CARS2

General Information

Gene Name       : CARS2
Gene ID             : ENSG00000134905.16
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: CARS2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CARS2ENSG00000134905.1617.3826.2621.82ENCSR000AEF
HepG2CARS2ENSG00000134905.1643.5026.2034.85ENCSR985KAT
K562CARS2ENSG00000134905.1615.6111.5213.56ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CARS2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CARS2 RNA is bound by 23 proteins.  







eCLIP assay for CARS2 is not avaliable on ENCORE database.





23 proteins are bound to CARS2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr13111340126111340174-3'-UTR,CDS,intron-Distal,intron-Proximal3.054933.78006HepG2PPIG
chr13111315368111315419-3'-UTR,CDS,intron-Distal4.717315.85494HepG2DROSHA
chr13111335331111335403-3'-UTR,CDS,intron-Distal,intron-Proximal3.884326.34662HepG2PRPF8
chr13111294736111294855-3'-UTR,CDS,intron-Distal,intron-Proximal5.134108.89358HepG2PABPN1
chr13111294720111294879-3'-UTR,CDS,intron-Distal,intron-Proximal4.007528.00190HepG2GRWD1
chr13111294658111294724-3'-UTR,CDS,intron-Distal,intron-Proximal4.335094.52184HepG2PABPN1
chr13111340290111340359-3'-UTR,CDS,intron-Distal,intron-Proximal3.707235.90680HepG2PPIG
chr13111335315111335424-3'-UTR,CDS,intron-Distal,intron-Proximal4.700764.97857HepG2AQR
chr13111329386111329437-3'-UTR,CDS,intron-Distal,intron-Proximal3.908066.98305HepG2PPIG
chr13111335391111335441-3'-UTR,CDS,intron-Distal,intron-Proximal3.559973.99124HepG2PPIG
chr13111329330111329386-3'-UTR,CDS,intron-Distal,intron-Proximal4.5919310.48252HepG2PPIG
chr13111340135111340179-3'-UTR,CDS,intron-Distal,intron-Proximal3.306924.74886HepG2BCLAF1
chr13111329340111329449-3'-UTR,CDS,intron-Distal,intron-Proximal4.732866.78401HepG2GRWD1
chr13111329413111329510-3'-UTR,CDS,intron-Distal,intron-Proximal4.376004.27476HepG2AQR
chr13111329319111329425-3'-UTR,CDS,intron-Distal,intron-Proximal3.472007.45037HepG2SRSF1
chr13111358055111358143-5'-UTR,CDS,intron-Distal,intron-Proximal3.082344.88392HepG2RBFOX2
chr13111298401111298458-CDS,intron-Distal,intron-Proximal3.624756.53375HepG2AQR
chr13111319642111319700-CDS,intron-Distal,intron-Proximal5.753247.70650HepG2PRPF8
chr13111315859111315930-CDS,intron-Distal,intron-Proximal4.3534712.83091HepG2SF3A3
chr13111358275111358435-CDS,intron-Distal,intron-Proximal3.6250314.05133HepG2DDX3X
chr13111299391111299455-CDS,intron-Distal,intron-Proximal4.3295111.40635HepG2PRPF8
chr13111299403111299451-CDS,intron-Distal,intron-Proximal4.292565.97994K562AQR
chr13111315828111315878-CDS,intron-Distal,intron-Proximal3.069825.19836HepG2U2AF2
chr13111319675111319778-CDS,intron-Distal,intron-Proximal3.310033.39306HepG2GRWD1
chr13111353763111353896-CDS,intron-Distal,intron-Proximal3.105655.53494HepG2BCLAF1
chr13111298313111298396-CDS,intron-Distal,intron-Proximal3.542164.77136HepG2PPIG
chr13111358171111358246-CDS,intron-Distal,intron-Proximal3.937785.73990HepG2PRPF8
chr13111303332111303424-CDS,intron-Distal,intron-Proximal4.9631913.44390HepG2PRPF8
chr13111299513111299588-CDS,intron-Distal,intron-Proximal3.542164.77136HepG2PPIG
chr13111298308111298440-CDS,intron-Distal,intron-Proximal4.266344.52184HepG2PABPN1
chr13111298402111298505-CDS,intron-Distal,intron-Proximal3.010278.15895HepG2PRPF8
chr13111298380111298460-CDS,intron-Distal,intron-Proximal4.344634.95909K562BUD13
chr13111315719111315807-CDS,intron-Distal,intron-Proximal3.328915.32296K562PRPF8
chr13111315830111315871-CDS,intron-Distal,intron-Proximal4.023903.20743HepG2PPIG
chr13111298254111298326-CDS,intron-Distal,intron-Proximal3.841465.73990HepG2PRPF8
chr13111298393111298514-CDS,intron-Distal,intron-Proximal4.4887610.81562K562AQR
chr13111357868111357919-CDS,intron-Distal,intron-Proximal3.107783.73413HepG2PPIG
chr13111330684111330756-intron-Distal3.932093.59342K562CSTF2T
chr13111314396111314430-intron-Distal5.043606.77255HepG2DROSHA
chr13111314643111314725-intron-Distal6.028859.75255K562DDX6
chr13111319592111319654-intron-Distal,intron-Proximal3.489885.58816K562PRPF8
chr13111314943111314972-intron-Distal5.030219.04913K562DROSHA
chr13111314430111314485-intron-Distal6.0736812.10665HepG2DROSHA
chr13111314656111314728-intron-Distal5.8967317.60458K562RBFOX2
chr13111314578111314656-intron-Distal7.1750535.93445K562DROSHA
chr13111299237111299272-intron-Distal4.734824.09264K562AQR
chr13111319603111319664-intron-Distal,intron-Proximal3.995823.31824HepG2TIAL1
chr13111314477111314532-intron-Distal8.39265100.53129HepG2RBFOX2
chr13111314578111314615-intron-Distal5.5843910.50484HepG2DROSHA
chr13111314385111314450-intron-Distal5.3105610.79882K562RBFOX2
chr13111314651111314776-intron-Distal6.6644720.14428HepG2DDX6
chr13111314561111314578-intron-Distal4.830875.35561HepG2DROSHA
chr13111314485111314501-intron-Distal6.0729211.85054HepG2DROSHA
chr13111314661111314692-intron-Distal8.98743148.54892HepG2RBFOX2
chr13111314601111314651-intron-Distal7.1816315.45271HepG2DDX6
chr13111314773111314832-intron-Distal6.2854484.76085HepG2RBFOX2
chr13111314450111314579-intron-Distal5.5195914.33398K562DDX6
chr13111299135111299220-intron-Distal,intron-Proximal3.994138.74054HepG2BUD13
chr13111296239111296306-intron-Distal,intron-Proximal3.762053.60408HepG2XPO5
chr13111335326111335375-intron-Distal,intron-Proximal5.270936.56171HepG2RBM22
chr13111314666111314734-intron-Distal6.012069.77930HepG2DROSHA
chr13111299234111299261-intron-Distal4.735734.28841HepG2BUD13
chr13111299118111299225-intron-Distal,intron-Proximal4.552155.02679K562BUD13
chr13111314902111314963-intron-Distal5.366637.70517K562RBFOX2
chr13111335502111335605-intron-Distal,intron-Proximal4.111604.76003K562KHSRP
chr13111314734111314797-intron-Distal5.299095.60212HepG2DROSHA
chr13111314501111314535-intron-Distal6.6457618.15216HepG2DROSHA
chr13111310220111310307-intron-Distal3.272243.91859HepG2SUGP2
chr13111323115111323238-intron-Distal3.485843.10883HepG2SUGP2
chr13111314725111314769-intron-Distal4.249145.56298K562DDX6
chr13111314728111314796-intron-Distal5.2475510.14384K562RBFOX2
chr13111314522111314579-intron-Distal7.1005914.86797HepG2DDX6
chr13111299339111299391-intron-Distal,intron-Proximal4.583525.32906HepG2AQR
chr13111314535111314561-intron-Distal5.210029.81562HepG2DROSHA
chr13111310300111310358-intron-Distal4.709695.02084HepG2HNRNPM
chr13111314692111314728-intron-Distal8.00628148.53499HepG2RBFOX2
chr13111314310111314379-intron-Distal4.003275.99272HepG2DROSHA
chr13111314456111314556-intron-Distal6.5303524.91744K562RBFOX2
chr13111314728111314773-intron-Distal6.66500114.63819HepG2RBFOX2
chr13111311477111311532-intron-Distal3.103713.77382HepG2HNRNPM
chr13111310207111310275-intron-Distal4.410484.90578HepG2HNRNPM
chr13111311532111311588-intron-Distal4.770424.31871HepG2HNRNPM
chr13111314531111314578-intron-Distal7.8793737.24301K562DROSHA
chr13111329233111329300-intron-Distal,intron-Proximal4.002107.91903HepG2RBM22
chr13111299391111299415-intron-Distal,intron-Proximal5.7702225.28613HepG2AQR
chr13111298458111298544-intron-Distal,intron-Proximal5.594059.96618HepG2AQR
chr13111314477111314531-intron-Distal6.2886123.93909K562DROSHA
chr13111335309111335395-intron-Distal,intron-Proximal4.721835.17615K562AQR
chr13111299175111299237-intron-Distal,intron-Proximal3.971797.53394K562AQR
chr13111329249111329294-intron-Distal,intron-Proximal4.809515.25641HepG2BUD13
chr13111299125111299249-intron-Distal,intron-Proximal3.484213.90917HepG2PRPF4
chr13111314615111314666-intron-Distal6.5466612.35143HepG2DROSHA
chr13111299415111299448-intron-Distal,intron-Proximal5.4495331.08267HepG2AQR
chr13111319610111319659-intron-Distal,intron-Proximal5.339683.69482HepG2RBM22
chr13111319613111319642-intron-Distal,intron-Proximal4.607703.96704HepG2PRPF8
chr13111315003111315059-intron-Distal4.5720413.61292K562DROSHA
chr13111314583111314643-intron-Distal5.000719.15602K562DDX6
chr13111299297111299391-intron-Distal,intron-Proximal3.179887.92471HepG2PRPF8
chr13111299595111299636-intron-Distal,intron-Proximal4.307267.21864HepG2SF3A3
chr13111314294111314353-intron-Distal5.335449.27533K562RBFOX2
chr13111314656111314736-intron-Distal7.8952238.09689K562DROSHA
chr13111299357111299441-intron-Distal,intron-Proximal4.003713.56076K562BUD13
chr13111314532111314584-intron-Distal7.79828130.75316HepG2RBFOX2
chr13111314145111314208-intron-Distal5.064048.38039K562RBFOX2
chr13111314976111315076-intron-Distal5.4018215.90436K562RBFOX2
chr13111314473111314509-intron-Distal5.227878.75370HepG2DDX6
chr13111311983111312056-intron-Distal3.673493.11181HepG2CSTF2
chr13111314556111314649-intron-Distal5.6827630.08579K562RBFOX2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CARS2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CARS2 is not available on ENCORE database.

  • 34 RBPs can affect the levels of CARS2.  








The Knockdown/knockout RNA-Seq assay for CARS2 is not available on ENCORE database.





34 RBPs can affect the gene expression of CARS2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CARS2ENSG00000134905.12505.92170380.683700.410202.329901.41420HepG2ADAR
CARS2ENSG00000134905.12359.02820506.77270-0.497202.793901.75240HepG2AKAP8
CARS2ENSG00000134905.12318.73090503.10690-0.658504.551603.57290HepG2CIRBP
CARS2ENSG00000134905.121001.76930710.819600.494906.259005.36550HepG2CELF1
CARS2ENSG00000134905.12880.70460613.028900.522603.765403.04680HepG2DDX3X
CARS2ENSG00000134905.12720.99970523.639500.461302.834402.16170HepG2G3BP1
CARS2ENSG00000134905.12754.88750556.073200.440902.813401.91440HepG2G3BP2
CARS2ENSG00000134905.12783.63400530.523200.562704.510603.63730HepG2HNRNPK
CARS2ENSG00000134905.12561.20730696.23910-0.311002.738302.06770HepG2HNRNPL
CARS2ENSG00000134905.12780.71740564.814100.466903.017902.33350HepG2MAGOH
CARS2ENSG00000134905.12843.57480567.936800.570703.949803.20820HepG2MATR3
CARS2ENSG00000134905.12497.98360381.395900.384702.721101.98950HepG2PPIL4
CARS2ENSG00000134905.12478.48350723.47420-0.596505.563604.75750HepG2PUF60
CARS2ENSG00000134905.121015.39390767.995600.402805.494304.71780HepG2PUM1
CARS2ENSG00000134905.12659.39790889.75070-0.432304.008102.99890HepG2RBM15
CARS2ENSG00000134905.12537.95130745.55120-0.470803.268202.53540HepG2RPLP0
CARS2ENSG00000134905.12505.92730338.090500.581403.114602.26750HepG2RPS3A
CARS2ENSG00000134905.12568.60370380.801400.578306.374705.45690HepG2SAFB2
CARS2ENSG00000134905.12565.73790444.064100.349302.841102.19000HepG2SMN1
CARS2ENSG00000134905.12774.52830998.25290-0.366104.226503.64580HepG2SRFBP1
CARS2ENSG00000134905.12349.88460576.04920-0.719307.884207.01610HepG2TAF15
CARS2ENSG00000134905.12384.19880529.30980-0.462303.359602.44280HepG2TIA1
CARS2ENSG00000134905.12511.42620298.724400.775605.672804.57800HepG2UCHL5
CARS2ENSG00000134905.12433.34320302.826000.516902.466901.44000HepG2XPO5
CARS2ENSG00000134905.12734.70410497.882400.561302.634401.92730HepG2XRN2
CARS2ENSG00000134905.12904.69000772.243000.228302.026001.53860HepG2ZNF622
CARS2ENSG00000134905.12835.66120656.034100.349003.265602.56680K562DDX47
CARS2ENSG00000134905.12272.80660170.001900.682204.245603.26960K562EIF3G
CARS2ENSG00000134905.12977.16870786.140500.313702.686101.75930K562EIF4G2
CARS2ENSG00000134905.12457.94670330.610600.469903.393202.73270K562FXR1
CARS2ENSG00000134905.12118.75820198.02920-0.737702.974502.23880K562G3BP2
CARS2ENSG00000134905.12359.87310242.100500.571803.744802.75780K562MAGOH
CARS2ENSG00000134905.12339.89220498.85150-0.553503.259102.35580K562PCBP3
CARS2ENSG00000134905.12270.52430382.62770-0.500203.053402.21050K562POLR2G
CARS2ENSG00000134905.12106.25010188.95830-0.830602.692901.30130K562RAVER1
CARS2ENSG00000134905.12330.44850233.376100.501702.639801.94700K562TARDBP
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CARS2 is not available on ENCORE database.





27 RBPs can affect the splicing of CARS2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SECARS2ENSG00000134905.12chr13-1113191171113192751113157971113158651113196861113198200.430000.000080.00232includedHepG2U2AF1
SECARS2ENSG00000134905.12chr13-1112964111112965291112946611112948681112967311112970280.510000.000130.01728includedK562XRCC6
SECARS2ENSG00000134905.12chr13-1113191171113192751113157971113158651113196861113198200.141000.000940.01163includedK562AQR
SECARS2ENSG00000134905.12chr13-1112964111112965291112946611112948681112967311112969530.237000.004460.04227includedK562AQR
SECARS2ENSG00000134905.12chr13-111296411111296529111294661111294868111296731111296830-0.254000.000160.08097excludedK562ABCF1
SECARS2ENSG00000134905.12chr13-1112964111112965291112946611112948681112967311112969530.455000.000010.00362includedHepG2TIA1
SECARS2ENSG00000134905.12chr13-111298851111298978111298313111298437111299447111299586-0.167000.001860.07141excludedHepG2SFPQ
SECARS2ENSG00000134905.12chr13-1113191171113192751113157971113158651113196861113198200.227000.000900.04735includedK562EFTUD2
SECARS2ENSG00000134905.12chr13-1113191171113192751113157971113158651113196861113198200.159000.003270.05877includedK562U2AF1
SECARS2ENSG00000134905.12chr13-1113191631113192751113157971113158651113196861113198200.112000.000010.00104includedHepG2HNRNPL
SECARS2ENSG00000134905.12chr13-1112964111112965291112946611112948681112967311112970280.251000.000360.03000includedHepG2HNRNPL
SECARS2ENSG00000134905.12chr13-1112964111112965291112946611112948681112967311112970280.366000.000400.03438includedK562HNRNPUL1
SECARS2ENSG00000134905.12chr13-1112964111112965291112946611112948681112967311112970280.328000.003260.09150includedK562HNRNPU
SECARS2ENSG00000134905.12chr13-1112964111112965291112946611112948681112967311112970280.436000.001840.07126includedK562HNRNPK
SECARS2ENSG00000134905.12chr13-1113033801113034471112994471112995861113157971113158650.209000.000030.05928includedK562CPEB4
SECARS2ENSG00000134905.12chr13-111298313111298437111296731111296830111299447111299586-0.323000.001180.02208excludedK562HNRNPC
A3SSCARS2ENSG00000134905.12chr13-1112967311112969531112967311112968301112983131112984370.149000.000040.01318longerHepG2PTBP1
A3SSCARS2ENSG00000134905.12chr13-1112967311112969531112967311112968301112983131112984370.286000.000010.00177longerK562EFTUD2
A3SSCARS2ENSG00000134905.12chr13-1112967311112969531112967311112968301112983131112984370.317000.000920.03499longerK562U2AF2
A3SSCARS2ENSG00000134905.12chr13-1112967311112969531112967311112968301112983131112984370.402000.000190.01402longerK562SF3B4
A3SSCARS2ENSG00000134905.12chr13-1112967311112969531112967311112968301112983131112984370.171000.000020.00533longerHepG2TAF15
A3SSCARS2ENSG00000134905.12chr13-1112967311112969531112967311112968301112983131112984370.133000.000430.06777longerHepG2TIAL1
A3SSCARS2ENSG00000134905.12chr13-111296731111296953111296731111296830111298313111298437-0.138000.000090.06508shorterK562EIF4G2
A3SSCARS2ENSG00000134905.12chr13-1113157971113159131113157971113158651113196861113198200.218000.000220.00181longerK562AQR
A3SSCARS2ENSG00000134905.12chr13-1112937891112939811112937891112939551112946611112948680.083000.001940.01253longerK562AQR
A3SSCARS2ENSG00000134905.12chr13-1112967311112969531112967311112968301112983131112984370.201000.018120.08761longerK562AQR
A3SSCARS2ENSG00000134905.12chr13-1113537841113539281113537841113539021113578671113579180.085000.008120.04421longerK562AQR
A3SSCARS2ENSG00000134905.12chr13-1112946611112965291112946611112948681112967311112968300.458000.000000.00152longerHepG2TIA1
RICARS2ENSG00000134905.12chr13-111298313111299586111298313111298437111299447111299586-0.097000.001630.01154excludedK562PUS1
RICARS2ENSG00000134905.12chr13-111294661111296529111294661111294868111296411111296529-0.728000.000140.00540excludedK562SRSF1
RICARS2ENSG00000134905.12chr13-111298313111299586111298313111298437111299447111299586-0.159000.000080.00612excludedK562HNRNPUL1
RICARS2ENSG00000134905.12chr13-1112983131112995861112983131112984371112994471112995860.110000.003140.03882includedHepG2PCBP1
RICARS2ENSG00000134905.12chr13-1112946611112965291112946611112948681112964111112965290.435000.001960.01985includedK562AKAP8L
RICARS2ENSG00000134905.12chr13-1112983131112995861112983131112984371112994471112995860.129000.002930.02851includedHepG2TAF15
RICARS2ENSG00000134905.12chr13-1112983131112995861112983131112984371112994471112995860.065000.001440.01576includedHepG2U2AF1
RICARS2ENSG00000134905.12chr13-111294661111296529111294661111294868111296411111296529-0.805000.000030.00458excludedK562KHSRP
RICARS2ENSG00000134905.12chr13-111294661111296529111294661111294868111296411111296529-0.372000.001650.09247excludedK562ZC3H8
RICARS2ENSG00000134905.12chr13-1112983131112995861112983131112984371112994471112995860.121000.000710.01023includedHepG2HNRNPK
RICARS2ENSG00000134905.12chr13-111294661111296529111294661111294868111296411111296529-0.774000.000070.03277excludedK562TRA2A
RICARS2ENSG00000134905.12chr13-111294661111296529111294661111294868111296411111296529-0.721000.000040.00288excludedK562TARDBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for CARS2 is not avaliable on ENCORE database.