RRM2B

General Information

Gene Name       : RRM2B
Gene ID             : ENSG00000048392.11
Essential Gene : No

Functions

Localization

Domains (AlphaFold: RRM2B)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878RRM2BENSG00000048392.1111.9710.6411.30ENCSR000AEF
HepG2RRM2BENSG00000048392.116.7113.5510.13ENCSR985KAT
K562RRM2BENSG00000048392.1111.959.8210.88ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for RRM2B is not avaliable on ENCORE database.



Proteins bound to RNA
  • RRM2B RNA is bound by 7 proteins.  







eCLIP assay for RRM2B is not avaliable on ENCORE database.





7 proteins are bound to RRM2B RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr8103218913103218975-3'-UTR,intron-Distal4.859774.92383K562FAM120A
chr8103216912103216978-3'-UTR,intron-Distal4.855125.08199HepG2FUBP3
chr8103218012103218060-3'-UTR,intron-Distal3.983055.67291HepG2U2AF2
chr8103219364103219378-3'-UTR,intron-Distal4.575636.75316K562YBX3
chr8103216919103216974-3'-UTR,intron-Distal4.155354.57464K562PUM2
chr8103218158103218208-3'-UTR,intron-Distal3.610343.32861HepG2U2AF2
chr8103217175103217257-3'-UTR,intron-Distal3.707343.88742K562FAM120A
chr8103251040103251170-5'-UTR,CDS,intron-Distal,intron-Proximal3.639766.98150K562DDX3X
chr8103236236103236322-CDS,intron-Distal,intron-Proximal5.243034.68690HepG2PRPF8
chr8103236154103236304-CDS,intron-Distal,intron-Proximal3.419623.88924K562PRPF8
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for RRM2B is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for RRM2B is not available on ENCORE database.

  • 111 RBPs can affect the levels of RRM2B.  








The Knockdown/knockout RNA-Seq assay for RRM2B is not available on ENCORE database.





111 RBPs can affect the gene expression of RRM2B :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
RRM2BENSG00000048392.71210.96080766.075500.660507.446005.78680HepG2AATF
RRM2BENSG00000048392.71743.172401030.338900.7585021.4013020.06640HepG2ACO1
RRM2BENSG00000048392.7770.18360996.10310-0.371102.231701.33670HepG2ADAR
RRM2BENSG00000048392.73629.453201734.429901.0652016.7292015.53280HepG2AKAP1
RRM2BENSG00000048392.72700.759101209.679901.1586020.2668017.78610HepG2AKAP8
RRM2BENSG00000048392.71800.879401035.303700.798506.409605.28800HepG2AKAP8L
RRM2BENSG00000048392.72125.401201711.161600.312704.429603.59680HepG2AUH
RRM2BENSG00000048392.7835.094401196.99200-0.519403.164702.16180HepG2BCCIP
RRM2BENSG00000048392.7627.319001040.20180-0.729606.295605.00200HepG2BCLAF1
RRM2BENSG00000048392.72546.111001153.135201.1426026.7182025.17650HepG2BOP1
RRM2BENSG00000048392.72010.612701008.252500.9957020.8307019.08020HepG2CALR
RRM2BENSG00000048392.7510.156601363.47000-1.4183019.2098017.39070HepG2CIRBP
RRM2BENSG00000048392.72005.597601030.264000.9609037.9109036.09910HepG2CKAP4
RRM2BENSG00000048392.71887.04690739.530101.3513032.3235029.58160HepG2CSTF2
RRM2BENSG00000048392.71290.00720784.150100.718103.865302.16250HepG2CSTF2T
RRM2BENSG00000048392.72125.44220845.735201.3294033.4017031.44620HepG2DDX21
RRM2BENSG00000048392.71036.75870827.184600.325702.422601.57290HepG2DDX24
RRM2BENSG00000048392.72306.208201661.558200.472904.247303.48560HepG2DDX3X
RRM2BENSG00000048392.71791.385501202.193600.575303.017601.99700HepG2DDX59
RRM2BENSG00000048392.72069.847601427.064300.536404.618603.83820HepG2DDX6
RRM2BENSG00000048392.7771.25340967.42610-0.326902.301501.40810HepG2DHX30
RRM2BENSG00000048392.7576.91370994.15020-0.7851017.3702015.86680HepG2DNAJC2
RRM2BENSG00000048392.71016.13710740.265600.456903.485502.23420HepG2EFTUD2
RRM2BENSG00000048392.7677.157001372.11820-1.0188011.5731010.41170HepG2EIF2S1
RRM2BENSG00000048392.72110.997901516.471200.477103.843503.09460HepG2EIF4A3
RRM2BENSG00000048392.72671.293801964.550500.443209.350008.35310HepG2ETF1
RRM2BENSG00000048392.71460.381701006.957500.536202.303101.54180HepG2EWSR1
RRM2BENSG00000048392.71951.443801079.238300.8544010.638809.26840HepG2FIP1L1
RRM2BENSG00000048392.7399.01400661.15670-0.728607.200305.96970HepG2FUBP3
RRM2BENSG00000048392.71659.508001089.462100.607004.312502.93340HepG2FUS
RRM2BENSG00000048392.7527.250501419.20620-1.4285020.5618018.82910HepG2G3BP1
RRM2BENSG00000048392.71178.232401506.42120-0.354502.513001.66640HepG2G3BP2
RRM2BENSG00000048392.72003.967601043.554700.941307.382805.03980HepG2HLTF
RRM2BENSG00000048392.7541.528601012.65230-0.9030012.9046011.67860HepG2HNRNPA1
RRM2BENSG00000048392.71917.956301349.252500.507307.196105.80910HepG2HNRNPA2B1
RRM2BENSG00000048392.71646.568501126.376600.547704.336503.48360HepG2HNRNPC
RRM2BENSG00000048392.71112.244301698.86130-0.611103.644701.89000HepG2HNRNPD
RRM2BENSG00000048392.71056.133801436.63150-0.443903.850403.03850HepG2HNRNPK
RRM2BENSG00000048392.71039.052701337.65190-0.364402.681702.01760HepG2HNRNPL
RRM2BENSG00000048392.71390.173801118.930500.313003.889803.18220HepG2HNRNPU
RRM2BENSG00000048392.72619.882801442.659700.8607013.2961011.93900HepG2IGF2BP2
RRM2BENSG00000048392.7922.982901142.95250-0.308404.077603.20450HepG2ILF2
RRM2BENSG00000048392.71332.07710992.127500.425004.055002.08960HepG2CCAR2
RRM2BENSG00000048392.71879.469801316.377400.513703.378001.99480HepG2KRR1
RRM2BENSG00000048392.72461.514301686.567800.545403.341102.42690HepG2LARP4
RRM2BENSG00000048392.73077.522001538.850500.999805.771204.88610HepG2MATR3
RRM2BENSG00000048392.71225.89540754.424300.700304.729203.37690HepG2METAP2
RRM2BENSG00000048392.7715.011601015.50550-0.506203.231502.42530HepG2NSUN2
RRM2BENSG00000048392.71096.694101402.99030-0.355302.336101.66840HepG2PABPC4
RRM2BENSG00000048392.71636.549001107.564500.5632010.775309.28540HepG2PARN
RRM2BENSG00000048392.7861.517601248.40980-0.535104.831004.06460HepG2PCBP1
RRM2BENSG00000048392.71925.494401031.386300.900508.342806.64070HepG2PCBP2
RRM2BENSG00000048392.7571.01240997.99870-0.8055014.1437012.54920HepG2PPIL4
RRM2BENSG00000048392.7860.40430709.594400.277902.316501.60190HepG2PRPF4
RRM2BENSG00000048392.72016.326801084.290600.894908.020606.05020HepG2PRPF6
RRM2BENSG00000048392.71539.41210908.142200.761309.760208.35400HepG2PRPF8
RRM2BENSG00000048392.71954.917201389.746800.492205.354304.55960HepG2PUF60
RRM2BENSG00000048392.7753.524401474.15300-0.9682011.089609.79340HepG2PUM2
RRM2BENSG00000048392.71803.72870995.462600.857406.098105.07880HepG2RAVER1
RRM2BENSG00000048392.71864.595001106.733400.7525014.3531012.63950HepG2RBM15
RRM2BENSG00000048392.7697.262301075.08430-0.624704.415003.07260HepG2RCC2
RRM2BENSG00000048392.73282.941401658.098000.9854022.4454020.88400HepG2RPLP0
RRM2BENSG00000048392.72238.87400977.572201.1954013.7685011.84110HepG2RPS10
RRM2BENSG00000048392.71377.86000701.493000.9738017.8373016.47930HepG2RPS19
RRM2BENSG00000048392.71904.729101221.057700.641408.164906.83520HepG2RPS2
RRM2BENSG00000048392.72839.18420898.371001.6600038.5438036.32230HepG2RRP9
RRM2BENSG00000048392.72521.570201082.641401.2197014.2541011.08910HepG2RTF1
RRM2BENSG00000048392.7826.58540996.46410-0.269702.620001.99060HepG2SAFB2
RRM2BENSG00000048392.71303.992301870.59330-0.520602.923701.31930HepG2SBDS
RRM2BENSG00000048392.71474.07000993.276300.569404.100403.27180HepG2SF3A3
RRM2BENSG00000048392.71559.688801322.517300.237902.426901.86820HepG2SF3B4
RRM2BENSG00000048392.7820.203301332.29540-0.699906.219705.23460HepG2SLBP
RRM2BENSG00000048392.71411.324501162.057400.280303.650602.92890HepG2SMN1
RRM2BENSG00000048392.73456.203301261.456701.454006.053004.89080HepG2SNRNP70
RRM2BENSG00000048392.75057.216801854.634901.44710111.44390109.42940HepG2SRFBP1
RRM2BENSG00000048392.73626.594601380.453601.3934073.9880072.30900HepG2SRSF1
RRM2BENSG00000048392.71724.777501219.738800.499703.196802.11150HepG2SRSF3
RRM2BENSG00000048392.73025.656601372.023601.1408018.9227017.49120HepG2SRSF5
RRM2BENSG00000048392.71578.703001123.099900.491209.317608.40950HepG2SRSF9
RRM2BENSG00000048392.71169.948401610.32140-0.460907.811107.03490HepG2SSB
RRM2BENSG00000048392.72432.756001312.263200.8904011.971609.58930HepG2SSRP1
RRM2BENSG00000048392.7395.24950721.14450-0.867506.760404.93960HepG2STAU1
RRM2BENSG00000048392.72241.732201560.496300.522508.229107.25220HepG2SUCLG1
RRM2BENSG00000048392.71919.950801171.610600.712508.289407.22030HepG2SUPV3L1
RRM2BENSG00000048392.73651.655701240.893801.5571080.4666077.98230HepG2TAF15
RRM2BENSG00000048392.71036.01490785.344100.399502.801101.80030HepG2TFIP11
RRM2BENSG00000048392.71825.775201087.294700.7477012.0851011.16830HepG2TIAL1
RRM2BENSG00000048392.72142.38010880.883801.2821059.0944056.81630HepG2UPF1
RRM2BENSG00000048392.7634.930901073.07290-0.757104.583003.27360HepG2UPF2
RRM2BENSG00000048392.71034.93040850.459300.283102.671602.08340HepG2UTP3
RRM2BENSG00000048392.72546.484401094.598901.2180015.7210013.45490HepG2XRCC6
RRM2BENSG00000048392.7515.309301153.31940-1.1623015.3330013.65130HepG2XRN2
RRM2BENSG00000048392.71344.03390700.276800.9405027.4383025.73020HepG2ZC3H8
RRM2BENSG00000048392.71151.87060968.804100.249602.737402.19240HepG2ZNF622
RRM2BENSG00000048392.71699.85780994.283100.773607.096404.91700HepG2ZRANB2
RRM2BENSG00000048392.71575.375101285.310400.293502.146901.61850K562AQR
RRM2BENSG00000048392.7800.71560607.475900.398402.555401.71830K562BOP1
RRM2BENSG00000048392.7586.337801112.29290-0.9237013.7278011.22740K562CIRBP
RRM2BENSG00000048392.72176.475501701.373200.355204.188202.97990K562CELF1
RRM2BENSG00000048392.7396.24950280.365400.499002.723801.39360K562DNAJC21
RRM2BENSG00000048392.7560.53940811.97720-0.534606.074904.91080K562EIF3G
RRM2BENSG00000048392.7538.68420674.07360-0.323502.388601.33820K562EIF4B
RRM2BENSG00000048392.7926.00000657.184800.494604.123303.07550K562FMR1
RRM2BENSG00000048392.71236.35520834.571500.566902.408001.75510K562G3BP2
RRM2BENSG00000048392.7395.38340542.78930-0.457102.911601.73890K562HNRNPF
RRM2BENSG00000048392.7708.51100526.565200.428102.149901.33840K562KRR1
RRM2BENSG00000048392.7433.44660616.37600-0.508002.899101.40510K562LIN28B
RRM2BENSG00000048392.7927.529901154.10650-0.315302.259801.45120K562MBNL1
RRM2BENSG00000048392.7429.45280593.45890-0.466603.069401.55530K562PHF6
RRM2BENSG00000048392.7638.82160830.40230-0.378402.130401.41500K562PPIG
RRM2BENSG00000048392.7373.51330545.05140-0.545202.158501.36940K562PSIP1
RRM2BENSG00000048392.7863.464701059.65750-0.295402.254101.64570K562PTBP1
RRM2BENSG00000048392.72022.401401509.829100.421604.246503.24120K562PUF60
RRM2BENSG00000048392.72079.392301605.850300.372703.696502.44970K562PUM1
RRM2BENSG00000048392.71303.04890796.356300.710304.522802.64390K562RAVER1
RRM2BENSG00000048392.7286.82870497.15630-0.793507.301505.68350K562RCC2
RRM2BENSG00000048392.7466.52620839.13380-0.846903.369802.00530K562SF1
RRM2BENSG00000048392.7300.90990471.30460-0.647304.509803.11190K562SRFBP1
RRM2BENSG00000048392.7592.05900878.04770-0.568603.563702.11090K562STAU1
RRM2BENSG00000048392.7792.730501014.16410-0.355402.905202.06400K562TIA1
RRM2BENSG00000048392.7363.68830524.26430-0.527603.174602.16610K562TIAL1
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for RRM2B is not available on ENCORE database.





6 RBPs can affect the splicing of RRM2B :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
A3SSRRM2BENSG00000048392.7chr8-1032444581032446021032444581032445321032510541032511020.088000.002960.01819longerK562AQR
A3SSRRM2BENSG00000048392.7chr8-1032310411032312121032310411032311751032362731032363680.111000.006040.03413longerK562AQR
A3SSRRM2BENSG00000048392.7chr8-1032262811032264301032262811032263861032310411032311750.051000.006910.03838longerK562AQR
MXERRM2BENSG00000048392.7chr8-103226281103226386103244458103244532103225003103225117103251054103251102-0.212000.003370.076222includedK562RBM15
MXERRM2BENSG00000048392.7chr8-103226281103226386103244458103244532103225003103225117103251054103251102-0.299000.000840.085552includedK562SMNDC1
MXERRM2BENSG00000048392.7chr8-1032262811032263861032444581032445321032250031032251171032510541032511020.222000.000050.002361includedHepG2DDX55
MXERRM2BENSG00000048392.7chr8-103226281103226386103244458103244532103225003103225117103251054103251102-0.242000.000460.004282includedHepG2U2AF2
MXERRM2BENSG00000048392.7chr8-1032262811032263861032444581032445321032250031032251171032510541032511020.191000.000410.018501includedHepG2SUPV3L1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for RRM2B is not avaliable on ENCORE database.