SPPL3

General Information

Gene Name       : SPPL3
Gene ID             : ENSG00000157837.15
Essential Gene : No

Functions

Localization

Domains (AlphaFold: SPPL3)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878SPPL3ENSG00000157837.1530.7730.9430.86ENCSR000AEF
HepG2SPPL3ENSG00000157837.1521.7425.0523.39ENCSR985KAT
K562SPPL3ENSG00000157837.1520.6421.6021.12ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for SPPL3 is not avaliable on ENCORE database.



Proteins bound to RNA
  • SPPL3 RNA is bound by 24 proteins.  







eCLIP assay for SPPL3 is not avaliable on ENCORE database.





24 proteins are bound to SPPL3 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr12121201621121201668-3'-UTR,intron-Distal5.8642711.95680K562PUM2
chr12121248634121248699-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.578635.45334K562U2AF2
chr12121201707121201794-3'-UTR,intron-Distal4.5525617.08117K562PUM2
chr12121248649121248702-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.065483.60286K562U2AF1
chr12121341679121341814-5'-UTR,intron-Distal5.1071437.01428HepG2DDX3X
chr12121341944121341980-5'-UTR,intron-Distal4.568964.82934K562RBM15
chr12121341212121341280-5'-UTR,intron-Distal,intron-Proximal4.719366.94957HepG2CSTF2T
chr12121341924121341944-5'-UTR,intron-Distal3.571163.34231K562RBM15
chr12121342030121342078-5'-UTR,intron-Distal4.8565211.01276HepG2DDX3X
chr12121341925121341958-5'-UTR,intron-Distal3.837754.85687K562DROSHA
chr12121341814121341956-5'-UTR,intron-Distal5.3102859.39729HepG2DDX3X
chr12121205275121205317-CDS,intron-Distal3.6057310.74873K562YBX3
chr12121205317121205356-CDS,intron-Distal5.6440313.44647K562YBX3
chr12121205251121205360-CDS,intron-Distal3.843673.82998HepG2YBX3
chr12121341475121341516-intron-Distal3.024573.28077K562EFTUD2
chr12121267960121268089-intron-Distal4.7541314.31105K562ILF3
chr12121269174121269266-intron-Distal4.680636.93487K562ILF3
chr12121341333121341418-intron-Distal,intron-Proximal3.390807.78496HepG2FAM120A
chr12121341310121341437-intron-Distal,intron-Proximal5.9945617.16577K562CSTF2T
chr12121341376121341531-intron-Distal,intron-Proximal5.8853614.85235K562GTF2F1
chr12121341031121341095-intron-Distal3.665254.91684K562CSTF2T
chr12121268799121268898-intron-Distal4.249168.35855K562ILF3
chr12121213272121213337-intron-Distal3.996283.30440HepG2QKI
chr12121341418121341546-intron-Distal3.6283510.77856HepG2FAM120A
chr12121269048121269107-intron-Distal3.438394.25110K562CSTF2T
chr12121341475121341541-intron-Distal4.979697.66618HepG2PRPF4
chr12121341565121341607-intron-Distal4.130054.48935K562CSTF2T
chr12121269058121269115-intron-Distal4.482795.50179K562ILF3
chr12121341329121341439-intron-Distal,intron-Proximal3.220388.44346HepG2RBFOX2
chr12121341326121341458-intron-Distal,intron-Proximal3.179847.82275HepG2CSTF2T
chr12121341320121341386-intron-Distal,intron-Proximal3.172144.01458K562RBFOX2
chr12121337239121337323-intron-Distal4.198488.08894HepG2QKI
chr12121341477121341523-intron-Distal3.406965.34973K562GEMIN5
chr12121341437121341537-intron-Distal4.303659.51280K562CSTF2T
chr12121341559121341621-intron-Distal4.434474.77477HepG2RBFOX2
chr12121315757121315825-intron-Distal3.007373.42293HepG2HNRNPC
chr12121341557121341624-intron-Distal3.244764.36876HepG2FAM120A
chr12121341022121341118-intron-Distal3.816673.21433HepG2TAF15
chr12121341482121341528-intron-Distal4.214184.13073HepG2GTF2F1
chr12121296368121296499-intron-Distal4.161363.74583HepG2PTBP1
chr12121323898121323936-intron-Distal3.183463.25288HepG2HNRNPC
chr12121294829121294895-intron-Distal4.639244.66737HepG2MATR3
chr12121268640121268717-intron-Distal3.664105.12237K562CSTF2T
chr12121268029121268113-intron-Distal4.812894.42259HepG2DDX59
chr12121268853121268908-intron-Distal3.393093.17504K562CSTF2T
chr12121341333121341452-intron-Distal,intron-Proximal3.7707016.32592K562DROSHA
chr12121313708121313796-intron-Distal3.830004.52298HepG2QKI
chr12121314571121314626-intron-Distal3.991923.46495K562TARDBP
chr12121268020121268109-intron-Distal6.1158413.95507HepG2PCBP2
chr12121341340121341475-intron-Distal,intron-Proximal5.5062812.62377HepG2PRPF4
chr12121267964121268063-intron-Distal4.928527.75663K562CSTF2T
chr12121341413121341475-intron-Distal3.746975.85206K562EFTUD2
chr12121269403121269444-intron-Distal3.789093.14687K562CSTF2T
chr12121341463121341498-intron-Distal4.215195.59743K562DROSHA
chr12121338331121338396-intron-Distal4.003643.43813HepG2HNRNPC
chr12121341556121341623-intron-Distal3.189215.21772HepG2CSTF2T
chr12121313365121313429-intron-Distal4.036604.25105HepG2HNRNPC
chr12121294739121294791-intron-Distal3.868963.24322HepG2MATR3
chr12121340527121340592-intron-Distal4.039213.37414K562CSTF2T
chr12121268786121268849-intron-Distal4.698816.92157K562CSTF2T
chr12121229028121229146-intron-Distal3.930233.89294K562KHSRP
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for SPPL3 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for SPPL3 is not available on ENCORE database.

  • 37 RBPs can affect the levels of SPPL3.  








The Knockdown/knockout RNA-Seq assay for SPPL3 is not available on ENCORE database.





37 RBPs can affect the gene expression of SPPL3 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
SPPL3ENSG00000157837.11869.39450469.780500.8879011.2694010.16870HepG2BOP1
SPPL3ENSG00000157837.11955.91440562.297200.765404.985303.95320HepG2CNOT7
SPPL3ENSG00000157837.11557.90390431.286500.371302.083401.47680HepG2CPSF6
SPPL3ENSG00000157837.11571.30600789.45260-0.466604.867004.05820HepG2CELF1
SPPL3ENSG00000157837.11705.11390557.845500.337903.301402.39870HepG2DDX19B
SPPL3ENSG00000157837.11642.37900509.527300.334201.930901.35150HepG2DDX21
SPPL3ENSG00000157837.11667.55220879.49320-0.397802.213101.65460HepG2DDX6
SPPL3ENSG00000157837.11693.51010837.44620-0.272102.202801.44150HepG2EIF4G1
SPPL3ENSG00000157837.111338.739601084.609100.303603.106102.47510HepG2ETF1
SPPL3ENSG00000157837.11888.78190677.135000.392302.080101.40850HepG2FIP1L1
SPPL3ENSG00000157837.11679.97280885.67880-0.381302.553701.88170HepG2HNRNPK
SPPL3ENSG00000157837.11640.31210466.568900.456602.840902.20410HepG2HNRNPLL
SPPL3ENSG00000157837.111184.61740838.686600.498103.235702.33560HepG2LARP4
SPPL3ENSG00000157837.11582.52520738.08970-0.341502.544601.71910HepG2RBM15
SPPL3ENSG00000157837.11433.56670561.54640-0.373203.046502.37680HepG2SAFB2
SPPL3ENSG00000157837.111133.88820756.713200.583402.690502.02620HepG2SF3A3
SPPL3ENSG00000157837.11628.66400461.814900.444902.909302.18500HepG2SF3B1
SPPL3ENSG00000157837.11708.89780513.848700.464102.077201.40440HepG2SNRNP70
SPPL3ENSG00000157837.11735.03870496.903600.564803.491302.35250HepG2SRSF3
SPPL3ENSG00000157837.11661.75880839.42550-0.343102.863502.29360HepG2TAF15
SPPL3ENSG00000157837.11633.17220454.742800.477403.262302.48170HepG2TARDBP
SPPL3ENSG00000157837.11432.21630618.19540-0.516305.448704.70850HepG2TRIM56
SPPL3ENSG00000157837.11398.85890671.08910-0.7506010.975109.75320HepG2UPF1
SPPL3ENSG00000157837.11841.52220647.909900.377103.810303.12500HepG2UTP3
SPPL3ENSG00000157837.11653.17280521.985200.323402.444701.90590K562AGGF1
SPPL3ENSG00000157837.11717.80840543.150200.402102.860002.19600K562AKAP8L
SPPL3ENSG00000157837.111471.98870719.729201.0321016.7768015.49330K562AQR
SPPL3ENSG00000157837.11816.61980623.797800.388503.273001.97700K562CCDC124
SPPL3ENSG00000157837.111030.60560825.074300.320803.010102.03090K562EIF4G2
SPPL3ENSG00000157837.11545.32540442.499800.301301.944101.41930K562FXR1
SPPL3ENSG00000157837.11776.86200576.414700.430503.643802.68050K562KIF1C
SPPL3ENSG00000157837.11892.53680645.730600.466904.196803.03970K562MBNL1
SPPL3ENSG00000157837.111229.15200900.220600.449204.017703.03890K562PUF60
SPPL3ENSG00000157837.111189.48010957.510100.312902.579201.55030K562PUM1
SPPL3ENSG00000157837.11693.02080538.649200.363502.182601.68890K562PUS1
SPPL3ENSG00000157837.11648.42420524.838100.305002.052901.52800K562RBM15
SPPL3ENSG00000157837.11587.56050354.082800.730602.597301.42340K562SNRNP200
SPPL3ENSG00000157837.11695.22210504.270700.463202.888801.65790K562UTP3
SPPL3ENSG00000157837.111000.56840810.753900.303402.101201.35940K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for SPPL3 is not available on ENCORE database.





3 RBPs can affect the splicing of SPPL3 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SESPPL3ENSG00000157837.11chr12-121222276121222396121221476121221555121229271121229360-0.070000.000890.01858excludedHepG2U2AF1
SESPPL3ENSG00000157837.11chr12-121222276121222396121221476121221555121229271121229360-0.103000.000010.00027excludedHepG2U2AF2
A3SSSPPL3ENSG00000157837.11chr12-1212204571212206491212204571212205701212214761212216620.327000.000000.00000longerK562AQR
A3SSSPPL3ENSG00000157837.11chr12-1212052361212054731212052361212053961212061271212063370.066000.000220.00181longerK562AQR
A3SSSPPL3ENSG00000157837.11chr12-1212061271212063371212061271212062911212067551212079400.111000.000070.00066longerK562AQR
A3SSSPPL3ENSG00000157837.11chr12-1212040651212041951212040651212041751212051961212053960.082000.000440.00334longerK562AQR
MXESPPL3ENSG00000157837.11chr12-1212222761212223961212292711212293601212214761212215551212486111212486890.131000.001980.036101includedHepG2U2AF1
MXESPPL3ENSG00000157837.11chr12-1212222761212223961212292711212293601212214761212215551212486111212486890.122000.002540.017761includedHepG2U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for SPPL3 is not avaliable on ENCORE database.