FXR2

General Information

Gene Name : FXR2
Gene ID : ENSG00000129245.11
Essential Gene : No

Functions

RNA stability & decay
Translation regulation

Localization(RBPImage: FXR2)

Cytoplasm
Compartment/Organelle
Mitochondria

Domains (AlphaFold: FXR2)

KH

Antibody Validation

View validation images for all FXR2 antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	FXR2	ENSG00000129245.11	14.04	22.68	18.36	ENCSR000AEF
HepG2	FXR2	ENSG00000129245.11	13.70	14.32	14.01	ENCSR985KAT
K562	FXR2	ENSG00000129245.11	29.60	33.14	31.37	ENCSR000AEO

Assays

6 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 237	ENCSR224QWC	FXR2	K562	Released	ENCAB069PGU	ENCSR411IMJ
eCLIP	eCLIP: 4002	ENCSR767OEY	FXR2	K562	Released	ENCAB479NSE	ENCSR325HDY
eCLIP	eCLIP: 4098	ENCSR270FOD	FXR2	HepG2	Released	ENCAB479NSE	ENCSR635EEO
knockdown followed by RNA-seq	FXR2-BGKLV08-K562	ENCSR577XBW	FXR2	K562	Released		ENCSR913CAE	shRNA	KD% = 24.1,35.8
knockdown followed by RNA-seq	FXR2-BGKcLV04-K562	ENCSR376GHG	FXR2	K562	Released		ENCSR828YEB	CRISPR	KD% = 78.5,82.3
knockdown followed by RNA-seq	FXR2-BGHcLV05-HepG2	ENCSR147RTA	FXR2	HepG2	Released		ENCSR834IFU	CRISPR	KD% = 99.9,99.5

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
FXR2	237	K562	ENCSR224QWC	ENCSR411IMJ	ENCAB069PGU	A303-894A	1	Released	ENCODE3
FXR2	4002	K562	ENCSR767OEY	ENCSR325HDY	ENCAB479NSE	MA1-16767	SD251451	Released	ENCODE4
FXR2	4098	HepG2	ENCSR270FOD	ENCSR635EEO	ENCAB479NSE	MA1-16767	SD251451	Released	ENCODE4

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
FXR2	ENCAB479NSE	MA1-16767	SD251451			Released, ENCODE4		BGKcLV04-13, Released, ENCODE4
FXR2	ENCAB069PGU	A303-894A	1		Released, ENCODE3	Released, ENCODE3	BGHcLV05-17, Released, ENCODE3	BGKcLV04-13, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
FXR2	K562	shRNA	ENCSR577XBW	ENCSR913CAE	FXR2-LV08-31,FXR2-LV08-32	Nontarget-LV08-1_00003527,nontarget-LV08-2_00003527	24.1,35.8	Released	ENCODE3
FXR2	HepG2	shRNA			BGHLV12-31,BGHLV12-32	BGHLV12-1,BGHLV12-2		NotSatisfied	ENCODE3
FXR2	HepG2	shRNA			BGHLV26-15,BGHLV26-16	BGHLV26-1,BGHLV26-2		NotSatisfied	ENCODE3
FXR2	K562	CRISPR	ENCSR376GHG	ENCSR828YEB	FXR2_BGKcLV04_13,FXR2_BGKcLV04_14	NT_BGKcLV04-1,NT_BGKcLV04-2	78.5,82.3	Released	ENCODE3
FXR2	K562	CRISPR			BGKcLV04-13-D12,BGKcLV04-14-D12	BGKcLV04-1,BGKcLV04-2		NotSatisfied	ENCODE3
FXR2	K562	CRISPR			BGKcLV04-14-D12,BGHcLV05-17	BGKcLV04-1,BGKcLV04-2	,99.9	NotSatisfied	ENCODE3
FXR2	HepG2	CRISPR	ENCSR147RTA	ENCSR834IFU	FXR2-BGHcLV05-17,FXR2-BGHcLV05-18	NT-BGHcLV05-1C,NT-BGHcLV05-2C	99.9,99.5	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

FXR2: Click to RBP Image Database

Cytoplasm

Compartment/Organelle

Mitochondria

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
FXR2	Product_ID: A303-894A Lot_ID: 1 Source: Bethyl Labs Target Name: FXR2-human
FXR2	Product_ID: MA1-16767 Lot_ID: SD251451 Source: Thermo Fisher Target Name: FXR2-human

RNA Targets

FXR2 protein binds to 7,924 RNA regions.

CanvasJS.com

Proteins bound to RNA

FXR2 RNA is bound by 12 proteins.

CanvasJS.com

FXR2 protein has 7,924 RNA targets:

Only display 100 entries as example. Please click "View All" button to see all 7,924 entries.

Show entries

Search:

RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
FXR2	chr6	7579774	7579830	+	4.20022	41.93708	HepG2	DSP	CDS
FXR2	chr19	57328056	57328145	-	3.63268	41.05295	HepG2	ZIM2, PEG3	CDS,intron-Distal,intron-Proximal
FXR2	chr5	154181801	154181852	+	6.44738	39.24074	K562	LARP1	CDS
FXR2	chr12	26639114	26639206	-	4.62832	33.19561	HepG2	ITPR2	5'-UTR,CDS,intron-Distal
FXR2	chrX	153591066	153591098	-	5.24543	29.75330	K562	FLNA	5'-UTR,CDS,intron-Distal
FXR2	chr12	6715547	6715605	-	4.78682	25.79929	K562	CHD4	5'-UTR,intron-Distal
FXR2	chr19	59059666	59059689	+	4.47248	25.15921	K562	TRIM28	CDS
FXR2	chr9	35704041	35704081	-	5.73353	24.92837	K562	TLN1	CDS,intron-Distal
FXR2	chrX	153587727	153587735	-	6.79711	24.25941	K562	FLNA	3'-UTR,CDS,intron-Distal
FXR2	chr5	154173159	154173250	+	3.74908	23.65421	HepG2	LARP1	3'-UTR,CDS

Showing 1 to 10 of 100 entries

12 proteins are bound to FXR2 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	7517725	7517771	-	CDS,intron-Distal	4.90368	12.77088	HepG2	PRPF8
chr17	7495167	7495268	-	CDS,intron-Distal	3.89559	10.66752	HepG2	U2AF2
chr17	7496719	7496779	-	CDS,intron-Distal,intron-Proximal	5.57105	9.18426	K562	FXR2
chr17	7515459	7515514	-	intron-Distal	3.43787	7.03905	HepG2	SUGP2
chr17	7516556	7516609	-	intron-Distal	3.45721	6.72722	HepG2	SUGP2
chr17	7495970	7496020	-	CDS,intron-Distal,intron-Proximal	4.98529	6.69228	HepG2	PRPF8
chr17	7515673	7515744	-	intron-Distal	4.62092	6.58366	HepG2	SUGP2
chr17	7494585	7494671	-	3'-UTR,intron-Distal,intron-Proximal	4.06792	6.36782	K562	UPF1
chr17	7516985	7517063	-	intron-Distal	4.65305	6.10726	HepG2	SUGP2
chr17	7516430	7516493	-	intron-Distal	3.70846	5.79523	HepG2	SUGP2
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 27 entries

The FXR2 protein binds to its own RNA.

Show entries

Search:

RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
FXR2	chr17	7496719	7496779	-	5.57105	9.18426	K562	FXR2	CDS,intron-Distal,intron-Proximal
FXR2	chr17	7496344	7496391	-	4.74159	5.42280	K562	FXR2	CDS,intron-Distal
FXR2	chr17	7495823	7495871	-	4.62718	4.75028	K562	FXR2	CDS,intron-Distal

Showing 1 to 3 of 3 entries

Diffrential Expression

70 differentially expressed genes after Knockdown/Knockout FXR2 protein.

CanvasJS.com

56 RBPs can affect the levels of FXR2.

CanvasJS.com

70 differentially expressed genes after Knockdown/Knockout FXR2 protein :

Only display 100 entries as example. Please click "View All" button to see all 70 entries.

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
RPS17L	ENSG00000182774.6	523.89170	4908.03980	-3.22780	18.91800	14.57350	K562	FXR2
MAGEA9B	ENSG00000123584.7	0.00000	60.70860	-99999.99999	15.99360	11.95010	K562	FXR2
MAGEA9	ENSG00000166008.5	69.64090	0.00000	99999.99990	15.02160	11.15420	K562	FXR2
EGR1	ENSG00000120738.7	962.14620	412.08070	1.22320	9.91530	6.19220	K562	FXR2
HIST1H2BD	ENSG00000158373.7	467.94640	1058.90230	-1.17820	9.83780	6.19220	K562	FXR2
HSPA1A	ENSG00000204389.8	5448.99570	10594.71840	-0.95930	8.86290	5.29650	K562	FXR2
ATP2A3	ENSG00000074370.13	969.75680	439.51150	1.14160	8.74110	5.24160	K562	FXR2
SPRY4	ENSG00000187678.8	339.90900	118.41630	1.52120	8.19730	4.75580	K562	FXR2
BCYRN1	ENSG00000236824.1	64.41080	5.46490	3.55890	8.10230	4.71200	K562	FXR2
RPS17	ENSG00000184779.8	8313.90630	4453.12800	0.90060	7.87810	4.53350	K562	FXR2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 70 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

56 RBPs can affect the gene expression of FXR2 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
FXR2	ENSG00000129245.7	2071.37300	1277.02610	0.69770	18.26730	16.92910	K562	AGGF1
FXR2	ENSG00000129245.7	3341.56610	1317.75600	1.34230	16.36900	15.08780	K562	PUS1
FXR2	ENSG00000129245.7	1340.49130	769.29680	0.80100	13.18000	11.63660	K562	SRSF1
FXR2	ENSG00000129245.7	2025.91400	1284.00520	0.65780	10.92930	9.77220	K562	RBM15
FXR2	ENSG00000129245.7	1272.56350	784.69420	0.69740	10.49530	9.26010	K562	PTBP1
FXR2	ENSG00000129245.7	834.40070	574.06470	0.53940	8.01050	7.20530	HepG2	ZNF622
FXR2	ENSG00000129245.7	1077.27700	588.56540	0.87200	8.16160	6.95890	HepG2	SF3A3
FXR2	ENSG00000129245.7	1066.61180	749.55180	0.50880	7.23270	6.52790	HepG2	SRFBP1
FXR2	ENSG00000129245.7	986.81710	586.95640	0.74940	7.33020	6.35700	HepG2	DDX3X
FXR2	ENSG00000129245.7	743.91480	452.31320	0.71770	7.21010	6.29740	HepG2	BOP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 64 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

427 alternative splicing events after Knockdown/Knockout FXR2 protein :

Only display 100 entries as example. Please click "View All" button to see all 427 entries.

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	NASP	ENSG00000132780.12	chr1	+	46072992	46074009	46072153	46072263	46078840	46078920	0.13700	0.00435	included	K562	FXR2
SE	HSPB11	ENSG00000081870.7	chr1	-	54394044	54394113	54389576	54389620	54395711	54395818	0.05100	0.00435	included	K562	FXR2
SE	DCAF8	ENSG00000132716.14	chr1	-	160213749	160213824	160209891	160210160	160232238	160232304	0.05100	0.00451	included	K562	FXR2
SE	SYCP2L	ENSG00000153157.8	chr6	+	10931672	10931722	10930186	10930747	10935290	10935407	0.09400	0.00083	included	K562	FXR2
SE	ASCC3	ENSG00000112249.9	chr6	-	101306832	101307078	101296023	101296583	101311939	101312090	0.07900	0.00435	included	K562	FXR2
SE	CALU	ENSG00000128595.12	chr7	+	128388626	128388858	128379345	128379486	128398924	128399091	0.12000	0.00006	included	K562	FXR2
SE	MARCH7	ENSG00000136536.10	chr2	+	160621136	160621185	160619390	160619504	160623794	160623880	0.16300	0.00435	included	K562	FXR2
SE	U2SURP	ENSG00000163714.13	chr3	+	142742816	142742860	142741694	142741906	142745990	142746095	0.26300	0.00006	included	K562	FXR2
SE	ANKIB1	ENSG00000001629.5	chr7	+	92019284	92019430	92017288	92017355	92020479	92020658	-0.18500	0.00054	excluded	K562	FXR2
SE	BIRC5	ENSG00000089685.10	chr17	+	76218908	76219073	76212744	76212862	76219545	76219635	-0.12600	0.00029	excluded	K562	FXR2

Showing 1 to 10 of 100 entries

6 RBPs can affect the splicing of FXR2 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	FXR2	ENSG00000129245.7	chr17	-	7495388	7495475	7494759	7495243	7495571	7495675	0.20500	0.00000	0.00006	included	K562	U2AF2
A3SS	FXR2	ENSG00000129245.7	chr17	-	7499141	7499328	7499141	7499312	7504726	7504843	0.16600	0.00000	0.00000	longer	K562	AQR
A3SS	FXR2	ENSG00000129245.7	chr17	-	7497555	7497752	7497555	7497665	7497996	7498075	0.11300	0.00000	0.00000	longer	K562	AQR
SE	FXR2	ENSG00000129245.7	chr17	-	7495388	7495475	7494759	7495243	7495571	7495675	0.08700	0.00003	0.00052	included	K562	AQR
A5SS	FXR2	ENSG00000129245.7	chr17	-	7509333	7509467	7509414	7509467	7508962	7509056	0.06400	0.00003	0.00500	longer	K562	RBM15
SE	FXR2	ENSG00000129245.7	chr17	-	7495388	7495475	7494759	7495243	7495571	7495675	-0.06100	0.00008	0.01127	excluded	K562	HNRNPUL1
A5SS	FXR2	ENSG00000129245.7	chr17	-	7509333	7509467	7509414	7509467	7508962	7509056	0.05200	0.00012	0.00641	longer	K562	PUS1
SE	FXR2	ENSG00000129245.7	chr17	-	7495388	7495475	7494759	7495243	7495571	7495675	0.12000	0.00036	0.00975	included	K562	U2AF1

Showing 1 to 8 of 8 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

FXR2

General Information

Functions

Localization(RBPImage: FXR2)

Domains (AlphaFold: FXR2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

FXR2 protein has 7,924 RNA targets:

12 proteins are bound to FXR2 RNA:

The FXR2 protein binds to its own RNA.

Diffrential Expression

70 differentially expressed genes after Knockdown/Knockout FXR2 protein :

56 RBPs can affect the gene expression of FXR2 :

427 alternative splicing events after Knockdown/Knockout FXR2 protein :

6 RBPs can affect the splicing of FXR2 :

No autoregularoty alternative splicing events between protein FXR2 and its RNA.