PPIE

General Information

Gene Name       : PPIE
Gene ID             : ENSG00000084072.16
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PPIE)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PPIEENSG00000084072.1633.7339.9536.84ENCSR000AEF
HepG2PPIEENSG00000084072.1617.1316.3916.76ENCSR985KAT
K562PPIEENSG00000084072.1686.2687.8387.05ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PPIE is not avaliable on ENCORE database.



Proteins bound to RNA
  • PPIE RNA is bound by 12 proteins.  







eCLIP assay for PPIE is not avaliable on ENCORE database.





12 proteins are bound to PPIE RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr14021872140218748+3'-UTR,CDS,intron-Proximal4.268384.49024K562AQR
chr14020587340205929+3'-UTR,5'-UTR,CDS4.1392210.17596K562DDX3X
chr14021104440211158+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.943454.66217K562ZNF800
chr14021925940219291+3'-UTR,intron-Distal3.613368.67981K562YBX3
chr14021924540219259+3'-UTR,intron-Distal3.367567.00311K562YBX3
chr14021908340219137+3'-UTR,intron-Distal4.118867.70026K562LIN28B
chr14020583240205944+3'-UTR,5'-UTR,CDS,intron-Proximal4.366235.70529K562GRWD1
chr14021913940219193+3'-UTR,intron-Distal5.7125914.37734K562LIN28B
chr14021116940211226+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.090314.49024K562AQR
chr14020756540207594+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.095417.94095K562LIN28B
chr14021104640211136+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.539306.43326K562UCHL5
chr14021107740211159+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal4.477884.36390K562PUM1
chr14021471940214769+3'-UTR,CDS,intron-Proximal3.117363.12941K562UCHL5
chr14021874840218770+3'-UTR,intron-Proximal5.388896.22530K562AQR
chr14020583940205900+3'-UTR,5'-UTR,CDS3.546183.01531K562YBX3
chr14021104540211222+3'-UTR,5'-UTR,CDS,intron-Distal,intron-Proximal3.170003.89662K562BUD13
chr14020583340205873+3'-UTR,5'-UTR,CDS,intron-Proximal3.589637.73893K562DDX3X
chr14021462640214742+3'-UTR,CDS4.130223.60906K562SND1
chr14021283240212953+3'-UTR,intron-Distal3.931034.10688K562KHSRP
chr14020706340207081+3'-UTR,5'-UTR,CDS,intron-Distal4.251184.13050K562LIN28B
chr14020949640209596+5'-UTR,CDS4.333077.79539K562UCHL5
chr14020949340209598+5'-UTR,CDS,intron-Proximal3.300334.44254K562GRWD1
chr14020459140204711+5'-UTR,CDS,intron-Distal,intron-Proximal4.945564.13847K562AQR
chr14020949540209587+5'-UTR,CDS,intron-Proximal3.399203.91115K562LIN28B
chr14021803440218213+intron-Distal5.170007.67538K562HNRNPL
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PPIE is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PPIE is not available on ENCORE database.

  • 45 RBPs can affect the levels of PPIE.  








The Knockdown/knockout RNA-Seq assay for PPIE is not available on ENCORE database.





45 RBPs can affect the gene expression of PPIE :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PPIEENSG00000084072.12302.56260394.56160-0.383002.375501.73070HepG2AUH
PPIEENSG00000084072.12159.03110103.464000.620102.137701.60660HepG2BOP1
PPIEENSG00000084072.12232.28960319.59700-0.460301.967501.45800HepG2EIF2S1
PPIEENSG00000084072.12235.64770343.88270-0.545302.175401.56340HepG2EIF4B
PPIEENSG00000084072.12275.92620196.815700.487302.384101.60980HepG2EWSR1
PPIEENSG00000084072.12272.28760192.300100.501702.998101.98400HepG2HDGF
PPIEENSG00000084072.12203.80770336.01970-0.721304.093103.28670HepG2IGF2BP2
PPIEENSG00000084072.12150.06000213.24990-0.507002.771402.03780HepG2ILF2
PPIEENSG00000084072.12111.40980211.00940-0.921403.664102.39270HepG2NONO
PPIEENSG00000084072.12199.24310326.76570-0.713704.091903.22520HepG2PABPC4
PPIEENSG00000084072.12282.95100356.27530-0.332401.843501.33090HepG2PCBP1
PPIEENSG00000084072.12212.26130362.50640-0.772206.791706.00930HepG2PTBP1
PPIEENSG00000084072.12285.36680378.64970-0.408002.385401.89480HepG2RBM22
PPIEENSG00000084072.12217.42180356.33200-0.712705.087204.19860HepG2RBM25
PPIEENSG00000084072.12235.80350403.44900-0.774806.961906.17220HepG2NELFE
PPIEENSG00000084072.12249.98400375.73220-0.587904.335903.58740HepG2RECQL
PPIEENSG00000084072.12283.84560188.472300.590702.766902.09250HepG2SF3A3
PPIEENSG00000084072.12278.96570377.44650-0.436202.716702.13010HepG2SF3B4
PPIEENSG00000084072.12289.19350393.96000-0.446002.877702.39790HepG2SRSF1
PPIEENSG00000084072.12222.83380320.49670-0.524303.564202.95500HepG2SRSF9
PPIEENSG00000084072.12155.02790228.67810-0.560802.119201.51690HepG2SUPV3L1
PPIEENSG00000084072.1285.01270135.07560-0.668002.390701.68470HepG2UCHL5
PPIEENSG00000084072.1285.29900147.05420-0.785703.471602.73250HepG2ZC3H8
PPIEENSG00000084072.122360.735901509.965700.6446017.0768015.79030K562AGGF1
PPIEENSG00000084072.122007.494301659.287500.274702.290701.40830K562AKAP8
PPIEENSG00000084072.122236.634301571.203300.509406.421405.39520K562AKAP8L
PPIEENSG00000084072.123961.589702691.526800.557607.938107.02980K562AQR
PPIEENSG00000084072.122216.571301648.600000.427006.719605.21220K562ATP5C1
PPIEENSG00000084072.12416.35720633.50960-0.605504.475303.07380K562CCAR1
PPIEENSG00000084072.122059.440301707.065800.270603.446602.73000K562DDX47
PPIEENSG00000084072.12534.07510709.17010-0.409102.681301.37390K562DHX30
PPIEENSG00000084072.122214.487701690.629400.389306.004904.63990K562DKC1
PPIEENSG00000084072.121549.403101183.366200.388704.510403.50490K562EIF3G
PPIEENSG00000084072.123212.431402509.086200.356403.735502.86160K562GRSF1
PPIEENSG00000084072.122199.341401583.309900.474005.137704.06840K562HSPD1
PPIEENSG00000084072.122152.845101667.384700.368603.631302.67010K562KIF1C
PPIEENSG00000084072.121845.148601309.267200.494903.568702.53690K562NAA15
PPIEENSG00000084072.121786.101301199.330800.574502.455201.53640K562PABPN1
PPIEENSG00000084072.121728.282801325.925400.382203.310002.39850K562PPIG
PPIEENSG00000084072.123086.011203535.09160-0.196002.246201.38010K562PUM2
PPIEENSG00000084072.122869.959701558.091100.8812015.7391014.48360K562PUS1
PPIEENSG00000084072.122137.522401518.217400.493507.966206.99130K562RBM15
PPIEENSG00000084072.12757.54100937.33590-0.307202.178301.30330K562RCC2
PPIEENSG00000084072.121794.621301346.192900.414703.113502.24460K562RPS19
PPIEENSG00000084072.12791.193101015.66140-0.360302.767401.71630K562SRSF4
PPIEENSG00000084072.121044.083501354.28780-0.375302.799101.77400K562UCHL5
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PPIE is not available on ENCORE database.





10 RBPs can affect the splicing of PPIE :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPPIEENSG00000084072.12chr1+402088874020896940205836402059354020949540209596-0.090000.000020.01565excludedK562TAF15
SEPPIEENSG00000084072.12chr1+402110464021117040209495402095964021457440214760-0.066000.000000.00036excludedK562PRPF8
SEPPIEENSG00000084072.12chr1+4020700540207081402057924020593540209495402097310.622000.000000.00000includedK562AQR
SEPPIEENSG00000084072.12chr1+402110464021117040209495402095964021457440214760-0.180000.000000.00000excludedK562AQR
SEPPIEENSG00000084072.12chr1+402110464021443940209495402095964021457440214760-0.078000.000860.06417excludedK562SUPV3L1
SEPPIEENSG00000084072.12chr1+402088874020896940205836402059354020949540209596-0.072000.000000.00002excludedK562PUS1
SEPPIEENSG00000084072.12chr1+402110464021443940209495402095964021457440214760-0.086000.000440.02749excludedK562EFTUD2
SEPPIEENSG00000084072.12chr1+402070374020708140205836402059354020949540209596-0.067000.000010.00042excludedK562U2AF1
SEPPIEENSG00000084072.12chr1+402070374020708140205836402059354020949540209596-0.070000.000010.00024excludedK562U2AF2
A3SSPPIEENSG00000084072.12chr1+4020886640208969402088874020896940207507402075930.072000.000000.00000longerK562AQR
A5SSPPIEENSG00000084072.12chr1+4020750740207703402075074020759340208887402089690.068000.000000.00000longerK562AQR
A5SSPPIEENSG00000084072.12chr1+4021104640214439402110464021117040214574402147600.087000.000000.00000longerK562AQR
A5SSPPIEENSG00000084072.12chr1+402045594020472740204559402045954020583640205935-0.170000.000230.03303shorterK562PTBP1
RIPPIEENSG00000084072.12chr1+4020756640208969402075664020759340208887402089690.148000.000000.00000includedK562AQR
MXEPPIEENSG00000084072.12chr1+40209495402095964021457440214760402058364020593540218581402189380.061000.000000.000131includedK562PUS1
MXEPPIEENSG00000084072.12chr1+40209495402095964021108540211170402075664020759340214574402147600.241000.000000.000001includedK562AQR
MXEPPIEENSG00000084072.12chr1+4020703740207081402075664020896940205836402059354020949540209596-0.071000.008020.052922includedK562AQR
MXEPPIEENSG00000084072.12chr1+4020583640205935402070374020708140204556402046034020756640207593-0.093000.008240.054132includedK562AQR
MXEPPIEENSG00000084072.12chr1+4020703740207081402088874020896940205836402059354020949540209596-0.083000.007260.073622includedK562U2AF2
MXEPPIEENSG00000084072.12chr1+40207566402075934020888740208969402070374020708140209495402095960.061000.009820.095671includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PPIE is not avaliable on ENCORE database.