CMTR1

General Information

Gene Name       : CMTR1
Gene ID             : ENSG00000137200.12
Essential Gene : Yes

Functions

Localization(RBPImage: CMTR1)

Domains (AlphaFold: CMTR1)


Antibody Validation

 View validation images for all CMTR1 antibodies

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CMTR1ENSG00000137200.1237.3339.1438.23ENCSR000AEF
HepG2CMTR1ENSG00000137200.1230.3435.5032.92ENCSR985KAT
K562CMTR1ENSG00000137200.1243.5641.6242.59ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq CMTR1-BGKcLV28-K562ENCSR697NDQCMTR1K562ReleasedENCSR220DTX   CRISPRKD% = 70.2,71.1
knockdown followed by RNA-seq CMTR1-BGHcLV29-HepG2ENCSR244OOVCMTR1HepG2ReleasedENCSR462MFN   CRISPRKD% = 76.9,75.9






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
CMTR1ENCAB701WNMA300-303A2Released, ENCODE4BGKcLV28-25, Released, ENCODE4
CMTR1ENCAB409TEBA300-304A1Released, ENCODE4BGKcLV28-25, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
CMTR1K562CRISPRENCSR697NDQENCSR220DTXCMTR1-BGKcLV28-25,CMTR1-BGKcLV28-26NT-BGKcLV28-1,NT-BGKcLV28-270.2,71.1ReleasedENCODE4
CMTR1HepG2CRISPRENCSR244OOVENCSR462MFNCMTR1-BGHcLV29-25,CMTR1-BGHcLV29-26NT-BGHcLV29-1,NT-BGHcLV29-276.9,75.9ReleasedENCODE4


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  
    CMTR1: Click to RBP Image Database
  • Nuclei
  • Nucleoplasm
  • Mutually Exclusive from Nucleolus
  • Speckles
  • Cytoplasm
  • Cytosolic
  • Nuclear release mitosis












    • RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
    CMTR1Product_ID: A300-303A
    Lot_ID: 2
    Source: Bethyl Labs
    Target Name: CMTR1-human    		 Bethyl_A300-303A_2_CMTR1.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the CMTR1 specific antibody, A300-303A. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the CMTR1-specific antibody, A300-303A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
    		 CMTR1-K562-CRISPR-A300-303A.png<br>Caption: Western blot following CRISPR against CMTR1 in K562 whole cell lysate using CMTR1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against CMTR1. CMTR1 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
    CMTR1Product_ID: A300-304A
    Lot_ID: 1
    Source: Bethyl Labs
    Target Name: CMTR1-human    		 Bethyl_A300-304A_1_CMTR1.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the CMTR1 specific antibody, A300-304A. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the CMTR1-specific antibody, A300-304A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
    		 CMTR1-K562-CRISPR-A300-304A.png<br>Caption: Western blot following CRISPR against CMTR1 in K562 whole cell lysate using CMTR1 specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against CMTR1. CMTR1 protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








    RNA Targets

    • eCLIP assay for CMTR1 is not avaliable on ENCORE database.



    Proteins bound to RNA
    • CMTR1 RNA is bound by 24 proteins.  







    eCLIP assay for CMTR1 is not avaliable on ENCORE database.





    24 proteins are bound to CMTR1 RNA:

    Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
    chr63744692437446973+3'-UTR,CDS3.420054.41784HepG2GRWD1
    chr63744833437448395+3'-UTR,intron-Distal4.5948710.03265HepG2AKAP1
    chr63744909237449140+3'-UTR,intron-Distal5.7063411.97438K562UPF1
    chr63744846037448556+3'-UTR,intron-Distal3.9654610.47028HepG2UPF1
    chr63744858237448635+3'-UTR,intron-Distal4.465105.04923HepG2AKAP1
    chr63744866337448742+3'-UTR,intron-Distal4.1069218.81113K562UPF1
    chr63744626537446297+3'-UTR,CDS3.904303.79347HepG2GRWD1
    chr63744846337448539+3'-UTR,intron-Distal4.1510924.24974K562UPF1
    chr63744866837448783+3'-UTR,intron-Distal4.9931312.76496HepG2UPF1
    chr63744901437449096+3'-UTR,intron-Distal5.5153211.96310HepG2AKAP1
    chr63744857237448632+3'-UTR,intron-Distal5.3631718.66766K562UPF1
    chr63744813937448201+3'-UTR,intron-Distal5.060017.98718HepG2UPF1
    chr63744874337448809+3'-UTR,intron-Distal4.456097.76684K562FAM120A
    chr63744830737448328+3'-UTR,intron-Distal3.460414.96603K562UPF1
    chr63744900037449076+3'-UTR,intron-Distal3.038203.84285K562DDX55
    chr63744904237449134+3'-UTR,intron-Distal4.4498112.90774HepG2UPF1
    chr63744619437446234+3'-UTR,CDS3.124043.39306HepG2GRWD1
    chr63744900737449079+3'-UTR,intron-Distal5.0025314.07914K562PABPC4
    chr63744901537449081+3'-UTR,intron-Distal4.534994.60160HepG2LARP4
    chr63744843637448463+3'-UTR,intron-Distal4.9291513.72135K562UPF1
    chr63744798837448077+3'-UTR,intron-Distal4.058316.42285HepG2AKAP1
    chr63744874237448806+3'-UTR,intron-Distal4.6706112.42207K562UPF1
    chr63744830837448398+3'-UTR,intron-Distal4.6037411.31667HepG2UPF1
    chr63744871437448762+3'-UTR,intron-Distal3.475904.40370K562AKAP1
    chr63744537037445396+3'-UTR,CDS3.378114.74755K562ZNF622
    chr63744901537449042+3'-UTR,intron-Distal3.984015.36498HepG2UPF1
    chr63744900537449073+3'-UTR,intron-Distal4.065538.05385K562DDX6
    chr63744834137448407+3'-UTR,intron-Distal4.3408821.91183K562UPF1
    chr63744802737448103+3'-UTR,intron-Distal5.9533115.15904HepG2UPF1
    chr63744873337448816+3'-UTR,intron-Distal3.593856.14481HepG2AKAP1
    chr63744914137449191+3'-UTR,intron-Distal4.636016.45671HepG2UPF1
    chr63744534237445384+3'-UTR,CDS,intron-Proximal4.118605.47926K562AQR
    chr63744900637449092+3'-UTR,intron-Distal4.7229232.67524K562UPF1
    chr63744845737448569+3'-UTR,intron-Distal4.4763210.90209HepG2AKAP1
    chr63744618537446227+3'-UTR,CDS3.306143.70975K562UCHL5
    chr63744866437448733+3'-UTR,intron-Distal3.952556.88718HepG2AKAP1
    chr63744886937448973+3'-UTR,intron-Distal4.8942720.03105K562UPF1
    chr63744396937443988+5'-UTR,CDS,intron-Proximal3.442344.98672K562AQR
    chr63744384837443913+5'-UTR,CDS,intron-Proximal3.5325118.12075K562SF3B4
    chr63744392337443967+5'-UTR,CDS4.008885.24452HepG2PPIG
    chr63740351137403531+CDS3.954746.22817K562DDX24
    chr63744778837447828+CDS,intron-Distal,intron-Proximal3.153734.02291HepG2GRWD1
    chr63742645737426522+CDS3.780965.97760HepG2G3BP1
    chr63742082937420882+CDS,intron-Distal3.118256.45823K562ZNF622
    chr63744309637443141+CDS,intron-Proximal3.705876.98305HepG2PPIG
    chr63742655137426585+CDS3.980303.80193HepG2GRWD1
    chr63741958937419654+CDS,intron-Proximal5.7286511.60475K562DDX24
    chr63742101637421051+CDS,intron-Distal5.0063511.37040K562DDX24
    chr63742082237420918+CDS,intron-Distal,intron-Proximal4.6480625.84028K562DDX24
    chr63744321937443269+CDS,intron-Proximal4.7189311.02544K562DDX24
    chr63742082737420913+CDS,intron-Distal4.1504015.36400K562UCHL5
    chr63742743937427446+CDS3.970443.20743HepG2PPIG
    chr63743067537430745+CDS4.377675.43239K562YBX3
    chr63740343737403508+CDS4.700326.29942HepG2G3BP1
    chr63744233337442387+CDS3.591529.21245K562DDX24
    chr63742654437426581+CDS4.849945.86613HepG2PPIG
    chr63744322137443266+CDS,intron-Proximal3.292205.30095HepG2PPIG
    chr63741418437414229+CDS,intron-Proximal3.508145.76104HepG2BCLAF1
    chr63741797637418056+CDS,intron-Proximal4.249155.63851K562SF3B4
    chr63742736237427438+CDS7.6946566.27946K562LIN28B
    chr63744321237443266+CDS,intron-Proximal4.054894.13881HepG2PRPF4
    chr63744024437440259+CDS4.217413.49905HepG2PPIG
    chr63741961237419649+CDS3.126903.24162HepG2G3BP1
    chr63742734037427362+CDS,intron-Proximal5.3569111.96654K562LIN28B
    chr63744129237441367+CDS4.765185.71225HepG2G3BP1
    chr63742082437420858+CDS,intron-Distal3.016953.80468K562BUD13
    chr63741413837414227+CDS,intron-Proximal4.8301211.08513HepG2PPIG
    chr63744133337441380+CDS,intron-Proximal3.684336.98305HepG2PPIG
    chr63742101537421086+CDS,intron-Distal,intron-Proximal4.037598.94445HepG2BCLAF1
    chr63742733937427415+CDS,intron-Proximal5.0688824.04460HepG2LIN28B
    chr63742106937421173+CDS,intron-Distal,intron-Proximal3.077144.34900K562PRPF8
    chr63742932537429365+CDS5.139489.83658K562DDX24
    chr63744317837443262+CDS,intron-Proximal4.5162710.27119HepG2PRPF8
    chr63742742937427455+CDS6.192698.32974K562DDX24
    chr63744239437442422+CDS3.912705.52342HepG2PPIG
    chr63742105137421083+CDS,intron-Distal4.622015.79396K562DDX24
    chr63740347237403508+CDS4.098036.95786K562UCHL5
    chr63744135537441364+CDS3.780774.66686K562DDX24
    chr63744127537441297+CDS3.946774.14015K562DDX24
    chr63742932537429366+CDS3.517716.13978HepG2PPIG
    chr63741412637414227+CDS,intron-Proximal4.045437.06750K562FMR1
    chr63744375137443789+intron-Distal,intron-Proximal3.693014.49347K562UCHL5
    chr63743530337435374+intron-Distal4.632215.62258K562KHSRP
    chr63744191437441988+intron-Distal4.457737.96448K562PTBP1
    chr63743315637433231+intron-Distal3.166843.46531K562KHSRP
    chr63741162137411738+intron-Distal,intron-Proximal3.878683.42844K562KHSRP
    chr63744190937441994+intron-Distal4.425555.04769HepG2PTBP1
    chr63744378537443819+intron-Distal,intron-Proximal4.198027.40437K562DDX24
    chr63744138037441420+intron-Proximal4.929354.65563K562AQR
    chr63744398837444015+intron-Proximal5.103316.75320K562AQR
    chr63744382137443901+intron-Proximal4.357988.45091HepG2SF3B4
    chr63742660137426644+intron-Proximal4.721835.17615K562AQR
    ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




    eCLIP assay for CMTR1 is not avaliable on ENCORE database.



    Diffrential Expression

    • The Knockdown/knockout assay for CMTR1 is not available on ENCORE database.

    • 51 RBPs can affect the levels of CMTR1.  








    The Knockdown/knockout RNA-Seq assay for CMTR1 is not available on ENCORE database.





    51 RBPs can affect the gene expression of CMTR1 :

    Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
    CMTR1ENSG00000137200.8942.555902007.20730-1.0905018.4506016.64270HepG2ASCC1
    CMTR1ENSG00000137200.8925.625201133.39840-0.292202.176701.48760HepG2CALR
    CMTR1ENSG00000137200.81433.239901640.86640-0.195202.149901.55280HepG2CKAP4
    CMTR1ENSG00000137200.81635.952701178.278500.473402.470601.75240HepG2CNOT7
    CMTR1ENSG00000137200.8608.52630947.13470-0.638206.182605.18590HepG2CPSF6
    CMTR1ENSG00000137200.8965.096401268.45180-0.394304.604703.29260HepG2YBX3
    CMTR1ENSG00000137200.81440.878201973.56510-0.453907.189206.24490HepG2CELF1
    CMTR1ENSG00000137200.81763.054901517.977100.215802.573701.76680HepG2DDX19B
    CMTR1ENSG00000137200.8880.657901354.20320-0.620804.960403.47150HepG2AGO1
    CMTR1ENSG00000137200.81477.871301919.03760-0.376902.784802.18960HepG2EIF2S1
    CMTR1ENSG00000137200.81008.010602064.75210-1.0345011.6495010.28570HepG2EIF4B
    CMTR1ENSG00000137200.82126.383802861.09220-0.428208.491407.53810HepG2ETF1
    CMTR1ENSG00000137200.81131.851601398.70450-0.305402.249501.61780HepG2HNRNPC
    CMTR1ENSG00000137200.81559.566201932.81470-0.309604.864003.98870HepG2HNRNPL
    CMTR1ENSG00000137200.8803.890401024.53370-0.349902.279001.70190HepG2HNRNPLL
    CMTR1ENSG00000137200.8747.815901389.45800-0.8938023.8930022.24880HepG2HNRNPU
    CMTR1ENSG00000137200.81166.141101419.28750-0.283402.893602.14540HepG2ILF2
    CMTR1ENSG00000137200.81620.587802152.30910-0.409402.928802.28230HepG2MATR3
    CMTR1ENSG00000137200.81062.774701344.94580-0.339702.738101.32890HepG2NIP7
    CMTR1ENSG00000137200.81157.571801375.34110-0.248702.466701.66270HepG2PARN
    CMTR1ENSG00000137200.8961.702101389.45510-0.530908.876907.60330HepG2PRPF4
    CMTR1ENSG00000137200.81332.025802008.56360-0.592508.068507.12240HepG2PUF60
    CMTR1ENSG00000137200.81733.070402132.23920-0.299004.868604.12730HepG2PUM1
    CMTR1ENSG00000137200.81357.420902130.64430-0.6504011.4595010.14450HepG2PUM2
    CMTR1ENSG00000137200.8868.851601432.28060-0.721104.260203.39450HepG2RAVER1
    CMTR1ENSG00000137200.81619.474701920.26850-0.245801.996301.41670HepG2RBM25
    CMTR1ENSG00000137200.81443.090901793.68640-0.313802.418601.49820HepG2RBM27
    CMTR1ENSG00000137200.81751.854302024.90410-0.209002.288801.72200HepG2RECQL
    CMTR1ENSG00000137200.81252.923501688.63720-0.430604.096202.77580HepG2RPS5
    CMTR1ENSG00000137200.81707.358802034.02660-0.252603.136702.51240HepG2SF3B4
    CMTR1ENSG00000137200.81523.376901926.02320-0.338405.467504.53810HepG2SLBP
    CMTR1ENSG00000137200.81261.344801443.00780-0.194102.059101.49190HepG2SMN1
    CMTR1ENSG00000137200.81721.588901983.23620-0.204101.933601.39850HepG2SRSF5
    CMTR1ENSG00000137200.81299.533701727.18520-0.410407.063206.25490HepG2SRSF9
    CMTR1ENSG00000137200.8859.479001440.64270-0.745208.052606.99510HepG2SUPV3L1
    CMTR1ENSG00000137200.81644.859501908.18680-0.214202.092401.59220HepG2TAF15
    CMTR1ENSG00000137200.81136.195101350.16460-0.248901.956101.52030HepG2TIAL1
    CMTR1ENSG00000137200.81103.611601362.18420-0.303703.597802.97290HepG2TRIM56
    CMTR1ENSG00000137200.8818.950501264.19440-0.626406.681005.71650HepG2U2AF1
    CMTR1ENSG00000137200.81083.932401371.22320-0.339204.737903.89770HepG2ZC3H8
    CMTR1ENSG00000137200.83359.868002972.169300.176802.006301.50800K562AGGF1
    CMTR1ENSG00000137200.82563.495903854.71070-0.588508.628007.68510K562AQR
    CMTR1ENSG00000137200.81690.288302129.91460-0.333502.660801.76770K562EFTUD2
    CMTR1ENSG00000137200.82162.911202578.57260-0.253602.983502.24120K562EIF2S2
    CMTR1ENSG00000137200.81996.531202314.00190-0.212902.181001.63250K562FXR1
    CMTR1ENSG00000137200.81363.034402046.58080-0.586404.689603.71450K562G3BP2
    CMTR1ENSG00000137200.82489.552403254.06360-0.386405.932104.61500K562HNRNPU
    CMTR1ENSG00000137200.81647.575102295.02990-0.478204.911403.59700K562PCBP2
    CMTR1ENSG00000137200.81461.396102072.65280-0.504105.217404.18760K562PRPF8
    CMTR1ENSG00000137200.83548.279904658.88190-0.392904.544503.50280K562PUF60
    CMTR1ENSG00000137200.84224.497204855.33530-0.200802.589301.65910K562PUM2
    CMTR1ENSG00000137200.83934.080003067.213400.359003.421402.82680K562PUS1
    CMTR1ENSG00000137200.81529.573102006.73880-0.391702.877901.84120K562SUPV3L1
    CMTR1ENSG00000137200.81345.591101983.57080-0.559905.184703.59140K562U2AF1
    CMTR1ENSG00000137200.81395.995802048.67250-0.553408.668507.23170K562U2AF2
    CMTR1ENSG00000137200.82223.451802619.97970-0.236803.231202.45780K562UPF1
    Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".






    The Knockdown/knockout RNA-Seq assay for CMTR1 is not available on ENCORE database.





    6 RBPs can affect the splicing of CMTR1 :

    Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
    SECMTR1ENSG00000137200.8chr6+374297453742987837429324374294213743060437430784-0.082000.002550.06401excludedK562AKAP8L
    SECMTR1ENSG00000137200.8chr6+374439013744397037443094374431883744536737445415-0.105000.000250.00623excludedK562U2AF2
    SECMTR1ENSG00000137200.8chr6+374297453742987837429324374294213743060437430784-0.166000.000070.00206excludedK562U2AF2
    A3SSCMTR1ENSG00000137200.8chr6+3744122037441377374412453744137737440194374402630.059000.000120.00669longerK562U2AF2
    A3SSCMTR1ENSG00000137200.8chr6+3744533137445415374453673744541537443845374439700.077000.000010.00013longerK562AQR
    A3SSCMTR1ENSG00000137200.8chr6+3741800837418119374180263741811937414066374142250.078000.000000.00000longerK562AQR
    A3SSCMTR1ENSG00000137200.8chr6+3744122037441377374412453744137737440155374402630.059000.000000.00002longerK562AQR
    A5SSCMTR1ENSG00000137200.8chr6+3744309637443692374430963744318837443901374439700.126000.000830.08926longerK562RBM22
    A5SSCMTR1ENSG00000137200.8chr6+3744309437443207374430943744318837443901374439700.056000.001650.05823longerK562PUS1
    A5SSCMTR1ENSG00000137200.8chr6+3744618437446403374461843744629737446922374470310.052000.000000.00000longerK562AQR
    A5SSCMTR1ENSG00000137200.8chr6+3744618437446403374461843744629737446922374470310.066000.000010.00192longerK562PRPF8

    *: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
    **: "-log(0)" was displayed as "99999.99999".





    The Knockdown/knockout RNA-Seq assay for CMTR1 is not avaliable on ENCORE database.