SPCS2

General Information

Gene Name : SPCS2
Gene ID : ENSG00000118363.11
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: SPCS2)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	SPCS2	ENSG00000118363.11	138.79	119.51	129.15	ENCSR000AEF
HepG2	SPCS2	ENSG00000118363.11	94.73	165.23	129.98	ENCSR985KAT
K562	SPCS2	ENSG00000118363.11	91.11	129.65	110.38	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for SPCS2 is not avaliable on ENCORE database.

Proteins bound to RNA

SPCS2 RNA is bound by 12 proteins.

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eCLIP assay for SPCS2 is not avaliable on ENCORE database.

12 proteins are bound to SPCS2 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr11	74688614	74688656	+	3'-UTR	3.81821	3.21228	K562	TIA1
chr11	74688189	74688267	+	3'-UTR	4.18445	25.61009	K562	FAM120A
chr11	74660313	74660441	+	5'-UTR,CDS,intron-Proximal	3.27100	13.82842	HepG2	RPS3
chr11	74680530	74680615	+	CDS,intron-Distal,intron-Proximal	3.13191	6.00234	K562	KHSRP
chr11	74680715	74680731	+	CDS,intron-Distal	3.61847	6.64821	HepG2	SND1
chr11	74687901	74687920	+	CDS,intron-Distal,intron-Proximal	3.92773	5.51172	HepG2	SND1
chr11	74680731	74680747	+	CDS,intron-Distal,intron-Proximal	3.66303	6.92877	HepG2	SND1
chr11	74680709	74680745	+	CDS,intron-Distal,intron-Proximal	6.10827	15.59328	K562	SND1
chr11	74687841	74687930	+	CDS,intron-Distal,intron-Proximal	5.82045	7.91936	K562	SF3B4
chr11	74687900	74687937	+	CDS,intron-Distal,intron-Proximal	4.99313	12.45981	K562	SND1
chr11	74676186	74676238	+	intron-Distal,intron-Proximal	4.38174	10.81737	K562	TIA1
chr11	74684618	74684678	+	intron-Distal	3.54292	3.39827	HepG2	MATR3
chr11	74667112	74667227	+	intron-Distal	4.29004	3.98115	K562	MATR3
chr11	74684602	74684675	+	intron-Distal	3.80042	6.43962	K562	MATR3
chr11	74686292	74686390	+	intron-Distal	3.50155	3.10639	HepG2	PTBP1
chr11	74686282	74686352	+	intron-Distal	3.61634	3.68462	HepG2	MATR3
chr11	74684928	74684974	+	intron-Distal	4.84332	5.43236	K562	PTBP1
chr11	74681998	74682100	+	intron-Distal	3.45394	5.35441	K562	HNRNPL
chr11	74685543	74685614	+	intron-Distal	3.29863	6.31916	HepG2	SUGP2
chr11	74684479	74684574	+	intron-Distal	3.21715	3.63194	K562	HNRNPL
chr11	74676167	74676220	+	intron-Distal,intron-Proximal	3.78990	3.65261	HepG2	TIA1
chr11	74667091	74667138	+	intron-Distal	3.68505	3.04224	HepG2	SUGP2
chr11	74685016	74685113	+	intron-Distal	4.99419	15.10611	K562	PTBP1
chr11	74676172	74676186	+	intron-Distal,intron-Proximal	4.93740	7.61377	K562	TIA1
chr11	74680744	74680802	+	intron-Distal,intron-Proximal	4.78459	5.26064	K562	AQR
chr11	74677030	74677113	+	intron-Distal,intron-Proximal	3.37479	4.30679	K562	KHSRP
chr11	74684923	74684974	+	intron-Distal	4.76459	6.08961	HepG2	PTBP1
chr11	74684057	74684119	+	intron-Distal	4.02364	3.80299	K562	HNRNPL
chr11	74682698	74682762	+	intron-Distal	3.74990	3.19036	K562	HNRNPL
chr11	74667560	74667632	+	intron-Distal	3.12229	3.23296	HepG2	SUGP2
chr11	74685028	74685110	+	intron-Distal	4.00571	7.92999	HepG2	PTBP1
chr11	74666927	74666989	+	intron-Distal	4.60314	4.80665	HepG2	QKI
chr11	74685163	74685206	+	intron-Distal	3.13762	3.45178	K562	MATR3
chr11	74684809	74684857	+	intron-Distal	3.25880	3.59523	HepG2	SUGP2
chr11	74686193	74686379	+	intron-Distal	4.15323	11.54864	K562	MATR3
chr11	74684463	74684529	+	intron-Distal	3.30812	3.80761	K562	PTBP1
chr11	74684706	74684783	+	intron-Distal	3.40585	4.36461	K562	MATR3
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for SPCS2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for SPCS2 is not available on ENCORE database.
107 RBPs can affect the levels of SPCS2.

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The Knockdown/knockout RNA-Seq assay for SPCS2 is not available on ENCORE database.

107 RBPs can affect the gene expression of SPCS2 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
SPCS2	ENSG00000118363.7	1430.38260	1732.74510	-0.27670	3.67130	2.98960	HepG2	ACO1
SPCS2	ENSG00000118363.7	1799.85440	3098.19600	-0.78350	9.31210	8.39930	HepG2	AKAP1
SPCS2	ENSG00000118363.7	1415.62100	1740.83880	-0.29830	3.69450	2.82090	HepG2	AKAP8L
SPCS2	ENSG00000118363.7	1721.44100	2293.35090	-0.41380	6.75140	5.75270	HepG2	AUH
SPCS2	ENSG00000118363.7	1455.56490	1212.03130	0.26410	2.23180	1.53430	HepG2	CALR
SPCS2	ENSG00000118363.7	813.15990	1763.88970	-1.11710	9.95260	8.12180	HepG2	CCAR1
SPCS2	ENSG00000118363.7	1123.34980	1732.31180	-0.62490	16.40780	15.07660	HepG2	CKAP4
SPCS2	ENSG00000118363.7	1356.09950	1602.51490	-0.24090	2.95130	2.09170	HepG2	DDX19B
SPCS2	ENSG00000118363.7	1013.88450	1404.80680	-0.47050	4.76300	3.89970	HepG2	DDX21
SPCS2	ENSG00000118363.7	2070.16160	2967.83900	-0.51970	5.17440	4.34230	HepG2	DDX3X
SPCS2	ENSG00000118363.7	1059.83780	1566.57670	-0.56380	4.69550	3.71560	HepG2	DDX55
SPCS2	ENSG00000118363.7	1246.30060	2549.43120	-1.03250	15.27730	13.98610	HepG2	DDX6
SPCS2	ENSG00000118363.7	1364.68020	1657.75280	-0.28070	3.24070	2.51750	HepG2	DKC1
SPCS2	ENSG00000118363.7	902.38400	1172.78500	-0.37810	4.20240	3.35170	HepG2	DNAJC21
SPCS2	ENSG00000118363.7	835.45040	1162.42740	-0.47650	8.13550	7.08940	HepG2	DNAJC2
SPCS2	ENSG00000118363.7	1734.13840	2450.83400	-0.49910	4.79740	4.02890	HepG2	EIF2S1
SPCS2	ENSG00000118363.7	1061.14260	2637.06380	-1.31330	18.76800	17.09050	HepG2	EIF4B
SPCS2	ENSG00000118363.7	1804.19070	2264.78460	-0.32800	3.09290	2.21690	HepG2	EIF4G1
SPCS2	ENSG00000118363.7	2694.36560	2169.53540	0.31250	2.01460	1.31250	HepG2	EIF4G2
SPCS2	ENSG00000118363.7	2140.90170	2632.95030	-0.29850	4.15800	3.44700	HepG2	ETF1
SPCS2	ENSG00000118363.7	1053.69320	1476.12490	-0.48640	3.56950	2.70240	HepG2	FIP1L1
SPCS2	ENSG00000118363.7	1786.27240	2732.71840	-0.61340	7.16600	6.08790	HepG2	FXR1
SPCS2	ENSG00000118363.7	1583.28220	2535.00000	-0.67910	7.66650	6.58580	HepG2	G3BP1
SPCS2	ENSG00000118363.7	2124.79690	2691.22360	-0.34090	2.66140	1.78950	HepG2	G3BP2
SPCS2	ENSG00000118363.7	669.18200	902.54340	-0.43160	3.10020	2.14840	HepG2	GEMIN5
SPCS2	ENSG00000118363.7	809.42970	1184.02060	-0.54870	5.85060	4.95780	HepG2	HNRNPA1
SPCS2	ENSG00000118363.7	1217.61330	1488.53360	-0.28980	3.02940	2.28110	HepG2	HNRNPF
SPCS2	ENSG00000118363.7	1316.83120	2566.91020	-0.96300	18.05740	16.42320	HepG2	HNRNPK
SPCS2	ENSG00000118363.7	1562.79090	2091.26660	-0.42030	9.21080	8.04940	HepG2	HNRNPL
SPCS2	ENSG00000118363.7	1573.44480	1169.52090	0.42790	2.80690	1.56600	HepG2	HSPD1
SPCS2	ENSG00000118363.7	1739.62070	2576.77320	-0.56680	6.07810	5.11420	HepG2	IGF2BP2
SPCS2	ENSG00000118363.7	1114.62950	1336.38150	-0.26180	3.26290	2.47270	HepG2	ILF2
SPCS2	ENSG00000118363.7	1374.33650	1583.91100	-0.20480	2.31940	1.38450	HepG2	KIF1C
SPCS2	ENSG00000118363.7	1881.31630	2733.67240	-0.53910	5.45700	4.54490	HepG2	MAGOH
SPCS2	ENSG00000118363.7	1815.40580	2748.97340	-0.59860	5.91600	5.01950	HepG2	MATR3
SPCS2	ENSG00000118363.7	743.16680	1060.90220	-0.51350	2.38140	1.40180	HepG2	METAP2
SPCS2	ENSG00000118363.7	1458.74260	2813.72790	-0.94780	14.52680	13.14930	HepG2	NCBP2
SPCS2	ENSG00000118363.7	699.65300	1438.55130	-1.03990	7.82880	5.96490	HepG2	NONO
SPCS2	ENSG00000118363.7	1447.56200	1052.88130	0.45920	2.09630	1.34000	HepG2	PABPC1
SPCS2	ENSG00000118363.7	1799.37170	2505.81160	-0.47780	4.33950	3.44830	HepG2	PABPC4
SPCS2	ENSG00000118363.7	998.83370	1294.99000	-0.37460	4.70380	3.63370	HepG2	PARN
SPCS2	ENSG00000118363.7	1598.27910	2358.44040	-0.56130	12.97370	11.81270	HepG2	PCBP1
SPCS2	ENSG00000118363.7	591.17650	838.27620	-0.50380	5.10060	3.44910	HepG2	PKM
SPCS2	ENSG00000118363.7	985.78030	1166.89590	-0.24330	2.01670	1.37850	HepG2	PPIL4
SPCS2	ENSG00000118363.7	1246.19580	2399.83810	-0.94540	30.70990	29.28070	HepG2	PTBP1
SPCS2	ENSG00000118363.7	1790.94810	2306.72780	-0.36510	8.07510	7.17240	HepG2	PUM1
SPCS2	ENSG00000118363.7	1390.40710	1764.90490	-0.34410	5.30360	4.50100	HepG2	PUS1
SPCS2	ENSG00000118363.7	1541.92860	2599.00560	-0.75320	17.52110	16.14270	HepG2	QKI
SPCS2	ENSG00000118363.7	1107.44560	1647.01180	-0.57260	2.99100	2.26010	HepG2	RAVER1
SPCS2	ENSG00000118363.7	1050.13120	1429.49080	-0.44490	5.62450	4.45510	HepG2	RBM15
SPCS2	ENSG00000118363.7	1443.11490	2200.68500	-0.60880	11.76160	10.84720	HepG2	RBM22
SPCS2	ENSG00000118363.7	1803.81030	2358.79420	-0.38700	4.30270	3.47690	HepG2	RBM25
SPCS2	ENSG00000118363.7	1201.68020	1664.96210	-0.47040	4.30320	3.04900	HepG2	RBM27
SPCS2	ENSG00000118363.7	1342.76350	2670.75890	-0.99200	36.43770	34.95330	HepG2	NELFE
SPCS2	ENSG00000118363.7	1580.50640	2487.50430	-0.65430	17.35430	16.02740	HepG2	RECQL
SPCS2	ENSG00000118363.7	1231.42870	1603.37430	-0.38080	3.26340	2.53110	HepG2	RPLP0
SPCS2	ENSG00000118363.7	620.57010	986.33730	-0.66850	8.01210	7.02900	HepG2	RPS19
SPCS2	ENSG00000118363.7	923.65960	1535.53370	-0.73330	9.38210	7.98240	HepG2	RPS2
SPCS2	ENSG00000118363.7	1888.06040	1165.09600	0.69640	19.73980	18.23970	HepG2	SAFB2
SPCS2	ENSG00000118363.7	728.26430	989.95290	-0.44290	3.25160	2.22870	HepG2	SERBP1
SPCS2	ENSG00000118363.7	1342.84330	2498.47530	-0.89580	30.26700	28.67900	HepG2	SF3B4
SPCS2	ENSG00000118363.7	1759.31640	2083.52070	-0.24400	3.52680	2.75010	HepG2	SLBP
SPCS2	ENSG00000118363.7	747.65450	1358.69940	-0.86180	25.70800	24.07240	HepG2	SMN1
SPCS2	ENSG00000118363.7	1261.81130	1678.70330	-0.41190	2.41080	1.52100	HepG2	SMNDC1
SPCS2	ENSG00000118363.7	583.82880	848.06800	-0.53860	2.72070	1.94570	HepG2	SNRNP70
SPCS2	ENSG00000118363.7	2038.25830	2485.63820	-0.28630	4.21630	3.63630	HepG2	SRFBP1
SPCS2	ENSG00000118363.7	2135.58380	2607.89420	-0.28830	4.48070	3.91480	HepG2	SRSF1
SPCS2	ENSG00000118363.7	1697.46160	2145.50430	-0.33790	5.24600	4.42640	HepG2	SRSF5
SPCS2	ENSG00000118363.7	1290.50680	2121.68400	-0.71730	20.80380	19.54770	HepG2	SRSF9
SPCS2	ENSG00000118363.7	2492.43590	2158.20190	0.20760	2.63860	2.13360	HepG2	SSB
SPCS2	ENSG00000118363.7	2002.76220	2440.06580	-0.28490	4.91250	4.12480	HepG2	SUCLG1
SPCS2	ENSG00000118363.7	1098.72650	1559.49550	-0.50520	3.94220	3.15710	HepG2	SUPV3L1
SPCS2	ENSG00000118363.7	929.34250	2344.15170	-1.33480	50.93580	48.92490	HepG2	TAF15
SPCS2	ENSG00000118363.7	1261.61640	2153.87680	-0.77170	15.09770	13.18180	HepG2	TIA1
SPCS2	ENSG00000118363.7	772.82050	1271.25620	-0.71800	11.93790	11.02720	HepG2	TIAL1
SPCS2	ENSG00000118363.7	1085.55020	1282.61830	-0.24070	2.37210	1.84160	HepG2	TRIM56
SPCS2	ENSG00000118363.7	1579.25900	2247.01480	-0.50880	4.50000	3.41490	HepG2	UBE2L3
SPCS2	ENSG00000118363.7	692.51760	921.23700	-0.41170	2.81780	2.05070	HepG2	UCHL5
SPCS2	ENSG00000118363.7	1099.20420	1497.33390	-0.44590	7.20550	6.31470	HepG2	UTP3
SPCS2	ENSG00000118363.7	1366.18390	1811.16430	-0.40680	2.27620	1.31840	HepG2	XRCC6
SPCS2	ENSG00000118363.7	1092.56620	899.89340	0.27980	2.51760	1.87150	HepG2	ZC3H8
SPCS2	ENSG00000118363.7	2791.96990	2482.22620	0.16950	1.83730	1.35560	K562	AGGF1
SPCS2	ENSG00000118363.7	1402.24920	1870.60230	-0.41580	7.02510	5.46850	K562	BCLAF1
SPCS2	ENSG00000118363.7	299.14760	655.77290	-1.13230	5.75190	4.09000	K562	CCAR1
SPCS2	ENSG00000118363.7	789.73530	1151.86370	-0.54450	6.20260	5.02980	K562	CPSF6
SPCS2	ENSG00000118363.7	1076.53340	1419.13060	-0.39860	4.63980	3.21800	K562	CSTF2
SPCS2	ENSG00000118363.7	400.26000	734.06240	-0.87500	4.39070	2.65250	K562	DHX30
SPCS2	ENSG00000118363.7	3224.37540	2779.36420	0.21420	2.31310	1.52170	K562	DKC1
SPCS2	ENSG00000118363.7	1056.41630	1281.89040	-0.27910	2.46560	1.39650	K562	EIF4B
SPCS2	ENSG00000118363.7	896.20230	1326.91700	-0.56620	6.08190	4.16110	K562	EXOSC5
SPCS2	ENSG00000118363.7	761.70720	993.39620	-0.38310	2.46920	1.60670	K562	FTO
SPCS2	ENSG00000118363.7	2016.63700	1480.33230	0.44590	7.19910	6.28590	K562	FXR1
SPCS2	ENSG00000118363.7	1459.62600	1747.66930	-0.25980	2.54980	1.45730	K562	GLRX3
SPCS2	ENSG00000118363.7	858.72590	1099.73810	-0.35690	2.68920	1.90550	K562	GPKOW
SPCS2	ENSG00000118363.7	2849.14660	3578.02980	-0.32860	3.43810	2.59710	K562	GRSF1
SPCS2	ENSG00000118363.7	967.36090	1226.35070	-0.34220	2.72610	2.13340	K562	HNRNPC
SPCS2	ENSG00000118363.7	2002.70680	1475.53150	0.44060	3.53290	2.46780	K562	HNRNPM
SPCS2	ENSG00000118363.7	3381.31260	2432.10350	0.47530	5.41620	4.31980	K562	HSPD1
SPCS2	ENSG00000118363.7	864.05240	1073.47060	-0.31310	2.42440	1.60780	K562	METAP2
SPCS2	ENSG00000118363.7	1433.35400	1837.43530	-0.35830	5.57830	4.45460	K562	MTPAP
SPCS2	ENSG00000118363.7	1559.79350	2041.61800	-0.38840	8.58940	7.37810	K562	NSUN2
SPCS2	ENSG00000118363.7	1271.35450	1687.83830	-0.40880	2.41560	1.63930	K562	PCBP3
SPCS2	ENSG00000118363.7	1876.62050	2445.81530	-0.38220	3.03320	1.39730	K562	PKM
SPCS2	ENSG00000118363.7	3306.00080	3980.46830	-0.26790	2.73620	1.30590	K562	PNPT1
SPCS2	ENSG00000118363.7	2024.16810	1489.59510	0.44230	4.34140	3.40270	K562	PRPF8
SPCS2	ENSG00000118363.7	793.27480	1099.51390	-0.47100	4.10070	2.96930	K562	PSIP1
SPCS2	ENSG00000118363.7	1794.71160	2150.32920	-0.26080	2.27630	1.66640	K562	PTBP1
SPCS2	ENSG00000118363.7	3525.98590	4405.01420	-0.32110	4.48340	3.25460	K562	PUM2
SPCS2	ENSG00000118363.7	3260.27580	2561.51200	0.34790	3.00300	2.44140	K562	PUS1
SPCS2	ENSG00000118363.7	1557.74550	2062.09790	-0.40470	3.93940	2.92190	K562	RBM22
SPCS2	ENSG00000118363.7	691.72650	1002.98060	-0.53600	5.56580	4.15350	K562	RCC2
SPCS2	ENSG00000118363.7	1671.48320	2169.98400	-0.37660	3.18000	1.99920	K562	NELFE
SPCS2	ENSG00000118363.7	2213.97830	1517.47240	0.54490	5.16280	4.04460	K562	RPS19
SPCS2	ENSG00000118363.7	1716.08700	2014.46310	-0.23130	2.46420	1.69160	K562	SF3A3
SPCS2	ENSG00000118363.7	715.41560	950.81780	-0.41040	3.10190	2.00130	K562	SRFBP1
SPCS2	ENSG00000118363.7	1592.50800	1298.52730	0.29430	2.71700	1.90620	K562	SYNCRIP
SPCS2	ENSG00000118363.7	1731.14390	2057.99690	-0.24950	2.09250	1.38790	K562	TIA1
SPCS2	ENSG00000118363.7	770.82480	1057.57070	-0.45630	3.33630	2.30310	K562	TIAL1
SPCS2	ENSG00000118363.7	827.99180	1123.32750	-0.44010	3.77650	2.63900	K562	TRIM56
SPCS2	ENSG00000118363.7	2115.08360	1654.28880	0.35440	2.42650	1.41340	K562	U2AF1
SPCS2	ENSG00000118363.7	2034.23100	1708.44010	0.25170	2.26560	1.53970	K562	U2AF2
SPCS2	ENSG00000118363.7	621.92780	2164.76590	-1.79940	101.37860	98.27190	K562	UPF1
SPCS2	ENSG00000118363.7	1516.17800	1852.32990	-0.28890	2.58630	1.73830	K562	WDR3
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for SPCS2 is not available on ENCORE database.

2 RBPs can affect the splicing of SPCS2 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP	Bound by RBP
A3SS	SPCS2	ENSG00000118363.7	chr11	+	74676744	74676970			74676898	74676970	74676042	74676162	0.60700	0.01662	0.08159	longer	K562	AQR
MXE	SPCS2	ENSG00000118363.7	chr11	+	74676078	74676162	74680684	74680744	74660308	74660444	74687901	74688393	0.11100	0.00048	0.03743	1included	K562	TRA2A

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

SPCS2

General Information

Functions

Localization

Domains (AlphaFold: SPCS2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for SPCS2 is not avaliable on ENCORE database.

12 proteins are bound to SPCS2 RNA:

eCLIP assay for SPCS2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for SPCS2 is not available on ENCORE database.

107 RBPs can affect the gene expression of SPCS2 :

The Knockdown/knockout RNA-Seq assay for SPCS2 is not available on ENCORE database.

2 RBPs can affect the splicing of SPCS2 :

The Knockdown/knockout RNA-Seq assay for SPCS2 is not avaliable on ENCORE database.