ZRANB2

General Information

Gene Name : ZRANB2
Gene ID : ENSG00000132485.13
Essential Gene : No

Functions

Splicing regulation

Localization(RBPImage: ZRANB2)

Nuclei
Nucleoplasm
Mutually Exclusive from Nucleolus
Speckles
Nuclear release mitosis

Domains (AlphaFold: ZRANB2)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A301-029A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	ZRANB2	ENSG00000132485.13	174.00	128.44	151.22	ENCSR000AEF
HepG2	ZRANB2	ENSG00000132485.13	35.44	69.44	52.44	ENCSR985KAT
K562	ZRANB2	ENSG00000132485.13	149.88	161.66	155.77	ENCSR000AEO

Assays

6 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 548	ENCSR663NRA	ZRANB2	K562	Released	ENCAB099IOB	ENCSR528HOM
knockdown followed by RNA-seq	ZRANB2-BGKLV13-K562	ENCSR850PWM	ZRANB2	K562	Released		ENCSR815CVQ	shRNA	KD% = 83.2,81.5
knockdown followed by RNA-seq	ZRANB2-BGHLV14-HepG2	ENCSR081QQH	ZRANB2	HepG2	Released		ENCSR491FOC	shRNA	KD% = 83.0,75.5
knockdown followed by RNA-seq	ZRANB2-BGRSLV02-RS293		ZRANB2	Ribo-STAMP-293T	Released			shRNA	KD% = ,
knockdown followed by RNA-seq	ZRANB2-BG293LV06-WT293		ZRANB2	293T	Released			shRNA	KD% = ,
RNA Bind-n-Seq	RBNS: ZRANB2	ENCSR927QJQ	ZRANB2	cell-free sample	Released		ENCSR537ATS

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
ZRANB2	548	K562	ENCSR663NRA	ENCSR528HOM	ENCAB099IOB	A301-029A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
ZRANB2	ENCAB099IOB	A301-029A	1			Released, ENCODE3	BGHLV14-71, Released, ENCODE3	BGKLV13-11, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
ZRANB2	K562	shRNA	ENCSR850PWM	ENCSR815CVQ	ZRANB2_BGKLV13_11,ZRANB2_BGKLV13_12	NT_BGKLV13_1,NT_BGKLV13_2	83.2,81.5	Released	ENCODE3
ZRANB2	HepG2	shRNA	ENCSR081QQH	ENCSR491FOC	ZRANB2_27_BGHLV14-71,ZRANB2_27_BGHLV14-72	NT_BGHLV14-1,NT_BGHLV14-2	83.0,75.5	Released	ENCODE3
ZRANB2	Ribo-STAMP-293T	shRNA			BGRSLV01-23,BGRSLV01-24	BGRSLV01-1,BGRSLV01-2		NotSatisfied	ENCORE2
ZRANB2	Ribo-STAMP-293T	shRNA			ZRANB2-BGRSLV02-21,ZRANB2-BGRSLV02-22	NT-BGRSLV02-1,NT-BGRSLV02-2	,	Released	ENCORE2
ZRANB2	293T	shRNA			BG293LV01-69,BG293LV01-70	BG293LV01-1,BG293LV01-2		NotSatisfied	ENCORE2
ZRANB2	293T	shRNA			ZRANB2-BG293LV02-53,ZRANB2-BG293LV02-54	NT-BG293LV02-1,NT-BG293LV02-2	,	Revoked	ENCORE2
ZRANB2	293T	shRNA			ZRANB2-BG293LV06-113B,ZRANB2-BG293LV06-114B	NT-BG293LV06-1B,NT-BG293LV06-2B	,	Released	ENCORE2

RNA Bind-n-Seqn

GeneName	gene_aliases	Status	Project	Note
ZRANB2	ZRANB2		Released	ENCODE4

Localization Image in HepG2

ZRANB2: Click to RBP Image Database

Nuclei

Nucleoplasm

Mutually Exclusive from Nucleolus

Speckles

Nuclear release mitosis

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
ZRANB2	Product_ID: A301-029A Lot_ID: 1 Source: Bethyl Labs Target Name: ZRANB2-human

RNA Targets

ZRANB2 protein binds to 347 RNA regions.

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The binding motifs of ZRANB2

Proteins bound to RNA

ZRANB2 RNA is bound by 26 proteins.

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ZRANB2 protein has 347 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
ZRANB2	chr19	34876654	34876690	+	6.36505	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34882791	34882822	+	8.42056	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34882200	34882224	+	7.13535	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34882936	34882944	+	6.85254	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34874676	34874696	+	7.12480	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34882321	34882342	+	7.09211	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34882822	34882838	+	8.92595	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34878869	34878939	+	6.58995	400.00000	K562	GPI	intron-Distal
ZRANB2	chr19	34881996	34882038	+	6.36379	400.00000	K562	GPI	intron-Distal
ZRANB2	chr17	74554919	74554948	+	5.12295	400.00000	K562	SNHG16	intron-Distal,intron-Proximal

Showing 1 to 10 of 100 entries

26 proteins are bound to ZRANB2 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	71533333	71533341	-	intron-Distal	9.87903	400.00000	K562	DGCR8
chr1	71533320	71533326	-	intron-Distal	10.16418	400.00000	K562	DGCR8
chr1	71533341	71533356	-	intron-Distal	9.92396	400.00000	K562	DGCR8
chr1	71533326	71533333	-	intron-Distal	9.86587	400.00000	K562	DGCR8
chr1	71533324	71533351	-	intron-Distal	9.21438	268.28559	HepG2	DGCR8
chr1	71533356	71533364	-	intron-Distal	8.38622	110.84611	K562	DGCR8
chr1	71533364	71533386	-	intron-Distal	7.39468	84.48737	K562	DGCR8
chr1	71533077	71533107	-	intron-Distal	3.44307	61.45236	K562	DROSHA
chr1	71533325	71533350	-	intron-Distal	6.25997	57.54946	K562	DROSHA
chr1	71544141	71544249	-	CDS,intron-Distal,intron-Proximal	4.46044	53.09135	K562	DDX24
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 133 entries

No autoregularoty interactions between protein ZRANB2 and its RNA.

Diffrential Expression

1,366 differentially expressed genes after Knockdown/Knockout ZRANB2 protein.

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82 RBPs can affect the levels of ZRANB2.

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1,366 differentially expressed genes after Knockdown/Knockout ZRANB2 protein :

Only display 100 entries as example. Please click "View All" button to see all 1,366 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ASNS	ENSG00000070669.12	1268.99420	296.23830	2.09880	38.64820	34.58520	HepG2	ZRANB2
HMGB3	ENSG00000029993.10	407.79620	940.31680	-1.20530	13.62660	10.70870	HepG2	ZRANB2
BCAT1	ENSG00000060982.10	2119.27850	993.47260	1.09290	13.62560	10.70870	HepG2	ZRANB2
ACSM2B	ENSG00000066813.10	905.05770	410.00490	1.14230	12.24560	9.44970	HepG2	ZRANB2
TDP1	ENSG00000042088.9	230.23770	542.37090	-1.23620	11.70120	8.94990	HepG2	ZRANB2
SLC2A3	ENSG00000059804.11	5294.82040	12680.32760	-1.25990	11.16700	8.48420	HepG2	ZRANB2
MTHFD2	ENSG00000065911.7	2760.24350	1555.81520	0.82700	8.55360	6.17630	HepG2	ZRANB2
POLA2	ENSG00000014138.4	167.65440	362.49680	-1.11250	8.22210	5.89140	HepG2	ZRANB2
MXD1	ENSG00000059728.6	510.54560	256.23280	0.99450	7.95550	5.64450	HepG2	ZRANB2
HSPA5	ENSG00000044574.7	14959.57810	24813.41120	-0.73010	7.62460	5.35390	HepG2	ZRANB2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

82 RBPs can affect the gene expression of ZRANB2 :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ZRANB2	ENSG00000132485.8	3678.83580	7677.91280	-1.06150	29.02140	26.48970	K562	CPSF6
ZRANB2	ENSG00000132485.8	9526.72690	5560.21340	0.77670	14.61430	13.40450	K562	PUS1
ZRANB2	ENSG00000132485.8	2421.44690	1447.34950	0.74240	13.20890	11.80000	HepG2	RBM25
ZRANB2	ENSG00000132485.8	1106.23180	2197.45790	-0.99020	11.43660	10.20730	HepG2	GPKOW
ZRANB2	ENSG00000132485.8	1001.26000	1559.37470	-0.63920	10.13520	9.12230	HepG2	ACO1
ZRANB2	ENSG00000132485.8	1735.96440	2477.05090	-0.51290	9.65550	8.82060	HepG2	RBM22
ZRANB2	ENSG00000132485.8	1115.50930	1609.64740	-0.52900	10.12790	8.81400	HepG2	ILF2
ZRANB2	ENSG00000132485.8	937.62250	1412.62340	-0.59130	9.97180	8.70090	HepG2	DNAJC21
ZRANB2	ENSG00000132485.8	5745.14800	8493.53650	-0.56400	8.93830	7.98080	K562	AQR
ZRANB2	ENSG00000132485.8	4369.68790	5818.29480	-0.41310	8.35620	7.20820	K562	EIF2S2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 94 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

82 alternative splicing events after Knockdown/Knockout ZRANB2 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	ZNF480	ENSG00000198464.9	chr19	+	52801042	52801201	52800431	52800476	52803646	52803737	0.26200	0.00687	included	K562	ZRANB2
SE	MRPL55	ENSG00000162910.14	chr1	-	228296137	228296234	228295990	228296019	228296655	228296737	0.42200	0.00000	included	K562	ZRANB2
SE	NASP	ENSG00000132780.12	chr1	+	46072992	46074009	46072153	46072263	46078840	46078920	0.23600	0.00000	included	K562	ZRANB2
SE	RPL17	ENSG00000265681.2	chr18	-	47018105	47018203	47017886	47017954	47018644	47018769	0.21100	0.00007	included	K562	ZRANB2
SE	FKBP5	ENSG00000096060.10	chr6	-	35614506	35614627	35610496	35610620	35656580	35656719	0.05900	0.00007	included	K562	ZRANB2
SE	HIST1H2AC	ENSG00000180573.8	chr6	+	26127925	26127989	26124430	26124861	26138281	26139344	0.12600	0.00018	included	K562	ZRANB2
SE	CENPE	ENSG00000138778.7	chr4	-	104060945	104061236	104059507	104059606	104061412	104061571	0.50300	0.00012	included	K562	ZRANB2
SE	RPS24	ENSG00000138326.14	chr10	+	79799961	79799983	79796951	79797062	79800372	79800455	0.07700	0.00027	included	K562	ZRANB2
SE	AC079466.1	ENSG00000266976.1	chr19	+	29101166	29101238	29097594	29098011	29103345	29106136	-0.13600	0.00717	excluded	K562	ZRANB2
SE	ECD	ENSG00000122882.6	chr10	-	74923490	74923708	74920191	74920309	74927623	74927829	-0.24400	0.00276	excluded	K562	ZRANB2

Showing 1 to 10 of 82 entries

30 RBPs can affect the splicing of ZRANB2 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.31400	0.00055	included	HepG2	G3BP1
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71530725	71530858	71532458	71532769	-0.16400	0.00000	excluded	K562	AQR
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.27000	0.00002	included	HepG2	SRSF7
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.22100	0.00000	included	K562	SUPV3L1
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.16700	0.00013	included	K562	NSUN2
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.19000	0.00022	included	K562	UCHL5
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.40200	0.00000	included	HepG2	HNRNPL
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.34200	0.00000	included	K562	HNRNPL
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.18500	0.00001	included	K562	SRSF7
SE	ZRANB2	ENSG00000132485.8	chr1	-	71531360	71531435	71529019	71530820	71532458	71532617	0.25400	0.00199	included	HepG2	DDX55

Showing 1 to 10 of 41 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

ZRANB2

General Information

Functions

Localization(RBPImage: ZRANB2)

Domains (AlphaFold: ZRANB2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

ZRANB2 protein has 347 RNA targets:

26 proteins are bound to ZRANB2 RNA:

No autoregularoty interactions between protein ZRANB2 and its RNA.

Diffrential Expression

1,366 differentially expressed genes after Knockdown/Knockout ZRANB2 protein :

82 RBPs can affect the gene expression of ZRANB2 :

82 alternative splicing events after Knockdown/Knockout ZRANB2 protein :

30 RBPs can affect the splicing of ZRANB2 :

No autoregularoty alternative splicing events between protein ZRANB2 and its RNA.