HMGCR

General Information

Gene Name : HMGCR
Gene ID : ENSG00000113161.15
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: HMGCR)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	HMGCR	ENSG00000113161.15	75.77	60.71	68.24	ENCSR000AEF
HepG2	HMGCR	ENSG00000113161.15	64.25	95.00	79.62	ENCSR985KAT
K562	HMGCR	ENSG00000113161.15	45.19	45.01	45.10	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for HMGCR is not avaliable on ENCORE database.

Proteins bound to RNA

HMGCR RNA is bound by 47 proteins.

CanvasJS.com

eCLIP assay for HMGCR is not avaliable on ENCORE database.

47 proteins are bound to HMGCR RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr5	74655418	74655448	+	intron-Distal,intron-Proximal	6.46036	53.05825	K562	AQR
chr5	74657145	74657242	+	3'-UTR	4.98778	45.92387	K562	PUM2
chr5	74655381	74655417	+	intron-Distal,intron-Proximal	5.95556	45.82689	K562	AQR
chr5	74657146	74657196	+	3'-UTR	5.34662	41.85755	HepG2	FUBP3
chr5	74655778	74655845	+	CDS,intron-Proximal	5.43431	39.98468	K562	AQR
chr5	74633163	74633215	+	intron-Distal,intron-Proximal	5.07872	37.29653	HepG2	EFTUD2
chr5	74657196	74657226	+	3'-UTR	5.17633	33.59370	HepG2	FUBP3
chr5	74633215	74633270	+	intron-Distal,intron-Proximal	5.46269	32.63304	HepG2	EFTUD2
chr5	74633137	74633264	+	intron-Distal,intron-Proximal	5.09452	26.72882	HepG2	PRPF4
chr5	74657518	74657592	+	3'-UTR	4.50853	25.51939	HepG2	FUBP3
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 197 entries

eCLIP assay for HMGCR is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for HMGCR is not available on ENCORE database.
180 RBPs can affect the levels of HMGCR.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for HMGCR is not available on ENCORE database.

180 RBPs can affect the gene expression of HMGCR :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
HMGCR	ENSG00000113161.11	1709.05240	5788.58780	-1.76000	195.26230	191.71710	HepG2	HNRNPL
HMGCR	ENSG00000113161.11	13481.77320	3724.03810	1.85600	70.83100	68.37640	HepG2	HNRNPLL
HMGCR	ENSG00000113161.11	1282.13170	4037.02260	-1.65470	66.92010	64.14580	K562	HNRNPC
HMGCR	ENSG00000113161.11	5677.88920	14693.67110	-1.37180	59.91110	58.17260	HepG2	NELFE
HMGCR	ENSG00000113161.11	11423.95530	5744.26790	0.99180	59.07320	57.02440	HepG2	DKC1
HMGCR	ENSG00000113161.11	5962.55590	13684.49290	-1.19850	58.39510	56.36220	HepG2	RECQL
HMGCR	ENSG00000113161.11	15690.94990	6764.82880	1.21370	57.19490	55.60670	HepG2	SSB
HMGCR	ENSG00000113161.11	7043.51340	3386.01090	1.05660	57.57000	55.06000	HepG2	PRPF4
HMGCR	ENSG00000113161.11	11988.21730	6115.60440	0.97100	53.45950	51.46540	HepG2	PUS1
HMGCR	ENSG00000113161.11	2225.04100	15950.47940	-2.84170	50.77200	48.93440	HepG2	AKAP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 245 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for HMGCR is not available on ENCORE database.

20 RBPs can affect the splicing of HMGCR :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	HMGCR	ENSG00000113161.11	chr5	+	74650880	74651039	74650327	74650522	74651189	74651347	-0.08300	0.00049	excluded	K562	IGF2BP2
SE	HMGCR	ENSG00000113161.11	chr5	+	74650880	74651039	74650327	74650522	74651189	74651347	-0.21800	0.00001	excluded	K562	XRCC6
SE	HMGCR	ENSG00000113161.11	chr5	+	74647281	74647427	74647104	74647140	74650327	74650522	-0.06800	0.00004	excluded	K562	AQR
SE	HMGCR	ENSG00000113161.11	chr5	+	74640069	74640157	74639677	74639789	74641398	74641483	-0.07800	0.00000	excluded	K562	AQR
SE	HMGCR	ENSG00000113161.11	chr5	+	74650880	74651039	74650327	74650522	74651189	74651347	-0.11300	0.00000	excluded	K562	AQR
SE	HMGCR	ENSG00000113161.11	chr5	+	74650880	74651039	74650327	74650522	74651189	74651347	-0.11700	0.00000	excluded	K562	KHSRP
SE	HMGCR	ENSG00000113161.11	chr5	+	74650880	74651039	74650327	74650522	74651189	74651347	-0.10100	0.00032	excluded	HepG2	HNRNPC
SE	HMGCR	ENSG00000113161.11	chr5	+	74650880	74651039	74650327	74650522	74651189	74651347	-0.15600	0.00180	excluded	K562	EIF3G
SE	HMGCR	ENSG00000113161.11	chr5	+	74650880	74651039	74650327	74650522	74651189	74651347	-0.16900	0.00000	excluded	K562	PTBP1
A3SS	HMGCR	ENSG00000113161.11	chr5	+	74647248	74647427	74647341	74647427	74646892	74647140	-0.07800	0.00000	shorter	HepG2	U2AF2

Showing 1 to 10 of 42 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

HMGCR

General Information

Functions

Localization

Domains (AlphaFold: HMGCR)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for HMGCR is not avaliable on ENCORE database.

47 proteins are bound to HMGCR RNA:

eCLIP assay for HMGCR is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for HMGCR is not available on ENCORE database.

180 RBPs can affect the gene expression of HMGCR :

The Knockdown/knockout RNA-Seq assay for HMGCR is not available on ENCORE database.

20 RBPs can affect the splicing of HMGCR :

The Knockdown/knockout RNA-Seq assay for HMGCR is not avaliable on ENCORE database.