PCSK9

General Information

Gene Name : PCSK9
Gene ID : ENSG00000169174.10
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: PCSK9)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	PCSK9	ENSG00000169174.10	0.00	0.00	0.00	ENCSR000AEF
HepG2	PCSK9	ENSG00000169174.10	53.73	18.42	36.08	ENCSR985KAT
K562	PCSK9	ENSG00000169174.10	23.42	17.27	20.34	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for PCSK9 is not avaliable on ENCORE database.

Proteins bound to RNA

PCSK9 RNA is bound by 37 proteins.

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eCLIP assay for PCSK9 is not avaliable on ENCORE database.

37 proteins are bound to PCSK9 RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr1	55505236	55505331	+	5'-UTR	4.08901	400.00000	HepG2	DDX3X
chr1	55505482	55505621	+	5'-UTR,CDS	4.19447	63.26155	HepG2	RPS3
chr1	55529645	55529763	+	3'-UTR	5.82080	61.74737	HepG2	UPF1
chr1	55529493	55529566	+	3'-UTR	5.86162	60.87538	HepG2	UPF1
chr1	55529374	55529427	+	3'-UTR	5.62767	53.27809	HepG2	UPF1
chr1	55512222	55512320	+	CDS,intron-Distal,intron-Proximal	5.81282	53.12836	K562	SND1
chr1	55505621	55505694	+	CDS	4.82223	52.33409	HepG2	RPS3
chr1	55529782	55529856	+	3'-UTR	7.38380	46.75927	HepG2	UPF1
chr1	55529588	55529645	+	3'-UTR	5.25756	46.09771	HepG2	UPF1
chr1	55517957	55518063	+	3'-UTR,CDS	4.45318	44.24052	HepG2	RPS3
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 232 entries

eCLIP assay for PCSK9 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for PCSK9 is not available on ENCORE database.
186 RBPs can affect the levels of PCSK9.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for PCSK9 is not available on ENCORE database.

186 RBPs can affect the gene expression of PCSK9 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
PCSK9	ENSG00000169174.9	11408.48170	3154.10770	1.85470	262.96310	258.58400	HepG2	SLBP
PCSK9	ENSG00000169174.9	1383.27240	11674.44660	-3.07720	220.00230	216.95480	HepG2	SRSF9
PCSK9	ENSG00000169174.9	1897.64880	14350.27880	-2.91880	199.59780	197.28310	HepG2	SRSF1
PCSK9	ENSG00000169174.9	2354.83800	14695.98790	-2.64170	167.64250	165.16280	HepG2	NELFE
PCSK9	ENSG00000169174.9	2546.47280	13204.76220	-2.37450	136.23500	133.90650	HepG2	PTBP1
PCSK9	ENSG00000169174.9	1229.54710	3491.85330	-1.50590	119.01490	116.45640	HepG2	PUM1
PCSK9	ENSG00000169174.9	826.09530	5016.27660	-2.60220	114.30850	110.81760	HepG2	RBM15
PCSK9	ENSG00000169174.9	1250.28650	15148.23250	-3.59880	109.01690	106.54700	HepG2	AKAP1
PCSK9	ENSG00000169174.9	4661.02350	1210.64710	1.94480	106.83250	102.95090	HepG2	PPIL4
PCSK9	ENSG00000169174.9	4357.09990	1330.70770	1.71110	99.67260	96.93350	HepG2	TRIM56
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 237 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for PCSK9 is not available on ENCORE database.

14 RBPs can affect the splicing of PCSK9 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	PCSK9	ENSG00000169174.9	chr1	+	55512195	55512319			55505430	55505717	55517950	55518084	-0.13500	0.00000	0.00054	excluded	K562	HNRNPL
MXE	PCSK9	ENSG00000169174.9	chr1	+	55509515	55509707	55512195	55512319	55505220	55505717	55517950	55518084	0.13300	0.00000	0.00000	1included	HepG2	NOLC1
MXE	PCSK9	ENSG00000169174.9	chr1	+	55509515	55509707	55512195	55512319	55505220	55505717	55517950	55518084	0.13500	0.00000	0.00000	1included	HepG2	NOL12
MXE	PCSK9	ENSG00000169174.9	chr1	+	55509515	55509707	55512195	55512319	55505220	55505717	55517950	55518084	0.14500	0.00000	0.00000	1included	HepG2	HNRNPL
SE	PCSK9	ENSG00000169174.9	chr1	+	55512195	55512319			55505220	55505717	55517950	55518084	-0.11100	0.00003	0.02055	excluded	K562	XRN2
SE	PCSK9	ENSG00000169174.9	chr1	+	55509515	55509707			55505220	55505717	55517950	55518084	-0.34900	0.00003	0.00629	excluded	K562	XRCC6
MXE	PCSK9	ENSG00000169174.9	chr1	+	55509515	55509707	55512195	55512319	55505220	55505717	55517950	55518084	0.14400	0.00010	0.00575	1included	HepG2	NCBP2
SE	PCSK9	ENSG00000169174.9	chr1	+	55509515	55509707			55505430	55505717	55517950	55518084	-0.11500	0.00018	0.00608	excluded	HepG2	SRSF1
MXE	PCSK9	ENSG00000169174.9	chr1	+	55524171	55524320	55525158	55525336	55523708	55523882	55527047	55527229	-0.14800	0.00026	0.01315	2included	HepG2	PTBP1
MXE	PCSK9	ENSG00000169174.9	chr1	+	55509515	55509707	55512195	55512319	55505220	55505717	55517950	55518084	0.11300	0.00028	0.05920	1included	HepG2	IGF2BP1

Showing 1 to 10 of 16 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

PCSK9

General Information

Functions

Localization

Domains (AlphaFold: PCSK9)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for PCSK9 is not avaliable on ENCORE database.

37 proteins are bound to PCSK9 RNA:

eCLIP assay for PCSK9 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for PCSK9 is not available on ENCORE database.

186 RBPs can affect the gene expression of PCSK9 :

The Knockdown/knockout RNA-Seq assay for PCSK9 is not available on ENCORE database.

14 RBPs can affect the splicing of PCSK9 :

The Knockdown/knockout RNA-Seq assay for PCSK9 is not avaliable on ENCORE database.