SRP68

General Information

Gene Name : SRP68
Gene ID : ENSG00000167881.14
Essential Gene : Yes

Functions

Other

Localization(RBPImage: SRP68)

Cytoplasm
Compartment/Organelle
Golgi
Cytosolic

Domains (AlphaFold: SRP68)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A303-955A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SRP68	ENSG00000167881.14	47.29	50.00	48.64	ENCSR000AEF
HepG2	SRP68	ENSG00000167881.14	90.56	109.96	100.26	ENCSR985KAT
K562	SRP68	ENSG00000167881.14	61.93	62.31	62.12	ENCSR000AEO

Assays

4 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Controls	Method	Note
knockdown followed by RNA-seq	SRP68-BGKLV19-K562	ENCSR312SRB	SRP68	K562	Released	ENCSR661HEL	shRNA	KD% = 68.9,47.2
knockdown followed by RNA-seq	SRP68-BGHLV17-HepG2	ENCSR167JPY	SRP68	HepG2	Released	ENCSR856ZRV	shRNA	KD% = 79.2,78.1
knockdown followed by RNA-seq	SRP68-BG293LV04-WT293		SRP68	293T	Released		shRNA	KD% = ,
knockdown followed by RNA-seq	SRP68-BG293LV06-WT293		SRP68	293T	Released		shRNA	KD% = ,

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SRP68	ENCAB434DUK	A303-955A	1		Released, ENCODE3	Released, ENCODE3	BGHLV17-29, Released, ENCODE3	BGKLV19-51, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
SRP68	K562	shRNA	ENCSR312SRB	ENCSR661HEL	SRP68_BGKLV19_51B,SRP68_BGKLV19_52B	NT_BGKLV19_1B,NT_BGKLV19_2B	68.9,47.2	Released	ENCODE3
SRP68	HepG2	shRNA			BGHLV16-53,BGHLV16-54	BGHLV16-1,BGHLV16-2		NotSatisfied	ENCODE3
SRP68	HepG2	shRNA	ENCSR167JPY	ENCSR856ZRV	SRP68_BGHLV17_29,SRP68_BGHLV17_30	NT_BGHLV17_63,NT_BGHLV17_64	79.2,78.1	Released	ENCODE3
SRP68	293T	shRNA			BG293LV01-65,BG293LV01-66	BG293LV01-1,BG293LV01-2		NotSatisfied	ENCORE2
SRP68	293T	shRNA			SRP68-BG293LV04-77,SRP68-BG293LV04-78	NT-BG293LV04-1,NT-BG293LV04-2	,	Released	ENCORE2
SRP68	293T	shRNA			BG293LV04-79,BG293LV04-80	BG293LV04-1,BG293LV04-2		NotSatisfied	ENCORE2
SRP68	293T	shRNA			SRP68-BG293LV06-53,SRP68-BG293LV06-54	NT-BG293LV06-1,NT-BG293LV06-2	,	Released	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

SRP68: Click to RBP Image Database

Cytoplasm

Compartment/Organelle

Golgi

Cytosolic

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SRP68	Product_ID: A303-955A Lot_ID: 1 Source: Bethyl Labs Target Name: SRP68-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SRP68 is not avaliable on ENCORE database.

Proteins bound to RNA

SRP68 RNA is bound by 21 proteins.

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eCLIP assay for SRP68 is not avaliable on ENCORE database.

21 proteins are bound to SRP68 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	74053443	74053527	-	5'-UTR,CDS,intron-Distal,intron-Proximal	4.35268	22.44460	HepG2	PRPF8
chr17	74039834	74039896	-	intron-Distal,intron-Proximal	5.77957	21.77166	K562	AQR
chr17	74037060	74037098	-	intron-Distal,intron-Proximal	6.34223	19.37666	HepG2	SF3B4
chr17	74037098	74037109	-	intron-Distal,intron-Proximal	6.24315	17.99892	HepG2	SF3B4
chr17	74041321	74041404	-	3'-UTR,CDS,intron-Distal,intron-Proximal	6.05630	14.22378	HepG2	PRPF8
chr17	74068387	74068510	-	5'-UTR,CDS,intron-Distal	4.07547	13.16675	HepG2	GRWD1
chr17	74039896	74039910	-	intron-Distal,intron-Proximal	6.06086	12.46873	K562	AQR
chr17	74042069	74042127	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.99873	11.76457	HepG2	PRPF8
chr17	74053536	74053625	-	5'-UTR,CDS,intron-Distal,intron-Proximal	5.35544	10.59349	HepG2	G3BP1
chr17	74036938	74037003	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.60388	9.78963	HepG2	PRPF8
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 78 entries

eCLIP assay for SRP68 is not avaliable on ENCORE database.

Diffrential Expression

945 differentially expressed genes after Knockdown/Knockout SRP68 protein.

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73 RBPs can affect the levels of SRP68.

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945 differentially expressed genes after Knockdown/Knockout SRP68 protein :

Only display 100 entries as example. Please click "View All" button to see all 945 entries.

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Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TNS1	ENSG00000079308.12	2290.42630	940.23490	1.28440	23.17300	19.50860	HepG2	SRP68
KRT23	ENSG00000108244.12	267.29270	736.14560	-1.46160	19.89880	16.38040	HepG2	SRP68
C5	ENSG00000106804.6	14567.04630	6898.39190	1.07830	17.98040	14.61700	HepG2	SRP68
CYP24A1	ENSG00000019186.5	277.21980	686.09550	-1.30740	16.05040	12.83310	HepG2	SRP68
HAL	ENSG00000084110.6	477.07900	170.67180	1.48290	14.71660	11.60850	HepG2	SRP68
SERPIND1	ENSG00000099937.6	11594.21260	6714.68460	0.78790	12.20050	9.26850	HepG2	SRP68
VCL	ENSG00000035403.12	553.82560	1070.21100	-0.95040	11.41200	8.53990	HepG2	SRP68
AFP	ENSG00000081051.3	149319.78520	92544.43650	0.69010	10.87830	8.08310	HepG2	SRP68
KIAA1199	ENSG00000103888.11	856.33360	1568.45020	-0.87310	10.73980	7.95610	HepG2	SRP68
CP	ENSG00000047457.9	26555.16620	16672.60750	0.67140	10.63270	7.87130	HepG2	SRP68
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

73 RBPs can affect the gene expression of SRP68 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SRP68	ENSG00000167881.10	1866.24370	3992.45160	-1.09710	52.17070	50.18630	HepG2	ETF1
SRP68	ENSG00000167881.10	912.24180	2239.11850	-1.29540	24.99070	21.22930	HepG2	SRP68
SRP68	ENSG00000167881.10	1958.32760	2976.44660	-0.60400	16.09270	14.84590	HepG2	SF3B4
SRP68	ENSG00000167881.10	4448.38150	3106.81350	0.51770	15.48980	14.56520	HepG2	SRSF1
SRP68	ENSG00000167881.10	862.30130	1752.51400	-1.02320	18.00560	13.93510	K562	SRP68
SRP68	ENSG00000167881.10	3202.99730	1958.07540	0.70990	14.11260	12.51160	K562	SRSF1
SRP68	ENSG00000167881.10	2795.84740	3768.25080	-0.43060	12.41990	11.35460	HepG2	PUM1
SRP68	ENSG00000167881.10	2953.04380	3985.93190	-0.43270	11.37790	10.26150	HepG2	SUCLG1
SRP68	ENSG00000167881.10	2245.81000	3549.65550	-0.66040	11.32080	10.22540	HepG2	PUF60
SRP68	ENSG00000167881.10	1255.40510	2039.13900	-0.69980	10.78380	9.63480	HepG2	HNRNPA1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 82 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SRP68 is not available on ENCORE database.

6 RBPs can affect the splicing of SRP68 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74057190	74057300	74060056	74060252	-0.06300	0.00000	0.00008	excluded	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74036983	74037220			74036983	74037059	74039909	74040102	0.06100	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74057572	74057680			74057572	74057655	74060056	74060252	0.09700	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74039909	74040102			74039909	74040039	74041372	74041597	0.08200	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74041372	74041597			74041372	74041467	74042118	74042352	0.08300	0.00000	0.00000	longer	K562	AQR
A3SS	SRP68	ENSG00000167881.10	chr17	-	74063297	74063447			74063297	74063411	74066458	74066525	0.09100	0.00000	0.00000	longer	K562	AQR
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74057190	74057300	74060056	74060252	-0.10400	0.00003	0.00102	excluded	K562	SF3B4
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74053483	74053624	74060056	74060252	-0.37800	0.00005	0.00100	excluded	HepG2	U2AF2
SE	SRP68	ENSG00000167881.10	chr17	-	74057572	74057655			74057190	74057300	74060056	74060252	-0.05500	0.00073	0.03664	excluded	HepG2	SF3B4
MXE	SRP68	ENSG00000167881.10	chr17	-	74036983	74037059	74039909	74040039	74036499	74036555	74041372	74041467	-0.14600	0.00075	0.06979	2included	K562	EWSR1

Showing 1 to 10 of 12 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SRP68

General Information

Functions

Localization(RBPImage: SRP68)

Domains (AlphaFold: SRP68)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SRP68 is not avaliable on ENCORE database.

21 proteins are bound to SRP68 RNA:

eCLIP assay for SRP68 is not avaliable on ENCORE database.

Diffrential Expression

945 differentially expressed genes after Knockdown/Knockout SRP68 protein :

73 RBPs can affect the gene expression of SRP68 :

The Knockdown/knockout RNA-Seq assay for SRP68 is not available on ENCORE database.

6 RBPs can affect the splicing of SRP68 :

The Knockdown/knockout RNA-Seq assay for SRP68 is not avaliable on ENCORE database.