OPTN

General Information

Gene Name : OPTN
Gene ID : ENSG00000123240.16
Essential Gene : No

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: OPTN)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	OPTN	ENSG00000123240.16	17.71	17.73	17.72	ENCSR000AEF
HepG2	OPTN	ENSG00000123240.16	6.21	7.68	6.95	ENCSR985KAT
K562	OPTN	ENSG00000123240.16	3.73	3.57	3.65	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for OPTN is not avaliable on ENCORE database.

Proteins bound to RNA

OPTN RNA is bound by 7 proteins.

CanvasJS.com

eCLIP assay for OPTN is not avaliable on ENCORE database.

7 proteins are bound to OPTN RNA:

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Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr10	13152352	13152430	+	CDS,intron-Distal	4.80565	22.88455	HepG2	BCLAF1
chr10	13169747	13169828	+	CDS	3.61011	14.34206	HepG2	BCLAF1
chr10	13160947	13161037	+	CDS	3.58766	13.63205	HepG2	BCLAF1
chr10	13167421	13167486	+	CDS	4.40227	12.53492	HepG2	BCLAF1
chr10	13164384	13164473	+	CDS,intron-Proximal	3.23748	11.79442	HepG2	BCLAF1
chr10	13154453	13154554	+	CDS	3.43155	10.70004	HepG2	BCLAF1
chr10	13174097	13174181	+	CDS	3.63871	10.10467	HepG2	BCLAF1
chr10	13152304	13152352	+	CDS,intron-Distal	3.66958	8.66838	HepG2	BCLAF1
chr10	13152430	13152477	+	CDS,intron-Distal,intron-Proximal	4.03911	6.97808	HepG2	BCLAF1
chr10	13154493	13154616	+	CDS	4.16801	6.61895	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 24 entries

eCLIP assay for OPTN is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for OPTN is not available on ENCORE database.
172 RBPs can affect the levels of OPTN.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for OPTN is not available on ENCORE database.

172 RBPs can affect the gene expression of OPTN :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
OPTN	ENSG00000123240.12	783.48240	2795.50870	-1.83510	96.90930	95.05290	HepG2	SRSF1
OPTN	ENSG00000123240.12	1004.65950	2862.92490	-1.51080	72.55630	70.72120	HepG2	NELFE
OPTN	ENSG00000123240.12	652.12960	2613.04610	-2.00250	56.58630	53.86100	HepG2	MAGOH
OPTN	ENSG00000123240.12	506.06770	1457.31470	-1.52590	51.97800	49.89750	HepG2	UTP3
OPTN	ENSG00000123240.12	2948.52180	999.67810	1.56040	47.84350	45.85250	HepG2	RPLP0
OPTN	ENSG00000123240.12	1085.31860	2666.61510	-1.29690	41.37400	39.55810	HepG2	RECQL
OPTN	ENSG00000123240.12	1274.38710	2678.15750	-1.07140	40.46270	38.70950	HepG2	SF3B4
OPTN	ENSG00000123240.12	1929.05050	911.76230	1.08110	38.65550	36.67910	HepG2	SRSF7
OPTN	ENSG00000123240.12	2655.59500	1329.32190	0.99820	38.86600	36.52300	HepG2	EIF4G1
OPTN	ENSG00000123240.12	1823.45790	505.97920	1.84940	37.11430	35.19160	HepG2	SUPV3L1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 225 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for OPTN is not available on ENCORE database.

15 RBPs can affect the splicing of OPTN :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	OPTN	ENSG00000123240.12	chr10	+	13150137	13150289	13142172	13142302	13151111	13151288	-0.18700	0.00000	0.00004	excluded	HepG2	HNRNPK
SE	OPTN	ENSG00000123240.12	chr10	+	13150137	13150289	13142172	13142302	13151111	13151288	-0.19300	0.00000	0.00001	excluded	HepG2	NCBP2
A3SS	OPTN	ENSG00000123240.12	chr10	+	13160887	13161040	13160905	13161040	13158266	13158340	-0.33900	0.00000	0.00000	shorter	HepG2	U2AF2
SE	OPTN	ENSG00000123240.12	chr10	+	13150137	13150289	13142172	13142302	13151111	13151288	0.16000	0.00001	0.00308	included	HepG2	DDX59
SE	OPTN	ENSG00000123240.12	chr10	+	13150961	13151015	13150137	13150289	13151111	13151288	-0.13300	0.00001	0.00026	excluded	HepG2	U2AF2
SE	OPTN	ENSG00000123240.12	chr10	+	13150137	13150289	13142172	13142302	13151111	13151288	-0.10700	0.00007	0.00971	excluded	HepG2	TBRG4
SE	OPTN	ENSG00000123240.12	chr10	+	13150137	13150289	13142172	13142302	13151111	13151288	0.19600	0.00013	0.02914	included	HepG2	TIA1
SE	OPTN	ENSG00000123240.12	chr10	+	13150137	13150289	13142172	13142302	13151111	13151288	-0.14500	0.00014	0.01687	excluded	HepG2	DDX3X
SE	OPTN	ENSG00000123240.12	chr10	+	13150137	13150289	13142172	13142302	13151111	13151288	0.21100	0.00023	0.04054	included	K562	ZC3H8
SE	OPTN	ENSG00000123240.12	chr10	+	13167784	13167836	13167417	13167567	13167945	13168039	0.13200	0.00028	0.00749	included	K562	SRSF1

Showing 1 to 10 of 16 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

OPTN

General Information

Functions

Localization

Domains (AlphaFold: OPTN)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for OPTN is not avaliable on ENCORE database.

7 proteins are bound to OPTN RNA:

eCLIP assay for OPTN is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for OPTN is not available on ENCORE database.

172 RBPs can affect the gene expression of OPTN :

The Knockdown/knockout RNA-Seq assay for OPTN is not available on ENCORE database.

15 RBPs can affect the splicing of OPTN :

The Knockdown/knockout RNA-Seq assay for OPTN is not avaliable on ENCORE database.