HPS4

General Information

Gene Name       : HPS4
Gene ID             : ENSG00000100099.20
Essential Gene : No

Functions

Localization

Domains (AlphaFold: HPS4)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878HPS4ENSG00000100099.2017.2421.1819.21ENCSR000AEF
HepG2HPS4ENSG00000100099.2018.9621.9020.43ENCSR985KAT
K562HPS4ENSG00000100099.2020.5219.6620.09ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for HPS4 is not avaliable on ENCORE database.



Proteins bound to RNA
  • HPS4 RNA is bound by 16 proteins.  







eCLIP assay for HPS4 is not avaliable on ENCORE database.





16 proteins are bound to HPS4 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr222684830226848373-3'-UTR,intron-Distal3.981033.97409HepG2LSM11
chr222686072926860792-3'-UTR,CDS,intron-Distal4.028596.02363HepG2U2AF2
chr222686052826860583-3'-UTR,CDS,intron-Distal3.999723.16051HepG2PPIG
chr222686150826861596-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.184716.66865HepG2SF3A3
chr222686142126861526-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.648473.99381K562BUD13
chr222686035526860425-3'-UTR,CDS,intron-Distal4.571164.15208K562RBM15
chr222686042526860493-3'-UTR,CDS,intron-Distal3.679844.22460K562RBM15
chr222685389926853966-3'-UTR,CDS,intron-Distal,intron-Proximal4.234826.77156K562AQR
chr222685434026854420-3'-UTR,CDS,intron-Distal,intron-Proximal3.762457.77750HepG2PRPF8
chr222686147826861528-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.435094.65237HepG2U2AF2
chr222686213726862238-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.557326.69747HepG2PRPF8
chr222686217026862238-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.3931610.07103K562U2AF1
chr222686217826862232-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.010135.08732HepG2PPIG
chr222686028026860324-3'-UTR,CDS,intron-Distal4.443145.16052K562RBM15
chr222685988726859960-3'-UTR,CDS,intron-Distal3.249683.73413HepG2PPIG
chr222686217826862237-3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.153244.46214K562U2AF2
chr222686004926860123-3'-UTR,CDS,intron-Distal,intron-Proximal3.080343.71797HepG2BCLAF1
chr222684891526848978-3'-UTR,intron-Distal,intron-Proximal3.054463.79156K562LIN28B
chr222686049526860551-3'-UTR,CDS,intron-Distal4.743866.83406K562RBM15
chr222686050526860582-3'-UTR,CDS,intron-Distal3.204154.62864K562ZNF622
chr222684774826847796-3'-UTR,intron-Distal4.242863.79000HepG2U2AF2
chr222686449826864576-5'-UTR,CDS,intron-Distal,intron-Proximal3.951708.98325HepG2PPIG
chr222686199826862070-5'-UTR,CDS,intron-Distal,intron-Proximal3.436843.66187K562ZNF622
chr222687777126877961-5'-UTR,intron-Distal,intron-Proximal3.261627.39995HepG2BCLAF1
chr222686676926866835-5'-UTR,CDS,intron-Distal,intron-Proximal3.163463.60305HepG2SF3B4
chr222686153426861597-5'-UTR,intron-Distal,intron-Proximal4.390044.50924HepG2SF3B4
chr222686198226862046-5'-UTR,CDS,intron-Distal,intron-Proximal4.903995.68502HepG2PRPF8
chr222686676626866838-5'-UTR,CDS,intron-Distal,intron-Proximal3.284698.18279K562SF3B4
chr222687787626877930-5'-UTR,intron-Distal4.190923.43980K562ZNF622
chr222686166026861775-5'-UTR,intron-Distal3.128308.53603HepG2U2AF2
chr222686452726864624-5'-UTR,CDS,intron-Distal,intron-Proximal4.445568.01338K562AQR
chr222687284526872992-CDS,intron-Distal,intron-Proximal3.411205.37652K562BUD13
chr222687298626873044-CDS,intron-Distal,intron-Proximal3.842093.34184HepG2GRWD1
chr222687290726872969-CDS,intron-Distal,intron-Proximal3.639914.35635K562PRPF8
chr222686885426868922-CDS,intron-Distal,intron-Proximal4.117716.58230HepG2AQR
chr222687523026875241-CDS,intron-Distal,intron-Proximal4.659553.89826HepG2BCLAF1
chr222686885726868929-CDS,intron-Distal,intron-Proximal4.1554818.48497K562AQR
chr222687291026872970-CDS,intron-Distal,intron-Proximal4.1679510.08968K562AQR
chr222686884826868915-CDS,intron-Distal,intron-Proximal3.325886.98138HepG2PRPF8
chr222687294526873097-CDS,intron-Distal,intron-Proximal3.262603.04831K562RBM15
chr222687522826875247-CDS,intron-Distal,intron-Proximal3.515934.41267HepG2PPIG
chr222687305726873103-CDS,intron-Distal,intron-Proximal3.034623.60157HepG2GRWD1
chr222684598526846092-intron-Distal4.401104.42400K562SLTM
chr222686662026866684-intron-Distal,intron-Proximal3.614673.49168K562AQR
chr222685436826854400-intron-Distal,intron-Proximal5.268387.81430K562AQR
chr222686232426862392-intron-Distal,intron-Proximal5.450837.29411HepG2XPO5
chr222687283826872910-intron-Distal,intron-Proximal4.407158.29266K562AQR
chr222685440026854411-intron-Distal,intron-Proximal5.103316.75320K562AQR
chr222686222826862279-intron-Distal,intron-Proximal4.513683.98315HepG2SF3B4
chr222684713126847246-intron-Distal3.479163.84914K562SLTM
chr222686223626862278-intron-Distal,intron-Proximal4.834499.24007HepG2SF3A3
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for HPS4 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for HPS4 is not available on ENCORE database.

  • 54 RBPs can affect the levels of HPS4.  








The Knockdown/knockout RNA-Seq assay for HPS4 is not available on ENCORE database.





54 RBPs can affect the gene expression of HPS4 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
HPS4ENSG00000100099.16671.035601181.42610-0.816107.947807.09780HepG2AKAP1
HPS4ENSG00000100099.161299.010401588.35100-0.290103.426802.67750HepG2AUH
HPS4ENSG00000100099.16668.43460825.40260-0.304302.132601.44940HepG2CALR
HPS4ENSG00000100099.161056.993701277.07030-0.272902.542501.92110HepG2CELF1
HPS4ENSG00000100099.161081.38100784.179700.463504.059503.25240HepG2DDX21
HPS4ENSG00000100099.16667.89720899.60700-0.429703.060402.25380HepG2DDX55
HPS4ENSG00000100099.16927.71090740.221500.325602.379701.37780HepG2EIF3G
HPS4ENSG00000100099.161633.073401032.728100.661006.407105.43440HepG2EIF4A3
HPS4ENSG00000100099.161479.334701823.67590-0.301903.841003.15250HepG2ETF1
HPS4ENSG00000100099.161035.77830739.461800.486104.429903.44900HepG2FUBP3
HPS4ENSG00000100099.161453.885401042.108700.480304.021103.19720HepG2FXR1
HPS4ENSG00000100099.161356.873701026.301900.402703.054102.11900HepG2G3BP2
HPS4ENSG00000100099.161192.17910871.380500.452104.203903.43010HepG2HNRNPA1
HPS4ENSG00000100099.16956.786301261.95800-0.399404.927003.73820HepG2HNRNPA2B1
HPS4ENSG00000100099.161070.972201250.79430-0.223902.270301.65160HepG2HNRNPL
HPS4ENSG00000100099.16906.36110718.216300.335601.963101.42500HepG2HNRNPLL
HPS4ENSG00000100099.16804.09260962.87060-0.260002.294601.73740HepG2HNRNPU
HPS4ENSG00000100099.16980.411901329.49570-0.439402.770201.54170HepG2HSPD1
HPS4ENSG00000100099.161407.31190982.544800.518204.582403.73350HepG2IGF2BP2
HPS4ENSG00000100099.161305.56240988.317500.401502.265401.37090HepG2KHSRP
HPS4ENSG00000100099.161444.756901042.473100.470703.758002.99320HepG2MAGOH
HPS4ENSG00000100099.161375.124201072.962600.357902.292901.71380HepG2NCBP2
HPS4ENSG00000100099.161249.78390955.464500.387302.640201.93370HepG2PABPC4
HPS4ENSG00000100099.161166.42000930.993900.325103.592502.92010HepG2PCBP1
HPS4ENSG00000100099.161077.51990858.798100.327203.177202.39230HepG2PPIL4
HPS4ENSG00000100099.161184.02480947.329900.321703.097402.52460HepG2PTBP1
HPS4ENSG00000100099.16961.051401299.76480-0.435604.146203.43320HepG2PUF60
HPS4ENSG00000100099.161435.733001033.483300.474208.374007.40140HepG2PUS1
HPS4ENSG00000100099.161402.574301025.963000.451005.463904.62950HepG2QKI
HPS4ENSG00000100099.161144.559701524.24800-0.413305.258104.60080HepG2RBM22
HPS4ENSG00000100099.161375.20950981.931700.485907.504406.56210HepG2RECQL
HPS4ENSG00000100099.16591.69400752.34130-0.346502.336501.76630HepG2RPS19
HPS4ENSG00000100099.16557.73270755.12990-0.437202.965601.98960HepG2SERBP1
HPS4ENSG00000100099.161016.94960837.531000.279902.774002.22180HepG2SRSF9
HPS4ENSG00000100099.16678.45110895.44690-0.400402.796002.11620HepG2SUPV3L1
HPS4ENSG00000100099.161115.89530925.342100.270002.301401.78210HepG2TAF15
HPS4ENSG00000100099.161140.35230850.244400.423404.257803.22930HepG2TIA1
HPS4ENSG00000100099.16722.12760953.40220-0.400805.038504.17770HepG2ZC3H8
HPS4ENSG00000100099.161449.220101938.43610-0.419604.983603.23970K562APOBEC3C
HPS4ENSG00000100099.161190.671101582.77170-0.410702.368601.81910K562AQR
HPS4ENSG00000100099.16678.82970928.01570-0.451103.505302.47110K562EFTUD2
HPS4ENSG00000100099.162686.085002196.897400.289903.393602.35700K562EIF4G2
HPS4ENSG00000100099.16901.643901184.24850-0.393304.428303.68700K562FXR1
HPS4ENSG00000100099.161329.207701604.63310-0.271702.046001.38980K562GRSF1
HPS4ENSG00000100099.16804.083901071.97930-0.414903.600502.93100K562HNRNPC
HPS4ENSG00000100099.16838.452301156.11190-0.463503.647202.20560K562HNRNPK
HPS4ENSG00000100099.161414.969201204.286000.232502.099001.38910K562MTPAP
HPS4ENSG00000100099.16824.491201082.43710-0.392703.122402.08380K562PCBP2
HPS4ENSG00000100099.16600.70680903.06760-0.588205.134704.11250K562PRPF8
HPS4ENSG00000100099.16936.890401182.03060-0.335302.917202.23790K562PTBP1
HPS4ENSG00000100099.161704.144702396.92350-0.492106.002304.80440K562PUF60
HPS4ENSG00000100099.162168.464502497.99270-0.204102.268401.39760K562PUM2
HPS4ENSG00000100099.16834.267101133.29380-0.441903.912802.90030K562RBM22
HPS4ENSG00000100099.16646.22420960.17810-0.571306.911105.52380K562SF3B4
HPS4ENSG00000100099.161558.990301352.709800.204702.155601.32050K562SRPK2
HPS4ENSG00000100099.16920.018701158.81120-0.332902.722002.02000K562SRSF1
HPS4ENSG00000100099.161504.978601214.009200.309902.656501.79600K562WDR3
HPS4ENSG00000100099.161531.573201262.428100.278703.569102.61500K562WDR43
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for HPS4 is not available on ENCORE database.





17 RBPs can affect the splicing of HPS4 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEHPS4ENSG00000100099.16chr22-2686201626862070268614202686151726862191268622280.176000.002520.04395includedK562SRSF1
SEHPS4ENSG00000100099.16chr22-268752302687532126872958268731022687768726878206-0.224000.000910.01947excludedK562SF3B4
SEHPS4ENSG00000100099.16chr22-268671782686735426866684268667792686826726868384-0.076000.010440.09437excludedHepG2U2AF2
SEHPS4ENSG00000100099.16chr22-2687871126878839268778232687820626879639268798020.232000.000020.00246includedHepG2NCBP2
SEHPS4ENSG00000100099.16chr22-268671782686735426866553268667792686826726868384-0.210000.000090.04026excludedK562UCHL5
SEHPS4ENSG00000100099.16chr22-2686201626862070268614202686151726862191268622280.434000.000250.00814includedHepG2SRSF1
SEHPS4ENSG00000100099.16chr22-268787112687883926877823268782062687963926879802-0.218000.001100.06918excludedK562HNRNPUL1
SEHPS4ENSG00000100099.16chr22-268752302687532126872958268731022687768726878206-0.191000.000050.00319excludedK562HNRNPU
SEHPS4ENSG00000100099.16chr22-2686201626862070268614202686151726862191268622280.220000.000300.01078includedK562AGGF1
A3SSHPS4ENSG00000100099.16chr22-2686668426866888268666842686677926868267268683840.154000.000120.01356longerHepG2SF3A3
A3SSHPS4ENSG00000100099.16chr22-2686451626864661268645162686458926866684268667790.104000.004240.02501longerK562AQR
A3SSHPS4ENSG00000100099.16chr22-2686668426866888268666842686677926868267268683840.122000.000300.04054longerK562HNRNPC
RIHPS4ENSG00000100099.16chr22-2686142026862228268614202686151726862191268622280.330000.000000.00002includedK562PUS1
RIHPS4ENSG00000100099.16chr22-2686142026862228268614202686151726862191268622280.316000.000420.04789includedK562HNRNPK
RIHPS4ENSG00000100099.16chr22-2686142026862228268614202686151726862191268622280.246000.005520.05655includedK562AGGF1
RIHPS4ENSG00000100099.16chr22-2686142026862228268614202686151726862191268622280.179000.008200.06612includedK562AKAP8L
RIHPS4ENSG00000100099.16chr22-2686142026862228268614202686151726862191268622280.224000.000960.01245includedK562RBM15
RIHPS4ENSG00000100099.16chr22-2686142026862228268614202686151726862191268622280.265000.005490.06258includedK562U2AF2
RIHPS4ENSG00000100099.16chr22-2686142026862228268614202686151726862191268622280.249000.004500.04772includedK562UTP18
RIHPS4ENSG00000100099.16chr22-268621912686458926862191268622282686451626864589-0.420000.000980.01842excludedK562FXR1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for HPS4 is not avaliable on ENCORE database.