LARS

General Information

Gene Name : LARS
Gene ID : ENSG00000133706.17
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: LARS)

Not Available

Antibody Validation

View validation images for all LARS antibodies

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	LARS	ENSG00000133706.17	66.50	55.98	61.24	ENCSR000AEF
HepG2	LARS	ENSG00000133706.17	42.76	50.04	46.40	ENCSR985KAT
K562	LARS	ENSG00000133706.17	108.77	125.59	117.18	ENCSR000AEO

Assays

2 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	LARS-BGKcLV23-K562	ENCSR381NPB	LARS	K562	Released		ENCSR877JEM	CRISPR	KD% = 75.9,79.6
knockdown followed by RNA-seq	LARS-BGHcLV24-HepG2	ENCSR213ILK	LARS	HepG2	Released		ENCSR671FDZ	CRISPR	KD% = 81.0,85.0

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
LARS	ENCAB154HAY	PA5-98918	UK2881575		BGHcLV24-35, Released, ENCODE4	BGKcLV23-45, Released, ENCODE4
LARS		83439S	1	Submitted, ENCORE2	BGHcLV24-35, Released, ENCODE4	BGKcLV23-45, Submitted, ENCORE2
LARS		A304-316A	1		BGHcLV24-35, Released, ENCODE4	BGKcLV23-45, Submitted, ENCORE2
LARS		35509S	1	Submitted, ENCORE2	BGHcLV24-35, Released, ENCODE4	BGKcLV23-45, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
LARS	K562	CRISPR	ENCSR381NPB	ENCSR877JEM	LARS-BGKcLV23-45,LARS-BGKcLV23-46	NT-BGKcLV23-1,NT-BGKcLV23-2	75.9,79.6	Released	ENCODE4
LARS	K562	CRISPR			BGKcLV23-47,BGKcLV23-48	BGKcLV23-1,BGKcLV23-2	46.3,43.9	NotSatisfied	ENCODE4
LARS	HepG2	CRISPR	ENCSR213ILK	ENCSR671FDZ	LARS-BGHcLV24-35,LARS-BGHcLV24-36	NT-BGHcLV24-1,NT-BGHcLV24-2	81.0,85.0	Released	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
LARS	Product_ID: 35509S Lot_ID: 1 Source: Cell Signaling Technology Target Name: LARS-human
LARS	Product_ID: 83439S Lot_ID: 1 Source: Cell Signaling Technology Target Name: LARS-human
LARS	Product_ID: PA5-98918 Lot_ID: UK2881575 Source: Thermo Fisher Target Name: LARS-human
LARS	Product_ID: A304-316A Lot_ID: 1 Source: Bethyl Labs Target Name: LARS-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for LARS is not avaliable on ENCORE database.

Proteins bound to RNA

LARS RNA is bound by 42 proteins.

CanvasJS.com

eCLIP assay for LARS is not avaliable on ENCORE database.

42 proteins are bound to LARS RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr5	145562107	145562189	-	5'-UTR,intron-Distal,intron-Proximal	5.81549	400.00000	HepG2	SUB1
chr5	145557108	145557205	-	CDS,intron-Distal,intron-Proximal	4.12180	51.68653	K562	DDX24
chr5	145493546	145493648	-	3'-UTR,intron-Distal	6.17348	45.38413	HepG2	SUB1
chr5	145524031	145524068	-	CDS,intron-Distal,intron-Proximal	4.13186	40.96690	K562	UCHL5
chr5	145533305	145533457	-	CDS,intron-Distal,intron-Proximal	4.00532	33.61313	K562	EFTUD2
chr5	145552321	145552337	-	5'-UTR,CDS,intron-Distal	4.18091	32.17050	K562	DDX24
chr5	145543952	145544034	-	CDS,intron-Distal,intron-Proximal	4.34650	31.72267	HepG2	BCLAF1
chr5	145557107	145557157	-	CDS,intron-Distal,intron-Proximal	5.54373	30.58958	HepG2	BCLAF1
chr5	145524068	145524101	-	CDS,intron-Distal,intron-Proximal	3.92810	29.96710	K562	UCHL5
chr5	145524065	145524101	-	CDS,intron-Distal,intron-Proximal	3.64447	28.81138	K562	ZNF622
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 275 entries

eCLIP assay for LARS is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for LARS is not available on ENCORE database.
111 RBPs can affect the levels of LARS.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for LARS is not available on ENCORE database.

111 RBPs can affect the gene expression of LARS :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
LARS	ENSG00000133706.13	1044.15380	2558.93040	-1.29320	78.16200	76.30900	HepG2	ZNF622
LARS	ENSG00000133706.13	1843.19670	6085.38640	-1.72310	79.38180	76.25560	K562	HNRNPC
LARS	ENSG00000133706.13	1350.18550	2326.70780	-0.78510	25.63470	23.95010	HepG2	UPF1
LARS	ENSG00000133706.13	6124.75330	11390.27440	-0.89510	25.17020	22.78950	K562	GRSF1
LARS	ENSG00000133706.13	6160.70950	11763.68230	-0.93320	22.79830	21.29420	K562	AQR
LARS	ENSG00000133706.13	5112.97630	9075.60450	-0.82780	22.46020	20.45260	K562	SRSF1
LARS	ENSG00000133706.13	3447.53890	6582.56650	-0.93310	22.27280	19.70030	K562	EIF4A3
LARS	ENSG00000133706.13	6601.96810	9654.72050	-0.54830	20.65820	18.91420	K562	UPF1
LARS	ENSG00000133706.13	2531.11570	3948.09450	-0.64140	19.91300	18.37920	HepG2	AUH
LARS	ENSG00000133706.13	1538.08690	2864.56070	-0.89720	19.47920	18.08810	HepG2	PUF60
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 142 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for LARS is not available on ENCORE database.

19 RBPs can affect the splicing of LARS :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
SE	LARS	ENSG00000133706.13	chr5	-	145522434	145522647	145519766	145519824	145522974	145523113	-0.10000	0.00000	excluded	K562	SRSF1
SE	LARS	ENSG00000133706.13	chr5	-	145532736	145532790	145531424	145531565	145533296	145533373	-0.30900	0.00000	excluded	K562	SF3B4
SE	LARS	ENSG00000133706.13	chr5	-	145510581	145510672	145509609	145509721	145512460	145512644	-0.10500	0.00000	excluded	K562	PUS1
SE	LARS	ENSG00000133706.13	chr5	-	145532736	145532790	145531424	145531565	145533296	145533373	-0.10100	0.00007	excluded	K562	U2AF1
SE	LARS	ENSG00000133706.13	chr5	-	145510581	145510672	145509580	145509721	145512460	145512644	-0.07600	0.00000	excluded	K562	U2AF1
SE	LARS	ENSG00000133706.13	chr5	-	145510581	145510672	145509609	145509721	145512460	145512644	-0.06100	0.00000	excluded	K562	UTP18
SE	LARS	ENSG00000133706.13	chr5	-	145532736	145532790	145531424	145531565	145533296	145533373	-0.16600	0.00000	excluded	K562	TARDBP
SE	LARS	ENSG00000133706.13	chr5	-	145510581	145510672	145509609	145509721	145512460	145512644	-0.06300	0.00000	excluded	K562	RBM15
SE	LARS	ENSG00000133706.13	chr5	-	145510581	145510672	145509609	145509721	145512460	145512644	-0.05400	0.00000	excluded	K562	AGGF1
SE	LARS	ENSG00000133706.13	chr5	-	145532736	145532790	145531424	145531565	145533296	145533373	-0.08500	0.00000	excluded	K562	SF3B1

Showing 1 to 10 of 30 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

LARS

General Information

Functions

Localization

Domains (AlphaFold: LARS)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for LARS is not avaliable on ENCORE database.

42 proteins are bound to LARS RNA:

eCLIP assay for LARS is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for LARS is not available on ENCORE database.

111 RBPs can affect the gene expression of LARS :

The Knockdown/knockout RNA-Seq assay for LARS is not available on ENCORE database.

19 RBPs can affect the splicing of LARS :

The Knockdown/knockout RNA-Seq assay for LARS is not avaliable on ENCORE database.