SETD1A

General Information

Gene Name : SETD1A
Gene ID : ENSG00000099381.17
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: SETD1A)

Not Available

Antibody Validation

Bethyl Labs: A300-290A

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SETD1A	ENSG00000099381.17	7.19	6.03	6.61	ENCSR000AEF
HepG2	SETD1A	ENSG00000099381.17	18.57	6.40	12.48	ENCSR985KAT
K562	SETD1A	ENSG00000099381.17	14.53	10.11	12.32	ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay Type	Exp_Name	ENCODE ID	Target label	Biosample	Status	Linked Antibody	Controls	Method	Note
knockdown followed by RNA-seq	SETD1A-BGKcLV33-K562	ENCSR558XPA	SETD1A	K562	Released		ENCSR271ZAB	CRISPR	KD% = 85.7,91.9

eCLIP

No eCLIP experiment available

Antibody Validation

GeneName	Antibody_DCC_ID	Product_ID	Lot_ID	Phosphate	HepG2 Primary Validation	K562 Primary Validation	HepG2 Secondary Validation	K562 Secondary Validation
SETD1A	ENCAB028FFK	A300-290A	2			Released, ENCODE4		BGKcLV33-49, Released, ENCODE4

KD RNA-Seq

GeneName	Cell_Line	Method	Exp_ID	Control_ID	Sample_reps	Control_reps	KD%	Status	Project
SETD1A	K562	CRISPR			BGKcLV33-43,BGKcLV33-44	BGKcLV33-1,BGKcLV33-2	no band on the position,	NotSatisfied	ENCODE4
SETD1A	K562	CRISPR	ENCSR558XPA	ENCSR271ZAB	SETD1A-BGKcLV33-49,SETD1A-BGKcLV33-50	NT-BGKcLV33-1,NT-BGKcLV33-2	85.7,91.9	Released	ENCODE4
SETD1A	HepG2	CRISPR			BGHcLV31-45,BGHcLV31-46	BGHcLV31-1,BGHcLV31-2	NO CLEAR BAND,	NotSatisfied	ENCODE4

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela
SETD1A	Product_ID: A300-290A Lot_ID: 2 Source: Bethyl Labs Target Name: SETD1A-human

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SETD1A is not avaliable on ENCORE database.

Proteins bound to RNA

SETD1A RNA is bound by 30 proteins.

CanvasJS.com

eCLIP assay for SETD1A is not avaliable on ENCORE database.

30 proteins are bound to SETD1A RNA:

Show entries

Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr16	30995838	30995916	+	3'-UTR	8.25411	57.14996	K562	PUM2
chr16	30995916	30995958	+	3'-UTR	8.01311	53.25001	K562	PUM2
chr16	30995558	30995665	+	3'-UTR	6.78109	40.32981	K562	PUM2
chr16	30970479	30970571	+	CDS,intron-Proximal	5.15747	19.60859	HepG2	PRPF8
chr16	30977065	30977163	+	CDS	5.13151	18.95097	HepG2	PCBP2
chr16	30969306	30969398	+	intron-Distal,intron-Proximal	5.15212	18.36545	HepG2	CSTF2T
chr16	30969300	30969407	+	intron-Distal,intron-Proximal	5.03137	17.68663	HepG2	PRPF4
chr16	30975642	30975700	+	CDS,intron-Proximal	6.25702	16.13178	K562	AQR
chr16	30970196	30970251	+	CDS,intron-Proximal	4.57783	14.46261	HepG2	PRPF8
chr16	30975657	30975688	+	intron-Proximal	3.17444	13.81082	HepG2	PRPF8
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 118 entries

eCLIP assay for SETD1A is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for SETD1A is not available on ENCORE database.
94 RBPs can affect the levels of SETD1A.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for SETD1A is not available on ENCORE database.

94 RBPs can affect the gene expression of SETD1A :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SETD1A	ENSG00000099381.12	1729.72720	946.95360	0.86910	30.63340	29.09020	HepG2	PUM1
SETD1A	ENSG00000099381.12	4442.95140	1987.31250	1.16060	28.19360	26.12030	HepG2	U2AF1
SETD1A	ENSG00000099381.12	1409.70310	699.09990	1.01170	24.28860	22.82400	HepG2	TRIM56
SETD1A	ENSG00000099381.12	1690.13000	1001.68250	0.75460	20.92650	19.47020	HepG2	SUCLG1
SETD1A	ENSG00000099381.12	1769.08630	880.77170	1.00610	19.60310	18.14110	HepG2	SRSF5
SETD1A	ENSG00000099381.12	987.71710	471.56860	1.06650	19.81460	18.11350	K562	PTBP1
SETD1A	ENSG00000099381.12	958.12050	462.32190	1.05120	17.80530	16.03390	K562	SRSF1
SETD1A	ENSG00000099381.12	607.89610	269.34180	1.17430	18.37390	15.99670	K562	SF3B4
SETD1A	ENSG00000099381.12	1375.60740	783.09560	0.81270	17.22060	15.82450	K562	FXR1
SETD1A	ENSG00000099381.12	1370.88670	855.33700	0.68040	16.09130	14.65620	HepG2	SLBP
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 111 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SETD1A is not available on ENCORE database.

2 RBPs can affect the splicing of SETD1A :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP	Bound by RBP
A5SS	SETD1A	ENSG00000099381.12	chr16	+	30978821	30978972			30978821	30978909	30980625	30980700	0.07400	0.00000	0.00002	longer	K562	AQR
MXE	SETD1A	ENSG00000099381.12	chr16	+	30972587	30972858	30974753	30974875	30970411	30970507	30975414	30975644	-0.14500	0.00613	0.09948	2included	K562	SBDS

Showing 1 to 2 of 2 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SETD1A

General Information

Functions

Localization

Domains (AlphaFold: SETD1A)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SETD1A is not avaliable on ENCORE database.

30 proteins are bound to SETD1A RNA:

eCLIP assay for SETD1A is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for SETD1A is not available on ENCORE database.

94 RBPs can affect the gene expression of SETD1A :

The Knockdown/knockout RNA-Seq assay for SETD1A is not available on ENCORE database.

2 RBPs can affect the splicing of SETD1A :

The Knockdown/knockout RNA-Seq assay for SETD1A is not avaliable on ENCORE database.