CDKL5

General Information

Gene Name       : CDKL5
Gene ID             : ENSG00000008086.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: CDKL5)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878CDKL5ENSG00000008086.117.266.376.81ENCSR000AEF
HepG2CDKL5ENSG00000008086.112.574.133.35ENCSR985KAT
K562CDKL5ENSG00000008086.110.030.030.03ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for CDKL5 is not avaliable on ENCORE database.



Proteins bound to RNA
  • CDKL5 RNA is bound by 4 proteins.  







eCLIP assay for CDKL5 is not avaliable on ENCORE database.





4 proteins are bound to CDKL5 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chrX1844372818443866+5'-UTR,intron-Proximal3.506204.11395HepG2NCBP2
chrX1847487618474990+intron-Distal4.582013.74583HepG2PTBP1
chrX1851592618516002+intron-Distal4.598593.74583HepG2PTBP1
chrX1864294718643078+intron-Distal3.879765.57156HepG2QKI
chrX1846523818465309+intron-Distal4.290864.10336HepG2SUGP2
chrX1853406818534156+intron-Distal4.941407.11021HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for CDKL5 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for CDKL5 is not available on ENCORE database.

  • 42 RBPs can affect the levels of CDKL5.  








The Knockdown/knockout RNA-Seq assay for CDKL5 is not available on ENCORE database.





42 RBPs can affect the gene expression of CDKL5 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
CDKL5ENSG00000008086.6298.30560176.791100.754603.555202.49410HepG2ABCF1
CDKL5ENSG00000008086.688.53430166.36010-0.910003.695702.92320HepG2AUH
CDKL5ENSG00000008086.683.86480196.60900-1.229205.966505.12760HepG2BOP1
CDKL5ENSG00000008086.6276.73240154.304000.842604.211202.99470HepG2CCAR1
CDKL5ENSG00000008086.6100.5439053.476500.910702.637801.88170HepG2CIRBP
CDKL5ENSG00000008086.627.2226059.33460-1.124102.235701.55390HepG2CNOT7
CDKL5ENSG00000008086.6164.5883083.248500.983304.577703.73000HepG2DDX21
CDKL5ENSG00000008086.6123.9497065.173900.927303.084402.42860HepG2DDX3X
CDKL5ENSG00000008086.658.9771095.36980-0.693402.209001.61340HepG2DNAJC2
CDKL5ENSG00000008086.6204.6872091.708901.158205.649404.36770HepG2EEF2
CDKL5ENSG00000008086.6113.9017059.494300.936903.071602.39880HepG2EIF4A3
CDKL5ENSG00000008086.6111.5644057.896800.946202.585101.91860HepG2EIF4B
CDKL5ENSG00000008086.6153.4651066.267401.211405.576404.29920HepG2GEMIN5
CDKL5ENSG00000008086.6428.37620204.641601.065707.648306.61780HepG2GPKOW
CDKL5ENSG00000008086.6199.2073097.167801.035604.100403.33710HepG2HNRNPA1
CDKL5ENSG00000008086.6271.58970195.291100.475701.966201.42770HepG2HNRNPLL
CDKL5ENSG00000008086.6142.9007056.591401.336306.122605.15540HepG2IGF2BP2
CDKL5ENSG00000008086.6138.9715053.073601.388603.499402.39180HepG2IGF2BP3
CDKL5ENSG00000008086.6106.2764060.001500.824702.402701.79000HepG2MAGOH
CDKL5ENSG00000008086.6158.0359061.772501.355106.494005.54180HepG2NCBP2
CDKL5ENSG00000008086.637.2949079.46810-1.091403.078702.27470HepG2NOL12
CDKL5ENSG00000008086.6157.7077076.620201.041403.517102.27600HepG2NONO
CDKL5ENSG00000008086.6119.9875054.384001.141504.572203.90770HepG2PTBP1
CDKL5ENSG00000008086.6189.5486099.797500.925403.238002.58410HepG2PUS1
CDKL5ENSG00000008086.696.9946058.902300.719501.866001.33800HepG2QKI
CDKL5ENSG00000008086.6101.14110159.66020-0.658602.508602.00910HepG2RBM22
CDKL5ENSG00000008086.6104.9485053.456500.973103.196702.47700HepG2RBM25
CDKL5ENSG00000008086.6148.4307060.525401.294106.197205.44170HepG2NELFE
CDKL5ENSG00000008086.6135.7518056.369001.267905.921505.06610HepG2RECQL
CDKL5ENSG00000008086.6129.1208072.440700.833702.483001.89750HepG2RPS19
CDKL5ENSG00000008086.6126.7228072.759600.800403.401102.63660HepG2SLBP
CDKL5ENSG00000008086.6344.9985059.101502.5452035.2764034.00970HepG2SRSF1
CDKL5ENSG00000008086.6124.2073074.915900.729302.849102.21420HepG2SRSF5
CDKL5ENSG00000008086.6232.18380156.544000.568602.870002.35010HepG2SSB
CDKL5ENSG00000008086.6130.1977085.192000.611802.224101.65550HepG2SUCLG1
CDKL5ENSG00000008086.6261.83160150.030900.803302.833401.75460HepG2TBRG4
CDKL5ENSG00000008086.656.47930105.24940-0.898003.453402.83910HepG2TRIM56
CDKL5ENSG00000008086.6172.3029074.130501.216706.701605.25290HepG2TUFM
CDKL5ENSG00000008086.6247.71030119.914901.046502.479501.55180HepG2U2AF2
CDKL5ENSG00000008086.619.3844076.22880-1.975402.360201.43900HepG2UPF2
CDKL5ENSG00000008086.61.8204012.91400-2.826601.992701.43670K562AKAP8L
CDKL5ENSG00000008086.629.129709.233401.657502.124601.41020K562PUF60
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for CDKL5 is not available on ENCORE database.






No RBPs affect the alternative splcing events of CDKL5 on ENCORE database.





The Knockdown/knockout RNA-Seq assay for CDKL5 is not avaliable on ENCORE database.