SUGP2

General Information

Gene Name : SUGP2
Gene ID : ENSG00000064607.16
Essential Gene : No

Functions

Splicing regulation

Localization(RBPImage: SUGP2)

Nuclei
Nucleoplasm
Nucleolus
Cytoplasm
Compartment/Organelle
Golgi
P bodies

Domains (AlphaFold: SUGP2)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A301-607A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SUGP2	ENSG00000064607.16	49.87	55.90	52.88	ENCSR000AEF
HepG2	SUGP2	ENSG00000064607.16	35.26	38.10	36.68	ENCSR985KAT
K562	SUGP2	ENSG00000064607.16	59.81	60.47	60.14	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 652	ENCSR506UPY	SUGP2	HepG2	Released	ENCAB433XTU	ENCSR895TTM
knockdown followed by RNA-seq	SUGP2-BGKLV28-K562	ENCSR192BPV	SUGP2	K562	Released		ENCSR164MUK	shRNA	KD% = 95.9,96.7
knockdown followed by RNA-seq	SUGP2-BGHLV27-HepG2	ENCSR837QDN	SUGP2	HepG2	Released		ENCSR246RRQ	shRNA	KD% = 87.7,85.2

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
SUGP2	652	HepG2	ENCSR506UPY	ENCSR895TTM	ENCAB433XTU	A301-607A	1	Released	ENCODE3

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SUGP2	ENCAB433XTU	A301-607A	1		Released, ENCODE3	Released, ENCODE3	BGHLV27-53, Released, ENCODE3	BGKLV28-55, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
SUGP2	K562	shRNA			BGKLV13-61,BGKLV13-62	BGKLV13-1,BGKLV13-2		NotSatisfied	ENCODE3
SUGP2	K562	shRNA	ENCSR192BPV	ENCSR164MUK	SUGP2_BGKLV28-55,SUGP2_BGKLV28-56	non-target_BGKLV28-1,non-target_BGKLV28-2	95.9,96.7	Released	ENCODE3
SUGP2	HepG2	shRNA	ENCSR837QDN	ENCSR246RRQ	SUGP2_BGHLV27-53,SUGP2_BGHLV27-54	non-target_BGHLV27-1,non-target_BGHLV27-2	87.7,85.2	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

SUGP2: Click to RBP Image Database

Nuclei

Nucleoplasm

Nucleolus

Cytoplasm

Compartment/Organelle

Golgi

P bodies

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SUGP2	Product_ID: A301-607A Lot_ID: 1 Source: Bethyl Labs Target Name: SUGP2-human

RNA Targets

SUGP2 protein binds to 14,663 RNA regions.

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Proteins bound to RNA

SUGP2 RNA is bound by 42 proteins.

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SUGP2 protein has 14,663 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
SUGP2	chr13	34421508	34421574	+	4.71675	21.77586	HepG2	RFC3	intron-Distal
SUGP2	chr7	138173380	138173473	+	5.97251	18.22156	HepG2	TRIM24	intron-Distal
SUGP2	chr16	24967569	24967615	-	4.19461	17.65950	HepG2	ARHGAP17	intron-Distal
SUGP2	chr16	87378077	87378126	-	3.27459	15.99400	HepG2	FBXO31	intron-Distal
SUGP2	chr2	75756278	75756349	-	3.36833	13.74333	HepG2	EVA1A	intron-Distal
SUGP2	chr10	21859966	21860050	+	4.99537	13.63506	HepG2	MLLT10	intron-Distal
SUGP2	chr16	52566169	52566214	-	4.12048	13.34088	HepG2	TOX3	intron-Distal
SUGP2	chr6	16744171	16744216	-	3.01095	12.93874	HepG2	ATXN1	intron-Distal
SUGP2	chr2	138747159	138747204	+	5.46787	12.61003	HepG2	HNMT	intron-Distal
SUGP2	chr12	11260247	11260303	-	5.59868	12.60653	HepG2	PRR4, TAS2R14	intron-Distal

Showing 1 to 10 of 100 entries

42 proteins are bound to SUGP2 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr19	19105254	19105316	-	3'-UTR,CDS,intron-Distal,intron-Proximal	5.15307	84.34333	K562	AQR
chr19	19105312	19105378	-	3'-UTR,intron-Distal,intron-Proximal	5.60190	74.61302	K562	SF3B4
chr19	19105908	19105942	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.78658	68.14223	K562	AQR
chr19	19105239	19105312	-	3'-UTR,CDS,intron-Distal,intron-Proximal	5.31170	58.08616	K562	SF3B4
chr19	19105315	19105393	-	3'-UTR,intron-Distal,intron-Proximal	5.66886	47.17546	HepG2	SF3A3
chr19	19105868	19105908	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.42292	40.66055	K562	AQR
chr19	19101894	19101968	-	3'-UTR,intron-Distal	4.39133	34.92742	HepG2	U2AF2
chr19	19105309	19105377	-	3'-UTR,intron-Distal,intron-Proximal	5.99607	32.54366	HepG2	SF3B4
chr19	19105255	19105313	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.94247	30.80407	HepG2	SF3A3
chr19	19105942	19105953	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.25829	30.60660	K562	AQR
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 180 entries

No autoregularoty interactions between protein SUGP2 and its RNA.

Diffrential Expression

1,492 differentially expressed genes after Knockdown/Knockout SUGP2 protein.

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113 RBPs can affect the levels of SUGP2.

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1,492 differentially expressed genes after Knockdown/Knockout SUGP2 protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
ASPM	ENSG00000066279.12	453.18480	1183.21750	-1.38450	18.47060	15.08510	HepG2	SUGP2
MGAT4A	ENSG00000071073.8	2083.43750	4382.02930	-1.07260	14.82650	11.64510	HepG2	SUGP2
CBFB	ENSG00000067955.9	317.19810	772.97950	-1.28500	12.35870	9.50470	HepG2	SUGP2
PLEKHB1	ENSG00000021300.9	877.54200	1771.63070	-1.01350	11.91090	9.15890	HepG2	SUGP2
NGFR	ENSG00000064300.4	48.63320	170.75600	-1.81190	10.48750	7.98280	HepG2	SUGP2
PRR11	ENSG00000068489.8	556.46080	1096.20450	-0.97820	9.83960	7.43180	HepG2	SUGP2
GCLC	ENSG00000001084.6	2788.89760	1554.70330	0.84300	9.24020	6.88000	HepG2	SUGP2
VCAN	ENSG00000038427.11	527.63570	1136.93230	-1.10750	9.22780	6.87170	HepG2	SUGP2
TACC3	ENSG00000013810.14	319.77170	641.74740	-1.00500	8.64210	6.34650	HepG2	SUGP2
GTSE1	ENSG00000075218.14	109.74790	263.14350	-1.26170	8.10310	5.84800	HepG2	SUGP2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

113 RBPs can affect the gene expression of SUGP2 :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SUGP2	ENSG00000064607.12	4065.43020	1743.86060	1.22100	48.84030	46.84670	HepG2	QKI
SUGP2	ENSG00000064607.12	3008.70850	1792.04440	0.74740	23.32020	22.05430	HepG2	NELFE
SUGP2	ENSG00000064607.12	2776.06240	1572.94540	0.81950	23.01000	21.61180	HepG2	TAF15
SUGP2	ENSG00000064607.12	2782.85100	1669.12650	0.73740	22.98980	21.51580	HepG2	RECQL
SUGP2	ENSG00000064607.12	2622.85300	1610.28170	0.70370	20.60930	19.38100	HepG2	PTBP1
SUGP2	ENSG00000064607.12	2682.84150	1676.41500	0.67830	19.23660	17.90110	HepG2	SF3B4
SUGP2	ENSG00000064607.12	1996.57950	3508.82000	-0.81350	16.85720	15.55730	HepG2	PUF60
SUGP2	ENSG00000064607.12	2248.82350	1236.88950	0.86240	16.72540	14.87460	HepG2	FUBP3
SUGP2	ENSG00000064607.12	8272.63050	6460.26150	0.35670	15.24620	13.68820	K562	NSUN2
SUGP2	ENSG00000064607.12	2375.43020	3464.50220	-0.54450	14.10240	12.84250	HepG2	SRSF5
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 125 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

154 alternative splicing events after Knockdown/Knockout SUGP2 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	ZCCHC10	ENSG00000155329.7	chr5	-	132358532	132358598	132342450	132342612	132362188	132362281	0.24400	0.00007	included	HepG2	SUGP2
SE	ZNF207	ENSG00000010244.12	chr17	+	30693683	30693776	30692348	30692506	30694790	30695033	0.17300	0.00002	included	HepG2	SUGP2
SE	RAB17	ENSG00000124839.8	chr2	-	238486646	238486798	238485899	238486025	238494640	238494800	0.10700	0.00092	included	HepG2	SUGP2
SE	SEC31A	ENSG00000138674.12	chr4	-	83752089	83752128	83750152	83750211	83763292	83763494	0.32800	0.00002	included	HepG2	SUGP2
SE	MMD	ENSG00000108960.3	chr17	-	53485078	53485181	53481127	53481229	53488617	53488778	0.06600	0.00198	included	HepG2	SUGP2
SE	SPTAN1	ENSG00000197694.9	chr9	+	131355261	131355321	131353755	131353904	131356453	131356652	0.20300	0.00566	included	HepG2	SUGP2
SE	TCERG1	ENSG00000113649.7	chr5	+	145841580	145841659	145838777	145838900	145843113	145843356	0.08900	0.00295	included	HepG2	SUGP2
SE	KHK	ENSG00000138030.8	chr2	+	27317667	27317802	27315199	27315316	27319596	27319669	0.53000	0.00000	included	HepG2	SUGP2
SE	ATP6V0A1	ENSG00000033627.10	chr17	+	40647051	40647206	40646351	40646491	40647643	40647734	0.15600	0.00629	included	HepG2	SUGP2
SE	SMPD4	ENSG00000136699.15	chr2	-	130918758	130918845	130914933	130914969	130921946	130922018	0.18600	0.00446	included	HepG2	SUGP2

Showing 1 to 10 of 100 entries

37 RBPs can affect the splicing of SUGP2 :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	SUGP2	ENSG00000064607.12	chr19	-	19104446	19104549	19101696	19101958	19105174	19105295	0.38500	0.00000	included	K562	SRSF1
SE	SUGP2	ENSG00000064607.12	chr19	-	19104446	19104549	19101696	19101958	19105174	19105295	0.35100	0.00001	included	K562	MATR3
SE	SUGP2	ENSG00000064607.12	chr19	-	19114304	19114417	19112421	19112483	19114976	19115455	0.63100	0.00000	included	HepG2	HNRNPK
SE	SUGP2	ENSG00000064607.12	chr19	-	19112421	19112528	19105952	19106089	19114976	19115455	-0.07100	0.00001	excluded	K562	AQR
SE	SUGP2	ENSG00000064607.12	chr19	-	19104446	19104549	19101696	19101958	19105174	19105295	0.60700	0.00000	included	K562	FXR1
SE	SUGP2	ENSG00000064607.12	chr19	-	19114304	19114417	19112421	19112483	19114976	19115455	0.45500	0.00000	included	K562	HNRNPK
A3SS	SUGP2	ENSG00000064607.12	chr19	-	19104456	19104608	19104456	19104549	19105174	19106089	-0.20200	0.00020	shorter	K562	EIF3G
A3SS	SUGP2	ENSG00000064607.12	chr19	-	19104446	19104608	19104446	19104549	19105174	19105295	-0.39700	0.00000	shorter	K562	FXR1
A3SS	SUGP2	ENSG00000064607.12	chr19	-	19129917	19130126	19129917	19130038	19135427	19137035	0.07300	0.00000	longer	K562	AQR
A3SS	SUGP2	ENSG00000064607.12	chr19	-	19119125	19119271	19119125	19119237	19120663	19121151	0.11600	0.00000	longer	K562	AQR

Showing 1 to 10 of 74 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The SUGP2 protein affects to its own RNA splicing after knockdown/knockout.

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP	Bound by RBP
RI	SUGP2	ENSG00000064607.12	chr19	-	19105174	19106089			19105174	19105295	19105952	19106089	0.21800	0.00001	0.00536	included	HepG2	SUGP2

Showing 1 to 1 of 1 entries