EIF2S2

General Information

Gene Name : EIF2S2
Gene ID : ENSG00000125977.6
Essential Gene : Yes

Functions

Ribosome & basic translation

Localization(RBPImage: EIF2S2)

Nuclei
Nucleoplasm
Cytoplasm
Compartment/Organelle
ER
Mitotic-Apparatus (Spindle; Centrosomes)

Domains (AlphaFold: EIF2S2)

ZNF

Antibody Validation

GeneTex: GTX106484

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	EIF2S2	ENSG00000125977.6	101.82	103.87	102.84	ENCSR000AEF
HepG2	EIF2S2	ENSG00000125977.6	117.86	167.81	142.84	ENCSR985KAT
K562	EIF2S2	ENSG00000125977.6	151.67	148.15	149.91	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	EIF2S2-BGKLV29-K562	ENCSR076PMZ	EIF2S2	K562	Released		ENCSR118EFE	shRNA	KD% = 80.6,81.0
knockdown followed by RNA-seq	EIF2S2-BGHLV30-HepG2	ENCSR110HAA	EIF2S2	HepG2	Released		ENCSR067GHD	shRNA	KD% = 66.0,59.4

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
EIF2S2	ENCAB485WQI	GTX106484	40135		Released, ENCODE3	Released, ENCODE3	BGHLV30-31, Released, ENCODE3	BGKLV29-27, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
EIF2S2	K562	shRNA	ENCSR076PMZ	ENCSR118EFE	EIF2S2_BGKLV29-27B,EIF2S2_BGKLV29-28B	NTB_BGKLV29-1,NTB_BGKLV29-2	80.6,81.0	Released	ENCODE3
EIF2S2	HepG2	shRNA	ENCSR110HAA	ENCSR067GHD	EIF2S2_BGHLV30-31,EIF2S2_BGHLV30-32	NT_BGHLV30-1,NT_BGHLV30-2	66.0,59.4	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

EIF2S2: Click to RBP Image Database

Nuclei

Nucleoplasm

Cytoplasm

Compartment/Organelle

ER

Mitotic-Apparatus (Spindle; Centrosomes)

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
EIF2S2	Product_ID: GTX106484 Lot_ID: 40135 Source: GeneTex Target Name: EIF2S2-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for EIF2S2 is not avaliable on ENCORE database.

Proteins bound to RNA

EIF2S2 RNA is bound by 30 proteins.

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eCLIP assay for EIF2S2 is not avaliable on ENCORE database.

30 proteins are bound to EIF2S2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr20	32693229	32693323	-	CDS,intron-Distal	3.27068	48.86069	K562	ZNF622
chr20	32686308	32686372	-	CDS,intron-Distal	5.66718	46.07623	HepG2	BCLAF1
chr20	32686306	32686363	-	CDS,intron-Distal	4.82889	44.08996	K562	UCHL5
chr20	32686303	32686306	-	CDS,intron-Distal,intron-Proximal	6.39848	41.67724	K562	UCHL5
chr20	32686303	32686373	-	CDS,intron-Distal,intron-Proximal	4.93970	41.31086	K562	ZNF622
chr20	32693174	32693241	-	CDS,intron-Distal	4.63812	40.20252	K562	UCHL5
chr20	32693241	32693298	-	CDS,intron-Distal	3.96631	36.07758	K562	UCHL5
chr20	32684462	32684545	-	CDS,intron-Distal,intron-Proximal	4.22906	32.22777	K562	PUM1
chr20	32681490	32681538	-	CDS,intron-Distal,intron-Proximal	3.56326	32.05705	K562	ZNF622
chr20	32685297	32685322	-	CDS,intron-Distal	4.83982	27.85029	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 113 entries

eCLIP assay for EIF2S2 is not avaliable on ENCORE database.

Diffrential Expression

7,898 differentially expressed genes after Knockdown/Knockout EIF2S2 protein.

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131 RBPs can affect the levels of EIF2S2.

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7,898 differentially expressed genes after Knockdown/Knockout EIF2S2 protein :

Only display 100 entries as example. Please click "View All" button to see all 7,898 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
RCN1	ENSG00000049449.4	2886.98240	1073.81900	1.42670	48.55840	44.89340	HepG2	EIF2S2
CYP24A1	ENSG00000019186.5	708.59610	184.18020	1.94370	37.41140	34.12660	HepG2	EIF2S2
SPAG9	ENSG00000008294.16	1462.39560	3020.77050	-1.04660	29.22010	26.21780	HepG2	EIF2S2
SARS	ENSG00000031698.8	3511.63280	1756.03020	0.99970	27.47300	24.58610	HepG2	EIF2S2
OAT	ENSG00000065154.7	559.24600	1152.82750	-1.04360	19.61510	16.98350	HepG2	EIF2S2
NGFR	ENSG00000064300.4	434.32800	173.19010	1.32630	16.20780	13.73030	HepG2	EIF2S2
BCAT1	ENSG00000060982.10	2589.85720	1038.52360	1.31820	14.45620	12.07450	HepG2	EIF2S2
BCAR1	ENSG00000050820.12	2781.42000	1673.30030	0.73300	13.33140	11.02810	HepG2	EIF2S2
PKD1	ENSG00000008710.13	1645.21420	985.88860	0.73870	11.89240	9.70450	HepG2	EIF2S2
TIMP2	ENSG00000035862.8	2114.27870	1318.53780	0.68110	11.53520	9.37680	HepG2	EIF2S2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

131 RBPs can affect the gene expression of EIF2S2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
EIF2S2	ENSG00000125977.6	1327.88090	6787.52600	-2.35380	209.26900	205.82820	K562	EIF2S2
EIF2S2	ENSG00000125977.6	2356.39760	5721.46120	-1.27980	45.64400	43.33940	K562	HNRNPC
EIF2S2	ENSG00000125977.6	4165.69610	8180.91310	-0.97370	37.56560	36.18370	HepG2	SSB
EIF2S2	ENSG00000125977.6	4176.00680	6862.63390	-0.71660	29.06180	27.69180	HepG2	NELFE
EIF2S2	ENSG00000125977.6	2883.17650	4624.98250	-0.68180	26.32070	24.61750	HepG2	UPF1
EIF2S2	ENSG00000125977.6	991.40030	4872.22330	-2.29700	25.56990	22.72440	HepG2	EIF2S2
EIF2S2	ENSG00000125977.6	3653.31670	5302.73760	-0.53750	20.78480	19.25850	HepG2	ZC3H8
EIF2S2	ENSG00000125977.6	5667.93460	8693.56970	-0.61710	20.58170	19.02270	HepG2	AUH
EIF2S2	ENSG00000125977.6	4294.51880	6391.47980	-0.57370	19.67440	18.28690	HepG2	RECQL
EIF2S2	ENSG00000125977.6	1586.03550	2845.87790	-0.84340	19.27650	17.11820	HepG2	DDX24
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 163 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for EIF2S2 is not available on ENCORE database.

10 RBPs can affect the splicing of EIF2S2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	EIF2S2	ENSG00000125977.6	chr20	-	32681480	32681537			32678322	32678408	32684462	32684611	-0.10300	0.00000	0.00000	excluded	K562	SF3B4
SE	EIF2S2	ENSG00000125977.6	chr20	-	32681480	32681537			32678322	32678408	32684462	32684611	-0.05600	0.00000	0.00001	excluded	HepG2	U2AF1
SE	EIF2S2	ENSG00000125977.6	chr20	-	32681480	32681537			32678322	32678408	32684462	32684611	-0.07200	0.00000	0.00000	excluded	K562	AQR
SE	EIF2S2	ENSG00000125977.6	chr20	-	32681480	32681537			32678322	32678408	32684462	32684611	-0.06800	0.00000	0.00000	excluded	HepG2	SF3A3
SE	EIF2S2	ENSG00000125977.6	chr20	-	32681480	32681537			32678322	32678408	32684462	32684611	-0.06700	0.00000	0.00001	excluded	HepG2	SF3B4
MXE	EIF2S2	ENSG00000125977.6	chr20	-	32678322	32678408	32681480	32681537	32676103	32677711	32684462	32684611	0.17300	0.00000	0.00000	1included	HepG2	U2AF2
MXE	EIF2S2	ENSG00000125977.6	chr20	-	32678322	32678408	32681480	32681537	32676103	32677711	32684462	32684611	0.08200	0.00000	0.00001	1included	HepG2	HNRNPUL1
MXE	EIF2S2	ENSG00000125977.6	chr20	-	32678322	32678408	32681480	32681537	32676103	32677711	32684462	32684611	-0.11100	0.00004	0.00523	2included	HepG2	BCCIP
MXE	EIF2S2	ENSG00000125977.6	chr20	-	32678322	32678408	32681480	32681537	32676103	32677711	32684462	32684611	-0.10500	0.00016	0.00867	2included	HepG2	XRN2
MXE	EIF2S2	ENSG00000125977.6	chr20	-	32685221	32685322	32686303	32686439	32684462	32684611	32691267	32691371	-0.10900	0.00027	0.00972	2included	K562	HNRNPUL1

Showing 1 to 10 of 13 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

EIF2S2

General Information

Functions

Localization(RBPImage: EIF2S2)

Domains (AlphaFold: EIF2S2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for EIF2S2 is not avaliable on ENCORE database.

30 proteins are bound to EIF2S2 RNA:

eCLIP assay for EIF2S2 is not avaliable on ENCORE database.

Diffrential Expression

7,898 differentially expressed genes after Knockdown/Knockout EIF2S2 protein :

131 RBPs can affect the gene expression of EIF2S2 :

The Knockdown/knockout RNA-Seq assay for EIF2S2 is not available on ENCORE database.

10 RBPs can affect the splicing of EIF2S2 :

The Knockdown/knockout RNA-Seq assay for EIF2S2 is not avaliable on ENCORE database.