DCP1A

General Information

Gene Name       : DCP1A
Gene ID             : ENSG00000272886.5
Essential Gene : No

Functions

Localization

Domains (AlphaFold: DCP1A)


Antibody Validation

 View validation images for all DCP1A antibodies

Expression Level in Cell lines

Cell Line Gene Name Ensembl ID Rep1 TPM Rep2 TPM Average TPM Experiment ID
Gm12878DCP1AENSG00000272886.510.1910.8210.50ENCSR000AEF
HepG2DCP1AENSG00000272886.511.1112.0211.56ENCSR985KAT
K562DCP1AENSG00000272886.510.918.999.95ENCSR000AEO

Assays

1 Released experiments are available on ENCORE database.

Assay TypeExp_NameENCODE IDTarget labelBiosampleStatusLinked AntibodyControlsMethodNote
knockdown followed by RNA-seq DCP1A-BGKcLV28-K562ENCSR911ITTDCP1AK562ReleasedENCSR220DTX   CRISPRKD% = 68.7,70.6






  eCLIP  

No eCLIP experiment available



  Antibody Validation  
  GeneName    Antibody_DCC_ID    Product_ID    Lot_ID    Phosphate    HepG2 Primary Validation    K562 Primary Validation    HepG2 Secondary Validation    K562 Secondary Validation  
DCP1AENCAB935HMJA303-590A1Released, ENCODE4BGKcLV28-61, Released, ENCODE4
DCP1AENCAB984AGCA303-591A1Released, ENCODE4BGKcLV28-61, Released, ENCODE4


  KD RNA-Seq  
  GeneName    Cell_Line    Method    Exp_ID    Control_ID    Sample_reps    Control_reps    KD%    Status    Project    Note  
DCP1AK562CRISPRENCSR911ITTENCSR220DTXDCP1A-BGKcLV28-61,DCP1A-BGKcLV28-62NT-BGKcLV28-1,NT-BGKcLV28-268.7,70.6ReleasedENCODE4
DCP1AHepG2CRISPRBGHcLV29-61,BGHcLV29-62BGHcLV29-1,BGHcLV29-2no clear band,NotSatisfiedENCODE4
DCP1AHepG2CRISPRBGHcLV34-21,BGHcLV34-22BGHcLV34-1,BGHcLV34-20.0,0.0NotSatisfiedENCORE2


  RNA Bind-n-Seqn  

No RBNS experiment available



  Localization Image in HepG2  

No Localization Information available













RBP Antibody InfoPrimary-HepG2Secondary-HepG2Primary-K562Secondary-K562Primary-UBERONPrimary-Hela
DCP1AProduct_ID: A303-590A
Lot_ID: 1
Source: Bethyl Labs
Target Name: DCP1A-human		 Bethyl_A303-590A_1_DCP1A.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the DCP1A specific antibody, A303-590A. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the DCP1A-specific antibody, A303-590A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 DCP1A-K562-CRISPR-A303-590A.png<br>Caption: Western blot following CRISPR against DCP1A in K562 whole cell lysate using DCP1A specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DCP1A. DCP1A protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.
DCP1AProduct_ID: A303-591A
Lot_ID: 1
Source: Bethyl Labs
Target Name: DCP1A-human		 Bethyl_A303-591A_1_DCP1A.png<br>Caption: IP-WB analysis of K562 whole cell lysate using the DCP1A specific antibody, A303-591A. Lanes 1 and 2 are 2.5% of five million whole cell lysate input and 50% of IP enrichment, respectively, using a normal IgG antibody. Lane 3 is 50% of IP enrichment from five million whole cell lysate using the DCP1A-specific antibody, A303-591A. The same antibody was used to detect protein levels via Western blot. This antibody passes preliminary validation and will be further pursued for secondary validation. *NOTE* Protein sizes are taken from Genecards.org and are only estimates based on sequence. Actual protein size may differ based on protein characteristics and electrophoresis method used.
 DCP1A-K562-CRISPR-A303-591A.png<br>Caption: Western blot following CRISPR against DCP1A in K562 whole cell lysate using DCP1A specific antibody. Lane 1 is a ladder, lane 2 is K562 non-targeting control knockdown, lane 3 and 4 are two different CRISPR against DCP1A. DCP1A protein appears as the green arrow, GAPDH serves as a control and appears in red arrow.








RNA Targets

  • eCLIP assay for DCP1A is not avaliable on ENCORE database.



Proteins bound to RNA
  • DCP1A RNA is bound by 21 proteins.  







eCLIP assay for DCP1A is not avaliable on ENCORE database.





21 proteins are bound to DCP1A RNA:

Chr Start End Strand Matched Area log2(fold change) -log(p-value) Cell Line Binding Protein Name
chr35332094353321010-3'-UTR,intron-Distal5.172577.71000K562FAM120A
chr35332088653320941-3'-UTR,intron-Distal4.171146.81876K562UPF1
chr35332108153321129-3'-UTR,intron-Distal4.473184.07810K562UPF1
chr35332079853320844-3'-UTR,intron-Distal4.199433.54010K562UPF1
chr35331999553320081-3'-UTR,intron-Distal4.691335.29571HepG2FUBP3
chr35332048353320552-3'-UTR,intron-Distal3.523835.75036K562PUM2
chr35332030653320465-3'-UTR,intron-Distal4.2251010.46383HepG2FUBP3
chr35332097753320996-3'-UTR,intron-Distal4.429157.12652K562UPF1
chr35331920753319276-3'-UTR,intron-Distal3.876855.15345K562UPF1
chr35332094153320977-3'-UTR,intron-Distal4.796629.43510K562UPF1
chr35332090553321012-3'-UTR,intron-Distal4.089457.03532HepG2UPF1
chr35332673453326805-CDS,intron-Distal3.086923.84771K562ZNF622
chr35334635253346410-CDS,intron-Distal,intron-Proximal3.437704.13746HepG2PPIG
chr35337624553376309-CDS,intron-Distal,intron-Proximal4.773296.08664K562BUD13
chr35332226753322302-CDS,intron-Distal,intron-Proximal3.575633.02850K562YBX3
chr35335346953353522-CDS,intron-Distal,intron-Proximal4.484863.77802HepG2U2AF2
chr35332618053326246-CDS,intron-Distal4.240403.81597K562RBM15
chr35338137953381473-CDS,intron-Distal3.073673.17635HepG2PPIG
chr35337886053378996-CDS,intron-Distal,intron-Proximal5.308245.69951K562AQR
chr35332604953326135-CDS,intron-Distal,intron-Proximal4.880857.02967HepG2PRPF8
chr35334627053346352-CDS,intron-Distal,intron-Proximal3.953164.96634HepG2PPIG
chr35338139553381412-CDS,intron-Distal5.220538.04585HepG2PRPF8
chr35337894753379015-CDS,intron-Distal,intron-Proximal5.298914.90235K562SF3B4
chr35332656653326633-CDS,intron-Distal,intron-Proximal4.328305.16886HepG2IGF2BP1
chr35338143553381491-CDS,intron-Distal3.753094.25541HepG2GRWD1
chr35332638853326546-CDS,intron-Distal4.331135.24403K562IGF2BP2
chr35334632653346436-CDS,intron-Distal,intron-Proximal3.095573.65461K562BUD13
chr35332659553326707-CDS,intron-Distal,intron-Proximal4.944457.23707K562RBM15
chr35332672653326855-CDS,intron-Distal3.304815.39266HepG2GRWD1
chr35334620953346271-intron-Distal,intron-Proximal3.831154.89208K562AQR
chr35338135353381395-intron-Distal5.384769.40852HepG2PRPF8
chr35333358153333722-intron-Distal4.345625.62258K562KHSRP
chr35338136053381410-intron-Distal5.260145.69951K562AQR
chr35334240053342482-intron-Distal5.9539666.75274HepG2DKC1
chr35332752953327576-intron-Distal4.838054.33458HepG2XPO5
chr35332842053328495-intron-Distal3.774485.42334HepG2QKI
chr35338136253381410-intron-Distal3.901033.96535HepG2AQR
chr35332491853324998-intron-Distal,intron-Proximal4.613524.17759HepG2QKI
chr35332520253325300-intron-Distal4.178978.59560HepG2HNRNPL
ChrStartEndStrandMatched Arealog2(fold change)-log(p-value)Cell LineBinding Protein Name




eCLIP assay for DCP1A is not avaliable on ENCORE database.



Diffrential Expression

  • The Knockdown/knockout assay for DCP1A is not available on ENCORE database.

  • 116 RBPs can affect the levels of DCP1A.  








The Knockdown/knockout RNA-Seq assay for DCP1A is not available on ENCORE database.





116 RBPs can affect the gene expression of DCP1A :

Gene NameGene IDKDMeanCNMeanlog2(fold change) *-log(pval) **-log(padj) **Cell LineAffected by RBPBound by RBP
DCP1AENSG00000162290.12916.237901342.64860-0.551304.629603.43700HepG2ABCF1
DCP1AENSG00000162290.12640.416601027.25770-0.6817012.9014011.79120HepG2ACO1
DCP1AENSG00000162290.12711.96870913.47030-0.359502.361801.43810HepG2ADAR
DCP1AENSG00000162290.12366.223201501.31900-2.0354042.2865040.56400HepG2AKAP1
DCP1AENSG00000162290.12969.096501390.47090-0.520904.325903.03410HepG2AKAP8
DCP1AENSG00000162290.12761.379801032.03510-0.438805.524904.47530HepG2AKAP8L
DCP1AENSG00000162290.12559.328001242.20470-1.1511017.5402015.75890HepG2ASCC1
DCP1AENSG00000162290.121180.065201396.69830-0.243202.416401.76600HepG2AUH
DCP1AENSG00000162290.12438.52970769.65490-0.811507.373605.80350HepG2BCCIP
DCP1AENSG00000162290.12653.801201005.74720-0.621307.223805.30830HepG2BUD13
DCP1AENSG00000162290.12893.721801180.18340-0.401102.901002.10910HepG2CIRBP
DCP1AENSG00000162290.12764.280901026.97560-0.426206.025805.11350HepG2CKAP4
DCP1AENSG00000162290.12849.175901281.46550-0.593703.475002.61050HepG2CNOT7
DCP1AENSG00000162290.12761.41980936.74700-0.299002.497201.53330HepG2YBX3
DCP1AENSG00000162290.12339.33940475.31880-0.486203.209002.05560HepG2CSTF2
DCP1AENSG00000162290.121595.868801330.506400.262303.368902.56560HepG2DAZAP1
DCP1AENSG00000162290.12472.43000950.03920-1.0079025.7276023.82490HepG2DDX19B
DCP1AENSG00000162290.12677.21690836.10900-0.304101.924201.34630HepG2DDX21
DCP1AENSG00000162290.12640.45680818.13110-0.353202.626401.73810HepG2DDX24
DCP1AENSG00000162290.121083.271401438.12690-0.408802.959102.31480HepG2DDX3X
DCP1AENSG00000162290.12627.91370826.83550-0.397003.059101.63550HepG2DDX52
DCP1AENSG00000162290.12859.206201235.43510-0.523903.975003.24530HepG2DDX6
DCP1AENSG00000162290.12684.14330982.79200-0.522606.892505.91440HepG2DKC1
DCP1AENSG00000162290.12621.97960911.68680-0.551708.986807.89160HepG2DNAJC2
DCP1AENSG00000162290.12760.74850986.58520-0.375002.331801.48340HepG2EEF2
DCP1AENSG00000162290.12520.93150822.53150-0.659006.024204.38780HepG2EFTUD2
DCP1AENSG00000162290.12421.55850769.87830-0.868907.539505.75110HepG2AGO1
DCP1AENSG00000162290.12551.422301187.59980-1.1068015.6882014.34800HepG2EIF2S1
DCP1AENSG00000162290.12752.195401312.41130-0.803008.408907.29560HepG2EIF4A3
DCP1AENSG00000162290.121827.853301277.866400.516303.412102.65080HepG2EIF4B
DCP1AENSG00000162290.121001.681901257.38820-0.328002.338301.58640HepG2EIF4G2
DCP1AENSG00000162290.121050.387301603.61050-0.6104011.9663010.85800HepG2ETF1
DCP1AENSG00000162290.12688.081901003.76210-0.544805.834204.61990HepG2EWSR1
DCP1AENSG00000162290.12425.27720715.75170-0.751109.210607.04860HepG2FAM120A
DCP1AENSG00000162290.12892.380301244.73960-0.480103.463201.60560HepG2FMR1
DCP1AENSG00000162290.121019.79430762.284900.419803.429602.55750HepG2FUBP3
DCP1AENSG00000162290.12669.623201109.57930-0.728605.570504.02550HepG2FUS
DCP1AENSG00000162290.121054.112801324.24700-0.329102.138501.52650HepG2FXR1
DCP1AENSG00000162290.12700.340301228.39170-0.810608.922807.76380HepG2G3BP1
DCP1AENSG00000162290.12594.03670980.70130-0.7233013.2708011.38830HepG2HDGF
DCP1AENSG00000162290.12736.752601083.95790-0.557103.577902.00510HepG2HNRNPA0
DCP1AENSG00000162290.12541.00470928.64090-0.779509.434308.34530HepG2HNRNPA1
DCP1AENSG00000162290.12822.685401032.93480-0.328302.256401.62370HepG2HNRNPC
DCP1AENSG00000162290.12894.620401243.95480-0.475604.161003.31890HepG2HNRNPK
DCP1AENSG00000162290.12742.86150935.23330-0.332202.594501.67190HepG2HNRNPM
DCP1AENSG00000162290.12461.739301026.10610-1.1520030.2993028.47940HepG2HNRNPU
DCP1AENSG00000162290.12765.011101514.25060-0.9851011.359008.96710HepG2HSPD1
DCP1AENSG00000162290.12999.955701248.61850-0.320401.993601.41120HepG2IGF2BP2
DCP1AENSG00000162290.12681.466601048.13460-0.6211012.6943011.24960HepG2ILF2
DCP1AENSG00000162290.12898.134301221.40690-0.443502.799001.60100HepG2KHDRBS1
DCP1AENSG00000162290.12835.210401255.92450-0.588504.247302.98030HepG2KHSRP
DCP1AENSG00000162290.121047.651501704.31580-0.702006.401205.12460HepG2LARP4
DCP1AENSG00000162290.12622.96550850.19300-0.448602.831501.68530HepG2LARP7
DCP1AENSG00000162290.12638.84550892.99620-0.483203.051601.77630HepG2LIN28B
DCP1AENSG00000162290.121009.224501324.70960-0.392402.755202.10190HepG2MAGOH
DCP1AENSG00000162290.12754.704501332.11100-0.819708.728307.65850HepG2MATR3
DCP1AENSG00000162290.12786.524301434.85380-0.867308.033505.65360HepG2NKRF
DCP1AENSG00000162290.121076.785501319.32560-0.293102.693701.94060HepG2NOL12
DCP1AENSG00000162290.121102.71910846.890100.380702.773602.02370HepG2NSUN2
DCP1AENSG00000162290.12804.034101015.67760-0.337103.492702.55120HepG2PARN
DCP1AENSG00000162290.12438.54720662.33930-0.594805.824304.06950HepG2PKM
DCP1AENSG00000162290.12718.73040915.20580-0.348603.233402.44210HepG2PPIL4
DCP1AENSG00000162290.12646.802901259.40180-0.9613016.4517015.16340HepG2PUF60
DCP1AENSG00000162290.12781.083001336.89910-0.7753021.2327019.90160HepG2PUM1
DCP1AENSG00000162290.121601.979701321.682900.277402.553801.94960HepG2QKI
DCP1AENSG00000162290.121478.357101013.765200.544202.721102.02180HepG2RAVER1
DCP1AENSG00000162290.12882.540901340.31870-0.602809.460408.63170HepG2RBM22
DCP1AENSG00000162290.121674.550601199.517800.481205.683904.74890HepG2RBM25
DCP1AENSG00000162290.121011.640501358.15590-0.425005.675904.94460HepG2NELFE
DCP1AENSG00000162290.121003.324501264.94800-0.334303.773803.06890HepG2RECQL
DCP1AENSG00000162290.12548.19190779.30160-0.507504.417703.65910HepG2RPS19
DCP1AENSG00000162290.12591.79500945.53240-0.676005.630004.51300HepG2RPS2
DCP1AENSG00000162290.12867.316501287.12250-0.569503.938802.98530HepG2RPS3A
DCP1AENSG00000162290.12488.30510782.20650-0.679805.021603.76540HepG2SERBP1
DCP1AENSG00000162290.121891.910701392.441600.442102.149701.55430HepG2SF3A3
DCP1AENSG00000162290.121466.55720945.405400.633307.589406.47250HepG2SF3B1
DCP1AENSG00000162290.121396.834501207.546300.210002.170601.53620HepG2SLBP
DCP1AENSG00000162290.12528.472901065.64790-1.0118028.2366026.53610HepG2SMN1
DCP1AENSG00000162290.12697.415301033.15090-0.567003.775002.64320HepG2SMNDC1
DCP1AENSG00000162290.12808.729501326.19130-0.7136014.6074013.70340HepG2SRSF1
DCP1AENSG00000162290.121382.305201017.221100.442302.755401.75670HepG2SRSF3
DCP1AENSG00000162290.121031.789801243.46200-0.269202.754602.12950HepG2SRSF5
DCP1AENSG00000162290.121424.873401078.931600.401106.079105.31780HepG2SRSF9
DCP1AENSG00000162290.12919.679501414.17070-0.6208013.3701012.17260HepG2SUCLG1
DCP1AENSG00000162290.12716.675401192.04640-0.7340012.5324011.46850HepG2TAF15
DCP1AENSG00000162290.12684.12270997.07840-0.543506.174405.48060HepG2TIAL1
DCP1AENSG00000162290.12377.870101005.96520-1.4126041.9592040.09990HepG2TRIM56
DCP1AENSG00000162290.121593.214401159.585500.458203.720702.99540HepG2U2AF1
DCP1AENSG00000162290.12318.32630444.95920-0.483202.956802.17480HepG2UCHL5
DCP1AENSG00000162290.121049.506401269.29500-0.274302.717801.67770HepG2UTP18
DCP1AENSG00000162290.12854.612301152.89760-0.431902.416401.40180HepG2XPO5
DCP1AENSG00000162290.12456.29160741.53800-0.700606.407705.31950HepG2XRN2
DCP1AENSG00000162290.12658.078301060.27170-0.6881013.6450012.34080HepG2ZC3H8
DCP1AENSG00000162290.121695.425101358.135100.319905.214904.52380HepG2ZNF622
DCP1AENSG00000162290.12858.23060642.063200.418603.218601.93100K562AARS
DCP1AENSG00000162290.121046.378301434.38510-0.455006.603305.78130K562AGGF1
DCP1AENSG00000162290.12347.30570694.26560-0.9993017.0468013.63880K562AKAP1
DCP1AENSG00000162290.121269.642301576.19320-0.312002.390701.48730K562AKAP8
DCP1AENSG00000162290.12859.874801492.54780-0.7956011.8268010.34730K562AKAP8L
DCP1AENSG00000162290.122241.800901215.476900.8830015.3227014.09410K562AQR
DCP1AENSG00000162290.121267.781001566.05160-0.304803.019802.06680K562ATP5C1
DCP1AENSG00000162290.12587.40580752.11720-0.356603.096502.08380K562BCLAF1
DCP1AENSG00000162290.121346.026401714.15230-0.348803.441802.10760K562CCDC124
DCP1AENSG00000162290.122261.705501837.943700.299203.222002.17140K562CELF1
DCP1AENSG00000162290.12978.511301682.92680-0.7823011.206208.41800K562DDX19B
DCP1AENSG00000162290.12548.11730703.51520-0.360102.492901.50670K562DDX3X
DCP1AENSG00000162290.121730.889401389.337200.317003.985103.22270K562DDX47
DCP1AENSG00000162290.12365.10740700.01980-0.939106.543603.47950K562AGO1
DCP1AENSG00000162290.12710.55120875.85750-0.301802.481301.79330K562EIF2S2
DCP1AENSG00000162290.121146.28440735.024400.641007.680206.31310K562EIF4A3
DCP1AENSG00000162290.12856.30360661.952900.371303.586302.24230K562EIF4B
DCP1AENSG00000162290.12678.89400969.72370-0.514404.609903.49520K562FIP1L1
DCP1AENSG00000162290.12652.07250887.80310-0.445203.145202.16660K562FTO
DCP1AENSG00000162290.12933.51830764.398700.288302.494101.91300K562FXR1
DCP1AENSG00000162290.12696.22190914.19600-0.393003.195301.63070K562G3BP1
DCP1AENSG00000162290.12790.993301167.19830-0.561306.015504.89600K562GRSF1
DCP1AENSG00000162290.12480.30830797.65120-0.731806.339904.84410K562HNRNPM
DCP1AENSG00000162290.12678.76680930.12260-0.454504.835803.64480K562HNRNPU
DCP1AENSG00000162290.12774.078301314.68400-0.764209.964008.48360K562HSPD1
DCP1AENSG00000162290.121172.512201583.94840-0.433904.081103.05250K562KIF1C
DCP1AENSG00000162290.12932.73710680.338300.455103.896002.19430K562LARP7
DCP1AENSG00000162290.12928.101901243.74480-0.422302.405401.59620K562NAA15
DCP1AENSG00000162290.121226.941301536.03790-0.324102.922001.44330K562PNPT1
DCP1AENSG00000162290.12864.052901100.88530-0.349502.382901.62340K562PPIG
DCP1AENSG00000162290.121930.117301631.055900.242802.045401.34340K562PUF60
DCP1AENSG00000162290.12816.410401480.16150-0.8584012.7733011.65230K562PUS1
DCP1AENSG00000162290.12962.639901442.22460-0.583208.717107.69110K562RBM15
DCP1AENSG00000162290.12776.19260574.703400.433503.506702.39360K562RCC2
DCP1AENSG00000162290.121360.360701038.338500.389604.659103.62390K562SF3A3
DCP1AENSG00000162290.12928.58130760.278200.288402.164701.40870K562SF3B4
DCP1AENSG00000162290.12760.83970968.66150-0.348402.347301.69310K562TARDBP
DCP1AENSG00000162290.12446.35670643.64480-0.528104.064702.87230K562TRIM56
DCP1AENSG00000162290.121105.281801440.39980-0.382103.503602.04250K562WRN
DCP1AENSG00000162290.121114.433401369.13560-0.297002.154301.40330K562ZC3H8
Gene NameGene IDKDMeanCNMeanlog2(fold change)-log(pval)-log(padj)Cell LineAffected by RBPBound by RBP

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".






The Knockdown/knockout RNA-Seq assay for DCP1A is not available on ENCORE database.





2 RBPs can affect the splicing of DCP1A :

Event TypeGene NameGene IDchrStrandExonStartExonEnd2ndExonStart2ndExonEndupstreamESupstreamEEdownstreamESdownstreamEEdPSIp-valueFDRis_includedCell LineAffected by RBPBound by RBP
SEDCP1AENSG00000162290.12chr3-533382065333832053326098533268575334627053346409-0.178000.001980.02175excludedK562AQR
SEDCP1AENSG00000162290.12chr3-533534335335350053346270533464095337617053376298-0.053000.003120.04317excludedK562PUS1

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".





The Knockdown/knockout RNA-Seq assay for DCP1A is not avaliable on ENCORE database.