SETDB2

General Information

Gene Name       : SETDB2
Gene ID             : ENSG00000136169.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SETDB2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SETDB2ENSG00000136169.165.505.605.55ENCSR000AEF
HepG2SETDB2ENSG00000136169.163.816.935.37ENCSR985KAT
K562SETDB2ENSG00000136169.164.755.365.05ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SETDB2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SETDB2 RNA is bound by 6 proteins.  







eCLIP assay for SETDB2 is not avaliable on ENCORE database.





6 proteins are bound to SETDB2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr135006806150068106+3'-UTR4.118184.28663HepG2SUGP2
chr135006782350067920+3'-UTR4.865788.07646HepG2SUGP2
chr135006853350068596+3'-UTR4.225244.28663HepG2SUGP2
chr135006820150068274+3'-UTR4.701826.08961HepG2PTBP1
chr135005686950056876+CDS,intron-Proximal4.026883.02457HepG2BCLAF1
chr135005687650056968+CDS5.5268810.12910HepG2BCLAF1
chr135005113550051182+CDS,intron-Proximal3.650844.51739HepG2BCLAF1
chr135005099050051101+CDS3.911827.23562HepG2BCLAF1
chr135005445150054558+CDS,intron-Proximal4.009743.56873HepG2PRPF8
chr135005698450057050+CDS4.335378.15024HepG2BCLAF1
chr135005432550054402+CDS,intron-Proximal3.367625.97243HepG2U2AF2
chr135005067750050855+CDS3.784405.80880HepG2GRWD1
chr135005521850055253+CDS,intron-Proximal4.523403.45943HepG2BCLAF1
chr135003428850034362+CDS3.438447.42278HepG2BCLAF1
chr135006272350062817+CDS,intron-Proximal4.531285.01842HepG2PRPF8
chr135005715850057256+intron-Distal,intron-Proximal4.367623.77802HepG2U2AF2
chr135002442450024498+intron-Distal4.047503.29248HepG2SUGP2
chr135002462050024687+intron-Distal4.486665.04879HepG2SUGP2
chr135002271750022779+intron-Distal4.300534.86548HepG2SUGP2
chr135002426550024323+intron-Distal4.224053.79098HepG2SUGP2
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SETDB2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SETDB2 is not available on ENCORE database.

  • 59 RBPs can affect the levels of SETDB2.  








The Knockdown/knockout RNA-Seq assay for SETDB2 is not available on ENCORE database.





59 RBPs can affect the gene expression of SETDB2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SETDB2ENSG00000136169.12398.92900274.884400.537203.160202.02290HepG2AATF
SETDB2ENSG00000136169.12393.77110267.722300.556503.324302.23820HepG2ADAR
SETDB2ENSG00000136169.12345.68720568.13780-0.716804.712304.04100HepG2AKAP1
SETDB2ENSG00000136169.12644.02820470.093700.454102.783601.99710HepG2ASCC1
SETDB2ENSG00000136169.12228.37960418.13420-0.872507.129606.22180HepG2BOP1
SETDB2ENSG00000136169.12423.86500339.054100.322002.043401.45980HepG2CKAP4
SETDB2ENSG00000136169.12237.45210383.86800-0.693004.244703.40900HepG2CPSF6
SETDB2ENSG00000136169.12409.50140514.53130-0.329402.528501.81460HepG2DAZAP1
SETDB2ENSG00000136169.12437.04840296.786200.558303.780802.70170HepG2DDX24
SETDB2ENSG00000136169.12203.93140269.58830-0.402701.908801.31340HepG2DNAJC21
SETDB2ENSG00000136169.12349.46890496.70250-0.507202.675502.04690HepG2EIF4A3
SETDB2ENSG00000136169.12696.73700507.577600.456904.376903.36710HepG2EIF4G1
SETDB2ENSG00000136169.12659.60420486.233900.439902.837002.01300HepG2EIF4G2
SETDB2ENSG00000136169.12338.56310501.09780-0.565703.447502.68050HepG2FXR1
SETDB2ENSG00000136169.12174.08830272.17090-0.644703.165402.48090HepG2HNRNPA1
SETDB2ENSG00000136169.12409.48980299.569900.450803.272102.49690HepG2HNRNPF
SETDB2ENSG00000136169.12644.80350470.656600.454102.931402.21260HepG2HNRNPK
SETDB2ENSG00000136169.12316.59060472.54060-0.577803.536102.78250HepG2IGF2BP2
SETDB2ENSG00000136169.12404.36070633.57860-0.647903.991302.99020HepG2LARP4
SETDB2ENSG00000136169.12330.01040501.27250-0.603103.895403.11790HepG2MAGOH
SETDB2ENSG00000136169.12229.41800504.08690-1.1357010.000208.85850HepG2MATR3
SETDB2ENSG00000136169.12397.40830510.20580-0.360502.428401.71620HepG2NOL12
SETDB2ENSG00000136169.12572.56720368.212700.636804.728603.76010HepG2NSUN2
SETDB2ENSG00000136169.12634.88990424.844500.579503.129102.02740HepG2PCBP2
SETDB2ENSG00000136169.12486.65130346.641000.489304.105803.18320HepG2PRPF4
SETDB2ENSG00000136169.12369.40270468.74610-0.343601.980801.50420HepG2PTBP1
SETDB2ENSG00000136169.12318.15650487.02340-0.614304.767204.01050HepG2PUF60
SETDB2ENSG00000136169.12273.64360531.56780-0.9580011.7711010.85640HepG2RBM22
SETDB2ENSG00000136169.12383.43620521.65500-0.444103.276402.69780HepG2NELFE
SETDB2ENSG00000136169.12436.93970322.690800.437202.388901.74670HepG2RPLP0
SETDB2ENSG00000136169.12139.88610275.34090-0.977006.864505.94430HepG2RPS19
SETDB2ENSG00000136169.12321.66780217.100600.567102.515801.76250HepG2RRP9
SETDB2ENSG00000136169.12203.33380267.81980-0.397401.963001.40490HepG2SAFB2
SETDB2ENSG00000136169.12291.66750411.02380-0.494902.794502.08420HepG2SF3B1
SETDB2ENSG00000136169.12232.50070312.32690-0.425802.559901.93670HepG2SMN1
SETDB2ENSG00000136169.12269.78650509.37290-0.9169010.9577010.15180HepG2SRSF1
SETDB2ENSG00000136169.12378.13330294.313100.361402.127901.50820HepG2SRSF7
SETDB2ENSG00000136169.12386.08910546.87070-0.502303.322602.65310HepG2SUCLG1
SETDB2ENSG00000136169.12409.30560292.234000.486003.204302.67250HepG2TIAL1
SETDB2ENSG00000136169.12281.48290167.306400.750504.384003.42680HepG2UCHL5
SETDB2ENSG00000136169.12338.52480456.88230-0.432603.265102.51760HepG2UPF1
SETDB2ENSG00000136169.12198.65790441.10290-1.1508014.2167013.02000HepG2UTP3
SETDB2ENSG00000136169.12300.69290450.88500-0.584503.002201.89570HepG2XRCC6
SETDB2ENSG00000136169.12271.50520502.48400-0.8881012.5097011.55730HepG2ZNF622
SETDB2ENSG00000136169.12292.20060443.69730-0.602605.047504.31990K562AGGF1
SETDB2ENSG00000136169.12319.16090461.67950-0.532603.599402.85030K562AKAP8L
SETDB2ENSG00000136169.12250.30380512.10780-1.032809.741108.74460K562AQR
SETDB2ENSG00000136169.12418.86900641.87370-0.615802.898201.80470K562CNOT7
SETDB2ENSG00000136169.12170.75380248.32840-0.540302.155501.34970K562EFTUD2
SETDB2ENSG00000136169.12812.47390668.581800.281102.215501.37060K562EIF4G2
SETDB2ENSG00000136169.12228.96230329.81590-0.526603.357102.69950K562FXR1
SETDB2ENSG00000136169.12495.42760325.461500.606103.488902.67620K562G3BP2
SETDB2ENSG00000136169.12264.96820446.69790-0.753505.805904.70640K562GRSF1
SETDB2ENSG00000136169.12185.65010298.18350-0.683603.847903.15840K562HNRNPC
SETDB2ENSG00000136169.12207.81270301.44490-0.536602.398901.53530K562HNRNPM
SETDB2ENSG00000136169.12300.85830417.98950-0.474402.340701.56390K562MAGOH
SETDB2ENSG00000136169.12343.92710469.01360-0.447502.310501.35730K562MAK16
SETDB2ENSG00000136169.12284.51600417.18260-0.552203.031402.06290K562MATR3
SETDB2ENSG00000136169.12281.24000439.92410-0.645502.288601.40500K562PABPN1
SETDB2ENSG00000136169.12253.18300406.08270-0.681604.233503.42830K562PTBP1
SETDB2ENSG00000136169.12522.66700729.47390-0.481003.031102.17690K562PUF60
SETDB2ENSG00000136169.12307.46960457.91440-0.574603.850703.22500K562PUS1
SETDB2ENSG00000136169.12314.90390446.12300-0.502503.593102.93120K562RBM15
SETDB2ENSG00000136169.12246.80290389.53270-0.658403.432502.49110K562RBM22
SETDB2ENSG00000136169.12250.16390338.64530-0.436902.410801.61550K562SF3B4
SETDB2ENSG00000136169.12187.07130398.06610-1.089407.564406.40370K562SRSF1
SETDB2ENSG00000136169.12221.30350402.93430-0.864504.313203.42280K562TARDBP
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SETDB2 is not available on ENCORE database.





7 RBPs can affect the splicing of SETDB2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESETDB2ENSG00000136169.12chr13+500575995005769950056872500570985005976550059859-0.159000.006110.08850excludedHepG2U2AF1
SESETDB2ENSG00000136169.12chr13+5002316750023297500185095001899350025688500260450.298000.000810.03688includedHepG2MATR3
SESETDB2ENSG00000136169.12chr13+5005616650056332500550825005525250056872500570980.165000.000000.00009includedHepG2HNRNPL
SESETDB2ENSG00000136169.12chr13+500509285005117550050611500508345005435450054517-0.379000.000700.02308excludedHepG2SF3A3
SESETDB2ENSG00000136169.12chr13+500509285005117550050611500508345005435450054517-0.206000.000140.08331excludedK562PUM2
SESETDB2ENSG00000136169.12chr13+500509285005117550050611500508345005435450054471-0.210000.000170.03712excludedK562EIF4G2
SESETDB2ENSG00000136169.12chr13+500509285005117550050611500508345005435450054499-0.281000.004090.05932excludedK562HNRNPC
A5SSSETDB2ENSG00000136169.12chr13+500506115005117550050611500508345005435450054471-0.354000.000120.01426shorterHepG2SF3A3

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SETDB2 is not avaliable on ENCORE database.