UTP3

General Information

Gene Name : UTP3
Gene ID : ENSG00000132467.3
Essential Gene : Yes

Functions

Novel RBP

Localization(RBPImage: UTP3)

Nuclei
Nucleolus
Cytoplasm
Compartment/Organelle
Mitochondria

Domains (AlphaFold: UTP3)

No checked domain (RRM, ZNF, KH, Helicase, Nuclease, dRBM or PUM_HD)

Antibody Validation

Bethyl Labs: A302-067A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	UTP3	ENSG00000132467.3	42.20	41.29	41.75	ENCSR000AEF
HepG2	UTP3	ENSG00000132467.3	20.62	25.80	23.21	ENCSR985KAT
K562	UTP3	ENSG00000132467.3	42.69	46.60	44.64	ENCSR000AEO

Assays

3 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
eCLIP	eCLIP: 475	ENCSR734ZHL	UTP3	K562	Released	ENCAB872CCU	ENCSR241ALC
knockdown followed by RNA-seq	UTP3-BGKLV38-K562	ENCSR473KFO	UTP3	K562	Released		ENCSR655JYC	shRNA	KD% = 51.7,50.8
knockdown followed by RNA-seq	UTP3-BGHLV33-HepG2	ENCSR910ECL	UTP3	HepG2	Released		ENCSR691IVR	shRNA	KD% = 70.3,65.4

eCLIP

RBP	Exp_UID	Cell_Line	ENCODE_ACCESSION	Control_ENCODE_ACCESSION	ENCODE_Antibody_ID	Antibody	Lot_num	Status	Project
UTP3	475	K562	ENCSR734ZHL	ENCSR241ALC	ENCAB872CCU	A302-067A	1	Released	ENCODE4

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
UTP3	ENCAB872CCU	A302-067A	1			Released, ENCODE3	BGHLV33-37, Released, ENCODE3	BGKLV38-103, Released, ENCODE3

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
UTP3	K562	shRNA			BGKLV34-47,BGKLV34-48	BGKLV34-1,BGKLV34-2	0.0,0.0	NotSatisfied	ENCODE3
UTP3	K562	shRNA			BGKLV38-101,BGKLV38-102	BGKLV38-1,BGKLV38-2		NotSatisfied	ENCODE3
UTP3	K562	shRNA	ENCSR473KFO	ENCSR655JYC	UTP3-BGKLV38-103D,UTP3-BGKLV38-104D	NT-BGKLV38-1D,NT-BGKLV38-2D	51.7,50.8	Released	ENCODE3
UTP3	K562	shRNA			BGKLV38-105,BGKLV38-106	BGKLV38-1,BGKLV38-2	26.3,19.3	NotSatisfied	ENCODE3
UTP3	K562	shRNA			BGKLV38-107,BGKLV38-108	BGKLV38-1,BGKLV38-2	0.0,1.6	NotSatisfied	ENCODE3
UTP3	HepG2	shRNA	ENCSR910ECL	ENCSR691IVR	UTP3_BGHLV33-37,UTP3_BGHLV33-38	NT_BGHLV33-1,NT_BGHLV33-2	70.3,65.4	Released	ENCODE3

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

UTP3: Click to RBP Image Database

Nuclei

Nucleolus

Cytoplasm

Compartment/Organelle

Mitochondria

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
UTP3	Product_ID: A302-067A Lot_ID: 1 Source: Bethyl Labs Target Name: UTP3-human

RNA Targets

UTP3 protein binds to 16 RNA regions.

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Proteins bound to RNA

UTP3 RNA is bound by 8 proteins.

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UTP3 protein has 16 RNA targets:

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RBP	Chr	Start	End	Strand	log2(fold change)	-log(p-value)	Cell Line	Matched Gene	Matched Area
UTP3	chr12	7076544	7076559	-	4.13126	400.00000	K562	PHB2	intron-Distal,intron-Proximal
UTP3	chr21	38120092	38120104	+	11.30409	110.30539	K562	SIM2	CDS
UTP3	chr21	38120082	38120092	+	11.30409	110.30539	K562	SIM2	CDS
UTP3	chr17	42993885	42993891	-	11.08681	92.32062	K562	GFAP	intron-Distal
UTP3	chr17	42993901	42993908	-	11.08681	92.32062	K562	GFAP	intron-Distal
UTP3	chr17	42993891	42993901	-	11.08681	92.32062	K562	GFAP	intron-Distal
UTP3	chr11	62620398	62620413	-	3.35080	87.12657	K562	SNHG1	intron-Distal,intron-Proximal
UTP3	chr5	892919	892930	+	10.89131	75.63463	K562	TRIP13	5'-UTR
UTP3	chr5	892908	892916	+	10.89131	75.63463	K562	TRIP13	5'-UTR
UTP3	chr1	45242197	45242207	+	3.18721	71.31059	K562	RPS8	intron-Distal

Showing 1 to 10 of 16 entries

8 proteins are bound to UTP3 RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr4	71554691	71554768	+	CDS	5.24714	15.84981	K562	UCHL5
chr4	71555763	71555823	+	CDS	4.80987	13.28384	K562	UCHL5
chr4	71554254	71554379	+	5'-UTR	3.24057	12.85699	K562	DDX3X
chr4	71554726	71554824	+	CDS	4.01736	11.84473	K562	LIN28B
chr4	71554702	71554760	+	CDS	5.46049	10.17900	K562	ZNF622
chr4	71555752	71555820	+	CDS	4.03034	5.65086	HepG2	BCLAF1
chr4	71555724	71555806	+	CDS	3.01043	4.88483	K562	ZNF622
chr4	71555243	71555293	+	CDS	3.27486	4.74886	HepG2	BCLAF1
chr4	71555248	71555273	+	CDS	4.34455	4.72838	K562	UCHL5
chr4	71554652	71554753	+	CDS	3.22830	4.51709	HepG2	BCLAF1
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 13 entries

No autoregularoty interactions between protein UTP3 and its RNA.

Diffrential Expression

9,503 differentially expressed genes after Knockdown/Knockout UTP3 protein.

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98 RBPs can affect the levels of UTP3.

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9,503 differentially expressed genes after Knockdown/Knockout UTP3 protein :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
GCLC	ENSG00000001084.6	3315.61150	1249.23290	1.40810	82.96600	80.45520	HepG2	UTP3
MAPK8IP2	ENSG00000008735.10	777.73980	153.34260	2.34240	70.88870	68.52810	HepG2	UTP3
VTA1	ENSG00000009844.11	612.71410	1772.68910	-1.53270	65.03330	62.74430	HepG2	UTP3
IBTK	ENSG00000005700.10	1038.16340	2552.71820	-1.29800	56.42180	54.25860	HepG2	UTP3
SLC7A2	ENSG00000003989.12	3080.65560	6947.50020	-1.17330	45.76880	43.76850	HepG2	UTP3
IFRD1	ENSG00000006652.9	1424.74190	587.93070	1.27690	43.46610	41.50180	HepG2	UTP3
TNFRSF12A	ENSG00000006327.9	1326.50470	408.03730	1.70080	36.41980	34.61820	HepG2	UTP3
ELAC2	ENSG00000006744.14	1636.98300	791.26330	1.04870	33.60630	31.87550	HepG2	UTP3
ZNF195	ENSG00000005801.12	1014.04100	430.88280	1.23460	31.97380	30.28250	HepG2	UTP3
ST3GAL1	ENSG00000008513.10	815.23190	1625.98550	-0.99600	30.35150	28.68660	HepG2	UTP3
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 100 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

98 RBPs can affect the gene expression of UTP3 :

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Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
UTP3	ENSG00000132467.2	2011.37450	578.15280	1.79860	36.91310	35.27300	HepG2	AKAP1
UTP3	ENSG00000132467.2	1450.39250	665.93440	1.12290	30.78900	28.91120	K562	FXR1
UTP3	ENSG00000132467.2	971.48730	474.24130	1.03450	23.60540	22.12460	HepG2	PCBP1
UTP3	ENSG00000132467.2	1798.23140	902.58100	0.99440	22.44780	20.62630	K562	PTBP1
UTP3	ENSG00000132467.2	1032.52080	524.40110	0.97730	20.97720	19.93180	HepG2	SRSF1
UTP3	ENSG00000132467.2	1251.12570	512.99560	1.28610	18.69270	17.17310	HepG2	MATR3
UTP3	ENSG00000132467.2	1255.43280	710.39290	0.82140	16.67910	15.36630	HepG2	CELF1
UTP3	ENSG00000132467.2	757.48220	426.64410	0.82810	14.60880	13.52030	HepG2	SRSF9
UTP3	ENSG00000132467.2	1374.81760	889.19460	0.62860	12.81990	11.95150	HepG2	SRFBP1
UTP3	ENSG00000132467.2	1607.51360	893.03720	0.84790	12.33660	10.74370	K562	PRPF8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 114 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

172 alternative splicing events after Knockdown/Knockout UTP3 protein :

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Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	EPB41L2	ENSG00000079819.12	chr6	-	131199243	131199390	131190702	131191266	131206235	131206408	0.22500	0.00081	included	K562	UTP3
SE	SNRNP70	ENSG00000104852.10	chr19	+	49605370	49606844	49604646	49604728	49607890	49607992	0.05500	0.00000	included	K562	UTP3
SE	VWDE	ENSG00000146530.7	chr7	-	12393440	12394113	12391198	12391339	12395736	12395956	0.17700	0.00205	included	K562	UTP3
SE	PICALM	ENSG00000073921.13	chr11	-	85689112	85689136	85687665	85687725	85692171	85692271	0.14300	0.00080	included	K562	UTP3
SE	MKNK1	ENSG00000079277.15	chr1	-	47039265	47039367	47037734	47037839	47040618	47040692	0.08000	0.00647	included	K562	UTP3
SE	RBM39	ENSG00000131051.16	chr20	-	34328446	34328519	34326889	34326939	34328745	34328809	0.13900	0.00127	included	K562	UTP3
SE	HIST1H2AC	ENSG00000180573.8	chr6	+	26127925	26127989	26124430	26124861	26138281	26139344	0.07500	0.00233	included	K562	UTP3
SE	RPS24	ENSG00000138326.14	chr10	+	79799961	79799983	79796951	79797062	79800372	79800455	0.16400	0.00000	included	K562	UTP3
SE	DNAJC10	ENSG00000077232.12	chr2	+	183602104	183602190	183600975	183601113	183605025	183605115	-0.12200	0.00706	excluded	K562	UTP3
SE	MORF4L2	ENSG00000123562.12	chrX	-	102939608	102939657	102933426	102933528	102940098	102940188	-0.14000	0.00647	excluded	K562	UTP3

Showing 1 to 10 of 100 entries

UTP3

General Information

Functions

Localization(RBPImage: UTP3)

Domains (AlphaFold: UTP3)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

UTP3 protein has 16 RNA targets:

8 proteins are bound to UTP3 RNA:

No autoregularoty interactions between protein UTP3 and its RNA.

Diffrential Expression

9,503 differentially expressed genes after Knockdown/Knockout UTP3 protein :

98 RBPs can affect the gene expression of UTP3 :

172 alternative splicing events after Knockdown/Knockout UTP3 protein :

No RBPs affect the alternative splcing events of UTP3 on ENCORE database.

No autoregularoty alternative splicing events between protein UTP3 and its RNA.