MTHFD2

General Information

Gene Name : MTHFD2
Gene ID : ENSG00000065911.11
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: MTHFD2)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	MTHFD2	ENSG00000065911.11	96.30	87.75	92.03	ENCSR000AEF
HepG2	MTHFD2	ENSG00000065911.11	80.42	108.30	94.36	ENCSR985KAT
K562	MTHFD2	ENSG00000065911.11	151.17	117.83	134.50	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

Proteins bound to RNA

MTHFD2 RNA is bound by 27 proteins.

CanvasJS.com

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

27 proteins are bound to MTHFD2 RNA:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr2	74441283	74441325	+	3'-UTR,CDS	3.55053	8.13949	K562	YBX3
chr2	74437175	74437231	+	3'-UTR,CDS,intron-Distal,intron-Proximal	4.99810	5.17615	K562	AQR
chr2	74441498	74441524	+	3'-UTR	3.88259	12.02478	K562	TIA1
chr2	74434926	74435001	+	3'-UTR,CDS,intron-Distal,intron-Proximal	3.51868	5.56806	HepG2	PRPF8
chr2	74442285	74442367	+	3'-UTR	5.28584	19.60667	HepG2	SUB1
chr2	74438957	74439016	+	3'-UTR,CDS,intron-Distal,intron-Proximal	4.22053	4.16174	HepG2	PRPF8
chr2	74441415	74441420	+	3'-UTR	3.58529	9.83933	K562	YBX3
chr2	74435761	74435833	+	3'-UTR,CDS,intron-Distal	4.53705	46.84741	K562	PUM2
chr2	74441566	74441629	+	3'-UTR	3.11908	4.95429	HepG2	IGF2BP3
chr2	74444558	74444640	+	3'-UTR	3.66771	6.19377	K562	KHSRP
chr2	74438867	74438974	+	3'-UTR,CDS,intron-Distal,intron-Proximal	5.33213	3.98311	K562	IGF2BP1
chr2	74438338	74438363	+	3'-UTR,CDS	4.08807	8.72318	K562	YBX3
chr2	74442134	74442199	+	3'-UTR	3.96991	10.61959	HepG2	FUBP3
chr2	74441455	74441492	+	3'-UTR	6.10623	10.65346	K562	PABPC4
chr2	74441395	74441409	+	3'-UTR	4.37773	39.67097	K562	YBX3
chr2	74441212	74441281	+	3'-UTR,CDS	3.46159	6.20035	HepG2	BCLAF1
chr2	74443210	74443231	+	3'-UTR	4.60392	6.75316	K562	YBX3
chr2	74437148	74437176	+	3'-UTR,CDS,intron-Distal	3.22057	7.41174	K562	YBX3
chr2	74441205	74441285	+	3'-UTR,CDS,intron-Proximal	3.16045	3.24162	HepG2	G3BP1
chr2	74441490	74441552	+	3'-UTR	4.31654	9.44359	HepG2	SUB1
chr2	74442159	74442198	+	3'-UTR	3.91519	6.93197	HepG2	SUB1
chr2	74441356	74441363	+	3'-UTR,CDS	3.02486	8.02777	K562	YBX3
chr2	74442082	74442141	+	3'-UTR	3.43695	7.64824	K562	TIA1
chr2	74437058	74437109	+	3'-UTR,CDS,intron-Distal,intron-Proximal	3.16958	6.58265	K562	GPKOW
chr2	74434945	74434954	+	3'-UTR,CDS,intron-Distal,intron-Proximal	4.10848	13.17475	K562	LIN28B
chr2	74444042	74444102	+	3'-UTR	4.12565	7.29826	K562	LIN28B
chr2	74435695	74435720	+	3'-UTR,CDS,intron-Distal,intron-Proximal	3.11539	8.53398	K562	LIN28B
chr2	74441281	74441353	+	3'-UTR,CDS	3.97102	7.01246	HepG2	BCLAF1
chr2	74434914	74434945	+	3'-UTR,CDS,intron-Distal	4.01592	13.96993	K562	LIN28B
chr2	74442038	74442121	+	3'-UTR	4.29679	3.04397	HepG2	TIA1
chr2	74442083	74442134	+	3'-UTR	4.55128	5.51967	HepG2	FUBP3
chr2	74442580	74442620	+	3'-UTR	4.66187	12.49410	K562	TIA1
chr2	74443690	74443720	+	3'-UTR	4.04520	8.28294	K562	YBX3
chr2	74441555	74441606	+	3'-UTR	3.20948	8.00779	HepG2	SUB1
chr2	74441336	74441356	+	3'-UTR,CDS	3.09382	8.65359	K562	YBX3
chr2	74441592	74441605	+	3'-UTR	3.64533	13.87251	K562	YBX3
chr2	74441561	74441629	+	3'-UTR	4.69340	8.92556	K562	IGF2BP1
chr2	74442160	74442211	+	3'-UTR	5.94672	16.93819	K562	TIA1
chr2	74442572	74442580	+	3'-UTR	5.04034	7.12263	K562	TIA1
chr2	74437068	74437148	+	3'-UTR,CDS,intron-Distal,intron-Proximal	3.56793	6.96594	HepG2	GRSF1
chr2	74441353	74441420	+	3'-UTR,CDS	3.27759	7.20615	HepG2	BCLAF1
chr2	74441363	74441370	+	3'-UTR,CDS	4.55081	44.94858	K562	YBX3
chr2	74441381	74441395	+	3'-UTR	4.45612	55.19753	K562	YBX3
chr2	74441258	74441357	+	3'-UTR,CDS	3.25312	3.92909	K562	GRWD1
chr2	74442016	74442076	+	3'-UTR	4.79614	3.01429	K562	IGF2BP1
chr2	74438324	74438376	+	3'-UTR,CDS,intron-Proximal	3.31867	5.15873	HepG2	IGF2BP1
chr2	74444389	74444432	+	3'-UTR	4.99471	4.77410	HepG2	SUB1
chr2	74441576	74441592	+	3'-UTR	3.39320	12.45510	K562	YBX3
chr2	74438927	74438991	+	3'-UTR,CDS,intron-Distal	3.58887	4.74886	HepG2	BCLAF1
chr2	74425860	74425904	+	5'-UTR,CDS,intron-Proximal	3.96928	6.20582	HepG2	PRPF8
chr2	74425866	74425869	+	5'-UTR,CDS	3.73763	14.96666	K562	YBX3
chr2	74425779	74425839	+	5'-UTR,CDS	3.01005	8.46568	K562	DDX3X
chr2	74425842	74425866	+	5'-UTR,CDS	3.75542	19.48629	K562	YBX3
chr2	74425778	74425822	+	5'-UTR,CDS	3.50390	29.45322	K562	YBX3
chr2	74425868	74425877	+	5'-UTR,CDS,intron-Proximal	3.13160	3.95292	K562	AQR
chr2	74432914	74432942	+	CDS,intron-Distal	3.44677	9.43411	K562	YBX3
chr2	74432952	74432970	+	CDS,intron-Distal	4.11306	22.29095	K562	YBX3
chr2	74433012	74433050	+	CDS,intron-Distal,intron-Proximal	6.40066	16.64887	HepG2	PRPF8
chr2	74432942	74432952	+	CDS,intron-Distal	3.86114	17.66001	K562	YBX3
chr2	74433003	74433015	+	CDS,intron-Distal	3.15251	8.45630	K562	YBX3
chr2	74432970	74432985	+	CDS,intron-Distal	3.95155	26.17428	K562	YBX3
chr2	74432983	74433012	+	CDS,intron-Distal	5.99204	14.91575	HepG2	PRPF8
chr2	74432831	74432839	+	CDS,intron-Distal,intron-Proximal	4.97949	18.09367	K562	YBX3
chr2	74432985	74433003	+	CDS,intron-Distal	3.43612	15.41633	K562	YBX3
chr2	74432839	74432855	+	CDS,intron-Distal	4.51964	16.96077	K562	YBX3
chr2	74434987	74435106	+	intron-Distal,intron-Proximal	4.61233	12.30245	HepG2	PCBP2
chr2	74425925	74426051	+	intron-Distal,intron-Proximal	3.66073	5.85821	K562	NONO
chr2	74426146	74426202	+	intron-Distal	3.14434	3.01436	K562	CSTF2T
chr2	74437202	74437247	+	intron-Distal,intron-Proximal	4.71480	4.68673	K562	RBM22
chr2	74439304	74439382	+	intron-Distal	3.84959	3.06084	HepG2	HNRNPK
chr2	74435484	74435560	+	intron-Distal	3.07709	3.31830	K562	KHSRP
chr2	74434989	74435096	+	intron-Distal,intron-Proximal	3.32183	3.38830	K562	ILF3
chr2	74433016	74433088	+	intron-Distal,intron-Proximal	4.81211	5.17615	K562	AQR
chr2	74439337	74439383	+	intron-Distal	4.44171	4.32196	HepG2	PCBP2
chr2	74441105	74441186	+	intron-Distal,intron-Proximal	5.01400	7.02918	K562	RBFOX2
chr2	74441086	74441184	+	intron-Distal,intron-Proximal	4.71330	4.53660	HepG2	KHSRP
chr2	74425916	74425993	+	intron-Distal,intron-Proximal	4.53021	5.48231	K562	DROSHA
chr2	74433092	74433158	+	intron-Distal,intron-Proximal	4.81139	9.99997	HepG2	U2AF2
chr2	74439289	74439337	+	intron-Distal	4.43215	4.59452	HepG2	PCBP2
chr2	74441089	74441162	+	intron-Distal,intron-Proximal	3.63780	7.81851	K562	KHSRP
chr2	74441061	74441089	+	intron-Distal	3.76403	5.78064	K562	KHSRP
chr2	74425910	74425953	+	intron-Proximal	4.28459	6.48405	K562	AQR
chr2	74425902	74425910	+	intron-Proximal	3.81083	3.49168	K562	AQR
chr2	74438418	74438497	+	intron-Proximal	4.19963	4.00320	K562	AQR
chr2	74425877	74425902	+	intron-Proximal	3.24438	4.60947	K562	AQR
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for MTHFD2 is not available on ENCORE database.
147 RBPs can affect the levels of MTHFD2.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

147 RBPs can affect the gene expression of MTHFD2 :

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
MTHFD2	ENSG00000065911.7	1173.29820	2370.74690	-1.01480	3.32910	2.29890	HepG2	ABCF1
MTHFD2	ENSG00000065911.7	1696.17110	1975.96440	-0.22030	2.65480	2.05720	HepG2	ACO1
MTHFD2	ENSG00000065911.7	2891.67480	1834.19830	0.65670	8.88420	7.22740	HepG2	ADAR
MTHFD2	ENSG00000065911.7	3240.52300	5695.46850	-0.81360	10.71190	9.73210	HepG2	AKAP1
MTHFD2	ENSG00000065911.7	2794.53790	3727.99770	-0.41580	3.40490	2.25930	HepG2	AKAP8
MTHFD2	ENSG00000065911.7	1537.41280	1985.30280	-0.36890	5.71050	4.64500	HepG2	AKAP8L
MTHFD2	ENSG00000065911.7	3104.09250	2141.40730	0.53550	2.87000	1.44070	HepG2	ATP5C1
MTHFD2	ENSG00000065911.7	2667.33100	6770.63010	-1.34390	24.76680	23.08810	HepG2	AUH
MTHFD2	ENSG00000065911.7	649.83720	1351.60050	-1.05650	10.98340	9.89420	HepG2	BOP1
MTHFD2	ENSG00000065911.7	2093.29190	5922.12630	-1.50030	7.14980	5.92370	HepG2	CNOT7
MTHFD2	ENSG00000065911.7	922.46720	1240.79550	-0.42770	3.13170	2.40570	HepG2	CPSF6
MTHFD2	ENSG00000065911.7	3180.33860	1953.78780	0.70280	4.70110	3.28980	HepG2	CPSF7
MTHFD2	ENSG00000065911.7	988.04010	1357.24850	-0.45800	4.63880	3.29130	HepG2	CSTF2
MTHFD2	ENSG00000065911.7	3609.44780	2896.78310	0.31720	4.71130	3.78330	HepG2	DAZAP1
MTHFD2	ENSG00000065911.7	1140.15170	1423.11310	-0.31980	2.56400	1.90740	HepG2	DDX21
MTHFD2	ENSG00000065911.7	2559.81130	1392.06290	0.87870	19.45020	17.27530	HepG2	DDX24
MTHFD2	ENSG00000065911.7	1478.25930	2021.69420	-0.45170	3.42610	2.00700	HepG2	DDX27
MTHFD2	ENSG00000065911.7	3596.86360	5456.03640	-0.60110	7.17060	6.20780	HepG2	DDX3X
MTHFD2	ENSG00000065911.7	936.87140	2161.01690	-1.20580	19.73690	17.95040	HepG2	DDX55
MTHFD2	ENSG00000065911.7	8588.84050	4686.35720	0.87390	12.81540	11.60200	HepG2	DDX6
MTHFD2	ENSG00000065911.7	1538.60580	1890.47950	-0.29710	2.14410	1.53610	HepG2	DKC1
MTHFD2	ENSG00000065911.7	3266.41020	1846.95050	0.82250	25.20370	23.31510	HepG2	DNAJC21
MTHFD2	ENSG00000065911.7	800.11270	1638.79370	-1.03440	16.83100	14.86460	HepG2	EEF2
MTHFD2	ENSG00000065911.7	2618.23100	1310.00380	0.99890	12.74110	10.56220	HepG2	AGO1
MTHFD2	ENSG00000065911.7	2576.42800	4505.59610	-0.80630	12.33540	11.14120	HepG2	EIF2S1
MTHFD2	ENSG00000065911.7	2954.87410	1799.47790	0.71540	7.30580	5.51580	HepG2	EIF2S2
MTHFD2	ENSG00000065911.7	2201.46570	4979.44900	-1.17750	21.19580	19.46360	HepG2	EIF4A3
MTHFD2	ENSG00000065911.7	6780.11260	4847.74260	0.48390	3.53320	2.76000	HepG2	EIF4B
MTHFD2	ENSG00000065911.7	3609.53300	2857.46650	0.33700	5.49000	4.37720	HepG2	EIF4G1
MTHFD2	ENSG00000065911.7	13447.57030	7774.22680	0.79050	29.64200	28.03470	HepG2	ETF1
MTHFD2	ENSG00000065911.7	1577.45790	1930.92880	-0.29170	2.50950	1.71320	HepG2	EWSR1
MTHFD2	ENSG00000065911.7	497.58760	1189.13400	-1.25690	14.26870	11.68260	HepG2	FAM120A
MTHFD2	ENSG00000065911.7	762.72780	1243.02080	-0.70460	2.82770	1.80160	HepG2	FTO
MTHFD2	ENSG00000065911.7	1342.38380	2311.50750	-0.78400	12.57600	10.95950	HepG2	FUBP3
MTHFD2	ENSG00000065911.7	693.23200	4660.26170	-2.74900	80.24390	76.94010	HepG2	G3BP1
MTHFD2	ENSG00000065911.7	3271.36270	4946.97500	-0.59670	7.57850	6.09090	HepG2	G3BP2
MTHFD2	ENSG00000065911.7	1561.88500	1184.33340	0.39910	2.17720	1.38900	HepG2	GEMIN5
MTHFD2	ENSG00000065911.7	1377.62860	2857.96480	-1.05280	6.24020	4.68640	HepG2	GNB2L1
MTHFD2	ENSG00000065911.7	1066.20300	1406.40850	-0.39950	2.79410	2.15020	HepG2	GPKOW
MTHFD2	ENSG00000065911.7	3358.58080	5481.44100	-0.70670	4.90420	3.42790	HepG2	GRSF1
MTHFD2	ENSG00000065911.7	3628.16880	1886.52030	0.94340	39.93590	37.01060	HepG2	HDGF
MTHFD2	ENSG00000065911.7	3139.53660	5003.89650	-0.67250	5.48700	3.48560	HepG2	HNRNPA0
MTHFD2	ENSG00000065911.7	2273.50330	2662.00950	-0.22760	2.51750	1.62140	HepG2	HNRNPA2B1
MTHFD2	ENSG00000065911.7	766.25670	2074.07130	-1.43660	37.84310	35.62430	HepG2	HNRNPC
MTHFD2	ENSG00000065911.7	1877.76010	2205.57760	-0.23210	2.56510	1.87340	HepG2	HNRNPF
MTHFD2	ENSG00000065911.7	2151.38300	4059.50510	-0.91600	11.93250	9.50360	HepG2	HSPD1
MTHFD2	ENSG00000065911.7	2952.27740	4737.18760	-0.68220	9.32500	8.16770	HepG2	IGF2BP2
MTHFD2	ENSG00000065911.7	760.02970	2104.58860	-1.46940	87.77170	84.82240	HepG2	ILF2
MTHFD2	ENSG00000065911.7	2279.91450	4764.55170	-1.06340	13.38370	11.07570	HepG2	KHSRP
MTHFD2	ENSG00000065911.7	3198.92310	1806.32020	0.82440	20.36480	17.94820	HepG2	KIF1C
MTHFD2	ENSG00000065911.7	2251.33120	4056.16930	-0.84930	9.30390	7.08290	HepG2	KRR1
MTHFD2	ENSG00000065911.7	1151.63900	2567.21500	-1.15650	16.65760	14.65180	HepG2	LARP4
MTHFD2	ENSG00000065911.7	1905.54290	2800.98410	-0.55570	2.76510	1.63030	HepG2	LARP7
MTHFD2	ENSG00000065911.7	2827.39900	5025.09280	-0.82970	12.78080	11.40910	HepG2	MAGOH
MTHFD2	ENSG00000065911.7	1009.63660	1392.08200	-0.46340	2.50640	1.50180	HepG2	METAP2
MTHFD2	ENSG00000065911.7	2364.02660	5172.46220	-1.12960	18.70450	17.15010	HepG2	NCBP2
MTHFD2	ENSG00000065911.7	2352.21360	2872.42010	-0.28820	2.06370	1.40230	HepG2	NOL12
MTHFD2	ENSG00000065911.7	985.92020	1984.96440	-1.00960	8.23950	6.30570	HepG2	NONO
MTHFD2	ENSG00000065911.7	1078.07100	4606.84820	-2.09530	60.19910	56.82700	HepG2	PABPC4
MTHFD2	ENSG00000065911.7	2658.42430	2039.40400	0.38230	6.78120	5.54710	HepG2	PARN
MTHFD2	ENSG00000065911.7	2869.42450	1837.67570	0.64280	15.08940	13.44670	HepG2	PPIL4
MTHFD2	ENSG00000065911.7	2287.39320	4700.56140	-1.03910	35.01090	33.50730	HepG2	PTBP1
MTHFD2	ENSG00000065911.7	2212.73740	2741.85140	-0.30930	3.16200	2.53100	HepG2	PUF60
MTHFD2	ENSG00000065911.7	4535.93140	2910.44990	0.64010	28.11090	26.61840	HepG2	PUM1
MTHFD2	ENSG00000065911.7	3983.14470	2908.41500	0.45360	6.87770	5.83770	HepG2	PUM2
MTHFD2	ENSG00000065911.7	3162.76930	5091.23640	-0.68680	12.61630	11.42370	HepG2	QKI
MTHFD2	ENSG00000065911.7	3702.13040	6497.68210	-0.81160	13.42650	12.45620	HepG2	RBM22
MTHFD2	ENSG00000065911.7	3241.88940	4620.46850	-0.51120	3.58050	2.82080	HepG2	RBM25
MTHFD2	ENSG00000065911.7	2406.65100	1552.66920	0.63220	4.51250	1.87240	HepG2	RBM34
MTHFD2	ENSG00000065911.7	710.51580	2312.35280	-1.70240	3.64800	1.74680	HepG2	RBM39
MTHFD2	ENSG00000065911.7	2328.24310	5231.43430	-1.16800	26.74730	25.41680	HepG2	NELFE
MTHFD2	ENSG00000065911.7	2977.94190	4872.07840	-0.71020	17.73790	16.39680	HepG2	RECQL
MTHFD2	ENSG00000065911.7	1765.81420	2854.87350	-0.69310	3.72370	1.31870	HepG2	RPL23A
MTHFD2	ENSG00000065911.7	927.32240	2375.85430	-1.35730	35.89620	34.07830	HepG2	RPLP0
MTHFD2	ENSG00000065911.7	664.96360	1529.67680	-1.20190	13.09280	11.21020	HepG2	RPS10
MTHFD2	ENSG00000065911.7	507.83290	1294.48040	-1.34990	28.73540	27.10570	HepG2	RPS19
MTHFD2	ENSG00000065911.7	1061.42960	3114.83260	-1.55310	10.12410	8.67750	HepG2	RPS2
MTHFD2	ENSG00000065911.7	2209.23820	5942.98470	-1.42760	14.46180	12.69540	HepG2	RPS3A
MTHFD2	ENSG00000065911.7	2033.39960	3179.90420	-0.64510	3.23300	2.06590	HepG2	RPS5
MTHFD2	ENSG00000065911.7	863.08100	1648.37640	-0.93350	12.75780	11.27320	HepG2	RRP9
MTHFD2	ENSG00000065911.7	2423.02600	1694.14270	0.51620	3.18190	1.54430	HepG2	RTF1
MTHFD2	ENSG00000065911.7	1224.50500	1834.84140	-0.58350	14.09120	12.80540	HepG2	SAFB2
MTHFD2	ENSG00000065911.7	8032.96770	5596.45840	0.52130	4.49630	2.83360	HepG2	SART3
MTHFD2	ENSG00000065911.7	3377.13550	5647.73710	-0.74190	5.07160	3.03340	HepG2	SBDS
MTHFD2	ENSG00000065911.7	914.51300	1298.99860	-0.50630	4.79000	3.56720	HepG2	SERBP1
MTHFD2	ENSG00000065911.7	1957.66810	1328.41140	0.55930	6.55760	5.50930	HepG2	SF3B1
MTHFD2	ENSG00000065911.7	3546.57160	1519.35410	1.22290	5.30530	3.16270	HepG2	SLTM
MTHFD2	ENSG00000065911.7	1424.99020	2139.73630	-0.58650	17.58120	16.17280	HepG2	SMN1
MTHFD2	ENSG00000065911.7	4128.66040	7338.65790	-0.82980	13.77070	12.87980	HepG2	SRFBP1
MTHFD2	ENSG00000065911.7	2797.00790	5108.38330	-0.86900	25.56340	24.44380	HepG2	SRSF1
MTHFD2	ENSG00000065911.7	5468.44470	4155.82000	0.39590	9.79840	8.87020	HepG2	SRSF9
MTHFD2	ENSG00000065911.7	1843.14230	6371.28220	-1.78940	41.08120	39.66170	HepG2	SSB
MTHFD2	ENSG00000065911.7	5235.98460	1455.41330	1.84690	27.36240	24.17800	HepG2	SUB1
MTHFD2	ENSG00000065911.7	4155.35410	3078.75890	0.43250	11.27870	10.16710	HepG2	SUCLG1
MTHFD2	ENSG00000065911.7	1315.52910	2151.07740	-0.70940	8.81160	7.71650	HepG2	SUPV3L1
MTHFD2	ENSG00000065911.7	7366.95050	4591.22120	0.68210	20.42310	19.09590	HepG2	TAF15
MTHFD2	ENSG00000065911.7	1804.18970	3972.42160	-1.13870	7.97720	6.26540	HepG2	TBRG4
MTHFD2	ENSG00000065911.7	1062.03600	1441.68110	-0.44090	3.75180	2.60980	HepG2	TFIP11
MTHFD2	ENSG00000065911.7	427.51730	2002.02820	-2.22740	100.20420	98.02230	HepG2	TIAL1
MTHFD2	ENSG00000065911.7	3981.37410	1563.64620	1.34830	19.69540	16.40770	HepG2	TRA2A
MTHFD2	ENSG00000065911.7	2065.57540	1056.91570	0.96660	12.23440	9.35670	HepG2	TROVE2
MTHFD2	ENSG00000065911.7	3281.63570	2678.43360	0.29290	2.72530	1.85860	HepG2	TUFM
MTHFD2	ENSG00000065911.7	3853.50980	2834.92260	0.44280	3.69810	2.72400	HepG2	UBE2L3
MTHFD2	ENSG00000065911.7	593.40910	1270.58350	-1.09840	17.86520	15.97360	HepG2	UCHL5
MTHFD2	ENSG00000065911.7	794.92700	1539.04920	-0.95310	16.24120	14.82290	HepG2	UPF1
MTHFD2	ENSG00000065911.7	954.74310	1969.24960	-1.04450	12.50230	10.29370	HepG2	UPF2
MTHFD2	ENSG00000065911.7	628.14450	1581.88200	-1.33250	27.43760	24.72430	HepG2	UTP18
MTHFD2	ENSG00000065911.7	2285.60610	1485.88220	0.62120	15.98870	14.72300	HepG2	UTP3
MTHFD2	ENSG00000065911.7	3178.99520	1531.31530	1.05370	12.12140	9.50810	HepG2	XRCC5
MTHFD2	ENSG00000065911.7	2792.76260	1712.64810	0.70540	5.99160	4.46990	HepG2	XRCC6
MTHFD2	ENSG00000065911.7	1216.42280	2117.50530	-0.79970	11.38560	9.93350	HepG2	XRN2
MTHFD2	ENSG00000065911.7	754.16710	2650.17810	-1.81310	16.55700	15.14510	HepG2	ZC3H8
MTHFD2	ENSG00000065911.7	2760.24350	1555.81520	0.82700	8.55360	6.17630	HepG2	ZRANB2
MTHFD2	ENSG00000065911.7	10646.85730	14550.35740	-0.45060	6.23490	5.22580	K562	AKAP8L
MTHFD2	ENSG00000065911.7	6040.81450	8560.58110	-0.50300	6.63680	5.79170	K562	AQR
MTHFD2	ENSG00000065911.7	12389.84100	15266.71990	-0.30120	4.82800	3.58580	K562	ATP5C1
MTHFD2	ENSG00000065911.7	4184.44970	4835.93900	-0.20880	2.53060	1.61480	K562	BCLAF1
MTHFD2	ENSG00000065911.7	1110.66690	1984.45870	-0.83730	7.02110	5.15720	K562	CCAR1
MTHFD2	ENSG00000065911.7	13676.09440	16711.17570	-0.28920	3.72870	2.33260	K562	CCDC124
MTHFD2	ENSG00000065911.7	6802.43630	8751.94920	-0.36360	3.92490	2.38820	K562	CIRBP
MTHFD2	ENSG00000065911.7	2728.91850	5169.55670	-0.92170	4.17690	2.82880	K562	CNOT7
MTHFD2	ENSG00000065911.7	4309.36130	5427.46190	-0.33280	5.66600	4.03360	K562	CPEB4
MTHFD2	ENSG00000065911.7	2137.05540	2598.09380	-0.28180	2.59830	1.83720	K562	CPSF6
MTHFD2	ENSG00000065911.7	4304.20660	5599.47120	-0.37950	4.89780	3.45900	K562	DDX3X
MTHFD2	ENSG00000065911.7	3562.32110	5615.40890	-0.65660	22.31100	20.63830	K562	DDX47
MTHFD2	ENSG00000065911.7	1249.41800	2221.40790	-0.83020	8.11340	5.66990	K562	DHX30
MTHFD2	ENSG00000065911.7	18333.09030	15657.58380	0.22750	3.26360	2.30240	K562	DKC1
MTHFD2	ENSG00000065911.7	1340.54460	2134.04200	-0.67080	5.86590	3.92360	K562	DNAJC21
MTHFD2	ENSG00000065911.7	2567.77410	4199.87680	-0.70980	7.00400	4.98060	K562	EEF2
MTHFD2	ENSG00000065911.7	2926.28360	4058.01590	-0.47170	5.13710	3.87280	K562	EFTUD2
MTHFD2	ENSG00000065911.7	6339.14090	5019.33520	0.33670	6.00270	5.00410	K562	EIF2S2
MTHFD2	ENSG00000065911.7	874.92540	2018.61500	-1.20610	8.60560	6.79890	K562	EIF3A
MTHFD2	ENSG00000065911.7	2966.19910	4345.09170	-0.55080	5.16270	3.69230	K562	EIF3D
MTHFD2	ENSG00000065911.7	2607.82280	6160.19500	-1.24010	18.18910	16.08430	K562	EIF3G
MTHFD2	ENSG00000065911.7	4207.33580	5850.00500	-0.47550	6.43400	5.19010	K562	EIF4A3
MTHFD2	ENSG00000065911.7	6677.23550	9092.47650	-0.44540	10.93890	9.12650	K562	EIF4G2
MTHFD2	ENSG00000065911.7	1976.09100	3612.18720	-0.87020	11.55810	8.53230	K562	FAM120A
MTHFD2	ENSG00000065911.7	1641.75530	2240.68430	-0.44870	3.95630	2.84740	K562	FTO
MTHFD2	ENSG00000065911.7	4240.83780	6083.74860	-0.52060	13.34060	12.11240	K562	FXR1
MTHFD2	ENSG00000065911.7	5886.22370	7807.09730	-0.40740	5.51850	3.41080	K562	G3BP1
MTHFD2	ENSG00000065911.7	8876.24500	6105.93790	0.53960	4.56110	3.60340	K562	G3BP2
MTHFD2	ENSG00000065911.7	2020.50480	2480.51420	-0.29590	2.18320	1.47610	K562	GPKOW
MTHFD2	ENSG00000065911.7	5111.20730	6688.86940	-0.38810	5.24910	4.20320	K562	GRSF1
MTHFD2	ENSG00000065911.7	1900.61340	4636.93610	-1.28670	8.04420	5.03230	K562	HNRNPA0
MTHFD2	ENSG00000065911.7	7432.69270	6019.30230	0.30420	3.47100	2.26270	K562	HNRNPA1
MTHFD2	ENSG00000065911.7	2027.60100	3759.07530	-0.89060	21.50190	19.91590	K562	HNRNPC
MTHFD2	ENSG00000065911.7	2233.18050	3357.17900	-0.58810	9.44320	7.28480	K562	HNRNPF
MTHFD2	ENSG00000065911.7	4223.47690	5074.98770	-0.26500	2.54800	1.53740	K562	HNRNPL
MTHFD2	ENSG00000065911.7	3821.15350	2922.53110	0.38670	2.67540	1.76010	K562	HNRNPM
MTHFD2	ENSG00000065911.7	7867.87360	6665.54270	0.23920	2.95000	2.02780	K562	HNRNPU
MTHFD2	ENSG00000065911.7	8982.78360	4816.55520	0.89910	20.03970	18.05000	K562	HSPD1
MTHFD2	ENSG00000065911.7	2571.52530	4715.56320	-0.87480	5.01570	3.05660	K562	ILF2
MTHFD2	ENSG00000065911.7	6550.65370	12718.47040	-0.95720	6.01510	2.82820	K562	LARP4
MTHFD2	ENSG00000065911.7	6664.19220	8582.06890	-0.36490	4.48200	3.40520	K562	MAGOH
MTHFD2	ENSG00000065911.7	6294.42180	8564.70550	-0.44430	6.78930	5.25790	K562	MATR3
MTHFD2	ENSG00000065911.7	1933.30300	2421.26960	-0.32470	3.19440	2.24950	K562	METAP2
MTHFD2	ENSG00000065911.7	7370.33230	9691.45300	-0.39500	4.71640	3.23940	K562	MSI2
MTHFD2	ENSG00000065911.7	2946.92280	4225.28380	-0.51980	7.70240	6.41390	K562	MTPAP
MTHFD2	ENSG00000065911.7	7878.94260	9946.15910	-0.33610	3.89510	2.10470	K562	NOL12
MTHFD2	ENSG00000065911.7	4607.00670	6456.49890	-0.48690	4.62590	2.26770	K562	PABPC4
MTHFD2	ENSG00000065911.7	4863.53980	7635.97260	-0.65080	12.07310	9.95180	K562	PCBP2
MTHFD2	ENSG00000065911.7	2080.55740	3554.91650	-0.77280	10.77240	9.13500	K562	PCBP3
MTHFD2	ENSG00000065911.7	11868.64910	9342.87690	0.34510	4.35100	2.59560	K562	PNPT1
MTHFD2	ENSG00000065911.7	1601.63260	2726.84750	-0.76770	14.92990	13.13620	K562	POLR2G
MTHFD2	ENSG00000065911.7	4850.41950	4033.56400	0.26600	2.18600	1.46070	K562	PPIG
MTHFD2	ENSG00000065911.7	3045.58730	3948.91190	-0.37470	3.48340	2.64060	K562	PRPF8
MTHFD2	ENSG00000065911.7	4801.02650	8337.99440	-0.79640	20.41620	18.68650	K562	PTBP1
MTHFD2	ENSG00000065911.7	6259.32990	9920.39860	-0.66440	12.72040	10.95790	K562	PUF60
MTHFD2	ENSG00000065911.7	7620.84950	10338.72110	-0.44000	10.97100	9.04960	K562	PUM2
MTHFD2	ENSG00000065911.7	8990.87460	14059.88350	-0.64510	19.24780	17.64820	K562	RBM15
MTHFD2	ENSG00000065911.7	7871.50530	6343.00120	0.31140	3.68530	1.81950	K562	RBM17
MTHFD2	ENSG00000065911.7	5420.39930	7995.30980	-0.56080	8.40120	6.82020	K562	RBM22
MTHFD2	ENSG00000065911.7	3900.94560	8413.74510	-1.10890	25.96380	22.81750	K562	NELFE
MTHFD2	ENSG00000065911.7	2223.98790	6066.45720	-1.44770	22.75490	19.23820	K562	RPS10
MTHFD2	ENSG00000065911.7	2282.57490	4022.54610	-0.81740	10.97890	9.32310	K562	RPS19
MTHFD2	ENSG00000065911.7	2726.12900	4609.27190	-0.75770	3.89680	2.00290	K562	RPS3A
MTHFD2	ENSG00000065911.7	2859.87750	6271.74560	-1.13290	12.97340	10.70450	K562	RPS3
MTHFD2	ENSG00000065911.7	1992.83090	4708.36490	-1.24040	6.35220	3.94520	K562	SBDS
MTHFD2	ENSG00000065911.7	2683.36210	4632.60150	-0.78780	18.35750	16.40840	K562	SF3A3
MTHFD2	ENSG00000065911.7	2279.52520	2915.51160	-0.35500	3.39860	2.23350	K562	SRFBP1
MTHFD2	ENSG00000065911.7	3539.76130	4746.24340	-0.42310	7.05420	5.63540	K562	SRPK2
MTHFD2	ENSG00000065911.7	3847.28040	8173.97970	-1.08720	37.16070	34.62730	K562	SRSF1
MTHFD2	ENSG00000065911.7	2636.45830	3823.64130	-0.53630	5.39380	3.93560	K562	SUPV3L1
MTHFD2	ENSG00000065911.7	4706.56700	8272.67550	-0.81370	15.08990	13.18110	K562	TARDBP
MTHFD2	ENSG00000065911.7	2084.38140	3241.79930	-0.63720	7.90100	6.25240	K562	TIAL1
MTHFD2	ENSG00000065911.7	1882.58010	4046.73290	-1.10400	23.61490	20.78300	K562	UCHL5
MTHFD2	ENSG00000065911.7	2934.32540	4977.54310	-0.76240	22.68400	20.87400	K562	UPF1
MTHFD2	ENSG00000065911.7	9003.67640	14630.47860	-0.70040	4.04200	2.38080	K562	UTP18
MTHFD2	ENSG00000065911.7	2943.46640	4429.23900	-0.58950	15.31270	13.53830	K562	WDR43
MTHFD2	ENSG00000065911.7	2913.38170	4120.51500	-0.50010	5.47210	3.56090	K562	XRN2
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

15 RBPs can affect the splicing of MTHFD2 :

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	p-value	FDR	is_included	Cell Line	Affected by RBP
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.08700	0.00005	0.00352	excluded	K562	PRPF8
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	0.05900	0.00132	0.07422	included	HepG2	RBM22
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.09200	0.00001	0.01206	excluded	K562	XRN2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74433108	74433215			74425741	74425869	74434830	74434953	0.31200	0.00002	0.00062	included	HepG2	U2AF1
SE	MTHFD2	ENSG00000065911.7	chr2	+	74433108	74433215			74425741	74425869	74434830	74434953	0.43000	0.00008	0.00160	included	HepG2	U2AF2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.07600	0.00041	0.03696	excluded	K562	SUPV3L1
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432797	74433016			74425688	74425869	74434830	74434953	-0.05100	0.00341	0.04637	excluded	K562	PUS1
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	0.06200	0.00013	0.01010	included	HepG2	SFPQ
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.10500	0.00000	0.00018	excluded	K562	EFTUD2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74433108	74433215			74432831	74433016	74434830	74434953	0.05700	0.00000	0.00000	included	K562	U2AF1
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	0.06100	0.00089	0.08893	included	HepG2	HNRNPUL1
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.09800	0.00000	0.00139	excluded	K562	SBDS
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.11700	0.00017	0.02316	excluded	HepG2	SUPV3L1
SE	MTHFD2	ENSG00000065911.7	chr2	+	74433108	74433215			74432831	74433016	74434830	74434953	0.07100	0.00000	0.00000	included	K562	U2AF2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.08500	0.00001	0.00085	excluded	K562	TARDBP
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.18600	0.00000	0.00000	excluded	K562	HNRNPU
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.12300	0.00022	0.07283	excluded	HepG2	XRN2
SE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016			74425742	74425869	74434830	74434953	-0.19200	0.00000	0.00000	excluded	HepG2	HNRNPU
A3SS	MTHFD2	ENSG00000065911.7	chr2	+	74435670	74435848			74435695	74435848	74434830	74434953	0.07200	0.00000	0.00000	longer	K562	AQR
MXE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016	74437068	74437176	74425742	74425869	74438325	74438418	-0.08800	0.00254	0.07559	2included	HepG2	TAF15
MXE	MTHFD2	ENSG00000065911.7	chr2	+	74432831	74433016	74433108	74433215	74425741	74425869	74434830	74434953	-0.05900	0.00000	0.00000	2included	K562	U2AF2

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

MTHFD2

General Information

Functions

Localization

Domains (AlphaFold: MTHFD2)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

27 proteins are bound to MTHFD2 RNA:

eCLIP assay for MTHFD2 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

147 RBPs can affect the gene expression of MTHFD2 :

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not available on ENCORE database.

15 RBPs can affect the splicing of MTHFD2 :

The Knockdown/knockout RNA-Seq assay for MTHFD2 is not avaliable on ENCORE database.