TIAL1

General Information

Gene Name : TIAL1
Gene ID : ENSG00000151923.17
Essential Gene : No

Functions

Splicing regulation
Translation regulation
Viral RNA regulation

Localization(RBPImage: TIAL1)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Variable Nuclear Intensity
Cytoplasm
Cytosolic
Nuclear release mitosis

Domains (AlphaFold: TIAL1)

RRM

Antibody Validation

View validation images for all TIAL1 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	TIAL1	ENSG00000151923.17	103.07	90.45	96.76	ENCSR000AEF
HepG2	TIAL1	ENSG00000151923.17	63.25	94.93	79.09	ENCSR985KAT
K562	TIAL1	ENSG00000151923.17	72.77	75.06	73.91	ENCSR000AEO

Assays

5 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 753	ENCSR322HHA	TIAL1	HepG2	Released	ENCAB050ZSG	ENCSR599YGK
eCLIP	eCLIP: 4221	ENCSR539DEW	TIAL1	K562	Released	ENCAB050ZSG	ENCSR932CJI
knockdown followed by RNA-seq	TIAL1-BGKLV21-K562	ENCSR927TSP	TIAL1	K562	Released		ENCSR572FFX	shRNA	KD% = 59.4,63.2
knockdown followed by RNA-seq	TIAL1-BGHLV20-HepG2	ENCSR450VQO	TIAL1	HepG2	Released		ENCSR305XWT	shRNA	KD% = 87.4,85.3
knockdown followed by RNA-seq	TIAL1-BG293LV06-WT293		TIAL1	293T	Released			shRNA	KD% = ,

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
TIAL1	753	HepG2	ENCSR322HHA	ENCSR599YGK	ENCAB050ZSG	RN059PW	1	Released	ENCODE4
TIAL1	4221	K562	ENCSR539DEW	ENCSR932CJI	ENCAB050ZSG	RN059PW	001	Released	ENCODE4

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
TIAL1	ENCAB050ZSG	RN059PW	1	Released, ENCODE3		BGHLV20-59, Released, ENCODE3	BGKLV21-61, Released, ENCODE3
TIAL1		8509S	2	Released, ENCODE3	Submitted, ENCORE2	BGHLV20-59, Released, ENCODE3	BGKLV21-61, Submitted, ENCORE2
TIAL1		8611S	1	Released, ENCODE3	Submitted, ENCORE2	BGHLV20-59, Released, ENCODE3	BGKLV21-61, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
TIAL1	K562	shRNA	ENCSR927TSP	ENCSR572FFX	TIAL1_BGKLV21_61_17588,TIAL1_BGKLV21_62_17589	non-target_BGKLV21_1,non-target_BGKLV21_2	59.4,63.2	Released	ENCODE3
TIAL1	HepG2	shRNA	ENCSR450VQO	ENCSR305XWT	TIAL1-BGHLV20-59_17738,TIAL1-BGHLV20-60_17739	non-target-BGHLV20-1_17706,non-target-BGHLV20-2_17707	87.4,85.3	Released	ENCODE3
TIAL1	293T	shRNA			BG293LV01-67,BG293LV01-68	BG293LV01-1,BG293LV01-2		NotSatisfied	ENCORE2
TIAL1	293T	shRNA			TIAL1-BG293LV02-49,TIAL1-BG293LV02-50	NT-BG293LV02-1,NT-BG293LV02-2	,	Revoked	ENCORE2
TIAL1	293T	shRNA			TIAL1-BG293LV06-111B,TIAL1-BG293LV06-112B	NT-BG293LV06-1B,NT-BG293LV06-2B	,	Released	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

TIAL1: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Variable Nuclear Intensity

Cytoplasm

Cytosolic

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
TIAL1	Product_ID: RN059PW Lot_ID: 1 Source: MBLI Target Name: TIAL1-human
TIAL1	Product_ID: 8509S Lot_ID: 2 Source: Cell Signaling Technology Target Name: TIAL1-human
TIAL1	Product_ID: 8611S Lot_ID: 1 Source: Cell Signaling Technology Target Name: TIAL1-human

RNA Targets

TIAL1 protein binds to 2,361 RNA regions.

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Proteins bound to RNA

TIAL1 RNA is bound by 41 proteins.

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TIAL1 protein has 2,361 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
TIAL1	chr8	101734073	101734137	-	4.33627	400.00000	HepG2	PABPC1	3'-UTR,5'-UTR,intron-Distal,intron-Proximal
TIAL1	chr20	61569021	61569137	-	5.94795	35.57994	HepG2	DIDO1	intron-Distal
TIAL1	chr5	42800432	42800449	-	5.01268	25.78882	HepG2	SEPP1	3'-UTR,intron-Distal
TIAL1	chr7	45932923	45932941	+	4.13605	24.18934	HepG2	IGFBP1	3'-UTR
TIAL1	chr17	74731085	74731132	-	5.58803	23.88766	HepG2	SRSF2	3'-UTR,intron-Distal,intron-Proximal
TIAL1	chr5	43296791	43296805	-	5.91243	21.51947	HepG2	HMGCS1	intron-Distal
TIAL1	chr19	1258907	1258984	+	3.64483	21.01962	HepG2	MIDN	3'-UTR
TIAL1	chr4	155511710	155511764	-	6.26617	19.10620	HepG2	FGA	intron-Distal
TIAL1	chr17	48828755	48828790	+	5.02736	18.43748	HepG2	LUC7L3	3'-UTR,intron-Distal,intron-Proximal
TIAL1	chr21	44269177	44269277	-	6.35972	17.91424	HepG2	WDR4	intron-Distal,intron-Proximal

Showing 1 to 10 of 100 entries

41 proteins are bound to TIAL1 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr10	121336570	121336665	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.46472	75.66659	HepG2	BCLAF1
chr10	121336665	121336695	-	3'-UTR,CDS,intron-Distal	4.85951	59.49295	HepG2	BCLAF1
chr10	121338284	121338341	-	3'-UTR,CDS,intron-Distal	4.36330	58.88071	HepG2	BCLAF1
chr10	121355944	121356032	-	5'-UTR,CDS,intron-Distal,intron-Proximal	5.40273	53.35609	HepG2	PCBP2
chr10	121336695	121336715	-	3'-UTR,CDS,intron-Distal	5.43844	49.74461	HepG2	BCLAF1
chr10	121336962	121336996	-	3'-UTR,CDS,intron-Distal,intron-Proximal	5.04402	48.44801	HepG2	BCLAF1
chr10	121336383	121336431	-	intron-Distal,intron-Proximal	5.46713	47.30736	K562	SF3B4
chr10	121337155	121337195	-	3'-UTR,CDS,intron-Distal	4.52505	46.49938	HepG2	BCLAF1
chr10	121336206	121336257	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.38059	43.26307	HepG2	U2AF2
chr10	121336139	121336206	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.22739	40.63697	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 197 entries

The TIAL1 protein binds to its own RNA.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
TIAL1	chr10	121336567	121336618	-	3.54722	10.02976	HepG2	TIAL1	3'-UTR,CDS,intron-Distal,intron-Proximal
TIAL1	chr10	121336270	121336344	-	3.07269	6.54694	HepG2	TIAL1	intron-Distal,intron-Proximal
TIAL1	chr10	121340138	121340207	-	3.62855	5.99889	HepG2	TIAL1	3'-UTR,intron-Distal,intron-Proximal
TIAL1	chr10	121340389	121340461	-	3.49088	4.21828	HepG2	TIAL1	intron-Distal,intron-Proximal

Showing 1 to 4 of 4 entries

Diffrential Expression

12,850 differentially expressed genes after Knockdown/Knockout TIAL1 protein.

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83 RBPs can affect the levels of TIAL1.

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12,850 differentially expressed genes after Knockdown/Knockout TIAL1 protein :

Only display 100 entries as example. Please click "View All" button to see all 12,850 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SLC7A2	ENSG00000003989.12	1037.52890	4951.12080	-2.25460	142.44030	139.87540	HepG2	TIAL1
CX3CL1	ENSG00000006210.6	5002.41750	1325.68640	1.91580	107.61740	105.38570	HepG2	TIAL1
JHDM1D	ENSG00000006459.6	601.47660	1966.72850	-1.70920	64.46270	62.65540	HepG2	TIAL1
CRLF1	ENSG00000006016.6	1109.84330	3009.00960	-1.43890	57.05120	55.32850	HepG2	TIAL1
LAMP2	ENSG00000005893.11	1545.03800	3988.21890	-1.36810	56.01350	54.30590	HepG2	TIAL1
TFPI	ENSG00000003436.10	3299.56900	7485.72940	-1.18190	48.14730	46.53810	HepG2	TIAL1
AP2B1	ENSG00000006125.12	1871.73560	4339.60300	-1.21320	46.07960	44.49900	HepG2	TIAL1
CROT	ENSG00000005469.7	662.89470	177.38690	1.90180	40.32410	38.82420	HepG2	TIAL1
FUCA2	ENSG00000001036.9	1560.78840	3452.53030	-1.14540	39.30820	37.82640	HepG2	TIAL1
KIAA0100	ENSG00000007202.10	1568.23420	3442.12640	-1.13420	38.09840	36.63700	HepG2	TIAL1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

83 RBPs can affect the gene expression of TIAL1 :

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TIAL1	ENSG00000151923.13	623.08350	1836.35560	-1.55930	53.41780	51.74920	HepG2	TIAL1
TIAL1	ENSG00000151923.13	1504.85130	3059.67210	-1.02380	25.34990	23.78900	HepG2	PUF60
TIAL1	ENSG00000151923.13	1139.78480	1889.90770	-0.72960	19.68540	18.18300	HepG2	HNRNPU
TIAL1	ENSG00000151923.13	554.40740	1286.57890	-1.21450	18.63950	16.81140	HepG2	PRPF8
TIAL1	ENSG00000151923.13	2373.06460	3435.66500	-0.53380	17.21410	15.87470	HepG2	SUCLG1
TIAL1	ENSG00000151923.13	2569.28730	1439.41450	0.83580	16.33590	14.50520	HepG2	FUBP3
TIAL1	ENSG00000151923.13	1572.40020	2316.48830	-0.55900	14.47460	13.25900	HepG2	PUS1
TIAL1	ENSG00000151923.13	5366.06410	3098.05900	0.79240	14.34710	13.15270	K562	PUS1
TIAL1	ENSG00000151923.13	687.81910	1409.07700	-1.03460	15.17730	12.87170	K562	TIAL1
TIAL1	ENSG00000151923.13	4482.33060	3018.78520	0.57020	13.25410	11.95240	K562	RBM15
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 93 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

1,175 alternative splicing events after Knockdown/Knockout TIAL1 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	DHX9	ENSG00000135829.12	chr1	+	182824711	182824848	182823175	182823313	182825666	182825707	0.09800	0.00017	included	HepG2	TIAL1
SE	ALDOA	ENSG00000149925.12	chr16	+	30077196	30077248	30075744	30075826	30078554	30078687	0.08600	0.00020	included	HepG2	TIAL1
SE	CIZ1	ENSG00000148337.15	chr9	-	130950141	130950213	130947825	130948055	130952607	130952723	0.28900	0.00006	included	HepG2	TIAL1
SE	SREK1	ENSG00000153914.11	chr5	+	65451892	65454760	65449290	65449424	65455046	65455162	0.53100	0.00000	included	HepG2	TIAL1
SE	ZNF207	ENSG00000010244.12	chr17	+	30693683	30693776	30692348	30692506	30694790	30695033	0.14600	0.00017	included	HepG2	TIAL1
SE	SEC31A	ENSG00000138674.12	chr4	-	83783686	83783725	83782783	83782861	83784470	83784545	0.19300	0.00000	included	HepG2	TIAL1
SE	CARHSP1	ENSG00000153048.6	chr16	-	8953961	8954075	8952769	8953192	8962822	8962863	0.06100	0.00049	included	HepG2	TIAL1
SE	SF3B1	ENSG00000115524.11	chr2	-	198283619	198283675	198283232	198283312	198285151	198285266	0.10700	0.00000	included	HepG2	TIAL1
SE	DDC	ENSG00000132437.13	chr7	-	50607612	50607726	50605557	50605677	50611582	50611817	0.45600	0.00049	included	HepG2	TIAL1
SE	LMO7	ENSG00000136153.15	chr13	+	76383289	76383319	76378424	76378677	76391296	76391414	0.29400	0.00000	included	HepG2	TIAL1

Showing 1 to 10 of 100 entries

74 RBPs can affect the splicing of TIAL1 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	TIAL1	ENSG00000151923.13	chr10	-	121336358	121336417	121336122	121336262	121336591	121336726	0.19300	0.00016	included	HepG2	G3BP1
SE	TIAL1	ENSG00000151923.13	chr10	-	121339982	121340358	121339446	121339522	121341433	121341521	0.37000	0.00000	included	HepG2	G3BP1
SE	TIAL1	ENSG00000151923.13	chr10	-	121339982	121340358	121339446	121339522	121341433	121341521	0.29900	0.01555	included	K562	RPS3
SE	TIAL1	ENSG00000151923.13	chr10	-	121336358	121336417	121336122	121336262	121336591	121336726	0.14900	0.00000	included	K562	FTO
SE	TIAL1	ENSG00000151923.13	chr10	-	121341970	121342069	121341680	121341735	121347663	121347760	-0.08900	0.00001	excluded	K562	SF3B4
SE	TIAL1	ENSG00000151923.13	chr10	-	121336358	121336417	121336122	121336262	121336591	121336726	-0.16500	0.00000	excluded	HepG2	RBM22
SE	TIAL1	ENSG00000151923.13	chr10	-	121336358	121336417	121336122	121336262	121336591	121336726	0.22200	0.00000	included	HepG2	U2AF1
SE	TIAL1	ENSG00000151923.13	chr10	-	121336358	121336417	121336122	121336262	121336591	121336726	0.17300	0.00000	included	K562	FMR1
SE	TIAL1	ENSG00000151923.13	chr10	-	121336358	121336417	121336122	121336262	121336591	121336726	0.37200	0.00000	included	HepG2	HNRNPK
SE	TIAL1	ENSG00000151923.13	chr10	-	121339982	121340358	121339446	121339522	121341433	121341521	0.24700	0.00000	included	HepG2	HNRNPK

Showing 1 to 10 of 186 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

TIAL1

General Information

Functions

Localization(RBPImage: TIAL1)

Domains (AlphaFold: TIAL1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

TIAL1 protein has 2,361 RNA targets:

41 proteins are bound to TIAL1 RNA:

The TIAL1 protein binds to its own RNA.

Diffrential Expression

12,850 differentially expressed genes after Knockdown/Knockout TIAL1 protein :

83 RBPs can affect the gene expression of TIAL1 :

1,175 alternative splicing events after Knockdown/Knockout TIAL1 protein :

74 RBPs can affect the splicing of TIAL1 :

No autoregularoty alternative splicing events between protein TIAL1 and its RNA.