PRPF18

General Information

Gene Name       : PRPF18
Gene ID             : ENSG00000165630.13
Essential Gene : Yes

Functions

Localization

Domains (AlphaFold: PRPF18)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878PRPF18ENSG00000165630.1327.1424.0725.61ENCSR000AEF
HepG2PRPF18ENSG00000165630.137.8812.7010.29ENCSR985KAT
K562PRPF18ENSG00000165630.1314.8017.4316.12ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for PRPF18 is not avaliable on ENCORE database.



Proteins bound to RNA
  • PRPF18 RNA is bound by 6 proteins.  







eCLIP assay for PRPF18 is not avaliable on ENCORE database.





6 proteins are bound to PRPF18 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr101365361413653685+3'-UTR,CDS,intron-Proximal4.545373.79199HepG2PPIG
chr101365849113658556+CDS,intron-Proximal3.156344.34695HepG2BCLAF1
chr101365601713656087+CDS,intron-Proximal4.480333.71570HepG2BCLAF1
chr101365839713658543+CDS,intron-Proximal3.405335.10069HepG2GRWD1
chr101365852713658596+CDS,intron-Proximal4.230263.86479HepG2PRPF8
chr101365840213658503+CDS3.207234.77136HepG2PPIG
chr101365839713658468+CDS,intron-Proximal4.998596.58593HepG2BCLAF1
chr101365206213652184+CDS3.848783.79347HepG2GRWD1
chr101364419713644372+intron-Distal3.803356.89441K562KHSRP
chr101367087713670970+intron-Distal4.511864.66899HepG2HNRNPM
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for PRPF18 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for PRPF18 is not available on ENCORE database.

  • 31 RBPs can affect the levels of PRPF18.  








The Knockdown/knockout RNA-Seq assay for PRPF18 is not available on ENCORE database.





31 RBPs can affect the gene expression of PRPF18 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
PRPF18ENSG00000165630.9446.56510321.792800.472602.136001.66260HepG2AKAP1
PRPF18ENSG00000165630.9286.20800212.799700.427502.375401.75130HepG2CKAP4
PRPF18ENSG00000165630.9146.59680209.68440-0.516402.085901.48750HepG2DDX21
PRPF18ENSG00000165630.9408.68670308.249600.406801.826601.30710HepG2DDX3X
PRPF18ENSG00000165630.9123.16030264.80120-1.104406.469505.55550HepG2DDX6
PRPF18ENSG00000165630.9102.22760177.10880-0.792903.305002.31550HepG2GEMIN5
PRPF18ENSG00000165630.9365.17240272.937500.419902.361001.48890HepG2HNRNPA2B1
PRPF18ENSG00000165630.9252.56630184.252000.454902.248001.47670HepG2PARN
PRPF18ENSG00000165630.9225.30600298.20120-0.404401.968001.39640HepG2PUM2
PRPF18ENSG00000165630.9419.91460221.103000.925304.739903.83100HepG2RAVER1
PRPF18ENSG00000165630.9415.83010282.669400.556804.105803.50660HepG2RBM22
PRPF18ENSG00000165630.9316.31400217.139900.542602.156801.32080HepG2RPS10
PRPF18ENSG00000165630.9229.49900156.530500.551902.414001.67480HepG2RRP9
PRPF18ENSG00000165630.9448.08600303.136400.563702.855202.16960HepG2SF3A3
PRPF18ENSG00000165630.9473.13810319.267600.567405.103804.48180HepG2SRFBP1
PRPF18ENSG00000165630.9207.45670291.37700-0.490102.845002.13990HepG2SRSF7
PRPF18ENSG00000165630.9340.03480238.804100.509802.565101.95790HepG2U2AF1
PRPF18ENSG00000165630.9276.28210200.887700.459702.568301.91690HepG2ZC3H8
PRPF18ENSG00000165630.9422.25620295.668000.514004.390003.74270HepG2ZNF622
PRPF18ENSG00000165630.9725.95510551.973100.395202.448101.88970K562AQR
PRPF18ENSG00000165630.9379.38450475.52470-0.325902.120101.32760K562ATP5C1
PRPF18ENSG00000165630.9375.39230260.943300.524603.587102.91230K562FXR1
PRPF18ENSG00000165630.9421.96570293.947600.521502.474301.55210K562PCBP2
PRPF18ENSG00000165630.9384.27820270.928000.504102.954902.12610K562POLR2G
PRPF18ENSG00000165630.9373.44270231.423100.690304.106203.19230K562PRPF8
PRPF18ENSG00000165630.9991.58280726.338400.449003.349302.45240K562PUF60
PRPF18ENSG00000165630.9713.60060449.561500.666505.437104.70820K562PUS1
PRPF18ENSG00000165630.9267.00320481.38640-0.850303.320801.84270K562SFPQ
PRPF18ENSG00000165630.9356.03140271.751400.389602.056901.34770K562SYNCRIP
PRPF18ENSG00000165630.9229.12350307.15000-0.422802.053501.35570K562TIA1
PRPF18ENSG00000165630.9155.82090239.58010-0.620602.964601.97920K562TRIM56
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for PRPF18 is not available on ENCORE database.





12 RBPs can affect the splicing of PRPF18 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEPRPF18ENSG00000165630.9chr10+136337671363388813628938136291521363945713639535-0.092000.000230.00989excludedK562AKAP8L
SEPRPF18ENSG00000165630.9chr10+1363376713633888136289381362915213639457136395350.145000.002590.05740includedHepG2HNRNPK
SEPRPF18ENSG00000165630.9chr10+136337671363388813628938136291521363945713639535-0.071000.006570.05819excludedK562AQR
SEPRPF18ENSG00000165630.9chr10+1363376713633888136289381362915213639457136395350.090000.000160.03350includedK562DROSHA
SEPRPF18ENSG00000165630.9chr10+136337671363388813628938136291521363945713639535-0.083000.000040.00104excludedK562PUS1
SEPRPF18ENSG00000165630.9chr10+1363376713633888136289381362915213639457136395350.126000.000000.00018includedHepG2SFPQ
SEPRPF18ENSG00000165630.9chr10+1363376713633888136289381362915213639457136395350.108000.000840.05255includedHepG2FTO
SEPRPF18ENSG00000165630.9chr10+1363376713633888136289381362915213639457136395350.153000.001720.06265includedHepG2MATR3
SEPRPF18ENSG00000165630.9chr10+136337671363388813628938136291521363945713639535-0.115000.001010.02566excludedHepG2SRSF1
SEPRPF18ENSG00000165630.9chr10+136337671363388813628938136291521363945713639535-0.072000.002290.06301excludedK562UTP18
SEPRPF18ENSG00000165630.9chr10+136337671363388813628938136291521363945713639535-0.087000.000130.00537excludedK562AGGF1
SEPRPF18ENSG00000165630.9chr10+136337671363388813628938136291521363945713639535-0.121000.002190.07208excludedK562PTBP1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for PRPF18 is not avaliable on ENCORE database.