ALAS1

General Information

Gene Name       : ALAS1
Gene ID             : ENSG00000023330.14
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: ALAS1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878ALAS1ENSG00000023330.1446.0770.1958.13ENCSR000AEF
HepG2ALAS1ENSG00000023330.1427.0027.9927.49ENCSR985KAT
K562ALAS1ENSG00000023330.1428.3127.9528.13ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for ALAS1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • ALAS1 RNA is bound by 2 proteins.  







eCLIP assay for ALAS1 is not avaliable on ENCORE database.





2 proteins are bound to ALAS1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr35223227052232315+5'-UTR,intron-Proximal4.012855.47926K562AQR
chr35223225852232317+5'-UTR,intron-Proximal3.148513.95099HepG2PRPF8
chr35224642752246481+CDS,intron-Proximal4.1663210.81845HepG2PRPF8
chr35224643452246479+CDS,intron-Proximal4.800453.62536K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for ALAS1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for ALAS1 is not available on ENCORE database.

  • 75 RBPs can affect the levels of ALAS1.  








The Knockdown/knockout RNA-Seq assay for ALAS1 is not available on ENCORE database.





75 RBPs can affect the gene expression of ALAS1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
ALAS1ENSG00000023330.101375.015001048.574100.390902.379201.88140HepG2AKAP1
ALAS1ENSG00000023330.101015.82490749.275300.439005.463004.41930HepG2AKAP8L
ALAS1ENSG00000023330.10905.52560708.698500.353502.917802.12810HepG2CALR
ALAS1ENSG00000023330.101471.09600824.275500.8356010.950309.50530HepG2CIRBP
ALAS1ENSG00000023330.101018.54160745.610200.449906.535005.59190HepG2CKAP4
ALAS1ENSG00000023330.101433.59590929.741400.6246012.1536010.99130HepG2CELF1
ALAS1ENSG00000023330.10793.86490587.606200.433903.228302.49930HepG2DDX21
ALAS1ENSG00000023330.101017.52760713.498700.512006.835305.86080HepG2DKC1
ALAS1ENSG00000023330.10774.54040618.070500.325502.654201.96170HepG2DNAJC21
ALAS1ENSG00000023330.101218.81670986.240800.305403.671502.72990HepG2EIF4G1
ALAS1ENSG00000023330.10867.888601284.73990-0.565906.519605.66130HepG2ETF1
ALAS1ENSG00000023330.101022.47940728.752400.488504.863203.76220HepG2EWSR1
ALAS1ENSG00000023330.10930.23410623.991200.576005.522704.65350HepG2HNRNPA1
ALAS1ENSG00000023330.101184.40400868.898100.446803.674702.87900HepG2HNRNPK
ALAS1ENSG00000023330.101395.63890833.133300.744208.933207.87330HepG2HNRNPLL
ALAS1ENSG00000023330.101615.47750872.052300.8894012.4275011.11250HepG2IGF2BP2
ALAS1ENSG00000023330.10822.27000681.728000.270302.493301.52370HepG2KIF1C
ALAS1ENSG00000023330.101425.61590930.409100.615505.353304.50070HepG2MATR3
ALAS1ENSG00000023330.101195.90660952.308600.328501.958301.42060HepG2NCBP2
ALAS1ENSG00000023330.10676.00160991.11370-0.552006.292605.14550HepG2NOL12
ALAS1ENSG00000023330.101193.17710716.456200.735803.839002.53490HepG2NONO
ALAS1ENSG00000023330.101030.17440568.927500.856505.670804.36560HepG2PABPC1
ALAS1ENSG00000023330.101123.44270848.015200.405702.784302.06020HepG2PABPC4
ALAS1ENSG00000023330.10532.41000682.47910-0.358203.044702.16040HepG2PARN
ALAS1ENSG00000023330.101008.73690710.150500.506302.824601.77380HepG2PCBP2
ALAS1ENSG00000023330.10859.80210601.665100.514903.527402.62650HepG2PRPF8
ALAS1ENSG00000023330.101230.92270946.160000.379503.585102.91820HepG2PUF60
ALAS1ENSG00000023330.101567.834001003.681400.6434010.913809.63110HepG2PUM2
ALAS1ENSG00000023330.10899.93080759.613400.244402.085001.53240HepG2PUS1
ALAS1ENSG00000023330.10717.046001022.94510-0.512605.333404.50680HepG2QKI
ALAS1ENSG00000023330.101404.92590685.183301.035808.104306.93760HepG2RAVER1
ALAS1ENSG00000023330.101187.10250928.444800.354503.153702.43890HepG2RBM25
ALAS1ENSG00000023330.10846.70510641.485000.400302.334801.36390HepG2RCC2
ALAS1ENSG00000023330.101270.629501051.261900.273302.438801.92560HepG2NELFE
ALAS1ENSG00000023330.10783.04560979.21300-0.322502.680302.07220HepG2RECQL
ALAS1ENSG00000023330.10720.48600508.932400.501403.589702.51480HepG2SERBP1
ALAS1ENSG00000023330.101539.199701014.579000.601204.349803.49440HepG2SF3A3
ALAS1ENSG00000023330.101204.58830983.391500.292602.435201.87560HepG2SF3B4
ALAS1ENSG00000023330.101717.123001026.499000.7422018.7249017.72320HepG2SRSF1
ALAS1ENSG00000023330.101033.26030835.155700.307003.453002.85100HepG2SRSF9
ALAS1ENSG00000023330.101579.260001053.125400.5845012.5208011.58490HepG2SSB
ALAS1ENSG00000023330.101581.94900776.547201.0265013.0431011.75550HepG2SUPV3L1
ALAS1ENSG00000023330.10755.25550922.79940-0.289102.133301.62910HepG2TAF15
ALAS1ENSG00000023330.101036.72560670.014400.629708.484807.69530HepG2TIAL1
ALAS1ENSG00000023330.10334.07320458.70590-0.457402.676701.92990HepG2UCHL5
ALAS1ENSG00000023330.10689.93960924.83580-0.422704.579403.27070HepG2UTP18
ALAS1ENSG00000023330.101153.54130868.698000.409005.368304.57970HepG2UTP3
ALAS1ENSG00000023330.101325.01910989.581400.421007.227706.45190HepG2ZNF622
ALAS1ENSG00000023330.10943.514601262.59760-0.420303.523702.12890K562ABCF1
ALAS1ENSG00000023330.10853.94160639.487400.417103.133201.76330K562CIRBP
ALAS1ENSG00000023330.10688.43010845.56300-0.296602.042001.35990K562CPSF6
ALAS1ENSG00000023330.101845.931701084.011100.7679019.6076018.02320K562DDX47
ALAS1ENSG00000023330.10405.38070651.56810-0.684604.677502.96970K562EEF2
ALAS1ENSG00000023330.10871.79350629.504700.469703.489102.45790K562EFTUD2
ALAS1ENSG00000023330.10683.50240443.290500.624606.975005.72070K562EIF3G
ALAS1ENSG00000023330.10585.86740464.598200.334502.403901.34940K562EIF4B
ALAS1ENSG00000023330.101140.904901379.91860-0.274402.242201.39340K562EIF4G2
ALAS1ENSG00000023330.10714.45330907.57090-0.345202.333001.55500K562FIP1L1
ALAS1ENSG00000023330.10850.07250536.518600.663909.107708.08400K562FXR1
ALAS1ENSG00000023330.10955.280501216.50260-0.348702.828202.06500K562GRSF1
ALAS1ENSG00000023330.10785.07550595.925000.397602.487201.32290K562HNRNPK
ALAS1ENSG00000023330.10915.03680675.876700.437003.553001.93040K562LARP7
ALAS1ENSG00000023330.10834.94440625.801900.415903.493002.44070K562MATR3
ALAS1ENSG00000023330.10484.86120788.02530-0.700707.546406.06740K562METAP2
ALAS1ENSG00000023330.10555.44470855.04000-0.622304.900003.84710K562MTPAP
ALAS1ENSG00000023330.10666.86090515.164100.372302.665301.45970K562NCBP2
ALAS1ENSG00000023330.10687.75750950.10310-0.466205.719704.70140K562NSUN2
ALAS1ENSG00000023330.10499.07350872.97060-0.806708.135706.71270K562PCBP3
ALAS1ENSG00000023330.10644.76650919.55330-0.512203.655201.83370K562PKM
ALAS1ENSG00000023330.101089.087201417.90000-0.380603.563401.94190K562PNPT1
ALAS1ENSG00000023330.10399.73250669.59810-0.744308.624107.24090K562POLR2G
ALAS1ENSG00000023330.10851.45670612.582200.474903.395602.56270K562PRPF8
ALAS1ENSG00000023330.10812.99450609.244000.416103.591602.84600K562PTBP1
ALAS1ENSG00000023330.101132.08990623.937400.859409.222507.71380K562RPS19
ALAS1ENSG00000023330.10808.92820447.244000.8548011.8936010.03930K562SF3B4
ALAS1ENSG00000023330.101007.36680597.263400.7540010.273408.92390K562SRSF1
ALAS1ENSG00000023330.10861.981801190.81270-0.466204.068102.39780K562SSRP1
ALAS1ENSG00000023330.10939.328601313.67440-0.483905.431103.41250K562SUCLG1
ALAS1ENSG00000023330.10425.21440627.68960-0.561904.100802.83610K562UCHL5
ALAS1ENSG00000023330.10671.995001007.40840-0.584107.851506.71450K562UPF1
ALAS1ENSG00000023330.10584.40850862.01740-0.560705.212303.99180K562WDR3
ALAS1ENSG00000023330.10472.56510639.22910-0.435802.794101.58100K562XRN2
ALAS1ENSG00000023330.10932.737401231.57450-0.401002.807101.93620K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for ALAS1 is not available on ENCORE database.





10 RBPs can affect the splicing of ALAS1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.203000.000010.00031excludedK562SRSF1
SEALAS1ENSG00000023330.10chr3+522420985224226352240587522407675224529852245567-0.117000.000440.01058excludedK562SRSF1
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223323652233456-0.230000.000940.01941excludedHepG2U2AF1
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223323652233456-0.390000.000000.00001excludedHepG2U2AF2
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.136000.000840.04945excludedHepG2NCBP2
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.204000.000000.00000excludedHepG2SRSF1
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.083000.000000.00107excludedHepG2SUPV3L1
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.136000.000160.01066excludedHepG2PCBP1
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.118000.000260.01592excludedHepG2SF3B4
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.280000.000480.01085excludedK562U2AF2
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.111000.001140.03019excludedK562RBM15
SEALAS1ENSG00000023330.10chr3+522326875223286452232109522322715223322552233456-0.138000.000120.01163excludedHepG2SRSF9
SEALAS1ENSG00000023330.10chr3+5223268752232864522321095223227152233225522334560.223000.001430.05291includedK562PTBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for ALAS1 is not avaliable on ENCORE database.