HHLA3

General Information

Gene Name       : HHLA3
Gene ID             : ENSG00000197568.13
Essential Gene : No

Functions

Localization

Domains (AlphaFold: HHLA3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HHLA3ENSG00000197568.135.986.186.08ENCSR000AEF
HepG2HHLA3ENSG00000197568.134.545.124.83ENCSR985KAT
K562HHLA3ENSG00000197568.1312.5612.4912.53ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HHLA3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • HHLA3 RNA is bound by 2 proteins.  







eCLIP assay for HHLA3 is not avaliable on ENCORE database.





2 proteins are bound to HHLA3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr17082059870820643+5'-UTR,CDS4.976635.39850K562DDX3X
chr17082073170820777+CDS4.392784.72754K562YBX3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HHLA3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HHLA3 is not available on ENCORE database.

  • 66 RBPs can affect the levels of HHLA3.  








The Knockdown/knockout RNA-Seq assay for HHLA3 is not available on ENCORE database.





66 RBPs can affect the gene expression of HHLA3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HHLA3ENSG00000197568.9103.6497066.426900.641801.960201.43180HepG2ACO1
HHLA3ENSG00000197568.9310.36480122.816501.337409.108608.20570HepG2AKAP1
HHLA3ENSG00000197568.9186.20440101.624000.873503.891902.96750HepG2ASCC1
HHLA3ENSG00000197568.9176.0883088.290400.995905.140704.12900HepG2CALR
HHLA3ENSG00000197568.9251.06500123.339201.025305.438804.04980HepG2CCAR1
HHLA3ENSG00000197568.9184.4990096.548600.934204.293803.34300HepG2CIRBP
HHLA3ENSG00000197568.9128.9935066.395500.958004.284403.49090HepG2CKAP4
HHLA3ENSG00000197568.9128.7304068.644600.907002.705801.95010HepG2CNOT7
HHLA3ENSG00000197568.9167.0154097.642100.774302.926101.79110HepG2CPSF7
HHLA3ENSG00000197568.9135.2074077.737400.798402.120801.54590HepG2CELF1
HHLA3ENSG00000197568.9141.8161083.575500.762803.435102.62500HepG2DAZAP1
HHLA3ENSG00000197568.9132.0225065.488801.011404.083203.27390HepG2DDX21
HHLA3ENSG00000197568.9164.84350101.051200.705902.483501.89630HepG2DDX6
HHLA3ENSG00000197568.9101.9389055.543100.875902.937602.21670HepG2DNAJC21
HHLA3ENSG00000197568.9115.4572055.030001.069003.579802.85590HepG2DNAJC2
HHLA3ENSG00000197568.9111.8058052.463801.091503.220802.23130HepG2EEF2
HHLA3ENSG00000197568.919.3651060.39620-1.641004.191502.81370HepG2AGO1
HHLA3ENSG00000197568.9156.7094097.161200.689502.309901.76410HepG2EIF2S1
HHLA3ENSG00000197568.9208.02620107.383300.953904.276303.48580HepG2EIF4A3
HHLA3ENSG00000197568.9178.37350104.535900.770802.577201.91180HepG2EIF4B
HHLA3ENSG00000197568.9170.94110100.495400.766303.071002.37180HepG2G3BP1
HHLA3ENSG00000197568.9103.5324056.074900.884602.492701.87650HepG2HNRNPA1
HHLA3ENSG00000197568.9172.8993062.365501.471007.879906.75650HepG2HNRNPC
HHLA3ENSG00000197568.9133.5876076.127400.811203.577602.81790HepG2HNRNPL
HHLA3ENSG00000197568.9287.57770151.266000.926805.749204.87520HepG2HNRNPLL
HHLA3ENSG00000197568.9116.1781061.953700.907003.550502.87170HepG2HNRNPU
HHLA3ENSG00000197568.9105.8760063.285000.742302.367701.68180HepG2ILF2
HHLA3ENSG00000197568.952.73310100.03350-0.923702.925202.36530HepG2PTBP1
HHLA3ENSG00000197568.9112.2361067.657600.730102.509801.91530HepG2PUS1
HHLA3ENSG00000197568.9178.0820073.965801.267507.633006.87190HepG2RBM22
HHLA3ENSG00000197568.938.3557098.31640-1.358004.902504.02790HepG2RBM25
HHLA3ENSG00000197568.9185.17500101.164800.872103.824003.04150HepG2RPLP0
HHLA3ENSG00000197568.995.1136041.441101.198503.801503.09150HepG2RPS19
HHLA3ENSG00000197568.9176.1550083.542901.076206.042605.38130HepG2SRFBP1
HHLA3ENSG00000197568.9152.9632080.838400.920003.960202.84660HepG2SUPT6H
HHLA3ENSG00000197568.9138.3618060.227701.199805.902305.22370HepG2TIAL1
HHLA3ENSG00000197568.9103.4979060.735900.768902.648702.09380HepG2TRIM56
HHLA3ENSG00000197568.9325.91030153.109401.089802.855401.85010HepG2U2AF2
HHLA3ENSG00000197568.967.3139033.422201.010002.648301.90650HepG2UCHL5
HHLA3ENSG00000197568.9150.8874086.577300.801303.745602.95240HepG2UPF1
HHLA3ENSG00000197568.9103.3027055.689300.891302.438001.75360HepG2XRN2
HHLA3ENSG00000197568.9138.9181087.775200.662202.548301.89880HepG2ZC3H8
HHLA3ENSG00000197568.9222.0730095.218301.2216010.202809.31870HepG2ZNF622
HHLA3ENSG00000197568.9277.41050382.38970-0.463002.488101.86850K562AKAP8L
HHLA3ENSG00000197568.9269.81550187.069900.528302.305901.76300K562AQR
HHLA3ENSG00000197568.9394.55180268.993400.552502.994602.08530K562BOP1
HHLA3ENSG00000197568.9367.87120240.351600.614003.303201.70580K562CKAP4
HHLA3ENSG00000197568.9304.13930224.716600.436502.441401.82380K562DDX47
HHLA3ENSG00000197568.9177.82380103.338700.783002.329001.41390K562EIF3A
HHLA3ENSG00000197568.9140.1140083.736200.742602.811701.98380K562EIF4A3
HHLA3ENSG00000197568.9182.14690109.064200.739803.031501.83990K562FKBP4
HHLA3ENSG00000197568.9341.01070246.667200.467202.120601.32540K562FTO
HHLA3ENSG00000197568.9367.21950204.352000.845505.880804.77430K562GRSF1
HHLA3ENSG00000197568.9387.42110125.566001.6254018.5953017.12490K562HNRNPC
HHLA3ENSG00000197568.9201.30070112.144900.843904.221002.77840K562HNRNPF
HHLA3ENSG00000197568.968.02050124.63990-0.873702.911501.64420K562HNRNPK
HHLA3ENSG00000197568.9307.48490203.083700.598303.580002.35720K562HNRNPL
HHLA3ENSG00000197568.9538.47770252.910701.0902011.6562010.05420K562HSPD1
HHLA3ENSG00000197568.9357.71820233.174800.617302.895101.93630K562KRR1
HHLA3ENSG00000197568.9405.20880266.548300.604203.486902.49830K562METAP2
HHLA3ENSG00000197568.9310.34420171.805700.853006.813605.59220K562MTPAP
HHLA3ENSG00000197568.9306.33580190.912600.682104.913403.95860K562NSUN2
HHLA3ENSG00000197568.9626.44860280.620501.1585012.6974010.92980K562PCBP3
HHLA3ENSG00000197568.9520.44530215.242501.2737017.1647015.25990K562POLR2G
HHLA3ENSG00000197568.9342.83530211.742900.695104.532703.44590K562PPIG
HHLA3ENSG00000197568.960.59400127.41500-1.072304.992004.12360K562PTBP1
HHLA3ENSG00000197568.9342.52640241.397800.504702.029401.33000K562PUF60
HHLA3ENSG00000197568.9399.53820251.574000.667304.381103.16710K562PUM2
HHLA3ENSG00000197568.9184.40140102.740200.843704.194802.97080K562RCC2
HHLA3ENSG00000197568.9223.24370108.287601.043705.875004.45880K562TIAL1
HHLA3ENSG00000197568.9173.04750115.062900.588602.185401.35950K562TRIM56
HHLA3ENSG00000197568.9327.13430202.427000.692405.008804.07240K562UPF1
HHLA3ENSG00000197568.9245.76200173.213100.504602.314601.51280K562WDR3
HHLA3ENSG00000197568.9244.80850180.102900.442702.148001.39520K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HHLA3 is not available on ENCORE database.





4 RBPs can affect the splicing of HHLA3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEHHLA3ENSG00000197568.9chr1+7083261570832667708321267083222070833299708337060.266000.001830.06253includedK562FXR1
SEHHLA3ENSG00000197568.9chr1+708326157083266770832126708322207083329970833706-0.193000.000050.00768excludedHepG2DDX3X
SEHHLA3ENSG00000197568.9chr1+708326157083266770832126708322207083329970833706-0.158000.003040.09555excludedHepG2MATR3
SEHHLA3ENSG00000197568.9chr1+7083261570832667708321267083222070833299708337060.291000.000410.01872includedK562HNRNPU

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HHLA3 is not avaliable on ENCORE database.