USP4

General Information

Gene Name       : USP4
Gene ID             : ENSG00000114316.12
Essential Gene : No

Functions

Localization

Domains (AlphaFold: USP4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878USP4ENSG00000114316.1251.0748.0749.57ENCSR000AEF
HepG2USP4ENSG00000114316.1218.8218.9418.88ENCSR985KAT
K562USP4ENSG00000114316.1217.8218.9818.40ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for USP4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • USP4 RNA is bound by 11 proteins.  







eCLIP assay for USP4 is not avaliable on ENCORE database.





11 proteins are bound to USP4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr34931534749315488-3'-UTR,intron-Distal,intron-Proximal3.816063.15006K562RBM15
chr34937735449377483-5'-UTR,CDS,intron-Distal,intron-Proximal3.940874.11309HepG2SRSF1
chr34933810749338125-CDS,intron-Distal,intron-Proximal4.054103.38968HepG2BCLAF1
chr34933525249335308-CDS,intron-Distal,intron-Proximal4.784665.50285K562PRPF8
chr34937291549373017-CDS,intron-Distal3.436075.12958K562UCHL5
chr34937286349372921-CDS,intron-Distal,intron-Proximal6.0804810.09256HepG2PRPF8
chr34936207749362171-CDS,intron-Distal,intron-Proximal5.2766414.79448HepG2PRPF8
chr34937282049372931-CDS,intron-Distal,intron-Proximal3.646214.23459K562PRPF8
chr34933789849337936-CDS,intron-Distal,intron-Proximal3.918753.44423K562BUD13
chr34933599049336063-CDS,intron-Distal3.834644.41267HepG2PPIG
chr34932356549323604-CDS,intron-Distal3.372823.28366HepG2BCLAF1
chr34932189549321937-CDS,intron-Distal,intron-Proximal3.834643.32039HepG2PPIG
chr34936238849362445-CDS,intron-Distal3.551124.52024HepG2PPIG
chr34933526249335332-CDS,intron-Distal,intron-Proximal4.610565.93840HepG2PRPF8
chr34933528749335306-CDS,intron-Distal,intron-Proximal5.591629.41643K562AQR
chr34933809449338125-CDS,intron-Distal,intron-Proximal4.147446.36347HepG2PPIG
chr34937292449373026-CDS,intron-Distal3.383984.41784HepG2GRWD1
chr34937291549373024-CDS,intron-Distal3.349926.60490HepG2BCLAF1
chr34936315149363188-CDS,intron-Distal,intron-Proximal4.013063.59941K562UCHL5
chr34933981549339836-CDS,intron-Distal,intron-Proximal3.580343.87469HepG2BCLAF1
chr34937735649377440-CDS,intron-Distal3.755785.08388K562UCHL5
chr34933984549339908-CDS,intron-Distal,intron-Proximal3.034623.60157HepG2GRWD1
chr34933981649339896-CDS,intron-Distal,intron-Proximal3.958497.83545HepG2PPIG
chr34932199649322017-CDS,intron-Distal3.310053.28366HepG2BCLAF1
chr34932362649323746-CDS,intron-Distal3.176894.68592HepG2PPIG
chr34932223149322288-CDS,intron-Distal,intron-Proximal3.992045.93840HepG2PRPF8
chr34931817649318204-CDS,intron-Distal,intron-Proximal4.372824.04372HepG2BCLAF1
chr34937735649377441-CDS,intron-Distal3.319344.27261HepG2GRWD1
chr34934846749348564-intron-Distal4.484244.77477HepG2RBFOX2
chr34935582449355918-intron-Distal4.235954.27476HepG2AQR
chr34936207149362135-intron-Distal,intron-Proximal5.292566.22530K562AQR
chr34936204749362118-intron-Distal,intron-Proximal4.059073.54514K562TIA1
chr34933525649335287-intron-Distal,intron-Proximal5.7785610.48996K562AQR
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for USP4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for USP4 is not available on ENCORE database.

  • 46 RBPs can affect the levels of USP4.  








The Knockdown/knockout RNA-Seq assay for USP4 is not available on ENCORE database.





46 RBPs can affect the gene expression of USP4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
USP4ENSG00000114316.8792.80530574.839500.463705.530504.72970HepG2ACO1
USP4ENSG00000114316.8877.92500641.105000.453402.635602.11570HepG2AKAP1
USP4ENSG00000114316.8580.38160801.44380-0.465602.568801.63460HepG2CCAR1
USP4ENSG00000114316.8603.52150355.914900.761804.356003.39260HepG2CNOT7
USP4ENSG00000114316.81040.83520738.018900.495905.096004.27170HepG2CELF1
USP4ENSG00000114316.8554.43080793.28140-0.516802.426001.72570HepG2DAZAP1
USP4ENSG00000114316.8505.95650673.66960-0.413002.017401.35430HepG2FIP1L1
USP4ENSG00000114316.8363.32830488.51300-0.427102.388301.78440HepG2HNRNPA1
USP4ENSG00000114316.8582.39880737.99460-0.341602.712602.00240HepG2HNRNPF
USP4ENSG00000114316.8344.88170486.70400-0.496902.846402.20870HepG2HNRNPLL
USP4ENSG00000114316.8439.97160551.38370-0.325602.605001.89130HepG2ILF2
USP4ENSG00000114316.8390.14260515.19810-0.401103.077702.44330HepG2PCBP1
USP4ENSG00000114316.8303.36910481.45460-0.666306.465405.37430HepG2PPIL4
USP4ENSG00000114316.8687.88610524.233300.391903.314402.72640HepG2PTBP1
USP4ENSG00000114316.8428.86790750.98270-0.808204.452403.71700HepG2PUF60
USP4ENSG00000114316.8655.88200890.46950-0.441104.481103.86350HepG2RBM22
USP4ENSG00000114316.8952.92210596.196600.676504.575103.69780HepG2SF3A3
USP4ENSG00000114316.8805.116201005.74180-0.321003.524202.97990HepG2SRFBP1
USP4ENSG00000114316.8934.39930569.691300.7138011.3475010.53070HepG2SRSF1
USP4ENSG00000114316.8655.65470873.20320-0.413404.783804.14580HepG2SSB
USP4ENSG00000114316.8411.23500524.47410-0.350902.254401.79350HepG2TIAL1
USP4ENSG00000114316.8328.56210493.53200-0.587003.855703.00810HepG2XRN2
USP4ENSG00000114316.8831.68780998.96060-0.264402.050301.54790K562AGGF1
USP4ENSG00000114316.81338.228701039.478800.364403.217402.51190K562AKAP8L
USP4ENSG00000114316.8879.342901210.29770-0.460903.079202.46690K562AQR
USP4ENSG00000114316.81335.062001090.691800.291603.017902.06520K562ATP5C1
USP4ENSG00000114316.8261.74040424.03570-0.696004.988503.47800K562CCAR1
USP4ENSG00000114316.81406.758001118.459400.330803.944902.87490K562DKC1
USP4ENSG00000114316.8524.97620679.96790-0.373202.215801.39900K562EFTUD2
USP4ENSG00000114316.8658.80370817.35890-0.311102.577601.87890K562EIF2S2
USP4ENSG00000114316.81373.136901602.41340-0.222802.205801.36210K562EIF4G2
USP4ENSG00000114316.8578.76420743.11140-0.360602.264201.49680K562FIP1L1
USP4ENSG00000114316.8618.91060775.50370-0.325402.599602.00910K562FXR1
USP4ENSG00000114316.8752.517301089.15330-0.533405.542204.46840K562GRSF1
USP4ENSG00000114316.8785.368801007.44160-0.359302.430801.68130K562HSPD1
USP4ENSG00000114316.81341.760801103.094100.282502.302501.55880K562KIF1C
USP4ENSG00000114316.8713.17070877.13160-0.298502.110301.37160K562MAGOH
USP4ENSG00000114316.8735.77670923.25130-0.327503.117702.25950K562MTPAP
USP4ENSG00000114316.8768.66490990.47180-0.365802.237901.49100K562PCBP3
USP4ENSG00000114316.8470.92520661.68670-0.490703.229102.41850K562PRPF8
USP4ENSG00000114316.81049.323801748.30550-0.7365010.993109.35150K562PUF60
USP4ENSG00000114316.81522.894901859.94140-0.288403.073901.94870K562PUM1
USP4ENSG00000114316.81337.312801822.02290-0.446207.123505.55790K562PUM2
USP4ENSG00000114316.81473.987001030.770400.515904.758704.07090K562PUS1
USP4ENSG00000114316.81324.710201004.419400.399204.764604.00690K562RBM15
USP4ENSG00000114316.8652.77230817.02140-0.323802.101401.37290K562RBM22
USP4ENSG00000114316.8403.97550674.01310-0.738505.775804.59040K562RPS19
USP4ENSG00000114316.8573.26400740.09190-0.368502.458001.47450K562SRSF4
USP4ENSG00000114316.8595.59100762.00960-0.355502.334401.57990K562SYNCRIP
USP4ENSG00000114316.8659.44950845.49390-0.358502.321701.67080K562TARDBP
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for USP4 is not available on ENCORE database.





15 RBPs can affect the splicing of USP4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEUSP4ENSG00000114316.8chr3-4934894649349087493480524934817049362134493621960.262000.000080.00252includedK562SRSF1
SEUSP4ENSG00000114316.8chr3-493162464931633549315590493158844931817649318280-0.184000.001780.03343excludedK562SF3B4
SEUSP4ENSG00000114316.8chr3-4931624649316335493152634931588449318176493182800.163000.000320.02604includedHepG2AKAP1
SEUSP4ENSG00000114316.8chr3-4935574149355849493489464934908749362134493621960.514000.000060.01879includedHepG2UCHL5
SEUSP4ENSG00000114316.8chr3-493489464934908749348052493481704936213449362196-0.191000.000820.01449excludedK562PUS1
SEUSP4ENSG00000114316.8chr3-4934894649349087493480524934817049362134493621960.272000.001420.06673includedHepG2PTBP1
SEUSP4ENSG00000114316.8chr3-4935574149355947493489464934908749362134493621960.193000.001300.02770includedK562U2AF1
SEUSP4ENSG00000114316.8chr3-4934894649349087493480524934817049362134493621960.233000.004360.07970includedHepG2SRSF1
SEUSP4ENSG00000114316.8chr3-493489464934908749348052493481704936213449362196-0.196000.000670.02521excludedK562UTP18
SEUSP4ENSG00000114316.8chr3-493489464934908749348052493481704936213449362196-0.336000.000370.01731excludedK562TARDBP
SEUSP4ENSG00000114316.8chr3-493489464934908749348052493481704936213449362196-0.247000.000520.02306excludedK562HNRNPU
SEUSP4ENSG00000114316.8chr3-493162464931633549315590493158844931817649318280-0.171000.001700.04071excludedK562RBM15
SEUSP4ENSG00000114316.8chr3-4937245249372540493651184936524949372901493730290.053000.004930.06861includedK562HNRNPC
A3SSUSP4ENSG00000114316.8chr3-4934894649349159493489464934908749362134493621960.082000.006010.03398longerK562AQR
A3SSUSP4ENSG00000114316.8chr3-4932228149322457493222814932235249323530493237580.055000.005610.03201longerK562AQR
A3SSUSP4ENSG00000114316.8chr3-4936232649362519493623264936247249363151493632780.168000.000000.00000longerK562AQR
A3SSUSP4ENSG00000114316.8chr3-4933981649340019493398164933997549343147493433430.239000.000000.00000longerK562AQR
A3SSUSP4ENSG00000114316.8chr3-4934314749343356493431474934332149348052493481700.128000.000020.00020longerK562AQR
A3SSUSP4ENSG00000114316.8chr3-4931624649316440493162464931633549318176493182800.106000.000000.00004longerK562AQR
A3SSUSP4ENSG00000114316.8chr3-493398164933997549339816493398964934314749343343-0.056000.015650.07749shorterK562AQR
A5SSUSP4ENSG00000114316.8chr3-493729014937302949372990493730294936511849365249-0.133000.000720.06004shorterK562AGGF1
MXEUSP4ENSG00000114316.8chr3-49348052493481704935574149355938493431474934332149362134493621960.064000.007500.050091includedK562AQR
MXEUSP4ENSG00000114316.8chr3-49348052493481704935574149355938493431474934332149362134493621960.051000.009740.090811includedK562U2AF2
MXEUSP4ENSG00000114316.8chr3-49348052493481704935574149355868493431474934332149362134493621960.064000.004280.049361includedK562U2AF2
MXEUSP4ENSG00000114316.8chr3-49348052493481704935574149355784493431474934332149362134493621960.086000.004910.054561includedK562U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for USP4 is not avaliable on ENCORE database.