.908800.283402.052301.58820HepG2RBM22
CRBNENSG00000113851.9636.73170848.76950-0.414703.175002.60330HepG2NELFE
CRBNENSG00000113851.9417.75650297.865600.487902.213201.50280HepG2RRP9
CRBNENSG00000113851.9301.75870421.18860-0.481103.741403.01190HepG2SAFB2
CRBNENSG00000113851.9887.32110602.196300.559103.721002.93490HepG2SF3A3
CRBNENSG00000113851.9369.34840491.18590-0.411303.367802.66950HepG2SMN1
CRBNENSG00000113851.91115.75230782.630800.511508.077707.34500HepG2SRFBP1
CRBNENSG00000113851.9550.06590828.81460-0.591405.170404.57540HepG2SRSF1
CRBNENSG00000113851.9495.33120672.37620-0.440904.465503.70430HepG2SRSF5
CRBNENSG00000113851.9859.48220679.536600.338803.461402.90240HepG2SSB
CRBNENSG00000113851.9568.83510764.71110-0.426904.946404.15670HepG2SUCLG1
CRBNENSG00000113851.9544.54900744.84910-0.451903.901103.25360HepG2TAF15
CRBNENSG00000113851.9245.67000463.66580-0.9164011.7709010.72560HepG2TRIM56
CRBNENSG00000113851.9427.49610534.05490-0.321102.324401.67630HepG2UPF1
CRBNENSG00000113851.9663.31280423.375000.647708.671007.59200HepG2ZC3H8
CRBNENSG00000113851.91113.203901374.69080-0.304403.508902.78730K562DDX47
CRBNENSG00000113851.9549.45060750.26400-0.449402.585901.58780K562EIF3D
CRBNENSG00000113851.9608.11140887.91420-0.546106.535605.32810K562EIF3G
CRBNENSG00000113851.91077.43170840.142700.358802.707901.86890K562FIP1L1
CRBNENSG00000113851.9662.97710973.51740-0.554207.142806.23250K562FXR1
CRBNENSG00000113851.91315.262001044.660600.332203.348702.36770K562HNRNPU
CRBNENSG00000113851.91869.643301505.537900.312402.586001.79110K562KIF1C
CRBNENSG00000113851.9906.460301282.04170-0.500105.670404.28640K562MATR3
CRBNENSG00000113851.91600.138301182.190200.436602.488801.66190K562NAA15
CRBNENSG00000113851.9804.589201001.38080-0.315703.653402.80870K562NSUN2
CRBNENSG00000113851.9730.643101248.03700-0.7724012.5207011.15980K562PTBP1
CRBNENSG00000113851.91792.226401406.801800.349202.881002.32930K562PUS1
CRBNENSG00000113851.9775.860501196.91180-0.625407.222805.78600K562RBM22
CRBNENSG00000113851.9860.218901166.61270-0.439503.476001.85970K562RBM34
CRBNENSG00000113851.9443.24730578.28840-0.383702.419901.49670K562RCC2
CRBNENSG00000113851.9944.330401259.51300-0.415502.663701.59410K562NELFE
CRBNENSG00000113851.9680.495101223.45270-0.8463013.7470012.16990K562SRSF1
CRBNENSG00000113851.9661.32770835.86050-0.337902.292901.35080K562SRSF4
CRBNENSG00000113851.9861.749901238.29950-0.523004.951403.99050K562TARDBP
CRBNENSG00000113851.9966.895601194.45720-0.304902.502201.72920K562TIA1
CRBNENSG00000113851.9486.75150647.67130-0.412102.677501.75010K562TRIM56
CRBNENSG00000113851.9736.120301061.78830-0.528507.893406.75380K562UPF1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CRBN is not available on ENCORE database.





21 RBPs can affect the splicing of CRBN :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.385000.000010.00029includedK562SRSF1
SECRBNENSG00000113851.9chr3-319564331957593195107319517231964303196515-0.233000.005770.08461excludedHepG2U2AF1
SECRBNENSG00000113851.9chr3-319413931942713191694319272931951073195172-0.226000.000540.01220excludedHepG2U2AF1
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.118000.000090.03146includedHepG2ILF3
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.125000.000010.00549excludedK562HNRNPA1
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.096000.000020.00068includedK562PUS1
SECRBNENSG00000113851.9chr3-319564331957463195107319517231979023197965-0.177000.000050.00145excludedK562PUS1
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.115000.000110.04548excludedK562UCHL5
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.266000.000030.04870includedK562ILF3
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.107000.000960.04175includedHepG2MATR3
SECRBNENSG00000113851.9chr3-321684632169533215742321594532213043221394-0.085000.000240.03209excludedHepG2LARP4
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.103000.000010.01867excludedK562DDX21
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.077000.000190.03254includedHepG2HNRNPUL1
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.123000.000010.00062includedHepG2SRSF1
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.059000.000020.00961excludedK562EIF4G2
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.106000.000030.00900excludedK562SRSF7
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.160000.000150.02941includedK562RBM22
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932146090.100000.000060.01150includedHepG2TAF15
SECRBNENSG00000113851.9chr3-319564331957593195107319517231964303196515-0.116000.000220.00552excludedK562U2AF2
SECRBNENSG00000113851.9chr3-319413931942713191694319272931951073195172-0.107000.006150.08468excludedK562U2AF2
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.072000.000020.00411excludedK562CPSF6
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.061000.001560.05673excludedK562SF3B1
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.074000.000700.08897excludedK562ZC3H8
SECRBNENSG00000113851.9chr3-3214189321433032093173209477321445932145990.150000.000610.02721includedK562PTBP1
SECRBNENSG00000113851.9chr3-321418932143303209317320947732144593214609-0.085000.000190.00462excludedK562HNRNPC
A3SSCRBNENSG00000113851.9chr3-3197902319801431979023197965320931732095210.058000.004430.02598longerK562AQR
A3SSCRBNENSG00000113851.9chr3-3209317320952132093173209477321445932145990.063000.000300.00236longerK562AQR
MXECRBNENSG00000113851.9chr3-31979023197965320931732094773195107319517232144593214609-0.058000.008610.091942includedK562U2AF1
MXECRBNENSG00000113851.9chr3-320931732094773214459321459931979023197965321574232159450.123000.007960.052581includedK562AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CRBN is not avaliable on ENCORE database.