HNRNPL

General Information

Gene Name : HNRNPL
Gene ID : ENSG00000104824.17
Essential Gene : Yes

Functions

Splicing regulation
Viral RNA regulation

Localization

Not Available

Domains (AlphaFold: HNRNPL)

RRM

Antibody Validation

View validation images for all HNRNPL antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	HNRNPL	ENSG00000104824.17	277.92	282.77	280.35	ENCSR000AEF
HepG2	HNRNPL	ENSG00000104824.17	236.16	269.02	252.59	ENCSR985KAT
K562	HNRNPL	ENSG00000104824.17	397.51	410.24	403.88	ENCSR000AEO

Assays

5 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 560	ENCSR795CAI	HNRNPL	K562	Released	ENCAB734ADP	ENCSR299AAB
eCLIP	eCLIP: 678	ENCSR724RDN	HNRNPL	HepG2	Released	ENCAB734ADP	ENCSR513UTE
knockdown followed by RNA-seq	HNRNPL-BGKLV25-K562	ENCSR563YIS	HNRNPL	K562	Released		ENCSR031RRO	shRNA	KD% = 65.4,58.2
knockdown followed by RNA-seq	HNRNPL-BGHLV23-HepG2	ENCSR155BMF	HNRNPL	HepG2	Released		ENCSR042QTH	shRNA	KD% = 72.4,71.8
RNA Bind-n-Seq	RBNS: HNRNPL	ENCSR954TYO	HNRNPL	cell-free sample	Released		ENCSR307EIC

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
HNRNPL	560	K562	ENCSR795CAI	ENCSR299AAB	ENCAB734ADP	ab6106	GR30383-24	Released	ENCODE3
HNRNPL	678	HepG2	ENCSR724RDN	ENCSR513UTE	ENCAB734ADP	ab6106	GR30383-24	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
HNRNPL	ENCAB678XLS	ab6106	GR30383-23		Released, ENCODE3	BGHLV23-21, Released, ENCODE3	BGKLV25-25, Released, ENCODE3
HNRNPL	ENCAB000AVZ	ARP40368_P050	QC9464	Released, ENCODE3	Released, ENCODE3	BGHLV23-21, Released, ENCODE3	BGKLV25-25, Released, ENCODE3
HNRNPL	ENCAB734ADP	ab6106	GR30383-24	Released, ENCODE3	Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project	Note
HNRNPL	K562	shRNA	ENCSR563YIS	ENCSR031RRO	HNRNPL_BGKLV25-25B,HNRNPL_BGKLV25-26B	NT_BGKLV25-1B,NT_BGKLV25-2B	65.4,58.2	Released	ENCODE3
HNRNPL	HepG2	shRNA	ENCSR155BMF	ENCSR042QTH	HNRNPL-BGHLV23-21,HNRNPL-BGHLV23-22	non-target-BGHLV23-1,non-target-BGHLV23-2	72.4,71.8	Released	ENCODE3

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
HNRNPL	HNRNPL		Released	ENCODE3

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
HNRNPL	Product_ID: ab6106 Lot_ID: GR30383-23 Source: Abcam Target Name: HNRNPL-human
HNRNPL	Product_ID: ARP40368_P050 Lot_ID: QC9464 Source: Aviva Target Name: HNRNPL-human

RNA Targets

HNRNPL protein binds to 14,839 RNA regions.

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The binding motifs of HNRNPL

Proteins bound to RNA

HNRNPL RNA is bound by 48 proteins.

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HNRNPL protein has 14,839 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 14,839 entries.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
HNRNPL	chr11	2152523	2152528	-	4.95905	400.00000	HepG2	IGF2	3'-UTR,intron-Distal
HNRNPL	chrM	10613	10622	+	3.38640	400.00000	K562	MT-ND4L	CDS
HNRNPL	chr11	2152883	2152889	-	5.50110	400.00000	HepG2	IGF2	3'-UTR,intron-Distal
HNRNPL	chr2	101458264	101458286	+	5.66224	86.86742	HepG2	NPAS2, AC092168.2	intron-Distal
HNRNPL	chr2	21254248	21254268	-	4.38004	56.56936	HepG2	APOB	intron-Distal
HNRNPL	chr17	80218680	80218748	-	4.90553	44.48484	HepG2	CSNK1D	intron-Distal
HNRNPL	chr16	89647526	89647539	+	5.67759	43.32634	K562	CPNE7	intron-Distal
HNRNPL	chr4	187124339	187124405	+	5.58590	39.55574	HepG2	CYP4V2	intron-Distal
HNRNPL	chr4	1218178	1218191	-	6.59620	38.58770	HepG2	CTBP1	intron-Distal
HNRNPL	chr19	54062980	54063026	+	6.23224	32.43919	HepG2	ZNF331	intron-Distal

Showing 1 to 10 of 100 entries

48 proteins are bound to HNRNPL RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	39336617	39336632	-	CDS,intron-Distal	5.10802	400.00000	K562	YBX3
chr19	39336613	39336617	-	CDS,intron-Distal	5.24156	84.08593	K562	YBX3
chr19	39336632	39336652	-	CDS,intron-Distal	5.52189	80.12925	K562	YBX3
chr19	39336652	39336656	-	CDS,intron-Distal	5.35385	70.04294	K562	YBX3
chr19	39336323	39336368	-	CDS,intron-Distal	3.62292	59.07008	K562	YBX3
chr19	39331139	39331220	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.23807	49.16795	K562	SF3B4
chr19	39336594	39336609	-	CDS,intron-Distal	3.99769	45.30318	K562	YBX3
chr19	39340425	39340546	-	CDS,intron-Distal	3.90971	43.02145	K562	DROSHA
chr19	39334663	39334690	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.65166	41.02479	K562	YBX3
chr19	39340502	39340616	-	5'-UTR,CDS,intron-Distal,intron-Proximal	3.70176	39.54955	K562	DDX3X
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 211 entries

The HNRNPL protein binds to its own RNA.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
HNRNPL	chr19	39332474	39332527	-	3.25043	4.25660	K562	HNRNPL	intron-Distal,intron-Proximal

Showing 1 to 1 of 1 entries

Diffrential Expression

9,561 differentially expressed genes after Knockdown/Knockout HNRNPL protein.

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143 RBPs can affect the levels of HNRNPL.

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9,561 differentially expressed genes after Knockdown/Knockout HNRNPL protein :

Only display 100 entries as example. Please click "View All" button to see all 9,561 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CYP51A1	ENSG00000001630.11	2073.46020	4717.63790	-1.18600	90.73200	87.90990	HepG2	HNRNPL
CX3CL1	ENSG00000006210.6	3665.03670	1819.30640	1.01030	60.37840	57.84540	HepG2	HNRNPL
RBM6	ENSG00000004534.10	2737.00800	4757.74860	-0.79770	43.02860	40.77820	HepG2	HNRNPL
BAZ1B	ENSG00000009954.6	1945.66110	3534.61990	-0.86130	42.73180	40.48770	HepG2	HNRNPL
PKD1	ENSG00000008710.13	966.56420	385.48390	1.32610	38.38860	36.22360	HepG2	HNRNPL
KDM1A	ENSG00000004487.11	2792.46060	4581.49470	-0.71430	34.86810	32.80000	HepG2	HNRNPL
TMEM132A	ENSG00000006118.10	1209.41490	609.85420	0.98770	28.84320	26.93860	HepG2	HNRNPL
NCAPD2	ENSG00000010292.8	3302.69050	5517.68480	-0.74040	24.05820	22.27860	HepG2	HNRNPL
ASB4	ENSG00000005981.8	436.85680	165.35410	1.40150	19.56970	17.92760	HepG2	HNRNPL
SKAP2	ENSG00000005020.8	373.95950	735.55980	-0.97600	19.45630	17.82190	HepG2	HNRNPL
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

143 RBPs can affect the gene expression of HNRNPL :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HNRNPL	ENSG00000104824.12	1366.43080	6916.31600	-2.33960	99999.99999	99999.99999	HepG2	HNRNPL
HNRNPL	ENSG00000104824.12	1999.19600	8318.72910	-2.05690	109.97240	105.56720	K562	HNRNPL
HNRNPL	ENSG00000104824.12	4650.74230	7629.60950	-0.71410	43.24840	41.47760	HepG2	PUM1
HNRNPL	ENSG00000104824.12	3946.76580	7096.41710	-0.84640	39.91770	37.92640	HepG2	SRSF5
HNRNPL	ENSG00000104824.12	3423.76580	7187.16860	-1.06980	31.90050	30.16410	HepG2	PUF60
HNRNPL	ENSG00000104824.12	2336.58210	3928.97870	-0.74980	28.16620	26.39920	HepG2	HNRNPU
HNRNPL	ENSG00000104824.12	2021.37100	3818.05210	-0.91750	26.55810	25.30440	HepG2	TIAL1
HNRNPL	ENSG00000104824.12	2770.72440	4368.02160	-0.65670	24.18760	22.85530	HepG2	SRSF9
HNRNPL	ENSG00000104824.12	4422.51960	6978.13030	-0.65800	23.10210	20.94140	HepG2	HNRNPA2B1
HNRNPL	ENSG00000104824.12	5557.90840	8070.46570	-0.53810	22.42920	20.93290	HepG2	SUCLG1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 167 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

1,744 alternative splicing events after Knockdown/Knockout HNRNPL protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	IGF2BP2	ENSG00000073792.11	chr3	-	185391587	185391672	185390328	185390457	185393083	185393219	0.07600	0.00000	included	HepG2	HNRNPL
SE	CGGBP1	ENSG00000163320.6	chr3	-	88106340	88106442	88104563	88105149	88107168	88107373	0.23600	0.00000	included	HepG2	HNRNPL
SE	EEF1E1-BLOC1S5	ENSG00000265818.1	chr6	-	8027439	8027632	8026599	8026658	8041371	8041501	0.48800	0.00000	included	HepG2	HNRNPL
SE	RILPL1	ENSG00000188026.7	chr12	-	123957430	123957574	123956713	123957229	123968726	123968819	0.37300	0.00000	included	HepG2	HNRNPL
SE	LUC7L3	ENSG00000108848.11	chr17	+	48814647	48814840	48814320	48814387	48817666	48817706	0.15500	0.00062	included	HepG2	HNRNPL
SE	PAAF1	ENSG00000175575.8	chr11	+	73597973	73598144	73589823	73589864	73598398	73598502	0.35000	0.00095	included	HepG2	HNRNPL
SE	SPG7	ENSG00000197912.9	chr16	+	89603172	89603356	89598870	89599044	89611055	89611180	0.16000	0.00093	included	HepG2	HNRNPL
SE	DHRS4	ENSG00000157326.14	chr14	+	24435491	24435626	24429110	24429212	24436419	24436475	0.32500	0.00000	included	HepG2	HNRNPL
SE	TMEM219	ENSG00000149932.12	chr16	+	29983362	29983461	29982728	29982899	29984270	29984369	0.20400	0.00000	included	HepG2	HNRNPL
SE	AC018865.8	ENSG00000180178.6	chr2	-	130792283	130792404	130791882	130791950	130792706	130792835	0.35800	0.00000	included	HepG2	HNRNPL

Showing 1 to 10 of 100 entries

9 RBPs can affect the splicing of HNRNPL :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	HNRNPL	ENSG00000104824.12	chr19	-	39332252	39332322	39331127	39331199	39334481	39334554	0.07000	0.00000	0.00009	included	HepG2	UCHL5
SE	HNRNPL	ENSG00000104824.12	chr19	-	39332252	39332322	39331127	39331199	39334481	39334554	0.06200	0.00000	0.00000	included	HepG2	SF3A3
SE	HNRNPL	ENSG00000104824.12	chr19	-	39332252	39332322	39331127	39331199	39334481	39334554	0.05900	0.00000	0.00000	included	HepG2	SSB
SE	HNRNPL	ENSG00000104824.12	chr19	-	39332252	39332322	39331127	39331199	39334481	39334554	0.05200	0.00000	0.00000	included	HepG2	TIAL1
SE	HNRNPL	ENSG00000104824.12	chr19	-	39332252	39332322	39331127	39331199	39334481	39334554	0.10100	0.00000	0.00000	included	HepG2	SUPV3L1
A3SS	HNRNPL	ENSG00000104824.12	chr19	-	39337955	39338110	39337955	39338074	39342935	39342965	0.38800	0.00000	0.00000	longer	K562	AQR
RI	HNRNPL	ENSG00000104824.12	chr19	-	39331004	39331199	39331004	39331016	39331127	39331199	0.17700	0.00000	0.00000	included	K562	PRPF8
RI	HNRNPL	ENSG00000104824.12	chr19	-	39331004	39331199	39331004	39331016	39331127	39331199	0.19600	0.00000	0.00000	included	K562	EFTUD2
RI	HNRNPL	ENSG00000104824.12	chr19	-	39334496	39334737	39334496	39334554	39334647	39334737	0.07000	0.00000	0.00000	included	K562	AQR
RI	HNRNPL	ENSG00000104824.12	chr19	-	39331004	39331199	39331004	39331016	39331127	39331199	0.13600	0.00020	0.02211	included	K562	SAFB

Showing 1 to 10 of 10 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

HNRNPL

General Information

Functions

Localization

Domains (AlphaFold: HNRNPL)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

HNRNPL protein has 14,839 RNA targets:

48 proteins are bound to HNRNPL RNA:

The HNRNPL protein binds to its own RNA.

Diffrential Expression

9,561 differentially expressed genes after Knockdown/Knockout HNRNPL protein :

143 RBPs can affect the gene expression of HNRNPL :

1,744 alternative splicing events after Knockdown/Knockout HNRNPL protein :

9 RBPs can affect the splicing of HNRNPL :

No autoregularoty alternative splicing events between protein HNRNPL and its RNA.