CPSF1

General Information

Gene Name : CPSF1
Gene ID : ENSG00000071894.16
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: CPSF1)

Not Available

Antibody Validation

Bethyl Labs: A301-580A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	CPSF1	ENSG00000071894.16	3.10	10.97	7.04	ENCSR000AEF
HepG2	CPSF1	ENSG00000071894.16	144.01	21.07	82.54	ENCSR985KAT
K562	CPSF1	ENSG00000071894.16	80.98	38.55	59.77	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
CPSF1	ENCAB113DER	A301-580A	2			Released, ENCODE4		BGKcLV44-7, Submitted, ENCORE2

KD RNA-Seq

GeneName	Cell_Line	Method	Sample_reps	Control_reps	KD%	Status	Project
CPSF1	K562	CRISPR	BGKcLV44-5,BGKcLV44-6	BGKcLV44-1,BGKcLV44-2	24.5,33.1	NotSatisfied	ENCORE2
CPSF1	K562	CRISPR	CPSF1-BGKcLV44-7,CPSF1-BGKcLV44-8	NT-BGKcLV44-1,NT-BGKcLV44-2	70.3,66.8	Submitting	ENCORE2
CPSF1	HepG2	CRISPR	BGHcLV45-13,BGHcLV45-14	BGHcLV45-1,BGHcLV45-2	no band on the position,	NotSatisfied	ENCORE2

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
CPSF1	Product_ID: A301-580A Lot_ID: 2 Source: Bethyl Labs Target Name: CPSF1-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for CPSF1 is not avaliable on ENCORE database.

Proteins bound to RNA

CPSF1 RNA is bound by 40 proteins.

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eCLIP assay for CPSF1 is not avaliable on ENCORE database.

40 proteins are bound to CPSF1 RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr8	145620746	145620862	-	CDS,intron-Distal,intron-Proximal	4.76907	54.61708	K562	SF3B4
chr8	145621512	145621553	-	intron-Distal,intron-Proximal	4.41510	40.31430	HepG2	PRPF8
chr8	145621439	145621513	-	intron-Distal,intron-Proximal	6.86258	38.96012	K562	DDX24
chr8	145620123	145620238	-	CDS,intron-Distal,intron-Proximal	4.28157	36.39499	HepG2	PPIG
chr8	145621553	145621571	-	CDS,intron-Distal,intron-Proximal	4.10024	33.73410	HepG2	PRPF8
chr8	145620758	145620815	-	CDS,intron-Distal,intron-Proximal	6.08838	32.27116	HepG2	SF3A3
chr8	145626444	145626469	-	CDS,intron-Distal,intron-Proximal	6.97044	31.78965	HepG2	PPIG
chr8	145623777	145623832	-	CDS,intron-Distal,intron-Proximal	5.63124	31.15633	K562	DDX24
chr8	145620749	145620815	-	CDS,intron-Distal,intron-Proximal	5.37276	28.69804	HepG2	SF3B4
chr8	145620176	145620236	-	CDS,intron-Distal,intron-Proximal	4.09401	27.57736	K562	DDX24
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 236 entries

eCLIP assay for CPSF1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for CPSF1 is not available on ENCORE database.
94 RBPs can affect the levels of CPSF1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for CPSF1 is not available on ENCORE database.

94 RBPs can affect the gene expression of CPSF1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
CPSF1	ENSG00000071894.10	3807.68170	1808.86770	1.07370	52.55310	50.31350	HepG2	SRSF5
CPSF1	ENSG00000071894.10	2423.88880	1161.25710	1.06150	43.18810	41.30410	HepG2	TRIM56
CPSF1	ENSG00000071894.10	3234.95530	1756.68360	0.88080	43.30640	41.24330	HepG2	SLBP
CPSF1	ENSG00000071894.10	3750.70710	2057.12580	0.86640	42.42190	40.50030	HepG2	SUCLG1
CPSF1	ENSG00000071894.10	1615.37740	3616.67050	-1.16280	35.13690	33.69310	HepG2	RBM22
CPSF1	ENSG00000071894.10	1990.52460	1054.82340	0.91600	33.16110	31.28780	HepG2	SAFB2
CPSF1	ENSG00000071894.10	3211.18470	1944.77050	0.72340	32.29420	30.71920	HepG2	PUM1
CPSF1	ENSG00000071894.10	84.37590	668.52240	-2.98610	28.36810	25.16550	K562	G3BP2
CPSF1	ENSG00000071894.10	1807.86940	1052.51400	0.78040	25.82170	24.02500	HepG2	DNAJC2
CPSF1	ENSG00000071894.10	3424.53880	1831.96980	0.90240	20.67840	19.25200	HepG2	PUF60
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 107 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for CPSF1 is not available on ENCORE database.

36 RBPs can affect the splicing of CPSF1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	FDR	is_included	Cell Line	Affected by RBP
A3SS	CPSF1	ENSG00000071894.10	chr8	-	145620649	145620864	145620649	145620766	145621562	145621715	0.14300	0.00000	longer	K562	EFTUD2
A3SS	CPSF1	ENSG00000071894.10	chr8	-	145622054	145622239	145622054	145622144	145622421	145622628	0.14600	0.00000	longer	K562	AQR
A3SS	CPSF1	ENSG00000071894.10	chr8	-	145620479	145620570	145620479	145620550	145620649	145620766	-0.07500	0.00000	shorter	K562	AQR
A5SS	CPSF1	ENSG00000071894.10	chr8	-	145619593	145619710	145619602	145619710	145619448	145619515	-0.12100	0.01410	shorter	K562	LARP7
RI	CPSF1	ENSG00000071894.10	chr8	-	145619448	145619770	145619448	145619515	145619593	145619770	-0.10100	0.00091	excluded	K562	DROSHA
RI	CPSF1	ENSG00000071894.10	chr8	-	145620312	145620550	145620312	145620397	145620479	145620550	0.12900	0.00000	included	HepG2	PCBP2
RI	CPSF1	ENSG00000071894.10	chr8	-	145625559	145625887	145625559	145625670	145625747	145625887	0.06000	0.00000	included	K562	PUS1
RI	CPSF1	ENSG00000071894.10	chr8	-	145620312	145620550	145620312	145620397	145620479	145620550	0.17500	0.00000	included	K562	PUS1
RI	CPSF1	ENSG00000071894.10	chr8	-	145620312	145620550	145620312	145620397	145620479	145620550	0.20800	0.00000	included	HepG2	U2AF2
RI	CPSF1	ENSG00000071894.10	chr8	-	145619448	145619770	145619448	145619515	145619602	145619770	-0.18000	0.00226	excluded	K562	LARP7

Showing 1 to 10 of 98 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

CPSF1

General Information

Functions

Localization

Domains (AlphaFold: CPSF1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for CPSF1 is not avaliable on ENCORE database.

40 proteins are bound to CPSF1 RNA:

eCLIP assay for CPSF1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for CPSF1 is not available on ENCORE database.

94 RBPs can affect the gene expression of CPSF1 :

The Knockdown/knockout RNA-Seq assay for CPSF1 is not available on ENCORE database.

36 RBPs can affect the splicing of CPSF1 :

The Knockdown/knockout RNA-Seq assay for CPSF1 is not avaliable on ENCORE database.