NUCB2

General Information

Gene Name       : NUCB2
Gene ID             : ENSG00000070081.16
Essential Gene : No

Functions

Localization

Domains (AlphaFold: NUCB2)


Antibody Validation

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878NUCB2ENSG00000070081.1637.7230.2834.00ENCSR000AEF
HepG2NUCB2ENSG00000070081.1645.2980.3762.83ENCSR985KAT
K562NUCB2ENSG00000070081.1647.7956.8752.33ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.







  eCLIP  

No eCLIP experiment available



  Antibody Validation  

No Antibody Primary Validation image or Secondary image available



  KD RNA-Seq  

No KD RNA-Seq experiment available



  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela








RNA Targets

  • eCLIP assay for NUCB2 is not avaliable on ENCORE database.



Proteins bound to RNA
  • NUCB2 RNA is bound by 17 proteins.  







eCLIP assay for NUCB2 is not avaliable on ENCORE database.





17 proteins are bound to NUCB2 RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr111730440517304462+3'-UTR,5'-UTR3.252724.11795K562YBX3
chr111730434817304472+3'-UTR,5'-UTR3.281364.02291HepG2GRWD1
chr111735174017351798+3'-UTR,CDS,intron-Distal4.484024.04372HepG2BCLAF1
chr111733245317332558+3'-UTR,CDS,intron-Proximal5.4520318.60206HepG2BCLAF1
chr111735246217352536+3'-UTR,CDS,intron-Proximal3.977423.22245K562GRWD1
chr111735244817352528+3'-UTR,CDS,intron-Proximal3.949596.09867K562PUM1
chr111733244917332515+3'-UTR,CDS3.199885.12210K562ZNF622
chr111735302117353057+3'-UTR3.141614.09989K562UCHL5
chr111730433517304354+3'-UTR,5'-UTR,intron-Proximal3.352674.08283K562DDX3X
chr111735295817353040+3'-UTR,CDS,intron-Proximal3.202104.01178K562ZNF622
chr111730435417304406+3'-UTR,5'-UTR4.814659.24431K562DDX3X
chr111735167117351722+3'-UTR,CDS,intron-Distal,intron-Proximal4.153717.52225K562UCHL5
chr111735302717353040+3'-UTR3.102653.69602K562TIA1
chr111735173617351796+3'-UTR,CDS,intron-Distal3.032393.70975K562UCHL5
chr111735167317351703+3'-UTR,CDS,intron-Distal,intron-Proximal3.567343.27569HepG2BCLAF1
chr111730438517304456+3'-UTR,5'-UTR3.787974.74268K562UCHL5
chr111733244817332558+3'-UTR,CDS,intron-Proximal5.049417.55143K562TRA2A
chr111735178217351835+3'-UTR,CDS,intron-Distal3.765375.32768K562YBX3
chr111735246417352527+3'-UTR,CDS4.837626.04243HepG2BCLAF1
chr111729829217298380+5'-UTR,intron-Distal,intron-Proximal4.8061115.60125K562DDX3X
chr111729829617298372+5'-UTR,intron-Distal3.359643.15824K562FTO
chr111729828217298396+5'-UTR,intron-Distal,intron-Proximal4.6699111.73310HepG2DDX3X
chr111733249517332558+CDS,intron-Proximal3.599054.15543HepG2HLTF
chr111733342917333478+CDS,intron-Proximal4.498593.89826HepG2BCLAF1
chr111733694517337023+CDS,intron-Distal,intron-Proximal5.533808.80307K562UCHL5
chr111733273617332770+CDS,intron-Proximal3.539306.18248K562UCHL5
chr111733252017332558+CDS,intron-Proximal4.038553.86058K562GRWD1
chr111733699317337026+CDS,intron-Distal,intron-Proximal3.061404.33023K562ZNF622
chr111733364217333668+CDS,intron-Proximal4.080343.02457HepG2BCLAF1
chr111733273817332798+CDS,intron-Proximal3.693636.53661K562AGGF1
chr111731766417317735+CDS3.310014.77467K562SND1
chr111733250917332558+CDS,intron-Proximal3.708694.14321K562MTPAP
chr111733277017332824+CDS4.644585.86954K562UCHL5
chr111733357317333642+CDS,intron-Proximal3.728303.68471HepG2BCLAF1
chr111733273517332807+CDS,intron-Proximal3.588129.12722K562ZNF622
chr111733250917332562+CDS,intron-Proximal3.247956.72164K562UCHL5
chr111733111717331192+CDS,intron-Proximal3.017573.17233HepG2BCLAF1
chr111733273817332809+CDS,intron-Proximal4.6316110.19430HepG2BCLAF1
chr111731691617317015+CDS,intron-Proximal4.238175.08507K562ZNF622
chr111732329517323359+CDS4.351883.43980K562ZNF622
chr111732332217323396+CDS3.359823.57857HepG2BCLAF1
chr111733693217336988+CDS,intron-Distal,intron-Proximal3.498593.27569HepG2BCLAF1
chr111731766117317743+CDS3.670713.04123K562LIN28B
chr111733251517332560+CDS,intron-Proximal3.597817.08969K562ZNF622
chr111733357417333597+CDS,intron-Proximal3.559403.95301K562ZNF622
chr111733341817333478+CDS,intron-Proximal3.720363.90826K562ZNF622
chr111733273917332805+CDS,intron-Proximal3.168813.71980K562TRA2A
chr111723122217231256+intron-Distal4.3362516.86037HepG2PTBP1
chr111731171317311816+intron-Distal5.756107.47823K562QKI
chr111731161217311738+intron-Distal4.276543.83958HepG2QKI
chr111723120417231222+intron-Distal4.5788618.36989HepG2PTBP1
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for NUCB2 is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for NUCB2 is not available on ENCORE database.

  • 116 RBPs can affect the levels of NUCB2.  








The Knockdown/knockout RNA-Seq assay for NUCB2 is not available on ENCORE database.





116 RBPs can affect the gene expression of NUCB2 :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
NUCB2ENSG00000070081.11759.045001156.75100-0.607805.139303.89600HepG2ABCF1
NUCB2ENSG00000070081.11786.69140957.97370-0.284202.442201.86490HepG2ACO1
NUCB2ENSG00000070081.11611.14700797.92290-0.384702.524101.57110HepG2ADAR
NUCB2ENSG00000070081.111934.941401089.011800.829209.414208.49700HepG2AKAP1
NUCB2ENSG00000070081.11835.37690568.839000.554304.228502.94950HepG2AKAP8
NUCB2ENSG00000070081.11658.48300962.56620-0.547707.757506.55040HepG2AKAP8L
NUCB2ENSG00000070081.111199.81590901.098000.413002.999002.18230HepG2ASCC1
NUCB2ENSG00000070081.111295.798001116.688100.214501.906401.31700HepG2AUH
NUCB2ENSG00000070081.11706.647501152.29970-0.705508.522407.54110HepG2BOP1
NUCB2ENSG00000070081.111197.77080866.867700.466405.019503.38440HepG2BUD13
NUCB2ENSG00000070081.111912.518701314.252200.541105.758004.69860HepG2CALR
NUCB2ENSG00000070081.11537.84350957.87570-0.8327018.1874016.80770HepG2CKAP4
NUCB2ENSG00000070081.111667.815901057.864500.656708.065606.94340HepG2CPSF6
NUCB2ENSG00000070081.11638.13340886.03910-0.473506.737805.52540HepG2DDX19B
NUCB2ENSG00000070081.11600.13110849.12190-0.500704.229303.40860HepG2DDX21
NUCB2ENSG00000070081.111067.14840830.477300.361602.920401.97910HepG2DDX24
NUCB2ENSG00000070081.111310.960901043.260000.329402.054201.50630HepG2DDX3X
NUCB2ENSG00000070081.111114.52220850.454800.390002.793802.01760HepG2DDX55
NUCB2ENSG00000070081.111546.11010896.019400.786908.297107.28170HepG2DDX6
NUCB2ENSG00000070081.11730.93910916.54980-0.326503.018502.31470HepG2DKC1
NUCB2ENSG00000070081.11513.45470796.34660-0.6332010.294009.13380HepG2DNAJC2
NUCB2ENSG00000070081.111325.18490845.429000.648307.114805.33880HepG2EFTUD2
NUCB2ENSG00000070081.111181.00670781.533900.595504.374202.96870HepG2AGO1
NUCB2ENSG00000070081.11553.71140952.16600-0.782107.145806.11950HepG2EIF4A3
NUCB2ENSG00000070081.11669.56130926.91830-0.469202.468501.81700HepG2EIF4B
NUCB2ENSG00000070081.111004.012301377.31900-0.456106.333205.15720HepG2EIF4G1
NUCB2ENSG00000070081.112162.266701319.368900.712603.376102.48180HepG2EIF4G2
NUCB2ENSG00000070081.11915.078301282.09740-0.486506.838605.96360HepG2ETF1
NUCB2ENSG00000070081.11542.81180936.20930-0.7864010.554508.95660HepG2EWSR1
NUCB2ENSG00000070081.11672.389301059.69730-0.656302.458701.50630HepG2FTO
NUCB2ENSG00000070081.11849.37430562.746800.593805.999204.86380HepG2FUBP3
NUCB2ENSG00000070081.111582.979501136.406800.478102.859201.72680HepG2FUS
NUCB2ENSG00000070081.11412.89900811.18870-0.9742013.1258011.89080HepG2HNRNPA1
NUCB2ENSG00000070081.111674.420101283.007800.384005.530304.28870HepG2HNRNPA2B1
NUCB2ENSG00000070081.11687.79450902.28090-0.391602.834902.13390HepG2HNRNPC
NUCB2ENSG00000070081.11835.532601055.73160-0.337503.628502.81620HepG2HNRNPF
NUCB2ENSG00000070081.111175.54440902.020600.382002.868002.15620HepG2HNRNPK
NUCB2ENSG00000070081.11881.686401144.36950-0.376202.603101.98900HepG2HNRNPLL
NUCB2ENSG00000070081.11598.59960896.31670-0.582408.470207.45080HepG2HNRNPU
NUCB2ENSG00000070081.111301.48860619.484201.0709012.7362010.21640HepG2HSPD1
NUCB2ENSG00000070081.11738.685701039.59310-0.493005.408404.42960HepG2IGF2BP1
NUCB2ENSG00000070081.11540.88100905.81900-0.743907.204306.16620HepG2IGF2BP2
NUCB2ENSG00000070081.11806.69260488.011700.725005.734703.92720HepG2KHDRBS1
NUCB2ENSG00000070081.111045.64670618.946100.756404.408402.82400HepG2KRR1
NUCB2ENSG00000070081.111116.98900841.205500.409003.723802.40700HepG2LARP7
NUCB2ENSG00000070081.11987.55420712.501300.470903.894302.00420HepG2MARK2
NUCB2ENSG00000070081.11604.95030966.20960-0.675505.569804.70020HepG2MATR3
NUCB2ENSG00000070081.111277.91910945.610800.434404.239303.24900HepG2MSI2
NUCB2ENSG00000070081.111174.18130793.977400.564406.569404.72210HepG2NAA15
NUCB2ENSG00000070081.11701.54820989.00050-0.495403.504302.79570HepG2NCBP2
NUCB2ENSG00000070081.11930.76620587.000400.665003.119801.60070HepG2NKRF
NUCB2ENSG00000070081.111162.812101384.27420-0.251501.982301.33400HepG2NOL12
NUCB2ENSG00000070081.111068.97330468.220301.1909010.130308.39290HepG2PABPC1
NUCB2ENSG00000070081.111132.87280887.220800.352503.939102.94820HepG2PARN
NUCB2ENSG00000070081.111091.69780918.211100.249602.298101.73490HepG2PCBP1
NUCB2ENSG00000070081.11327.93820656.33810-1.001007.954806.66830HepG2PRPF8
NUCB2ENSG00000070081.11765.71680934.34310-0.287102.377901.86420HepG2PTBP1
NUCB2ENSG00000070081.111079.919201321.43690-0.291202.093901.56510HepG2PUF60
NUCB2ENSG00000070081.111137.987001402.79390-0.301804.091603.40030HepG2PUM1
NUCB2ENSG00000070081.111912.070301401.750400.447804.017403.21440HepG2PUM2
NUCB2ENSG00000070081.11482.11840975.77450-1.0172024.8208023.31850HepG2PUS1
NUCB2ENSG00000070081.11680.760501011.85500-0.571806.897005.97610HepG2QKI
NUCB2ENSG00000070081.11494.053801071.59830-1.1170023.7428022.52330HepG2RBM22
NUCB2ENSG00000070081.111231.73870918.346700.423502.553501.90260HepG2RBM25
NUCB2ENSG00000070081.11530.52250823.67980-0.634704.215402.90200HepG2RCC2
NUCB2ENSG00000070081.11761.226001039.81010-0.449905.171104.46940HepG2NELFE
NUCB2ENSG00000070081.11401.915901137.29800-1.5006032.1816030.42540HepG2RPLP0
NUCB2ENSG00000070081.11425.90240801.01170-0.9113012.3382011.15280HepG2RPS19
NUCB2ENSG00000070081.11621.93240935.52740-0.589004.928803.87990HepG2RPS2
NUCB2ENSG00000070081.11475.97200649.28180-0.448002.016201.33530HepG2RRP9
NUCB2ENSG00000070081.112306.21600798.219401.5306087.5514084.91120HepG2SAFB2
NUCB2ENSG00000070081.11850.023301132.68480-0.414203.386502.61270HepG2SF3B1
NUCB2ENSG00000070081.112422.243801260.315800.942504.843503.79630HepG2SNRNP70
NUCB2ENSG00000070081.11512.399501210.33450-1.2401037.0888035.80330HepG2SRFBP1
NUCB2ENSG00000070081.11704.440201218.81510-0.790907.222605.54550HepG2SRSF3
NUCB2ENSG00000070081.111042.083501304.76280-0.324303.633102.93390HepG2SRSF5
NUCB2ENSG00000070081.11717.872201037.22520-0.530907.752906.68440HepG2SRSF7
NUCB2ENSG00000070081.11990.09560826.043400.261302.100901.60620HepG2SRSF9
NUCB2ENSG00000070081.111183.309401483.84360-0.326504.264903.52250HepG2SUCLG1
NUCB2ENSG00000070081.111288.48160788.952000.7076010.955409.19960HepG2SUPT6H
NUCB2ENSG00000070081.111484.067501115.474300.411803.560502.75060HepG2TARDBP
NUCB2ENSG00000070081.111021.23290838.563600.284202.204701.45590HepG2TIA1
NUCB2ENSG00000070081.11382.56690871.00130-1.1870022.6728021.50020HepG2TIAL1
NUCB2ENSG00000070081.11699.33870999.36040-0.515004.198503.43270HepG2U2AF1
NUCB2ENSG00000070081.11690.074801799.13620-1.382504.191502.96390HepG2U2AF2
NUCB2ENSG00000070081.11864.192901366.57540-0.661106.143904.86920HepG2UBE2L3
NUCB2ENSG00000070081.11291.33560500.22510-0.779904.403803.44520HepG2UCHL5
NUCB2ENSG00000070081.111449.880301209.012600.262003.004702.28280HepG2UPF1
NUCB2ENSG00000070081.111720.834901242.717700.469507.663106.02450HepG2UTP18
NUCB2ENSG00000070081.11973.894101167.25870-0.261302.676502.08760HepG2UTP3
NUCB2ENSG00000070081.111433.964501020.804900.490202.828901.55120HepG2XRCC5
NUCB2ENSG00000070081.11581.47820833.47700-0.519402.870502.13180HepG2XRN2
NUCB2ENSG00000070081.113026.600102647.898800.192802.291601.76730K562AGGF1
NUCB2ENSG00000070081.111055.424801553.07170-0.557305.852905.05380K562AQR
NUCB2ENSG00000070081.113719.901702890.906400.363605.628204.27190K562ATP5C1
NUCB2ENSG00000070081.111548.800901215.907000.349002.564701.72570K562BOP1
NUCB2ENSG00000070081.114077.635703164.409900.365704.879403.27310K562CCDC124
NUCB2ENSG00000070081.112140.304201567.801400.449003.176801.79160K562CIRBP
NUCB2ENSG00000070081.111208.201502014.85400-0.737804.780603.33390K562CNOT7
NUCB2ENSG00000070081.111643.673501292.865000.346303.395402.52340K562CPSF6
NUCB2ENSG00000070081.11933.54230638.980400.546803.714002.20020K562EEF2
NUCB2ENSG00000070081.114017.364501079.436801.89590122.23570119.38480K562EIF2S2
NUCB2ENSG00000070081.11871.44800549.560500.665005.488303.12110K562FAM120A
NUCB2ENSG00000070081.11849.999601308.52310-0.622408.359407.37810K562FXR1
NUCB2ENSG00000070081.112194.345701396.407400.652005.053304.03210K562G3BP2
NUCB2ENSG00000070081.111571.421701234.373500.348203.013202.18580K562GPKOW
NUCB2ENSG00000070081.111116.43840889.450500.327802.576601.99760K562HNRNPC
NUCB2ENSG00000070081.114779.823101508.278501.6640056.7258053.98110K562HSPD1
NUCB2ENSG00000070081.113544.731002924.037400.277602.628301.82700K562KIF1C
NUCB2ENSG00000070081.113662.009402799.000900.387604.680403.17320K562MAK16
NUCB2ENSG00000070081.11928.560601204.88390-0.375803.172502.23160K562METAP2
NUCB2ENSG00000070081.111027.583901299.04110-0.338204.883303.93140K562NSUN2
NUCB2ENSG00000070081.112007.908001476.269600.443603.530601.46670K562PABPC4
NUCB2ENSG00000070081.111018.360901367.99010-0.425803.009001.99190K562PCBP2
NUCB2ENSG00000070081.113374.004102295.929400.555307.499705.67140K562PUM1
NUCB2ENSG00000070081.112761.010902248.997900.295803.177902.14910K562PUM2
NUCB2ENSG00000070081.113890.529902732.509500.509606.215905.44160K562PUS1
NUCB2ENSG00000070081.111105.919701432.55140-0.373302.407601.62730K562RBM22
NUCB2ENSG00000070081.111119.775301507.44040-0.428903.148001.97430K562NELFE
NUCB2ENSG00000070081.11881.57620612.021300.526403.884802.91570K562RPS19
NUCB2ENSG00000070081.11863.238801240.89350-0.523503.301402.19930K562RPS3
NUCB2ENSG00000070081.11899.51140614.334700.550003.467301.96520K562RRP9
NUCB2ENSG00000070081.11942.956701452.22310-0.623009.630507.98610K562SF3B4
NUCB2ENSG00000070081.111549.170002378.18140-0.618402.575601.33840K562SFPQ
NUCB2ENSG00000070081.111110.084301313.34500-0.242602.502501.60690K562SRPK2
NUCB2ENSG00000070081.111011.547101464.12470-0.533504.836003.90590K562SRSF1
NUCB2ENSG00000070081.11875.990501198.11960-0.451802.500501.50740K562SRSF4
NUCB2ENSG00000070081.111679.625401398.108500.264602.341701.60370K562U2AF2
NUCB2ENSG00000070081.112116.833801377.405100.6199015.5662014.02540K562UPF1
NUCB2ENSG00000070081.111640.162601171.557500.485304.079302.61190K562UTP3
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for NUCB2 is not available on ENCORE database.





16 RBPs can affect the splicing of NUCB2 :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SENUCB2ENSG00000070081.11chr11+1733693217337022173335741733366717351673173518440.132000.000000.00046includedK562MATR3
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.109000.000010.00082excludedK562AKAP8L
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.083000.001960.04668excludedHepG2HNRNPK
SENUCB2ENSG00000070081.11chr11+173127861731291217304335173044901731687017317014-0.068000.001070.02843excludedHepG2HNRNPK
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.089000.000540.03731excludedHepG2AKAP1
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.136000.000000.00001excludedK562PUS1
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.134000.000130.03964excludedHepG2EFTUD2
SENUCB2ENSG00000070081.11chr11+1730818017308264173043351730449017316870173170140.230000.000030.00996includedHepG2HNRNPA1
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.218000.001290.06156excludedK562EFTUD2
SENUCB2ENSG00000070081.11chr11+173127861731291217304335173044901731687017317014-0.095000.000070.00291excludedHepG2SRSF1
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.072000.000150.01793excludedK562HNRNPUL1
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.092000.000400.01688excludedK562UTP18
SENUCB2ENSG00000070081.11chr11+173369321733702217333574173336671735167317351844-0.110000.000020.00101excludedK562RBM15
SENUCB2ENSG00000070081.11chr11+173127861731291217304335173044901731687017317014-0.089000.000590.01812excludedK562RBM15
SENUCB2ENSG00000070081.11chr11+1731278617312912173043351730449017316870173170140.182000.000220.01319includedHepG2HNRNPU
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516731735184417333574173336671735244817352530-0.154000.002320.032732includedK562DROSHA
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516731735184417333574173336671735244817352530-0.090000.003180.049622includedK562PUS1
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516021735184417333574173336671735244817352530-0.103000.006510.044752includedK562AQR
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516731735184417333574173336671735244817352530-0.095000.015940.091872includedK562AQR
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516361735184417333574173336671735244817352530-0.103000.007780.051622includedK562AQR
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516731735184417333574173336671735244817352530-0.259000.000000.000862includedHepG2DROSHA
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516731735184417333574173336671735244817352530-0.168000.000090.006272includedK562DDX55
MXENUCB2ENSG00000070081.11chr11+17336932173370221735167317351844173335741733366717352448173525300.142000.002560.049861includedK562SUPV3L1
MXENUCB2ENSG00000070081.11chr11+1733693217337022173516731735184417333574173336671735244817352530-0.160000.001690.033522includedK562HNRNPUL1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for NUCB2 is not avaliable on ENCORE database.