TOP1

General Information

Gene Name : TOP1
Gene ID : ENSG00000198900.5
Essential Gene : Yes

Functions

Not Available

Localization

Not Available

Domains (AlphaFold: TOP1)

Not Available

Antibody Validation

Not Avaiable

Expression Level in Cell lines

Cell Line	Gene Name	Ensembl ID	Rep1 TPM	Rep2 TPM	Average TPM	Experiment ID
Gm12878	TOP1	ENSG00000198900.5	100.35	87.35	93.85	ENCSR000AEF
HepG2	TOP1	ENSG00000198900.5	53.75	92.99	73.37	ENCSR985KAT
K562	TOP1	ENSG00000198900.5	73.32	85.73	79.53	ENCSR000AEO

Assays

0 Released experiments are available on ENCORE database.

eCLIP

No eCLIP experiment available

Antibody Validation

No Antibody Primary Validation image or Secondary image available

KD RNA-Seq

No KD RNA-Seq experiment available

RNA Bind-n-Seqn

No RBNS experiment available

Localization Image in HepG2

No Localization Information available

RBP	Antibody Info	Primary-HepG2	Secondary-HepG2	Primary-K562	Secondary-K562	Primary-UBERON	Primary-Hela

Summary
Proteins Bound to RBP RNA

RNA Targets

eCLIP assay for TOP1 is not avaliable on ENCORE database.

Proteins bound to RNA

TOP1 RNA is bound by 46 proteins.

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eCLIP assay for TOP1 is not avaliable on ENCORE database.

46 proteins are bound to TOP1 RNA:

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Search:

Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name
chr20	39722047	39722182	+	intron-Distal	5.36981	74.97786	HepG2	PCBP2
chr20	39729848	39729936	+	CDS,intron-Proximal	4.59401	44.23423	K562	UCHL5
chr20	39721111	39721161	+	CDS,intron-Proximal	4.44540	37.34663	K562	UCHL5
chr20	39728767	39728825	+	CDS	4.46979	37.31811	K562	UCHL5
chr20	39721161	39721218	+	CDS	4.78564	36.75567	K562	UCHL5
chr20	39728765	39728853	+	CDS	4.19511	33.70174	K562	ZNF622
chr20	39721150	39721214	+	CDS	3.71921	31.78497	K562	ZNF622
chr20	39721154	39721218	+	CDS	5.25660	31.33478	HepG2	BCLAF1
chr20	39706245	39706276	+	CDS	5.96811	30.74869	K562	UCHL5
chr20	39726891	39726963	+	CDS	4.75713	29.85421	K562	UCHL5
Chr	Start	End	Strand	Matched Area	log2(fold change)	-log(p-value)	Cell Line	Binding Protein Name

Showing 1 to 10 of 265 entries

eCLIP assay for TOP1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout assay for TOP1 is not available on ENCORE database.
103 RBPs can affect the levels of TOP1.

CanvasJS.com

The Knockdown/knockout RNA-Seq assay for TOP1 is not available on ENCORE database.

103 RBPs can affect the gene expression of TOP1 :

Show entries

Search:

Gene Name	Gene ID	KDMean	CNMean	log2(fold change) *	-log(pval) **	-log(padj) **	Cell Line	Affected by RBP	Bound by RBP
TOP1	ENSG00000198900.5	5781.78150	3527.09050	0.71290	31.02900	29.82170	HepG2	SRSF1
TOP1	ENSG00000198900.5	2183.11340	3481.08940	-0.67320	22.22580	20.62490	HepG2	HNRNPU
TOP1	ENSG00000198900.5	2045.49720	3473.04240	-0.76370	19.98840	18.55740	HepG2	DKC1
TOP1	ENSG00000198900.5	1963.03970	3382.36630	-0.78490	19.23760	18.13670	HepG2	TIAL1
TOP1	ENSG00000198900.5	7570.81090	4874.29150	0.63520	19.10390	17.99220	HepG2	RBM22
TOP1	ENSG00000198900.5	7770.37860	5505.34540	0.49710	17.77370	16.79520	HepG2	SRFBP1
TOP1	ENSG00000198900.5	1963.28170	3170.53670	-0.69150	17.58390	16.34490	HepG2	TAF15
TOP1	ENSG00000198900.5	2662.74900	4587.21370	-0.78470	17.39160	15.97830	K562	HNRNPC
TOP1	ENSG00000198900.5	2852.19980	4819.55220	-0.75680	16.00860	14.73510	HepG2	PUF60
TOP1	ENSG00000198900.5	4663.68850	3245.77860	0.52280	14.97930	13.90350	HepG2	PTBP1
Gene Name	Gene ID	KDMean	CNMean	log2(fold change)	-log(pval)	-log(padj)	Cell Line	Affected by RBP	Bound by RBP

Showing 1 to 10 of 114 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

The Knockdown/knockout RNA-Seq assay for TOP1 is not available on ENCORE database.

1 RBPs can affect the splicing of TOP1 :

Show entries

Search:

Event Type	Gene Name	Gene ID	chr	Strand	ExonStart	ExonEnd	2ndExonStart	2ndExonEnd	upstreamES	upstreamEE	downstreamES	downstreamEE	dPSI	is_included	Cell Line	Affected by RBP
SE	TOP1	ENSG00000198900.5	chr20	+	39725465	39725653			39721090	39721227	39725859	39725981	0.10100	included	K562	AQR
A3SS	TOP1	ENSG00000198900.5	chr20	+	39750605	39750795			39750645	39750795	39750335	39750430	0.07400	longer	K562	AQR
MXE	TOP1	ENSG00000198900.5	chr20	+	39721090	39721227	39725465	39725653	39713075	39713208	39725859	39725981	-0.16000	2included	K562	AQR
MXE	TOP1	ENSG00000198900.5	chr20	+	39721051	39721227	39725465	39725653	39713075	39713208	39725859	39725981	-0.15600	2included	K562	AQR
MXE	TOP1	ENSG00000198900.5	chr20	+	39721069	39721227	39725465	39725653	39713075	39713208	39725859	39725981	-0.16000	2included	K562	AQR
MXE	TOP1	ENSG00000198900.5	chr20	+	39721111	39721227	39725465	39725653	39713075	39713208	39725859	39725981	-0.07200	2included	K562	AQR

Showing 1 to 6 of 6 entries

*: "Inf" was shown as "99999.99999" and "-Inf" was shown as "-99999.99999".
**: "-log(0)" was displayed as "99999.99999".

TOP1

General Information

Functions

Localization

Domains (AlphaFold: TOP1)

Antibody Validation

Expression Level in Cell lines

Assays

RNA Targets

Proteins bound to RNA

eCLIP assay for TOP1 is not avaliable on ENCORE database.

46 proteins are bound to TOP1 RNA:

eCLIP assay for TOP1 is not avaliable on ENCORE database.

Diffrential Expression

The Knockdown/knockout RNA-Seq assay for TOP1 is not available on ENCORE database.

103 RBPs can affect the gene expression of TOP1 :

The Knockdown/knockout RNA-Seq assay for TOP1 is not available on ENCORE database.

1 RBPs can affect the splicing of TOP1 :

The Knockdown/knockout RNA-Seq assay for TOP1 is not avaliable on ENCORE database.