SPOP

General Information

Gene Name       : SPOP
Gene ID             : ENSG00000121067.17
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: SPOP)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPOPENSG00000121067.1728.6728.3328.50ENCSR000AEF
HepG2SPOPENSG00000121067.1734.8441.0037.92ENCSR985KAT
K562SPOPENSG00000121067.1735.8836.7936.34ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPOP is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPOP RNA is bound by 18 proteins.  







eCLIP assay for SPOP is not avaliable on ENCORE database.





18 proteins are bound to SPOP RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr174768872447688786-3'-UTR,CDS,intron-Distal,intron-Proximal3.310053.28366HepG2BCLAF1
chr174767705447677093-3'-UTR,intron-Distal4.600465.25389K562UPF1
chr174767684447676907-3'-UTR,intron-Distal3.305234.72451K562CPEB4
chr174768460947684727-3'-UTR,CDS,intron-Distal,intron-Proximal3.097845.00751HepG2BCLAF1
chr174769634347696440-3'-UTR,CDS,intron-Distal,intron-Proximal3.300625.79905HepG2BCLAF1
chr174767673947676829-3'-UTR,intron-Distal3.277288.47743K562UPF1
chr174767752847677581-3'-UTR,intron-Distal,intron-Proximal3.899854.23488K562FAM120A
chr174767715247677215-3'-UTR,intron-Distal4.016169.04309K562UPF1
chr174770009447700221-3'-UTR,CDS,intron-Distal,intron-Proximal3.664329.47757K562YBX3
chr174769922947699335-3'-UTR,CDS,intron-Distal,intron-Proximal4.580594.96013K562PRPF8
chr174769669947696756-3'-UTR,CDS,intron-Distal,intron-Proximal3.610344.21358HepG2U2AF2
chr174767743447677487-3'-UTR,intron-Distal,intron-Proximal4.947416.29854K562UPF1
chr174767749247677528-3'-UTR,intron-Distal,intron-Proximal3.252123.29111K562FAM120A
chr174767721547677283-3'-UTR,intron-Distal,intron-Proximal4.618799.20161K562UPF1
chr174767749047677567-3'-UTR,intron-Distal,intron-Proximal5.431677.60978K562UPF1
chr174775533347755440-5'-UTR,intron-Distal,intron-Proximal4.2141912.49859K562TARDBP
chr174774540647745456-5'-UTR,intron-Distal,intron-Proximal3.494414.35314HepG2U2AF2
chr174769962247699678-CDS,intron-Distal,intron-Proximal4.791625.13577HepG2U2AF2
chr174767780147677883-CDS,intron-Distal3.276854.53005K562YBX3
chr174770004947700096-CDS,intron-Distal,intron-Proximal4.116074.52312K562AQR
chr174769723347697343-intron-Distal3.917633.77875HepG2ILF3
chr174774567847745783-intron-Distal3.151063.68839K562KHSRP
chr174768714947687292-intron-Distal4.894177.55950K562MATR3
chr174768711747687238-intron-Distal5.270576.76922HepG2PTBP1
chr174768704347687143-intron-Distal4.154123.39827HepG2MATR3
chr174775491947754949-intron-Distal3.849064.59145HepG2XPO5
chr174769995447700085-intron-Distal,intron-Proximal3.091954.21588K562PRPF8
chr174771129847711367-intron-Distal4.183804.10336HepG2SUGP2
chr174768685347686915-intron-Distal3.381214.36650HepG2SUGP2
chr174770163847701716-intron-Distal3.924803.22972K562TARDBP
chr174775501247755073-intron-Distal4.359764.33022HepG2HNRNPK
chr174767913247679226-intron-Distal,intron-Proximal3.831154.89208K562AQR
chr174768704747687122-intron-Distal3.493074.24981K562MATR3
chr174768425647684338-intron-Distal,intron-Proximal4.517194.17759HepG2QKI
chr174768688347686938-intron-Distal4.908315.37222HepG2MATR3
chr174774066847740759-intron-Distal3.184443.40206HepG2HNRNPC
chr174769171447691863-intron-Distal4.918508.72817K562KHSRP
chr174768704247687126-intron-Distal5.144336.95895K562PTBP1
chr174769161847691701-intron-Distal4.152834.76003K562KHSRP
chr174768729247687455-intron-Distal4.804836.01663K562MATR3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPOP is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPOP is not available on ENCORE database.

  • 46 RBPs can affect the levels of SPOP.  








The Knockdown/knockout RNA-Seq assay for SPOP is not available on ENCORE database.





46 RBPs can affect the gene expression of SPOP :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPOPENSG00000121067.131905.162901416.270500.427702.966702.41800HepG2AKAP1
SPOPENSG00000121067.13445.55440824.48600-0.887904.145102.08050HepG2APOBEC3C
SPOPENSG00000121067.131258.15160905.283400.474804.436203.69890HepG2BOP1
SPOPENSG00000121067.13887.416501113.31510-0.327202.043401.37220HepG2CIRBP
SPOPENSG00000121067.131288.92790882.877000.545803.001402.20090HepG2CNOT7
SPOPENSG00000121067.131005.72800762.467400.399403.123102.40560HepG2DDX21
SPOPENSG00000121067.13958.84800745.965300.362102.843801.91540HepG2DDX24
SPOPENSG00000121067.13619.10240911.95700-0.558803.868102.96880HepG2DDX55
SPOPENSG00000121067.13651.17400888.57140-0.448403.387402.27780HepG2DDX5
SPOPENSG00000121067.13698.210601120.28680-0.682106.651205.75580HepG2EIF2S1
SPOPENSG00000121067.13933.96120719.915400.375403.070101.93680HepG2EIF3G
SPOPENSG00000121067.131889.307401641.739300.202502.101401.56270HepG2ETF1
SPOPENSG00000121067.131036.70930812.221700.352002.289101.36630HepG2GNB2L1
SPOPENSG00000121067.13576.16170899.04360-0.641905.804104.92680HepG2HNRNPLL
SPOPENSG00000121067.13712.03070898.92250-0.336303.905303.04980HepG2ILF2
SPOPENSG00000121067.13838.254101286.25180-0.617705.654204.76380HepG2NCBP2
SPOPENSG00000121067.131248.42410827.276000.5936010.046208.70780HepG2PRPF4
SPOPENSG00000121067.13846.031101285.71990-0.603808.307007.17160HepG2PUM2
SPOPENSG00000121067.131637.303501362.851800.264602.389501.80180HepG2QKI
SPOPENSG00000121067.13854.018701112.80070-0.381903.866902.87300HepG2RBM15
SPOPENSG00000121067.131768.653601372.203600.366104.774004.14010HepG2RBM22
SPOPENSG00000121067.131114.429001304.35660-0.227002.038401.49830HepG2RECQL
SPOPENSG00000121067.131161.30330844.048500.460202.408901.52690HepG2RPS10
SPOPENSG00000121067.13934.727401162.19920-0.314203.686602.89550HepG2SLBP
SPOPENSG00000121067.13578.35330913.93480-0.6601012.0899010.89190HepG2SMN1
SPOPENSG00000121067.131794.012701549.877000.210902.449901.96830HepG2SRFBP1
SPOPENSG00000121067.131568.023001367.503100.197301.846901.43840HepG2SRSF1
SPOPENSG00000121067.131801.595401345.701300.420807.487506.72380HepG2SSB
SPOPENSG00000121067.13974.436301229.18470-0.335103.432302.81840HepG2TAF15
SPOPENSG00000121067.13458.12380608.49500-0.409502.305901.38930HepG2TFIP11
SPOPENSG00000121067.13723.49330862.75850-0.254002.174601.66250HepG2TRIM56
SPOPENSG00000121067.131491.11040979.038800.606806.630505.67190HepG2U2AF1
SPOPENSG00000121067.131061.78780901.699700.235702.113301.48870HepG2UPF1
SPOPENSG00000121067.131106.98190870.553100.346503.995003.29470HepG2UTP3
SPOPENSG00000121067.13717.01220991.69470-0.467907.117406.34490HepG2ZNF622
SPOPENSG00000121067.131436.468101170.286100.295603.264002.65690K562AGGF1
SPOPENSG00000121067.13946.590901541.23130-0.7033010.385007.93990K562APOBEC3C
SPOPENSG00000121067.13897.831201246.14940-0.473004.474502.83460K562CIRBP
SPOPENSG00000121067.13769.15820956.57000-0.314602.907201.66290K562EIF2S1
SPOPENSG00000121067.13564.11990794.82190-0.494603.325301.74360K562GEMIN5
SPOPENSG00000121067.131437.718801014.761600.502503.190602.22950K562NAA15
SPOPENSG00000121067.13716.34490908.55460-0.342902.722701.50430K562NCBP2
SPOPENSG00000121067.13922.662801187.22060-0.363703.353202.62960K562PTBP1
SPOPENSG00000121067.131664.708701207.707100.462904.334203.67690K562PUS1
SPOPENSG00000121067.131598.636501176.683100.442005.761804.93240K562RBM15
SPOPENSG00000121067.13559.05110742.42520-0.409303.055402.00780K562RCC2
SPOPENSG00000121067.13723.878101094.20780-0.596108.647607.26310K562SF3A3
SPOPENSG00000121067.13626.61090820.93580-0.389702.874101.79610K562SRSF4
SPOPENSG00000121067.13560.03540747.10930-0.415802.318601.39280K562SUPV3L1
SPOPENSG00000121067.131024.34530826.798500.309002.403501.63850K562SYNCRIP
SPOPENSG00000121067.13692.452201177.90490-0.766409.453308.02960K562TARDBP
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPOP is not available on ENCORE database.





22 RBPs can affect the splicing of SPOP :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.159000.000000.00027includedHepG2G3BP1
SESPOPENSG00000121067.13chr17-477141204771417147700094477002384775529447755367-0.207000.000000.00045excludedK562PRPF8
SESPOPENSG00000121067.13chr17-477141204771417147700094477002384775529447755367-0.105000.000530.01896excludedK562AKAP8L
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.163000.000000.00006includedHepG2HNRNPK
SESPOPENSG00000121067.13chr17-477141204771417147700094477002384774538847745440-0.542000.000030.00139excludedHepG2HNRNPK
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.112000.000040.00489includedHepG2AKAP1
SESPOPENSG00000121067.13chr17-477141204771417147700094477002384774538847745440-0.480000.000110.01086excludedHepG2AKAP1
SESPOPENSG00000121067.13chr17-477532564775337847700094477002384775529447755461-0.078000.001830.02038excludedK562AQR
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.126000.000350.01707includedK562FXR1
SESPOPENSG00000121067.13chr17-4769798247698032476966694769674747699307476994290.120000.000020.01669includedHepG2FAM120A
SESPOPENSG00000121067.13chr17-4771412047714171477000944770023847755294477553670.191000.000010.00720includedHepG2BCLAF1
SESPOPENSG00000121067.13chr17-4769798247698032476966694769674747699307476994290.070000.000100.04990includedK562KHSRP
SESPOPENSG00000121067.13chr17-4769956747699645476993074769942947700094477002380.074000.000250.01717includedHepG2PTBP1
SESPOPENSG00000121067.13chr17-477141204771417147700094477002384775529447755367-0.197000.000090.00809excludedK562EFTUD2
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.252000.000000.00000includedHepG2MATR3
SESPOPENSG00000121067.13chr17-477141204771417147700094477002384774538847745440-0.461000.000310.01718excludedHepG2MATR3
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.123000.003410.06597includedHepG2SRSF1
SESPOPENSG00000121067.13chr17-4769956747699645476993074769942947700094477002380.083000.000770.07850includedHepG2SSB
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.155000.000020.00334includedHepG2IGF2BP3
SESPOPENSG00000121067.13chr17-477141204771417147700094477002384774538847745440-0.522000.001780.09668excludedHepG2IGF2BP3
SESPOPENSG00000121067.13chr17-4771412047714171477000944770023847755294477553670.176000.000060.00945includedHepG2SUPV3L1
SESPOPENSG00000121067.13chr17-477453884774544047700094477002384775529447755387-0.093000.000590.03175excludedHepG2PCBP1
SESPOPENSG00000121067.13chr17-4769798247698032476966694769674747699307476994290.060000.000810.03204includedK562TARDBP
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.286000.000450.02298includedHepG2HNRNPU
SESPOPENSG00000121067.13chr17-4775325647753378477000944770023847755294477554610.266000.000340.01625includedHepG2HNRNPC
SESPOPENSG00000121067.13chr17-4771412047714171477000944770023847755294477553670.292000.000050.02126includedHepG2FUS
SESPOPENSG00000121067.13chr17-4769956747699645476993074769942947700094477002380.083000.000290.04681includedHepG2KHSRP
SESPOPENSG00000121067.13chr17-4774538847745440477000944770023847755294477553870.157000.000010.00337includedHepG2KHSRP
SESPOPENSG00000121067.13chr17-4769586547695925476886414768881947696342476964700.065000.000610.02719includedK562PTBP1
SESPOPENSG00000121067.13chr17-4769798247698032476966694769674747699307476994290.072000.000090.00587includedK562PTBP1
SESPOPENSG00000121067.13chr17-4775325647753378477000944770023847755294477554610.373000.003810.05610includedK562HNRNPC
A3SSSPOPENSG00000121067.13chr17-4768523547685392476852354768529147688641476888190.110000.000210.00174longerK562AQR
A3SSSPOPENSG00000121067.13chr17-4767922647679445476792264767936947684611476847480.089000.000000.00000longerK562AQR
MXESPOPENSG00000121067.13chr17-47714120477141714774538847745440477000944770023847753256477533780.393000.001320.036131includedHepG2MATR3
MXESPOPENSG00000121067.13chr17-4774538847745440477532564775337847700094477002384775529447755472-0.460000.000010.000802includedHepG2MATR3
MXESPOPENSG00000121067.13chr17-47745388477454404775325647753378477000944770023847755294477554720.516000.002430.066641includedHepG2PCBP1
MXESPOPENSG00000121067.13chr17-47714120477141714774538847745440477000944770023847753256477533780.411000.000610.041581includedHepG2AKAP1
MXESPOPENSG00000121067.13chr17-47714120477141714774538847745440477000944770023847753256477533780.487000.000230.008361includedHepG2HNRNPK
MXESPOPENSG00000121067.13chr17-4774538847745440477532564775337847700094477002384775529447755472-0.506000.000010.000672includedHepG2HNRNPK

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPOP is not avaliable on ENCORE database.