PGS1

General Information

Gene Name       : PGS1
Gene ID             : ENSG00000087157.18
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PGS1)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PGS1ENSG00000087157.188.4312.9810.71ENCSR000AEF
HepG2PGS1ENSG00000087157.1823.3314.7119.02ENCSR985KAT
K562PGS1ENSG00000087157.1819.5115.0317.27ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PGS1 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PGS1 RNA is bound by 22 proteins.  







eCLIP assay for PGS1 is not avaliable on ENCORE database.





22 proteins are bound to PGS1 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr177641579676415857+3'-UTR,intron-Distal,intron-Proximal3.020944.65130K562PRPF8
chr177642007076420156+3'-UTR,intron-Proximal4.211938.59763HepG2SF3A3
chr177639963376399682+3'-UTR,CDS,intron-Distal,intron-Proximal4.112013.65740K562U2AF2
chr177639963176399680+3'-UTR,CDS,intron-Distal,intron-Proximal3.814459.27521HepG2U2AF2
chr177639993176400006+3'-UTR,CDS,intron-Distal,intron-Proximal4.590623.81597K562RBM15
chr177641091276411021+3'-UTR,CDS,intron-Distal,intron-Proximal4.236883.56713HepG2SF3B4
chr177639960076399670+3'-UTR,CDS,intron-Distal,intron-Proximal4.335784.07325HepG2SF3B4
chr177640002176400066+3'-UTR,CDS,intron-Proximal5.497959.33028K562RBM15
chr177640013776400217+3'-UTR,CDS,intron-Proximal3.306917.39618HepG2PRPF8
chr177639976076399812+3'-UTR,CDS,intron-Distal4.419183.81597K562RBM15
chr177639433076394352+3'-UTR,5'-UTR,CDS,intron-Proximal4.849946.91190HepG2PPIG
chr177640009476400144+3'-UTR,CDS3.849623.15006K562RBM15
chr177641593676416048+3'-UTR,intron-Distal3.934553.57018HepG2HNRNPK
chr177641575376415849+3'-UTR,CDS,intron-Proximal3.9468614.09634HepG2PRPF8
chr177639693076397061+5'-UTR,CDS,intron-Distal,intron-Proximal3.042516.97029HepG2PRPF8
chr177639682676396907+5'-UTR,CDS,intron-Distal3.712097.36645HepG2PPIG
chr177639558376395620+5'-UTR,CDS,intron-Distal,intron-Proximal3.419603.05161HepG2PPIG
chr177637483576374895+5'-UTR,CDS,intron-Proximal3.318623.52645HepG2NCBP2
chr177639688376397065+5'-UTR,CDS,intron-Distal,intron-Proximal3.024564.05481K562BUD13
chr177637754676377629+intron-Distal3.979065.62053HepG2HNRNPM
chr177641881176418862+intron-Distal4.065363.77875HepG2ILF3
chr177640502876405102+intron-Distal3.263573.50009K562CSTF2T
chr177640314676403201+intron-Distal3.859703.03048HepG2GTF2F1
chr177640370276403801+intron-Distal4.231276.49292HepG2CSTF2T
chr177641078976410866+intron-Distal,intron-Proximal4.028503.82050HepG2SF3B4
chr177639812976398199+intron-Distal3.352734.01088HepG2RBFOX2
chr177640480576404848+intron-Distal4.535004.94096HepG2SFPQ
chr177640467876404771+intron-Distal4.562724.46290K562EWSR1
chr177641875976418811+intron-Distal4.571834.95918HepG2ILF3
chr177641659876416682+intron-Distal4.069913.59342K562CSTF2T
chr177640327076403350+intron-Distal3.255954.84495K562EWSR1
chr177640904176409091+intron-Distal4.841407.09445K562NONO
chr177640327176403344+intron-Distal5.065165.84281K562GTF2F1
chr177641112776411211+intron-Distal,intron-Proximal3.993008.08550HepG2RBM22
chr177637776976377828+intron-Distal4.606375.94008HepG2HNRNPM
chr177640314876403196+intron-Distal3.004293.25653K562CSTF2T
chr177640389176403966+intron-Distal3.229963.12257HepG2CSTF2T
chr177640327976403349+intron-Distal3.593057.73925K562CSTF2T
chr177640268476402741+intron-Distal4.052383.34098HepG2HNRNPM
chr177640729176407404+intron-Distal4.462054.75718K562EWSR1
chr177640325276403349+intron-Distal3.8908611.41717HepG2CSTF2T
chr177639696776397062+intron-Distal,intron-Proximal5.874629.61799HepG2EFTUD2
chr177639695676397034+intron-Distal,intron-Proximal3.407445.78766HepG2RBM22
chr177640903276409083+intron-Distal3.098055.89444HepG2CSTF2T
chr177640294176402985+intron-Distal4.139714.23759K562NONO
chr177640256776402684+intron-Distal3.908635.62053HepG2HNRNPM
chr177639402876394131+intron-Distal3.238363.39857HepG2HNRNPM
chr177641993376420005+intron-Distal3.152603.12257HepG2CSTF2T
chr177640282576402884+intron-Distal3.726594.60046HepG2CSTF2T
chr177640946676409531+intron-Distal4.383324.48497K562NONO
chr177640729076407387+intron-Distal3.530066.71496HepG2CSTF2T
chr177640478176404861+intron-Distal3.544303.64784K562EWSR1
chr177639694276397024+intron-Distal,intron-Proximal4.176913.85435K562PRPF8
chr177640323776403346+intron-Distal4.3401210.36696HepG2PRPF4
chr177638005776380109+intron-Distal4.713345.37406HepG2HNRNPM
chr177640293976402986+intron-Distal4.730456.05659HepG2CSTF2T
chr177640502076405068+intron-Distal4.102384.33692K562NONO
chr177638230976382413+intron-Distal3.680975.45871HepG2HNRNPM
chr177640468076404788+intron-Distal5.2391610.50469K562NONO
chr177640312376403200+intron-Distal3.368084.36876HepG2FAM120A
chr177640502876405079+intron-Distal4.388403.70291HepG2FAM120A
chr177640326976403345+intron-Distal4.056107.69118HepG2FAM120A
chr177640487476404966+intron-Distal3.685295.37486K562NONO
chr177638192276381984+intron-Distal4.093613.60235HepG2HNRNPM
chr177641111076411205+intron-Distal,intron-Proximal4.105797.13970HepG2PRPF8
chr177640460676404676+intron-Distal4.200273.86024K562EWSR1
chr177640946376409531+intron-Distal3.961543.80512K562CSTF2T
chr177640946576409519+intron-Distal4.481513.99130HepG2FAM120A
chr177640329276403350+intron-Distal4.633416.40241K562NONO
chr177640282276402891+intron-Distal3.413134.09779K562NONO
chr177640314076403187+intron-Distal3.199863.58549K562NONO
chr177638011776380163+intron-Distal4.143373.60235HepG2HNRNPM
chr177641436776414469+intron-Distal4.046055.57156HepG2QKI
chr177641024176410320+intron-Distal3.378795.59719HepG2CSTF2T
chr177641556576415624+intron-Proximal4.333528.87128HepG2SF3B4
chr177642099676421061+intron-Proximal3.190893.46580HepG2CSTF2T
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PGS1 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PGS1 is not available on ENCORE database.

  • 39 RBPs can affect the levels of PGS1.  








The Knockdown/knockout RNA-Seq assay for PGS1 is not available on ENCORE database.





39 RBPs can affect the gene expression of PGS1 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PGS1ENSG00000087157.14441.18420259.545900.765306.050205.20500HepG2BOP1
PGS1ENSG00000087157.14850.23030624.236200.445701.978101.33620HepG2CNOT7
PGS1ENSG00000087157.14948.24240577.633200.715006.001905.12070HepG2DDX6
PGS1ENSG00000087157.14451.72480370.504000.285901.867201.31260HepG2DNAJC2
PGS1ENSG00000087157.14799.76530555.203700.526503.813803.12490HepG2EIF2S1
PGS1ENSG00000087157.14718.94780564.395400.349103.133302.09730HepG2HDGF
PGS1ENSG00000087157.14519.62060377.363100.461402.963202.29650HepG2HNRNPA1
PGS1ENSG00000087157.14670.72020454.771100.560506.674605.62600HepG2HNRNPF
PGS1ENSG00000087157.14908.45660581.673400.643106.092405.08580HepG2HNRNPK
PGS1ENSG00000087157.14570.06740447.822500.348102.444801.76240HepG2IGF2BP1
PGS1ENSG00000087157.14568.86360393.869700.530302.670601.65000HepG2PCBP2
PGS1ENSG00000087157.14856.60710559.880600.613403.357801.68700HepG2PNPT1
PGS1ENSG00000087157.14626.95240379.993700.722303.572602.77390HepG2RAVER1
PGS1ENSG00000087157.14953.93010756.401700.334602.958002.42750HepG2RBM22
PGS1ENSG00000087157.14462.28000371.333300.316002.057201.48840HepG2SAFB2
PGS1ENSG00000087157.14850.16500571.552000.572803.538402.77220HepG2SF3A3
PGS1ENSG00000087157.14384.35380255.162900.590903.604802.80850HepG2SF3B1
PGS1ENSG00000087157.14953.05560606.990900.650809.822608.80920HepG2SF3B4
PGS1ENSG00000087157.14532.03060387.984700.455402.237901.38570HepG2SMNDC1
PGS1ENSG00000087157.14500.98380283.910600.819204.712003.68080HepG2SNRNP70
PGS1ENSG00000087157.141308.36760854.323900.6148011.6807010.84120HepG2SRFBP1
PGS1ENSG00000087157.14497.07170633.57490-0.350102.538902.08110HepG2SRSF1
PGS1ENSG00000087157.14609.32360446.788100.447504.324303.48450HepG2SRSF7
PGS1ENSG00000087157.14740.89680515.453700.523306.546705.76180HepG2SRSF9
PGS1ENSG00000087157.14446.11120569.50360-0.352302.310901.79030HepG2TAF15
PGS1ENSG00000087157.14604.86430405.144100.578105.364404.71460HepG2TIAL1
PGS1ENSG00000087157.14392.49050245.719800.675504.027203.11200HepG2UCHL5
PGS1ENSG00000087157.14946.218401154.50440-0.287002.227401.35320K562CELF1
PGS1ENSG00000087157.14752.54580605.153100.314402.472901.78620K562EIF2S2
PGS1ENSG00000087157.14657.28850424.501700.630705.739204.56220K562EIF4A3
PGS1ENSG00000087157.14254.02040369.51930-0.540702.826301.68650K562FKBP4
PGS1ENSG00000087157.14118.53450257.86960-1.121306.769805.55550K562G3BP2
PGS1ENSG00000087157.14591.00550399.003300.566704.820903.70290K562MAGOH
PGS1ENSG00000087157.14496.61180355.004900.484203.119702.08130K562PCBP2
PGS1ENSG00000087157.14567.21290426.696500.410602.873102.05670K562POLR2G
PGS1ENSG00000087157.14515.61960377.917600.448102.393901.69460K562PRPF8
PGS1ENSG00000087157.14584.22240387.660400.591605.490604.58230K562PTBP1
PGS1ENSG00000087157.14534.87620371.692600.525003.161802.25810K562RBM22
PGS1ENSG00000087157.14703.34090331.449501.085304.752703.04000K562SF1
PGS1ENSG00000087157.14752.26560559.455200.427103.222802.34570K562SF3A3
PGS1ENSG00000087157.14438.26410268.029300.709306.353905.02340K562SF3B4
PGS1ENSG00000087157.14527.89120384.615300.456702.834902.11940K562TARDBP
PGS1ENSG00000087157.14476.22450371.008000.360102.029101.33500K562TIA1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PGS1 is not available on ENCORE database.





6 RBPs can affect the splicing of PGS1 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPGS1ENSG00000087157.14chr17+763923887639246676388594763887467639433276394395-0.237000.003040.08469excludedK562PRPF8
SEPGS1ENSG00000087157.14chr17+7639922076399328763967577639693676399648764001700.134000.000180.00644includedHepG2HNRNPK
SEPGS1ENSG00000087157.14chr17+7641927276419376764156267641575676420141764206380.230000.000020.00121includedHepG2HNRNPK
SEPGS1ENSG00000087157.14chr17+763923887639246676388594763887467639433276394395-0.270000.001810.07854excludedK562EFTUD2
SEPGS1ENSG00000087157.14chr17+763923887639246676388594763887467639433276394432-0.257000.000220.03289excludedHepG2SSB
A3SSPGS1ENSG00000087157.14chr17+7639667476396905763967577639690576395428763956180.083000.000110.00098longerK562AQR
MXEPGS1ENSG00000087157.14chr17+76395428763956187640005676400170763943327639443276411032764111080.139000.001460.049741includedHepG2NCBP2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PGS1 is not avaliable on ENCORE database.