POLG2

General Information

Gene Name : POLG2
Gene ID : ENSG00000256525.6
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: POLG2)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	POLG2	ENSG00000256525.6	15.72	15.23	15.48	ENCSR000AEF
HepG2	POLG2	ENSG00000256525.6	14.54	20.65	17.59	ENCSR985KAT
K562	POLG2	ENSG00000256525.6	22.38	25.14	23.76	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for POLG2 is not avaliable on ENCORE database.

Proteins bound to RNA

POLG2 RNA is bound by 13 proteins.

eCLIP assay for POLG2 is not avaliable on ENCORE database.

13 proteins are bound to POLG2 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr17	62487007	62487086	-	3'-UTR,CDS,intron-Distal	3.52660	9.32936	K562	ZNF622
chr17	62487022	62487086	-	3'-UTR,CDS,intron-Distal	4.89084	10.19430	HepG2	BCLAF1
chr17	62488781	62488819	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.61184	8.66838	HepG2	BCLAF1
chr17	62474002	62474059	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.01287	6.22576	HepG2	BCLAF1
chr17	62487022	62487088	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.66723	4.86518	HepG2	BUD13
chr17	62486936	62487007	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.23692	9.05280	HepG2	GRWD1
chr17	62486904	62487002	-	3'-UTR,CDS,intron-Distal,intron-Proximal	3.72053	4.16174	HepG2	PRPF8
chr17	62488856	62488874	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.24789	3.35169	HepG2	U2AF2
chr17	62486933	62487018	-	3'-UTR,CDS,intron-Distal,intron-Proximal	4.17163	7.65975	HepG2	BCLAF1
chr17	62476405	62476448	-	CDS,intron-Distal,intron-Proximal	3.56898	5.40132	HepG2	BCLAF1
chr17	62492497	62492563	-	CDS,intron-Distal	4.11151	7.29769	HepG2	PRPF8
chr17	62481917	62481988	-	CDS,intron-Distal,intron-Proximal	3.60332	8.25092	HepG2	BCLAF1
chr17	62481948	62481994	-	CDS,intron-Distal,intron-Proximal	3.61491	3.99908	K562	BUD13
chr17	62479030	62479078	-	CDS,intron-Distal,intron-Proximal	4.51891	13.76607	HepG2	U2AF2
chr17	62481947	62481996	-	CDS,intron-Distal,intron-Proximal	4.05692	3.88088	K562	U2AF2
chr17	62492739	62492819	-	CDS,intron-Distal	3.00812	4.29277	HepG2	GRWD1
chr17	62479078	62479158	-	CDS,intron-Distal,intron-Proximal	4.60289	26.67873	HepG2	U2AF2
chr17	62481944	62481998	-	CDS,intron-Distal,intron-Proximal	4.05203	13.18729	HepG2	U2AF2
chr17	62479028	62479157	-	CDS,intron-Distal,intron-Proximal	4.63498	6.12255	K562	U2AF2
chr17	62481943	62481996	-	CDS,intron-Distal,intron-Proximal	3.47409	5.12879	HepG2	U2AF1
chr17	62481834	62481895	-	CDS,intron-Distal,intron-Proximal	3.82431	5.80935	K562	ZNF622
chr17	62492729	62492828	-	CDS,intron-Distal	4.55115	5.65349	K562	RBM15
chr17	62486603	62486697	-	intron-Distal	3.90637	6.48117	K562	KHSRP
chr17	62480164	62480253	-	intron-Distal	4.18137	31.15222	K562	AQR
chr17	62485922	62486004	-	intron-Distal	4.15331	3.82619	K562	ILF3
chr17	62486837	62486901	-	intron-Distal,intron-Proximal	3.65659	3.88924	K562	PRPF8
chr17	62483252	62483342	-	intron-Distal	3.58620	3.51696	K562	KHSRP
chr17	62479126	62479172	-	intron-Distal,intron-Proximal	4.11860	4.49024	K562	AQR
chr17	62481800	62481839	-	intron-Distal,intron-Proximal	6.43567	34.23192	K562	AQR
chr17	62481839	62481844	-	intron-Distal,intron-Proximal	6.17615	29.88239	K562	AQR
chr17	62480166	62480218	-	intron-Distal	4.27361	4.70109	K562	U2AF2
chr17	62481751	62481794	-	intron-Distal,intron-Proximal	3.49869	3.99381	K562	BUD13
chr17	62481626	62481715	-	intron-Distal	3.26748	9.59462	K562	PRPF8
chr17	62489215	62489270	-	intron-Distal,intron-Proximal	4.76504	7.91159	K562	KHSRP
chr17	62476000	62476169	-	intron-Distal	4.75809	6.23114	K562	TARDBP
chr17	62486685	62486743	-	intron-Distal	3.35645	3.81210	HepG2	KHSRP
chr17	62489141	62489215	-	intron-Distal,intron-Proximal	5.43103	11.96615	K562	KHSRP
chr17	62481748	62481790	-	intron-Distal,intron-Proximal	4.82359	8.52787	K562	AQR
chr17	62485828	62485864	-	intron-Distal	4.26196	4.18168	HepG2	ILF3
chr17	62478113	62478209	-	intron-Distal	3.38255	3.68839	K562	KHSRP
chr17	62477007	62477050	-	intron-Distal	4.52005	3.77802	HepG2	U2AF2
chr17	62481790	62481800	-	intron-Distal,intron-Proximal	4.10331	4.00320	K562	AQR
chr17	62476873	62476942	-	intron-Distal	4.46184	6.59655	K562	PTBP1
chr17	62486602	62486685	-	intron-Distal	3.24355	4.65228	HepG2	KHSRP
chr17	62479179	62479282	-	intron-Distal,intron-Proximal	3.68960	5.78005	K562	KHSRP
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for POLG2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for POLG2 is not available on ENCORE database.
34 RBPs can affect the levels of POLG2.

The Knockdown/knockout RNA-Seq assay for POLG2 is not available on ENCORE database.

34 RBPs can affect the gene expression of POLG2 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
POLG2	ENSG00000256525.2	185.48950	313.07150	-0.75520	4.30160	3.33130	HepG2	ASCC1
POLG2	ENSG00000256525.2	161.09010	246.17260	-0.61180	2.38890	1.55560	HepG2	BCLAF1
POLG2	ENSG00000256525.2	311.74050	409.43300	-0.39330	2.61110	1.98480	HepG2	CELF1
POLG2	ENSG00000256525.2	401.22150	270.35630	0.56940	4.43560	3.69730	HepG2	PCBP1
POLG2	ENSG00000256525.2	202.99370	416.77120	-1.03780	10.30910	9.25680	HepG2	PUF60
POLG2	ENSG00000256525.2	374.80720	285.13400	0.39440	2.18900	1.63230	HepG2	RECQL
POLG2	ENSG00000256525.2	370.40670	243.21030	0.60680	4.90480	4.20880	HepG2	SRSF9
POLG2	ENSG00000256525.2	430.18990	268.69890	0.67890	5.82150	5.05990	HepG2	TAF15
POLG2	ENSG00000256525.2	345.53000	246.90970	0.48470	2.88620	2.03390	HepG2	TIA1
POLG2	ENSG00000256525.2	603.94100	807.55080	-0.41910	4.13370	3.46480	K562	AGGF1
POLG2	ENSG00000256525.2	621.30660	840.28870	-0.43560	3.38470	2.66020	K562	AKAP8L
POLG2	ENSG00000256525.2	482.38670	616.29390	-0.35340	2.59490	1.33420	K562	BCCIP
POLG2	ENSG00000256525.2	435.34010	595.59190	-0.45220	4.17940	2.98470	K562	BCLAF1
POLG2	ENSG00000256525.2	659.00710	965.08240	-0.55040	6.27950	4.47410	K562	CCDC124
POLG2	ENSG00000256525.2	625.63020	924.70120	-0.56370	2.78230	1.71680	K562	CNOT7
POLG2	ENSG00000256525.2	170.08140	299.82140	-0.81790	3.20330	2.11370	K562	EIF3A
POLG2	ENSG00000256525.2	337.29980	501.55210	-0.57240	3.26930	2.13770	K562	EIF3D
POLG2	ENSG00000256525.2	346.41060	523.52730	-0.59580	4.78890	3.70870	K562	EIF4A3
POLG2	ENSG00000256525.2	431.90510	544.44250	-0.33410	2.28360	1.72540	K562	FXR1
POLG2	ENSG00000256525.2	281.33250	397.75980	-0.49960	2.84810	2.24380	K562	HNRNPC
POLG2	ENSG00000256525.2	545.08260	716.92300	-0.39530	3.34550	2.36540	K562	HNRNPU
POLG2	ENSG00000256525.2	772.04590	999.00800	-0.37180	2.73990	1.83670	K562	MBNL1
POLG2	ENSG00000256525.2	843.00000	1174.69570	-0.47870	4.20630	2.81610	K562	MSI2
POLG2	ENSG00000256525.2	357.70430	513.59430	-0.52190	3.08380	2.20440	K562	PCBP3
POLG2	ENSG00000256525.2	270.95410	393.93490	-0.53990	3.42790	2.52940	K562	POLR2G
POLG2	ENSG00000256525.2	442.56400	555.51880	-0.32790	2.03390	1.44800	K562	PTBP1
POLG2	ENSG00000256525.2	746.13300	1202.43960	-0.68850	7.60230	6.24510	K562	PUF60
POLG2	ENSG00000256525.2	563.59930	833.36850	-0.56430	4.58530	3.90930	K562	PUS1
POLG2	ENSG00000256525.2	604.77300	811.96490	-0.42500	3.84310	3.16050	K562	RBM15
POLG2	ENSG00000256525.2	303.58040	464.31950	-0.61300	3.58140	2.64970	K562	RPS19
POLG2	ENSG00000256525.2	539.89500	656.68170	-0.28250	2.16490	1.32770	K562	SRPK2
POLG2	ENSG00000256525.2	311.06660	441.36350	-0.50470	2.60310	1.61940	K562	SUPV3L1
POLG2	ENSG00000256525.2	576.45680	784.35460	-0.44430	4.36690	2.76970	K562	TROVE2
POLG2	ENSG00000256525.2	310.41030	471.47960	-0.60300	4.98660	3.90990	K562	U2AF2
POLG2	ENSG00000256525.2	299.45480	467.11130	-0.64140	4.34970	3.04670	K562	UCHL5
POLG2	ENSG00000256525.2	841.05020	1073.38110	-0.35190	2.73690	1.87910	K562	ZC3H8
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for POLG2 is not available on ENCORE database.

10 RBPs can affect the splicing of POLG2 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	POLG2	ENSG00000256525.2	chr17	-	62486672	62486794			62481844	62481985	62486912	62487086	0.22000	0.00000	0.00115	included	K562	SUPV3L1
SE	POLG2	ENSG00000256525.2	chr17	-	62483014	62483138			62481844	62481985	62486912	62487086	0.28800	0.00016	0.01743	included	HepG2	IGF2BP3
SE	POLG2	ENSG00000256525.2	chr17	-	62486736	62486794			62481844	62481985	62486912	62487086	0.06000	0.00011	0.01393	included	K562	HNRNPUL1
SE	POLG2	ENSG00000256525.2	chr17	-	62477362	62477598			62476464	62476506	62479035	62479116	0.09700	0.00026	0.04043	included	K562	RBM22
SE	POLG2	ENSG00000256525.2	chr17	-	62477362	62477594			62476464	62476506	62479035	62479116	0.10500	0.00061	0.01320	included	K562	U2AF2
SE	POLG2	ENSG00000256525.2	chr17	-	62483014	62483138			62481844	62481985	62486912	62487086	-0.06500	0.00024	0.01221	excluded	K562	HNRNPU
SE	POLG2	ENSG00000256525.2	chr17	-	62476405	62476525			62473901	62474105	62479035	62479116	0.27200	0.00117	0.09841	included	K562	CPSF6
SE	POLG2	ENSG00000256525.2	chr17	-	62477362	62477598			62476464	62476506	62479035	62479116	0.07900	0.00173	0.06777	included	K562	HNRNPK
SE	POLG2	ENSG00000256525.2	chr17	-	62486672	62486794			62481844	62481985	62486912	62487086	0.16100	0.00014	0.03897	included	K562	SERBP1
A3SS	POLG2	ENSG00000256525.2	chr17	-	62476405	62476566			62476405	62476506	62479035	62479116	0.38700	0.00000	0.00000	longer	K562	AQR
MXE	POLG2	ENSG00000256525.2	chr17	-	62486912	62487086	62488783	62488889	62476405	62476506	62489011	62489138	-0.06100	0.00080	0.00749	2included	K562	AQR

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

POLG2

General Information

Functions

Localization

Domains (AlphaFold: POLG2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for POLG2 is not avaliable on ENCORE database.

13 proteins are bound to POLG2 RNA:

eCLIP assay for POLG2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for POLG2 is not available on ENCORE database.

34 RBPs can affect the gene expression of POLG2 :

The Knockdown/knockout RNA-Seq assay for POLG2 is not available on ENCORE database.

10 RBPs can affect the splicing of POLG2 :

The Knockdown/knockout RNA-Seq assay for POLG2 is not avaliable on ENCORE database.