METTL2B

General Information

Gene Name       : METTL2B
Gene ID             : ENSG00000165055.15
Essential Gene : No

Functions

Localization

Domains (AlphaFold: METTL2B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878METTL2BENSG00000165055.1532.6124.9228.77ENCSR000AEF
HepG2METTL2BENSG00000165055.1516.5724.4320.50ENCSR985KAT
K562METTL2BENSG00000165055.1546.3146.3546.33ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for METTL2B is not avaliable on ENCORE database.



Proteins bound to RNA
  • METTL2B RNA is bound by 11 proteins.  







eCLIP assay for METTL2B is not avaliable on ENCORE database.





11 proteins are bound to METTL2B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr7128143374128143424+3'-UTR4.786629.12746K562FAM120A
chr7128143705128143720+3'-UTR4.1880710.02205K562UPF1
chr7128128548128128604+3'-UTR,CDS,intron-Distal3.453137.08481K562KHSRP
chr7128143558128143612+3'-UTR3.120655.05540K562AKAP1
chr7128143006128143029+3'-UTR3.928867.04160K562FAM120A
chr7128142984128143025+3'-UTR3.556288.73107K562UPF1
chr7128142469128142552+3'-UTR,intron-Distal3.146587.17679K562UPF1
chr7128128188128128265+3'-UTR,CDS,intron-Proximal3.564388.60356K562PRPF8
chr7128143499128143506+3'-UTR3.4814418.08890K562UPF1
chr7128143182128143211+3'-UTR3.643926.25570K562UPF1
chr7128142595128142697+3'-UTR,CDS,intron-Proximal4.394966.86851K562FAM120A
chr7128143506128143549+3'-UTR3.5236822.08897K562UPF1
chr7128142992128143006+3'-UTR4.013834.66555K562FAM120A
chr7128143726128143751+3'-UTR3.391508.83660K562UPF1
chr7128144285128144347+3'-UTR4.878664.90799K562UPF1
chr7128143386128143412+3'-UTR3.842878.73107K562UPF1
chr7128138064128138178+3'-UTR,CDS,intron-Proximal3.341503.91614K562BUD13
chr7128143380128143386+3'-UTR3.593217.02949K562UPF1
chr7128119285128119369+5'-UTR,CDS3.638324.24220K562ZNF622
chr7128119320128119492+5'-UTR,CDS3.259113.85381HepG2BCLAF1
chr7128116873128116999+5'-UTR,CDS,intron-Distal,intron-Proximal3.904303.79347HepG2GRWD1
chr7128123069128123151+intron-Distal,intron-Proximal3.719107.12596K562QKI
chr7128126390128126459+intron-Distal5.4590914.57532HepG2XPO5
chr7128123032128123171+intron-Distal,intron-Proximal4.9231811.16135HepG2QKI
chr7128123003128123069+intron-Distal,intron-Proximal4.378317.06206K562QKI
chr7128128269128128330+intron-Distal,intron-Proximal3.458623.88924K562PRPF8
chr7128141023128141062+intron-Proximal3.953183.02181K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for METTL2B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for METTL2B is not available on ENCORE database.

  • 56 RBPs can affect the levels of METTL2B.  








The Knockdown/knockout RNA-Seq assay for METTL2B is not available on ENCORE database.





56 RBPs can affect the gene expression of METTL2B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
METTL2BENSG00000165055.11313.25150433.50110-0.468702.092001.30590HepG2BCLAF1
METTL2BENSG00000165055.11338.72910487.01620-0.523803.705502.83110HepG2CALR
METTL2BENSG00000165055.11392.79810484.37800-0.302302.043901.46010HepG2CKAP4
METTL2BENSG00000165055.11454.97210691.75180-0.604504.472603.69150HepG2DDX3X
METTL2BENSG00000165055.11364.83720571.24340-0.646904.717403.95470HepG2EIF2S1
METTL2BENSG00000165055.11338.23920614.70010-0.861805.955804.97410HepG2EIF4B
METTL2BENSG00000165055.11545.48410690.85390-0.340802.117801.39910HepG2EIF4G2
METTL2BENSG00000165055.11672.09990825.32960-0.296302.196701.65010HepG2ETF1
METTL2BENSG00000165055.11432.28850600.58240-0.474402.891202.20360HepG2IGF2BP2
METTL2BENSG00000165055.11326.63900442.86840-0.439203.540302.38610HepG2KIF1C
METTL2BENSG00000165055.11532.69920691.98910-0.377402.710702.11980HepG2PUF60
METTL2BENSG00000165055.11560.97170734.02770-0.387903.201202.47950HepG2PUM2
METTL2BENSG00000165055.11311.25270510.33840-0.713403.257102.49420HepG2RAVER1
METTL2BENSG00000165055.11570.99270718.44730-0.331402.700502.16430HepG2NELFE
METTL2BENSG00000165055.11490.72960663.44070-0.435004.667403.79290HepG2SLBP
METTL2BENSG00000165055.11572.25040683.19820-0.255701.950001.41320HepG2SRSF5
METTL2BENSG00000165055.11397.65090573.29430-0.527805.456404.52680HepG2UPF1
METTL2BENSG00000165055.11778.24680553.497800.491605.362204.57400HepG2UTP3
METTL2BENSG00000165055.11517.31250630.51830-0.285502.209301.70500HepG2ZNF622
METTL2BENSG00000165055.11851.119401364.84240-0.6813013.5313012.37870K562AGGF1
METTL2BENSG00000165055.111127.330701420.16160-0.333102.396701.78790K562AKAP8L
METTL2BENSG00000165055.111405.984501754.90260-0.319803.745302.16880K562BCCIP
METTL2BENSG00000165055.111434.604201695.86790-0.241402.729801.77510K562BCLAF1
METTL2BENSG00000165055.11783.691801065.29660-0.442903.383602.41850K562BOP1
METTL2BENSG00000165055.11791.430601132.71340-0.517205.529604.42860K562CPSF6
METTL2BENSG00000165055.11741.607601073.64920-0.533806.075404.46120K562DDX3X
METTL2BENSG00000165055.113295.772402320.128600.5063011.123209.91370K562DDX47
METTL2BENSG00000165055.11957.522201179.16580-0.300403.283401.95260K562EIF2S1
METTL2BENSG00000165055.111381.529902067.00250-0.5813011.7060010.37810K562EIF2S2
METTL2BENSG00000165055.111441.551201108.984800.378304.123903.16170K562EIF3G
METTL2BENSG00000165055.11809.669901010.04970-0.319002.964501.75650K562EIF4B
METTL2BENSG00000165055.11909.581901203.43250-0.403902.810901.67550K562FKBP4
METTL2BENSG00000165055.11880.104801152.51390-0.389002.931702.05060K562FMR1
METTL2BENSG00000165055.11756.61720976.86160-0.368602.308601.47740K562FTO
METTL2BENSG00000165055.111794.596901166.453500.6214012.0130010.84410K562FXR1
METTL2BENSG00000165055.111982.014702754.41490-0.474806.256605.11450K562GRSF1
METTL2BENSG00000165055.11863.107301364.47750-0.660705.991004.23710K562IGF2BP2
METTL2BENSG00000165055.111111.230201507.21220-0.439704.537103.44010K562KIF1C
METTL2BENSG00000165055.11675.00280923.43770-0.452102.554101.66100K562KRR1
METTL2BENSG00000165055.111886.780001434.248900.395504.182203.14380K562MAGOH
METTL2BENSG00000165055.111116.325401442.71960-0.370002.957301.83580K562MAK16
METTL2BENSG00000165055.11797.265401055.62690-0.405003.523602.52860K562METAP2
METTL2BENSG00000165055.111361.517001759.21010-0.369705.515504.39710K562MTPAP
METTL2BENSG00000165055.111583.537201954.60330-0.303705.325104.33870K562NSUN2
METTL2BENSG00000165055.11471.894301080.98740-1.195807.609605.68980K562PABPN1
METTL2BENSG00000165055.111407.773401869.75110-0.409403.205702.31050K562PCBP3
METTL2BENSG00000165055.111191.031001434.15740-0.268002.062101.37150K562POLR2G
METTL2BENSG00000165055.112214.399501393.445000.6682011.6937010.38480K562PTBP1
METTL2BENSG00000165055.112734.349003306.17660-0.274002.639701.70160K562PUM2
METTL2BENSG00000165055.11941.479501408.54500-0.581205.668904.92470K562PUS1
METTL2BENSG00000165055.11993.876001372.30360-0.465505.998105.15130K562RBM15
METTL2BENSG00000165055.11720.863401329.96000-0.883604.192102.19220K562RBM39
METTL2BENSG00000165055.11857.249801134.25990-0.404003.452902.34990K562RCC2
METTL2BENSG00000165055.111839.225701488.149300.305502.090901.38520K562RPS19
METTL2BENSG00000165055.111128.82360781.239400.530902.877101.85410K562RPS3
METTL2BENSG00000165055.11734.935201075.27540-0.549005.336403.77180K562SRFBP1
METTL2BENSG00000165055.111998.053001366.014100.548507.741806.56530K562SRSF1
METTL2BENSG00000165055.11944.532701143.92180-0.276302.522801.30330K562SSB
METTL2BENSG00000165055.111758.080201438.504800.289302.715101.90450K562SYNCRIP
METTL2BENSG00000165055.11907.719101196.06170-0.398002.742701.81060K562TIAL1
METTL2BENSG00000165055.111133.141501497.09580-0.401802.436401.48710K562UCHL5
METTL2BENSG00000165055.111553.401502072.51030-0.415907.568006.45260K562UPF1
METTL2BENSG00000165055.111262.108701773.37680-0.490705.840304.54510K562WDR3
METTL2BENSG00000165055.111930.873602645.28170-0.454205.335004.07160K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for METTL2B is not available on ENCORE database.





13 RBPs can affect the splicing of METTL2B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEMETTL2BENSG00000165055.11chr7+128140956128141022128138089128138196128141815128142180-0.062000.005410.04957excludedK562AQR
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.728000.000740.07102includedHepG2DROSHA
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.053000.007740.07358includedK562AGGF1
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.167000.000390.00740includedHepG2PCBP1
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.077000.000180.02532includedK562XRN2
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.105000.000000.00003includedK562AKAP8L
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.183000.000400.00562includedHepG2TAF15
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.166000.000440.00467includedHepG2SF3B4
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.195000.000010.01907includedHepG2IGF2BP1
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.218000.000110.00213includedHepG2HNRNPK
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.065000.003340.03321includedK562EFTUD2
RIMETTL2BENSG00000165055.11chr7+128116782128117227128116782128116929128117135128117227-0.555000.000800.05699excludedK562FXR2
RIMETTL2BENSG00000165055.11chr7+1281167821281172271281167821281169291281171351281172270.080000.000770.00530includedK562AQR
MXEMETTL2BENSG00000165055.11chr7+1281206831281207501281338571281339971281192111281195671281380891281381960.095000.000010.000151includedK562AQR
MXEMETTL2BENSG00000165055.11chr7+1281281541281282151281338571281339971281207001281207501281380891281381960.104000.002310.089701includedK562UTP18

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for METTL2B is not avaliable on ENCORE database.