ZNF622

General Information

Gene Name : ZNF622
Gene ID : ENSG00000173545.4
Essential Gene : Yes

Functions

rRNA processing

Localization(RBPImage: ZNF622)

Nuclei
Unknown Nuclear Foci
Unknown Nuclear Territory
Cytoplasm
Compartment/Organelle
Golgi
Cytoskeleton
Microtubule
Cytosolic
Mitotic-Apparatus (Spindle; Centrosomes)

Domains (AlphaFold: ZNF622)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A304-075A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	ZNF622	ENSG00000173545.4	12.38	15.12	13.75	ENCSR000AEF
HepG2	ZNF622	ENSG00000173545.4	21.98	17.35	19.66	ENCSR985KAT
K562	ZNF622	ENSG00000173545.4	26.47	18.65	22.56	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 570	ENCSR657TZZ	ZNF622	K562	Released	ENCAB041OEQ	ENCSR594RFP
knockdown followed by RNA-seq	ZNF622-BGHLV33-HepG2	ENCSR518JXY	ZNF622	HepG2	Released		ENCSR691IVR	shRNA	KD% = 68.7,68.1

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
ZNF622	570	K562	ENCSR657TZZ	ENCSR594RFP	ENCAB041OEQ	A304-075A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
ZNF622	ENCAB041OEQ	A304-075A	1		Released, ENCODE3	Released, ENCODE3	BGHLV33-47, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
ZNF622	K562	shRNA			BGKLV34-59,BGKLV34-60	BGKLV34-1,BGKLV34-2	0.0,0.0	NotSatisfied	ENCODE3
ZNF622	K562	shRNA			BGKLV36-47,BGKLV36-48	BGKLV36-1,BGKLV36-2	26.1,35.8	NotSatisfied	ENCODE3
ZNF622	K562	shRNA			BGKLV38-147,BGKLV38-148	BGKLV38-1,BGKLV38-2	0.0,0.0	NotSatisfied	ENCODE3
ZNF622	K562	shRNA			BGKLV38-149,BGKLV38-150	BGKLV38-1,BGKLV38-2	33.3,37.9	NotSatisfied	ENCODE3
ZNF622	K562	shRNA			BGKLV38-151,BGKLV38-152	BGKLV38-1,BGKLV38-2	0.0,0.0	NotSatisfied	ENCODE3
ZNF622	HepG2	shRNA			BGHLV23-61,BGHLV23-62	BGHLV23-1,BGHLV23-2	35.7,41.5	NotSatisfied	ENCODE3
ZNF622	HepG2	shRNA	ENCSR518JXY	ENCSR691IVR	ZNF622_BGHLV33-47,ZNF622_BGHLV33-48	NT_BGHLV33-1,NT_BGHLV33-2	68.7,68.1	Released	ENCODE3
ZNF622	K562	CRISPR			BGKcLV08-91,BGKcLV08-92	BGKcLV08-1,BGKcLV08-2	39.8,39.3	NotSatisfied	ENCODE4
ZNF622	K562	CRISPR			BGKcLV11-121,BGKcLV11-122	BGKcLV11-1,BGKcLV11-2	14.8,33.7	NotSatisfied	ENCODE4
ZNF622	K562	CRISPR			BGKcLV11-123,BGKcLV11-124	BGKcLV11-1,BGKcLV11-2	46.4,41.8	NotSatisfied	ENCODE4
ZNF622	K562	CRISPR			BGKcLV48-85,BGKcLV48-86	BGKcLV48-1,BGKcLV48-2		Experimented	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

ZNF622: Click to RBP Image Database

Nuclei

Unknown Nuclear Foci

Unknown Nuclear Territory

Cytoplasm

Compartment/Organelle

Golgi

Cytoskeleton

Microtubule

Cytosolic

Mitotic-Apparatus (Spindle; Centrosomes)

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
ZNF622	Product_ID: A304-075A Lot_ID: 1 Source: Bethyl Labs Target Name: ZNF622-human

RNA Targets

ZNF622 protein binds to 14,813 RNA regions.

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Proteins bound to RNA

ZNF622 RNA is bound by 5 proteins.

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ZNF622 protein has 14,813 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 14,813 entries.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
ZNF622	chr2	232329065	232329118	-	3.17505	46.75865	K562	NCL	5'-UTR,intron-Distal,intron-Proximal
ZNF622	chr10	120809313	120809410	-	4.93959	45.16497	K562	EIF3A	CDS,intron-Distal
ZNF622	chr6	99860555	99860616	-	4.16714	40.82391	K562	PNISR	CDS,intron-Distal,intron-Proximal
ZNF622	chr12	76444393	76444399	-	3.76508	38.62753	K562	NAP1L1	3'-UTR,CDS,intron-Distal
ZNF622	chr2	27606857	27606881	-	4.49631	33.38496	K562	PPM1G	CDS,intron-Distal
ZNF622	chr17	46052527	46052615	+	3.18286	30.55145	K562	CDK5RAP3	3'-UTR,5'-UTR,CDS,intron-Proximal
ZNF622	chr5	33445429	33445452	+	4.52669	27.27947	K562	TARS	3'-UTR,5'-UTR,CDS,intron-Proximal
ZNF622	chr3	47727596	47727636	-	4.17634	25.77859	K562	SMARCC1	CDS,intron-Distal
ZNF622	chr2	85768864	85768869	+	3.19970	23.91261	K562	MAT2A	CDS,intron-Proximal
ZNF622	chr6	26234646	26234702	-	4.09073	21.94558	K562	HIST1H1D	CDS

Showing 1 to 10 of 100 entries

5 proteins are bound to ZNF622 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr5	16463765	16463845	-	CDS,intron-Distal	4.77065	12.34367	K562	UCHL5
chr5	16465371	16465435	-	CDS,intron-Distal	4.62426	9.30180	K562	UCHL5
chr5	16465693	16465880	-	5'-UTR,CDS,intron-Distal	3.82643	7.37356	K562	DDX3X
chr5	16465378	16465424	-	CDS,intron-Distal	3.38060	6.36421	K562	ZNF622
chr5	16463328	16463365	-	CDS,intron-Distal	3.72954	5.08388	K562	UCHL5
chr5	16465380	16465461	-	CDS,intron-Distal	3.45101	4.58459	K562	GRWD1
chr5	16463764	16463826	-	CDS,intron-Distal	4.25660	3.71570	HepG2	BCLAF1
chr5	16465725	16465785	-	5'-UTR,CDS,intron-Distal	4.01285	3.31827	HepG2	GRWD1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 8 of 8 entries

The ZNF622 protein binds to its own RNA.

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
ZNF622	chr5	16465378	16465424	-	3.38060	6.36421	K562	ZNF622	CDS,intron-Distal

Showing 1 to 1 of 1 entries

Diffrential Expression

8,369 differentially expressed genes after Knockdown/Knockout ZNF622 protein.

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60 RBPs can affect the levels of ZNF622.

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8,369 differentially expressed genes after Knockdown/Knockout ZNF622 protein :

Only display 100 entries as example. Please click "View All" button to see all 8,369 entries.

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
LASP1	ENSG00000002834.13	17291.86470	8361.86870	1.04810	109.44810	107.37840	HepG2	ZNF622
TNFRSF12A	ENSG00000006327.9	1730.86980	464.81750	1.89670	98.10570	96.11620	HepG2	ZNF622
TFPI	ENSG00000003436.10	32345.52420	15991.06540	1.01620	74.56990	72.74650	HepG2	ZNF622
DBF4	ENSG00000006634.3	127.02630	610.98420	-2.26600	62.99500	61.28780	HepG2	ZNF622
KDM1A	ENSG00000004487.11	1967.64300	3733.82980	-0.92420	53.15090	51.53830	HepG2	ZNF622
E2F2	ENSG00000007968.6	29.57620	296.95530	-3.32770	52.55180	50.94570	HepG2	ZNF622
PSMB1	ENSG00000008018.8	5306.26990	3141.05350	0.75630	42.88640	41.40400	HepG2	ZNF622
DBNDD1	ENSG00000003249.9	2018.15870	1038.21430	0.95880	40.13710	38.68890	HepG2	ZNF622
CRLF1	ENSG00000006016.6	1429.33630	3117.28320	-1.12490	33.59410	32.23210	HepG2	ZNF622
CD99	ENSG00000002586.13	5179.61690	3324.23600	0.63970	31.21510	29.88940	HepG2	ZNF622
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

60 RBPs can affect the gene expression of ZNF622 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ZNF622	ENSG00000173545.4	77.08860	504.92670	-2.71150	67.34330	65.58600	HepG2	ZNF622
ZNF622	ENSG00000173545.4	1186.57470	448.54400	1.40340	25.34170	23.06660	K562	PRPF8
ZNF622	ENSG00000173545.4	1223.61780	676.58940	0.85470	20.17760	19.14950	HepG2	SRFBP1
ZNF622	ENSG00000173545.4	2486.70520	1137.56380	1.12820	16.76320	15.48030	K562	AQR
ZNF622	ENSG00000173545.4	771.34480	374.67660	1.04160	11.65650	10.33760	HepG2	U2AF1
ZNF622	ENSG00000173545.4	918.82160	559.36770	0.71590	10.91960	9.80310	K562	FXR1
ZNF622	ENSG00000173545.4	305.74920	543.84430	-0.83080	10.12110	9.15650	HepG2	TAF15
ZNF622	ENSG00000173545.4	789.23100	487.09410	0.69610	8.18750	7.05990	HepG2	PUM2
ZNF622	ENSG00000173545.4	2089.09770	1373.74190	0.60470	8.34790	6.92480	K562	PUF60
ZNF622	ENSG00000173545.4	930.20730	526.37130	0.82140	7.49250	6.43710	K562	PTBP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 67 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for ZNF622 is not available on ENCORE database.

1 RBPs can affect the splicing of ZNF622 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	is_included	Cell Line	Affected by RBP
A3SS	ZNF622	ENSG00000173545.4	chr5	-	16453121	16453364	16453121	16453265	16458625	16458757	0.18000	longer	K562	AQR
A3SS	ZNF622	ENSG00000173545.4	chr5	-	16458625	16458835	16458625	16458738	16463216	16463379	0.06400	longer	K562	AQR
A3SS	ZNF622	ENSG00000173545.4	chr5	-	16463216	16463440	16463216	16463379	16463590	16463851	0.05200	longer	K562	AQR

Showing 1 to 3 of 3 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

ZNF622

General Information

Functions

Localization(RBPImage: ZNF622)

Domains (AlphaFold: ZNF622)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

ZNF622 protein has 14,813 RNA targets:

5 proteins are bound to ZNF622 RNA:

The ZNF622 protein binds to its own RNA.

Diffrential Expression

8,369 differentially expressed genes after Knockdown/Knockout ZNF622 protein :

60 RBPs can affect the gene expression of ZNF622 :

The Knockdown/knockout RNA-Seq assay for ZNF622 is not available on ENCORE database.

1 RBPs can affect the splicing of ZNF622 :

The Knockdown/knockout RNA-Seq assay for ZNF622 is not avaliable on ENCORE database.